Abstract:
:We determined the extent and duration of activation of coagulation during the first 24 hours after carotid endarterectomy. Serial blood samples were collected before, during and after surgery from 10 patients with severe stenosis (> 70%) undergoing carotid endarterectomy with heparinization. Platelet poor plasmas prepared from these samples, were analysed for activated prothrombin fragment F1 + 2 and thrombin-antithrombin III (TAT) levels, using commercially available ELISA kits. F1 + 2 and TATs were measured as indices of thrombin generation and inhibition respectively. Baseline F1 + 2 and TAT levels were 1.19 +/- 0.27 nMol/ml and 17 +/- 10 pMol/ml, respectively. Neither the F1 + 2 nor TAT level increased during surgery at a time when the patients were heparinized. However, both the F1 + 2 and TAT levels increased significantly within 3 hours after surgery and after the heparin had been neutralized with protamine, (p < 0.01). Moreover, both the F1 + 2 and TAT levels remained elevated in 75% of the patients for at least 24 hours, p < 0.01. We conclude that i) thrombin generation is significant post surgery in patients undergoing carotid endarterectomy despite their receiving heparin during surgery; ii) heparin may not be the ideal anticoagulant for carotid endarterectomy; and iii) persistent thrombin generation may contribute to early post-endarterectomy ischemic events.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Wells J,Nicosia S,Wale C,Smith LJ,Buchanan MRdoi
10.1016/0049-3848(94)90257-7subject
Has Abstractpub_date
1994-08-15 00:00:00pages
419-26issue
4eissn
0049-3848issn
1879-2472pii
0049-3848(94)90257-7journal_volume
75pub_type
杂志文章abstract:INTRODUCTION:Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS:Thrombi removed by t...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.02.004
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:Plasminogen activator inhibitor (PAI-1) may have an independent prognostic value in breast cancer (BC). PAI-1 4G/5G polymorphism may have significance for antigen expression. Thus, we analyzed the possible associations between PAI-1 4G/5G polymorphism, plasma PAI-1 levels, and clinicopathological features ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2009.02.014
更新日期:2009-09-01 00:00:00
abstract::Cancer-associated arterial thrombotic events (ATEs) are increasingly recognized in specific malignancies and in association with the expanding armamentarium of novel chemotherapeutic agents. The improved cancer survival led to cardiovascular complications becoming clinically relevant many years after cancer diagnosis....
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.01.003
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION:Plasma viscosity (PV) constitutes an independent important predictor of initial and recurrent cardiac events and mortality. It has been suggested that there is a geographical variation in PV values related to coronary event rates. Little information exists regarding PV in Spain. Therefore, our objective wa...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2006.11.009
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Unicompartmental knee arthroplasty (UKA) has increased due to potential favourable complication rates when compared to total knee arthroplasty (TKA). Although venous thromboembolism (VTE) is a well-documented complication after TKA limited data is available after UKA and mostly presented as secondary findi...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2020.07.002
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether the administration of multiple boluses of oral and intravenous tranexamic acid (TXA) postoperatively was equivalent in reducing blood loss in primary THA. METHODS:A total of 108 patients were randomized into two groups: oral TXA group (54 patients receiving...
journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.thromres.2018.02.007
更新日期:2018-04-01 00:00:00
abstract::The effect of extracellular matrix components on lipopolysaccharide-induced vascular endothelial cell injury was studied by using lipopolysaccharide-susceptible bovine aortic endothelial cells. For evaluation of lipopolysaccharide-induced injury, we estimated DNA synthesis and cell detachment of bovine aortic endothel...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(99)00226-1
更新日期:2000-04-15 00:00:00
abstract:INTRODUCTION:Aspirin is a common antiplatelet drug used in the prevention of ischemic stroke due to its inhibitory effect on platelet cyclooxygenase-1 (Cox-1). Patients can be categorized as either aspirin 'responders' or 'non-responders' depending on whether they are protected against a secondary stroke event or not. ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2003.12.005
更新日期:2003-01-01 00:00:00
abstract::A tritium-labelled low molecular weight heparin fragment with an average molecular weight of 4000-6000 (Fragmin), was fractionated into its high and low affinity forms for antithrombin. The fractions obtained were injected into rabbits, and the plasma half-life (t1/2) volume of distribution (Vd), area under the curve ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90345-8
更新日期:1987-10-01 00:00:00
abstract::[3H]-Platelet activating factor (Paf-acether, 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) binds to washed human platelets in a specific, dose-dependent, and saturable manner. Scatchard analysis reveals a high affinity site with a KD value of 0.25 +/- 0.033 nM (245 +/- 30 sites per platelet), and a second low a...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90233-1
更新日期:1986-01-15 00:00:00
abstract::To compare Canola a terrestrial (n-3) oil with fish oil (n-3) and common vegetable oil (n-6) in decreasing serum lipids and platelet aggregation, various oils were included in Chow-based diets and fed to rats in an eight-weeks feeding trial. The Chow diet contained 2% cholesterol along with either Canola, menhaden, sa...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90420-h
更新日期:1990-08-01 00:00:00
abstract::Washed human platelets were incubated with commercial factor VIII concentrate, or with purified factor VIII coagulant moiety. Platelets were then washed again and lysed by sonication. VIII:Ag and vWf:Ag were measured in the platelet lysate prior to and after incubation of the lysate with phospholipase C (PL-C). Platel...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90223-4
更新日期:1987-02-15 00:00:00
abstract::The use of oral contraceptives (OCs) has been associated with vascular complications. The mechanism(s) by which OCs predispose to thrombotic events remains unclear. Recent studies have demonstrated that postmenopausal (PM) women who take estrogen replacement therapy (ERT) have a decreased incidence of myocardial infar...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(93)90043-n
更新日期:1993-01-15 00:00:00
abstract::Twenty-five men and 26 women were studied to investigate the effects of acute strenuous exercise on hemostasis after obtaining their informed consent. After familiarization, they performed exercise on a bicycle ergometer at 75% of their predetermined maximal workload until exhaustion. Bleeding time, measured by the Si...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90058-3
更新日期:1989-08-15 00:00:00
abstract::In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfuncti...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.10.006
更新日期:2013-01-01 00:00:00
abstract::Although significant advances in hemophilia treatment have improved patient outcomes and quality of life, one of the greatest complications in severe hemophilia A is the development of anti-Factor VIII (FVIII) antibodies that inhibit FVIII activity in almost 30% of previously untreated patients (PUPs). Inhibitors make...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2018.05.027
更新日期:2018-08-01 00:00:00
abstract::This study evaluates the role of neutrophil granulocytes in mediating acute phase stimulation of fibrinogen synthesis. Turpentine was administered to neutropenic and non-neutropenic rats and fibrinogen synthetic rates measured in an isolated liver perfusion system. Using the (14C) carbonate technique for the measureme...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90032-9
更新日期:1982-10-01 00:00:00
abstract::Although effective therapies for haemophilia have been available for decades, the prevention and treatment of joint disease remain major clinical concerns for all haemophilia patients. Early identification of joint disease is vital to initiate or modify treatment, and prevent arthropathy. However, there remains a need...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2014.02.015
更新日期:2014-06-01 00:00:00
abstract:INTRODUCTION:Coagulation factor XIII (FXIII) is a fibrin-stabilizing factor, which contributes to hemostasis, wound healing, and maintenance of pregnancy. Accordingly, patients with congenital FXIII deficiency manifest a life-long bleeding tendency, abnormal wound healing and recurrent miscarriage. In order to understa...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2012.05.003
更新日期:2012-09-01 00:00:00
abstract::Antiphospholipid antibodies (APAs) are considered risk factors in patients with thromboembolic diseases. Although the incidence of such acquired coagulation disturbances in adults are well described, only few data exist for children. Therefore, in a first step to collect new data we analyzed the presence of different ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(99)00241-8
更新日期:2000-05-15 00:00:00
abstract::We report an inbred family with two cases of homozygous protein C deficiency and review 11 other such cases. Both patients presented in the second half of their first year of life with recurrent rapidly disappearing ecchymotic skin lesions, disseminated intravascular coagulation, and venous thrombosis. Successful trea...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/0049-3848(89)90202-8
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS:Patients with newly diagnosed cancer ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.08.001
更新日期:2017-10-01 00:00:00
abstract::The specific thromboxane A2/prostaglandin H2 (TXA2/PGH2) antagonist 13-azaprostanoic acid (13-APA) reverses platelet aggregation stimulated by TXA2/PGH2 and the prostaglandin endoperoxide analog U46619. The present report demonstrates that the deaggregatory properties of 13-APA are potentiated by prostacyclin (PGI2). ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90097-4
更新日期:1982-12-15 00:00:00
abstract::A semi-synthetic 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine (alkylacetyl-GPC) was shown to be highly species selective in its capacity to cause platelet aggregation and serotonin release. No effects were elicited on the rat or mouse platelets while platelets from human, dog, cat, rabbit, guinea pig and horse were ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90234-1
更新日期:1982-02-15 00:00:00
abstract::Several inflammatory particles (zymosan, two forms of asbestos, carrageenan) and the soluble inflammatory agent dextran sulphate induced a dose- and time-dependent increase in thromboplastin activity of cultured human monocytes. Two weakly inflammatory particles (latex and anatase) had little effect. The increase larg...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90227-x
更新日期:1983-05-15 00:00:00
abstract:INTRODUCTION:In reconstructive head and neck cancer surgery, tissue flaps are transferred to the surgical defect and revascularized by anastomosis of small vessels. Cancer patients are in a hypercoagulable state with high risk of peri- and postoperative thrombotic events. Thrombosis to the tissue flap anastomoses or mi...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/S0049-3848(16)30195-5
更新日期:2016-04-01 00:00:00
abstract::Activated platelets secrete different chemokines, among others CCL5, thereby triggering inflammatory cell recruitment into the vessel wall. Here, we investigated how CCL5 deficiency influences vascular remodeling processes. Experiments were performed in apolipoprotein E and CCL5 double deficient (ApoE(-/-)×CCL5(-/-)) ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2016.06.013
更新日期:2016-08-01 00:00:00
abstract::The effect of a low molecular weight heparin (Fragmin) (20-80 U/kg) was studied in 10 healthy male volunteers after intravenous administration. Clotting abnormalities are extensive shortly after injection, lasting for 1-2 hours depending on heparin dosage. Dilute thrombin time, showing a close correlation to anti-F-Xa...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(88)90257-5
更新日期:1988-03-15 00:00:00
abstract:INTRODUCTION:Unfractionated heparin (UFH) potentiates platelet aggregation induced by some agonists. P2Y12 and P2Y1 receptors play a major role in amplifying platelet aggregation. We assessed the ability of cangrelor, a selective P2Y12 antagonist, A2P5P, a selective P2Y1 antagonist, and aspirin to block the potentiatin...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2004.09.004
更新日期:2005-01-01 00:00:00
abstract::Fasting plasma homocysteine level and the related clinical findings were analysed in 240 consecutive patients with venous thromboembolism. Hyperhomocysteinemia, defined as a plasma level above 20 micromol/l (corresponding to the percentile 95th in the controls), was present in 11.2% of the patients. Plasma homocystein...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(02)00096-8
更新日期:2002-04-15 00:00:00