Discovering novel risk factors for venous thrombosis: a candidate-gene approach.

abstract：INTRODUCTION:Proteasome inhibitor bortezomib (PS-341) has been the first proteasome inhibitor that has entered clinical trials with its antiproliferative and proapoptotic effects in patients with multiple myeloma. Recent studies indicate that proteasome inhibitors can be useful in prevention of experimental arterial th...

journal_title：Thrombosis research

authors： Avcu F,Ural AU,Cetin T,Nevruz O

更新日期：2008-01-01 00:00:00

abstract：:Antithrombotic activity of ten pyrazolo pyrimidine derivatives was tested in mouse pulmonary thromboembolism model. Out of these compounds, Thiopurinol (C5H4N4S) showed dose-dependent protection in mice from death/paralysis induced by collagen + adrenaline. It also caused dose-dependent inhibition of thrombus formatio...

journal_title：Thrombosis research

authors： Srivastava R,Mishra A,Pratap R,Bhakuni DS,Srimal RC

更新日期：1989-06-15 00:00:00

abstract：:The present study has evaluated the effect of some newly synthesized triphenylethylene (TPE) analogs on platelet arachidonic acid metabolism and function. All compounds tested inhibited arachidonic acid induced platelet aggregation and several were superior to aspirin in their relative potency. Introduction of a carbo...

journal_title：Thrombosis research

authors： Rao GH,John V,Hill TD,Vennerstrom JL,White JG,Holmes TJ Jr

更新日期：1986-11-15 00:00:00

abstract：:Clinically unsuspected pulmonary embolism (UPE) is frequently diagnosed in cancer patients undergoing routine computed tomography scans for staging purposes or treatment response evaluation. The reported incidence of UPE ranges from 1% to 5% which probably represents an underestimation. A significant proportion of can...

journal_title：Thrombosis research

authors： van Es N,Bleker SM,Di Nisio M

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Ductal carcinoma in-situ (DCIS) is a preinvasive breast cancer where cancer cells remain confined within the ductal basement membrane. However, genotypic changes have been identified in stroma surrounding DCIS, outside the basement membrane. Stromal fibroblasts undergo phenotypic change in cancer to promot...

journal_title：Thrombosis research

authors： Shaker H,Bundred NJ,Albadry H,Nicholson S,Castle J,Lumsden LJ,Pritchard S,Landberg G,Kirwan CC

更新日期：2016-04-01 00:00:00

abstract：:We previously reported that the expression of thrombomodulin on the MEG-01, a cell line from human megakaryoblastic leukemia, was increased by agents that increase intracellular cAMP. In this paper we examine the effect of these agents on cultured human umbilical vein endothelial cells (HUVEC) and mouse hemangioma cel...

journal_title：Thrombosis research

authors： Maruyama I,Soejima Y,Osame M,Ito T,Ogawa K,Yamamoto S,Dittman WA,Saito H

更新日期：1991-02-01 00:00:00

abstract：:Severe bleeding took place in a patient when abdominal aneurysm was removed by operation. Bleeding continued after infusion of heparin, antithrombin III (ATIII), fresh platelets and fresh blood. Infusion of tranexamic acid resulted in an immediate cessation of bleeding and improvement of his general condition. Sometim...

journal_title：Thrombosis research

authors： Takada A,Takada Y,Mori T,Sakaguchi S

更新日期：1990-04-15 00:00:00

abstract：INTRODUCTION:A fraction of fibrinogen molecules contain an alternatively spliced variant chain called gamma'. Plasma levels of this variant have been associated with both myocardial infarction and venous thrombosis. Because clot structure has been associated with cardiovascular risk, we examined the effect of gamma' ch...

journal_title：Thrombosis research

authors： Gersh KC,Nagaswami C,Weisel JW,Lord ST

更新日期：2009-07-01 00:00:00

abstract：:The specific thromboxane A2/prostaglandin H2 (TXA2/PGH2) antagonist 13-azaprostanoic acid (13-APA) reverses platelet aggregation stimulated by TXA2/PGH2 and the prostaglandin endoperoxide analog U46619. The present report demonstrates that the deaggregatory properties of 13-APA are potentiated by prostacyclin (PGI2). ...

journal_title：Thrombosis research

authors： Parise LV,Venton DL,Le Breton GC

更新日期：1982-12-15 00:00:00

abstract：BACKGROUND:Advances in medical and surgical therapy in children have resulted in increased survival in children with primary illnesses. However, thrombosis is a serious complication of this success and results in mortality and morbidity. Prevention or treatment of thrombosis using warfarin is challenging in children du...

journal_title：Thrombosis research

authors： Bauman ME,Black K,Kuhle S,Wang L,Legge L,Callen-Wicks D,Mitchell L,Bajzar L,Massicotte MP,Western Canadian Children's Heart Network WCCHN.

更新日期：2009-03-01 00:00:00

abstract：:The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific ...

journal_title：Thrombosis research

authors： Hoffmeister KM,Falet H

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:Type 2 diabetes mellitus (T2DM) patients have a variable response profile to the P2Y(12) receptor antagonist clopidogrel. P2Y(12) receptor signalling promotes platelet procoagulant activity. The aim of this study was to determine if T2DM patients with suboptimal clopidogrel response have greater platelet p...

journal_title：Thrombosis research

authors： Angiolillo DJ,Capranzano P,Desai B,Shoemaker SB,Charlton R,Zenni MM,Guzman LA,Bass TA

更新日期：2009-07-01 00:00:00

abstract：:In rabbits, a clear microscopic image of individual, fluorescent blood platelets flowing in a mesenteric microvessel could be obtained over the whole cross-sectional area of the vessel, following an intravenous injection of a solution containing 5-15 mg of the fluorochrome Acridine Red. Most of the circulating platele...

journal_title：Thrombosis research

authors： Tangelder GJ,Slaaf DW,Reneman RS

更新日期：1982-12-15 00:00:00

abstract：:Patients with hematologic malignancies have an increased risk of venous thromboembolism (VTE), particularly at diagnosis and during the treatment with chemotherapy, asparaginase or immunomodulatory drugs (IMiDs). A disease-dependent hypercoagulable condition associated with other risk factors like drugs, central venou...

journal_title：Thrombosis research

authors： Elice F,Rodeghiero F

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. METHODS:Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenect...

journal_title：Thrombosis research

authors： Comerota AJ,Oostra C,Fayad Z,Gunning W,Henke P,Luke C,Lynn A,Lurie F

更新日期：2015-05-01 00:00:00

abstract：:The concentrations of tissue plasminogen activator (t-PA) and urokinase (UK) were measured in the plasma of patients with benign or malignant ovarian and uterine tumors. Plasma levels of t-PA were higher in patients with malignant ovarian and uterine tumors than in patients with benign tumors. Plasma UK levels were, h...

journal_title：Thrombosis research

authors： Saito K,Nagashima M,Iwata M,Hamada H,Sumiyoshi K,Takada Y,Takada A

更新日期：1990-05-15 00:00:00

abstract：INTRODUCTION:We conducted this prospective study in order to investigate the hypotheses that an alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass (CPB) surgery and major abdominal surgery and that the levels of fibrin degradation products digested by polymorphonucle...

journal_title：Thrombosis research

authors： Gando S,Kameue T,Sawamura A,Hayakawa M,Hoshino H,Kubota N

更新日期：2007-01-01 00:00:00

abstract：:The time course and degree of collagen induced platelet shape change, aggregation and ATP-secretion in citrated human platelet rich plasma was monitored with a lumi-aggregometer. Onset of ATP-secretion was measurable within seconds after collagen challenge and always distinctly before onset of shape change. In absence...

journal_title：Thrombosis research

authors： Malmgren R

更新日期：1986-08-15 00:00:00

abstract：:The extrinsic pathway of coagulation is initiated when zymogen factor VII binds to its cell surface receptor tissue factor. Recently recombinant human tissue factor has become available and therefore in this study the direct binding of human factor VII in plasma to recombinant tissue factor was explored. Factor VII bi...

journal_title：Thrombosis research

authors： Sridhara S,Clarke BJ,Ofosu FA,High KA,Blajchman MA

更新日期：1993-05-15 00:00:00

abstract：:We investigated the effects of Defibrotide (D), a natural polydeoxyribonucleotide, on acute myocardial ischemia (AMI) in anesthetized cats. A permanent ligature was placed around the left anterior descending coronary artery (LAD) 12-14 mm from its origin. Ventricular fibrillation and death were exceptional and when th...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Histamine is classified as an inflammatory mediator and has been reported to have anti- as well as pro-inflammatory properties. The aim of this study was to explore the role of histamine on the production of LPS-induced tissue factor (TF) activity and TNFα in monocytes of whole blood in the absence and prese...

journal_title：Thrombosis research

authors： Østerud B,Olsen JO

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...

journal_title：Thrombosis research

authors： Vucelic D,Jesic R,Jovicic S,Zivotic M,Grubor N,Trajkovic G,Canic I,Elezovic I,Antovic A

更新日期：2015-06-01 00:00:00

abstract：:Microheterogeneity of antithrombin III (ATIII) was examined in pooled normal human plasma and serum by IEF/PA and immunoblotting techniques. A pattern consisting of 8 bands varying in isoelectric point from 4.7 to 5.2 was observed in citrated plasma following IEF in a pH range of 4-6. A similar pattern was observed in...

journal_title：Thrombosis research

authors： Daly M,Hallinan F

更新日期：1985-10-15 00:00:00

abstract：:Heparin is known to exert its antithrombotic effects by accelerating the effect of antithrombin (AT) and by mobilizing tissue factor pathway inhibitor (TFPI) into the circulation from vascular endothelium. Heparin treatment has been reported to decrease FVIIa activity by 40%; this was suggested as a new antithrombotic...

journal_title：Thrombosis research

authors： Hansen JB,Svensson B,Sandset PM,Thijssen F

更新日期：2000-12-01 00:00:00

abstract：:The ability of the COA-SET Fibrin monomer (COA-SET FM) test to detect soluble fibrin was evaluated by comparing the results of the COA-SET FM test with fibrinopeptide A (FPA) determinations following thrombin incubation of plasma or whole blood. In addition, two semiquantitative tests (erythrocytes-agglutination test ...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Ruyter R,Godal HC

更新日期：1990-02-15 00:00:00

abstract：:Blood platelets have recently been shown to express PYK2, a nonreceptor tyrosine kinase belonging to the FAK gene family. In this study, we examined the involvement of protein kinase C (PKC) in PYK2-related responses in human platelets. While PYK2 tyrosine phosphorylation induced by thrombin was inhibited by preincuba...

journal_title：Thrombosis research

authors： Ohmori T,Yatomi Y,Asazuma N,Satoh K,Ozaki Y

更新日期：1999-03-15 00:00:00

abstract：BACKGROUND:An association between high red cell distribution width (RDW) and venous thromboembolism (VTE) has been observed. However, it is not known whether this association differs within various manifestations of VTE, nor if there is an interaction between RDW and thrombophilia abnormalities on the risk of VTE. AIM...

journal_title：Thrombosis research

authors： Bucciarelli P,Maino A,Felicetta I,Abbattista M,Passamonti SM,Artoni A,Martinelli I

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR). MATERIALS AND METHODS:To test the hypothesis of relative warfarin resistance i...

journal_title：Thrombosis research

authors： Ames PR,Margaglione M,Ciampa A,Colaizzo D,Ferrara F,Iannaccone L,Vincenzobrancaccio

更新日期：2011-06-01 00:00:00

abstract：:The pharmacodynamic and pharmacokinetic properties of endpoint-attached N'alkylamine derivatives of low molecular mass heparin (LMMH), low molecular mass heparin (LMMH), low molecular mass heparin-tyramine (LMMH-tyr) and low molecular mass heparin-tyramine-fluorescein-5-isothiocyanate (LMMH-tyr-fitc) were investigated...

journal_title：Thrombosis research

authors： Malsch R,Piazolo L,Harenberg J,Heene DL

更新日期：1995-11-01 00:00:00

abstract：:Human and bovine alpha-thrombins (greater than 90% alpha form) with high fibrinogen clotting activities (approximately 3,000 U.S. units/mg protein) exhibit similar Michaelis menten kinetics with the p-nitroanilide tripeptide substrates Tos-Gly-Pro-arg-pNA (Chromozym-TH) and D-Phe-Pip-Arg-pNA (S-2238). The kinetic para...

journal_title：Thrombosis research

authors： Lottenberg R,Hall JA,Fenton JW 2nd,Jackson CM

更新日期：1982-11-01 00:00:00