当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Impact of P2Y(12) inhibitory effects induced by clopidogrel on platelet procoagulant activity in type 2 diabetes mellitus patients.

Impact of P2Y(12) inhibitory effects induced by clopidogrel on platelet procoagulant activity in type 2 diabetes mellitus patients.

Abstract：

INTRODUCTION:Type 2 diabetes mellitus (T2DM) patients have a variable response profile to the P2Y(12) receptor antagonist clopidogrel. P2Y(12) receptor signalling promotes platelet procoagulant activity. The aim of this study was to determine if T2DM patients with suboptimal clopidogrel response have greater platelet procoagulant activity compared with optimal responders and evaluate if this can be modulated by enhancing P2Y(12) receptor inhibition. MATERIALS AND METHODS:A total of 50 T2DM patients in a steady state phase of clopidogrel therapy were studied. Suboptimal responders were randomly assigned to standard (75 mg) or high (150 mg) clopidogrel maintenance therapy for one-month. Afterwards, all patients resumed standard therapy. Platelet procoagulant activity assessed by thrombin-induced platelet-fibrin clot formation using thrombelastography (TEG) was determined at baseline, one-month post-randomization, and one-month after resuming standard therapy. RESULTS:In the overall study population, the reaction time (R), a measure of time to initial thrombin induced platelet-fibrin clot formation, and the time to maximum rate of thrombin generation (TMRTG) values were 6.3+/-1.7 and 7.6+/-1.9 minutes, respectively. Suboptimal clopidogrel responders (n=30) had acceleration of R (p=0.002) and TMRTG (p=0.002) compared to optimal responders (n=20). Suboptimal clopidogrel responders treated with a 150 mg dose showed prolongation of R (p=0.0001) and TMRTG (p<0.0001), which returned to baseline values after resuming standard dosage. No differences were observed among patients randomized to 75 mg. CONCLUSIONS:T2DM patients with suboptimal clopidogrel response have enhanced platelet procoagulant activity compared to patients with optimal response, which can be down-regulated by more potent platelet P2Y(12) inhibition using high clopidogrel maintenance dosing.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Angiolillo DJ,Capranzano P,Desai B,Shoemaker SB,Charlton R,Zenni MM,Guzman LA,Bass TA

doi

10.1016/j.thromres.2008.10.001

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

318-22

issue

3

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(08)00453-2

journal_volume

124

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • No firm association between N-terminal pro-brain natriuretic peptide and percentage of pulmonary vascular obstruction in patients with acute pulmonary embolism.

    abstract：INTRODUCTION:High concentrations of N-terminal-pro-brain natriuretic peptide (NT-proBNP) are found in patients with right ventricular overload. Right ventricular overload may be the result of large perfusion defects in patients with pulmonary embolism (PE). NT-proBNP levels are associated with poorer outcome in patient...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2011.02.014

    authors： Agterof MJ,Schutgens RE,Verzijlbergen JF,van Buul MM,Tromp EA,Eijkemans MJ,van der Griend R,Biesma DH

    更新日期：2011-06-01 00:00:00

  • Recanalization rate in patients with proximal vein thrombosis treated with the direct oral anticoagulants.

    abstract：BACKGROUND:The recanalization rate in patients with deep venous thrombosis (DVT) of the legs treated with the direct oral anticoagulants (DOAC) is unknown. METHODS:In an Italian cohort, we investigated the rate of residual vein thrombosis (RVT) after three and/or six months in 352 patients with proximal DVT who had be...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.03.022

    authors： Prandoni P,Ageno W,Mumoli N,Zanatta N,Imberti D,Visonà A,Ciammaichella M,Simioni L,Cappelli R,Bucherini E,Di Nisio M,Avruscio G,Camporese G,Parisi R,Cuppini S,Turatti G,Noventa F,Sarolo L

    更新日期：2017-05-01 00:00:00

  • No evidence for increased platelet activation in patients with hepatitis B- or C-related cirrhosis and hepatocellular carcinoma.

    abstract：INTRODUCTION:Cancer is a major risk factor for developing venous thromboembolism (VTE). Plasma hypercoagulability is an established risk factor for cancer-related VTE. In addition, thrombocytosis and hyperreactive platelets have been implicated in VTE and cancer progression. Cirrhosis is associated with changes in plat...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.11.016

    authors： Alkozai EM,Porte RJ,Adelmeijer J,Zanetto A,Simioni P,Senzolo M,Lisman T

    更新日期：2015-02-01 00:00:00

  • Inhibitory effect of fibronectin on the fibrin formation.

    abstract：:125I-fibronectin is incorporated into fibrin when blood plasma is clotted with thrombin. This process is dependent upon fibronectin concentration, temperature, and the presence of calcium ions. Fibronectin appears to be a very strong inhibitor of fibrin formation and influences both the thrombin clotting time and fibr...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90308-5

    authors： Niewiarowska J,Cierniewski CS

    更新日期：1982-09-01 00:00:00

  • Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways.

    abstract：:This study investigates the effect on human platelet function of two sesquiterpene lactones from Arnica montana L., helenalin (H) and 11 alpha,13-dihydrohelenalin (DH). Both compounds inhibited collagen-induced platelet aggregation, thromboxane formation and 5-hydroxytryptamine secretion in a concentration-dependent m...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90151-2

    authors： Schröder H,Lösche W,Strobach H,Leven W,Willuhn G,Till U,Schrör K

    更新日期：1990-03-15 00:00:00

  • Anticoagulant activity of a bacterial glycopeptide.

    abstract：:The anticoagulant properties of myxalin, a glycopeptide secreted by a Gram negative bacterium strain (Myxococcus xanthus) are studied and compared to those of heparin. This soluble material exhibits an anticoagulant activity which implies the inhibition of some serine proteases, thrombin and factor Xa. In the presence...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90335-a

    authors： Akoum A,Josefonvicz J,Sigot M

    更新日期：1990-10-01 00:00:00

  • Variants in chondroitin sulfate metabolism genes in thrombotic storm.

    abstract：INTRODUCTION:Thrombotic storm (TS) presents as a severe, acute thrombotic phenotype, characterized by multiple clotting events and frequently affecting younger adults. Understanding the extensive hypercoagulation of an extreme phenotype as TS will also provide insight into the pathogenesis of a wider spectrum of thromb...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.11.016

    authors： Nuytemans K,Ortel TL,Gomez L,Hofmann N,Alves N,Dueker N,Beecham A,Whitehead P,Hahn Estabrooks S,Kitchens CS,Erkan D,Brandão LR,James AH,Kulkarni R,Manco-Johnson MJ,Pericak-Vance MA,Vance JM

    更新日期：2018-01-01 00:00:00

  • Gastrointestinal bleeding in von Willebrand disease.

    abstract：:Gastrointestinal bleeding due to colonic angiodysplasia is a well-recognised complication of von Willebrand disease (vWD), occurring almost exclusively in subtypes of the disease associated with a reduction in high-molecular-weight (HMW) multimers of von Willebrand factor (vWF). A deficiency of vWF HMW multimers also ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2006.01.022

    authors： Makris M

    更新日期：2006-01-01 00:00:00

  • The action of thrombin on peptide p-nitroanilide substrates: hydrolysis of Tos-Gly-Pro-Arg-pNA and D-Phe-Pip-Arg-pNA by human alpha and gamma and bovine alpha and beta-thrombins.

    abstract：:Human and bovine alpha-thrombins (greater than 90% alpha form) with high fibrinogen clotting activities (approximately 3,000 U.S. units/mg protein) exhibit similar Michaelis menten kinetics with the p-nitroanilide tripeptide substrates Tos-Gly-Pro-arg-pNA (Chromozym-TH) and D-Phe-Pip-Arg-pNA (S-2238). The kinetic para...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90114-1

    authors： Lottenberg R,Hall JA,Fenton JW 2nd,Jackson CM

    更新日期：1982-11-01 00:00:00

  • Measurement of prethrombotic markers in the assessment of acquired hypercoagulable states.

    abstract：:Hypercoagulable states can be detected by measuring activation peptides, enzyme-inhibitor complexes, and fibrin/fibrinogen degradation products, which are markers of hemostatic activation. A series of these prethrombotic markers has been evaluated in the elderly, pregnancy, diabetes and acute myocardial infarction pat...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(98)00165-0

    authors： López Y,Paloma MJ,Rifón J,Cuesta B,Páramo JA

    更新日期：1999-01-15 00:00:00

  • Treatment of venous thromboembolism in patients with cancer: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET).

    abstract：BACKGROUND:The treatment of venous thromboembolism (VTE) in cancer patients remains controversial. PURPOSE:The Italian Society for Thrombosis and Haemostasis (SISET) commissioned a project to develop clinical practice guidelines for the therapy of VTE in patients with malignancies. METHODS:Key questions about the tre...

    journal_title：Thrombosis research

    pub_type： 杂志文章,实务指引

    doi：10.1016/j.thromres.2009.08.006

    authors： Imberti D,Di Nisio M,Donati MB,Falanga A,Ghirarduzzi A,Guarneri D,Piovella F,Santoro RC,Baldini E,Zampogna S,Italian Society for Thrombosis and Haemostasis.

    更新日期：2009-11-01 00:00:00

  • Venous thrombosis during assisted reproduction: novel risk reduction strategies.

    abstract：:Ovarian hyperstimulation syndrome (OHSS) affects 5% of IVF cycles and incurs a 100-fold increase in risk of venous thrombosis over natural conceptions. Identification of women at risk of OHSS can be achieved using antral follicle count (AFC) and anti-Müllerian hormone (AMH). For those women with a high AFC or AMH comb...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/S0049-3848(13)00023-6

    authors： Nelson SM

    更新日期：2013-01-01 00:00:00

  • Parallel characterization of bovine von Willebrand protein (factor VIII-associated protein) by light scattering and SDS gel electrophoresis.

    abstract：:Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90289-0

    authors： Binnie C,Wagner RH,Cooper H,Hermans J

    更新日期：1985-11-15 00:00:00

  • Neutropenia fails to prevent the acute phase stimulation of fibrinogen synthesis.

    abstract：:This study evaluates the role of neutrophil granulocytes in mediating acute phase stimulation of fibrinogen synthesis. Turpentine was administered to neutropenic and non-neutropenic rats and fibrinogen synthetic rates measured in an isolated liver perfusion system. Using the (14C) carbonate technique for the measureme...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90032-9

    authors： Kernoff L,Colman J

    更新日期：1982-10-01 00:00:00

  • Effects of acetylthrombin on protein C activation and fibrinogen clotting.

    abstract：:Thrombin was acetylated by treatment with acetic anhydride, and the potency for protein C activation and the fibrinogen clotting activity of the resultant acetylthrombin were investigated in vitro and in vivo. The acetylthrombin retained an amidolytic activity to the synthetic substrate, S-2238, and reduced both of th...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90053-f

    authors： Nakagomi K,Ajisaka K,Yokota I

    更新日期：1990-08-15 00:00:00

  • A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study.

    abstract：INTRODUCTION:Circulating levels of fibrinogen are associated with atherosclerosis and predict future coronary heart disease and stroke. Levels of fibrinogen are correlated among family members, suggesting a heritable component. Variants of the beta-fibrinogen gene subunit on 4q28 are associated with fibrinogen levels b...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(03)00288-3

    authors： Yang Q,Tofler GH,Cupples LA,Larson MG,Feng D,Lindpaintner K,Levy D,D'Agostino RB,O'Donnell CJ

    更新日期：2003-04-15 00:00:00

  • The effect of operation and subcutaneous heparin on plasma levels of antithrombin-III.

    abstract：:Plasma antithrombin III (AT-III) levels were measured in 61 patients undergoing general surgery. The patients were randomly allocated to a test or a control group. The test group received 5000iu of subcutaneous heparin two hours before operation and then twelve hourly for seven days. The control group received subcuta...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0049-3848(86)90102-7

    authors： Harbourne T,Nicolaides AN

    更新日期：1986-09-15 00:00:00

  • Residual perfusion defects in patients with pulmonary embolism are related to impaired fibrinolytic capacity.

    abstract：BACKGROUND:Few studies investigated the relationship between fibrinolysis abnormalities and residual pulmonary perfusion defects after acute pulmonary embolism (PE). OBJECTIVE:To assess the fibrinolytic profile in patients with prior PE in relation to the extent of scintigraphically detectable residual perfusion abnor...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.07.013

    authors： Lami D,Cellai AP,Antonucci E,Fiorillo C,Becatti M,Grifoni E,Cenci C,Marcucci R,Mannini L,Miniati M,Abbate R,Prisco D

    更新日期：2014-09-01 00:00:00

  • Mechanism of thrombin inhibition by heparin cofactor II and antithrombin in the presence of the ray (Raja radula) skin dermatan sulfate.

    abstract：INTRODUCTION:The kinetics of the thrombin inhibition by heparin cofactor II (HCII) and antithrombin (AT) have been studied as a function of the concentration of a dermatan sulfate (DS) from the skin of the ray Raja radula. MATERIALS AND METHODS:The initial concentrations of inhibitor (I), HCII or AT, and thrombin (E) ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.10.003

    authors： Ben Mansour M,Dhahri M,Vénisse L,Jandrot-Perrus M,Chaubet F,Maaroufi RM

    更新日期：2009-04-01 00:00:00

  • Validation of the Caprini risk assessment model in Chinese hospitalized patients with venous thromboembolism.

    abstract：INTRODUCTION:Venous thromboembolism (VTE) occurs frequently in at-risk hospitalized patients, and prophylaxis of VTE is significantly underused. We sought to preliminarily assess the validity of Caprini risk assessment model, a famous individual VTE risk assessment model, in Chinese hospitalized patients with VTE. MAT...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.08.001

    authors： Zhou HX,Peng LQ,Yan Y,Yi Q,Tang YJ,Shen YC,Feng YL,Wen FQ

    更新日期：2012-11-01 00:00:00

  • Effect of a collagen derived octapeptide on different steps of the platelet/collagen interaction.

    abstract：:The interaction of platelets with collagen involves short aminoacid sequences which recur along the fibres. Platelet aggregation by collagen and serotonin release is inhibited by a synthetic octapeptide LYS-PRO-GLY-GLU- PRO-GLY-PRO-LYS- derived from type III collagen. In contrast, this octapeptide inhibits only weakly...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90061-0

    authors： Karniguian A,Legrand YJ,Lefrancier P,Caen JP

    更新日期：1983-12-15 00:00:00

  • The effect of uremia on platelet contractile force, clot elastic modulus and bleeding time in hemodialysis patients.

    abstract：INTRODUCTION:Uremic bleeding frequently occurs in dialysis patients. Although its mechanism is not well characterized, acquired platelet dysfunction has been implicated in its pathogenesis. Skin bleeding time has been used to characterize platelet dysfunction in this population. However, the bleeding time is prone to e...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2006.02.013

    authors： Brophy DF,Martin EJ,Carr SL,Kirschbaum B,Carr ME Jr

    更新日期：2007-01-01 00:00:00

  • The inactivation of one- and two-chain forms of tissue plasminogen activator by a series of peptidyl chloromethyl ketones.

    abstract：:The inhibition of one- and two-chain forms of tissue-type plasminogen activator by a series of peptide derivatives of arginine chloromethyl ketone was studied. Both forms of the enzyme were inhibited by such reagents at varying rates, dependent on the peptide sequence of the inhibitor. The order of relative effectiven...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90133-7

    authors： Green GD

    更新日期：1986-10-15 00:00:00

  • Thrombo-hemorrhagic deaths in acute promyelocytic leukemia.

    abstract：:Acute promyelocytic leukemia (APL) has become the most curable form of acute myeloid leukemia after the advent of all-trans retinoic acid (ATRA). However, early deaths (ED) mostly due to the disease-associated coagulopathy remain the major cause of treatment failure. In particular, hemorrhagic events account for 40-65...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/S0049-3848(14)50019-9

    authors： Breccia M,Lo Coco F

    更新日期：2014-05-01 00:00:00

  • Human platelet aggregation is not altered by Shiga toxins 1 or 2.

    abstract：:The hemolytic uremic syndrome involves the presence of Shiga toxin producing strains of Escherichia coli and is associated with thrombocytopenia, platelet activation, and microthrombi formation. We have, therefore, investigated the ability of Shiga toxin isotypes 1 and 2 to cause or enhance platelet aggregation under ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(00)00191-2

    authors： Viisoreanu D,Polanowska-Grabowska R,Suttitanamongkol S,Obrig TG,Gear AR

    更新日期：2000-06-01 00:00:00

  • PO-21 - Stromal fibroblasts in preinvasive breast cancer (ductal carcinoma in situ, DCIS) demonstrate a cancer-like procoagulant phenotypic switch that may facilitate invasion.

    abstract：INTRODUCTION:Ductal carcinoma in-situ (DCIS) is a preinvasive breast cancer where cancer cells remain confined within the ductal basement membrane. However, genotypic changes have been identified in stroma surrounding DCIS, outside the basement membrane. Stromal fibroblasts undergo phenotypic change in cancer to promot...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/S0049-3848(16)30154-2

    authors： Shaker H,Bundred NJ,Albadry H,Nicholson S,Castle J,Lumsden LJ,Pritchard S,Landberg G,Kirwan CC

    更新日期：2016-04-01 00:00:00

  • Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis.

    abstract：:Individuals with more than one defect in the natural anticoagulant system exhibit an increased risk for thrombosis. We report on a family with two cases of combined protein C (PROC) and protein S (PROS) deficiency, five cases of isolated PROC deficiency Type I, and two cases of isolated PROS deficiency Type I. PROC an...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00232-8

    authors： Knoll B,Hach-Wunderle V,Rieger S,Häring D,Mannhalter C

    更新日期：2001-07-01 00:00:00

  • Elevated plasma neutrophil elastase concentration is associated with disease activity in patients with thrombotic thrombocytopenic purpura.

    abstract：INTRODUCTION:Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease. The aim of the study was to investigate the association of neutrophil activation with acute TTP, to assess whether neutrophil activation chang...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.01.034

    authors： Mikes B,Sinkovits G,Farkas P,Csuka D,Schlammadinger A,Rázsó K,Demeter J,Domján G,Réti M,Prohászka Z

    更新日期：2014-04-01 00:00:00

  • Factors that affect the size of platelet aggregates in epinephrine-induced activation: a study using the particle counting method based upon light scattering.

    abstract：:Platelet aggregate size was determined with a newly-developed platelet aggregometer, PA-100 (KOWA), which can quantitatively evaluate the size and number of platelet aggregates by means of the particle counting method based upon light scattering. Epinephrine-induced platelet aggregation consists of two phases, the for...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(96)00026-6

    authors： Satoh K,Ozaki Y,Qi R,Yang L,Asazuma N,Yatomi Y,Kume S

    更新日期：1996-03-01 00:00:00

  • Magnetic resonance imaging and ultrasonography in diagnosis of pelvic vein thrombosis during pregnancy.

    abstract：INTRODUCTION:Pelvic deep vein thrombosis (DVT) is difficult to diagnose during pregnancy. In a two-center trial, we evaluated the agreement between ultrasonography and magnetic resonance imaging (MRI) in diagnosing the extent of DVT into the pelvic veins during pregnancy. MATERIALS AND METHODS:Pregnant women with prox...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2010.05.011

    authors： Torkzad MR,Bremme K,Hellgren M,Eriksson MJ,Hagman A,Jörgensen T,Lund K,Sandgren G,Blomqvist L,Kälebo P

    更新日期：2010-08-01 00:00:00