Venous thrombosis during assisted reproduction: novel risk reduction strategies.

abstract：:The fibrinolytic potential of tissue-type plasminogen activator (t-PA) either incorporated in a clot (endogenous) or added to the surrounding plasma (exogenous), was studied in an in vitro system consisting of 125I-labeled human plasma clots (200 microliters) immersed in human plasma (2 ml). Clot lysis was measured as...

journal_title：Thrombosis research

authors： Zamarron C,Lijnen HR,Collen D

更新日期：1984-08-01 00:00:00

abstract：INTRODUCTION:Normal pregnancy is associated with hypercoagulable state. Elevated markers of coagulation and fibrinolytic system activation indicate increased thrombin activity and increased fibrinolysis following fibrin formation throughout pregnancy. These changes exceed the biological variability in most cases. Haemo...

journal_title：Thrombosis research

authors： Réger B,Péterfalvi A,Litter I,Pótó L,Mózes R,Tóth O,Kovács GL,Losonczy H

更新日期：2013-04-01 00:00:00

abstract：:The influence of red blood cells on platelet aggregation has recently been a subject of considerable interest. We have studied the effect of red cells on spontaneously formed platelet aggregates in rotating vials at 37 degrees C. Platelet aggregation was quantified by measuring the fall in number of single platelets w...

journal_title：Thrombosis research

authors： Saniabadi AR,Lowe GD,Barbenel JC,Forbes CD

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Atherosclerosis occurs as a result of a chronic inflammatory response in the arterial wall associated with an increased uptake of low-density lipoprotein by macrophages and the subsequent transformation of this lipoprotein into foam cells. It has been found that miR-188-3p can suppress autophagy and myocardi...

journal_title：Thrombosis research

authors： Zhang XF,Yang Y,Yang XY,Tong Q

更新日期：2018-11-01 00:00:00

abstract：:Anticoagulants are effective for preventing both venous and arterial thrombosis. Although antithrombotic agents have been reported to reduce thrombin formation, to our knowledge, the relation between blood viscosity (BV) and antithrombotic agents has not been examined. We examined the effects on whole BV of various do...

journal_title：Thrombosis research

authors： Hitosugi M,Niwa M,Takatsu A

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:According to US Food and Drugs Administration (FDA), 2 hour recombinant tissue plasminogen activator (rt-PA) 100mg infusion is recommended for eligible patients with acute pulmonary embolism (PE). However,there exists evidence implying that a lower dosage of rt-PA can be equally effective but p...

journal_title：Thrombosis research

authors： Zhang Z,Zhai ZG,Liang LR,Liu FF,Yang YH,Wang C

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and inc...

journal_title：Thrombosis research

authors： Pike MM,Larson NB,Wassel CL,Cohoon KP,Tsai MY,Pankow JS,Hanson NQ,Decker PA,Berardi C,Alexander KS,Cushman M,Zakai NA,Bielinski SJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:There is a need to identify and develop novel thrombolytic agents that can directly digest fibrin clots from various biological resources. OBJECTIVE:To clone, express, purify, and characterize a recombinant protease named rvFMP capable of cleaving fibrinogen, fibrin polymer, and cross-linked fibrin in human...

journal_title：Thrombosis research

authors： Lim DS,Park JE,Park JW,Cho YH,Park JK,Lee JS

更新日期：2020-07-01 00:00:00

abstract：:Platelet activation plays an important role in the development of sepsis. During sepsis, platelet activation leads to endothelial cell injury and promotes neutrophil extracellular trap and microthrombus formation, exacerbating septic coagulation and inflammatory reactions. The resultant induction or aggravation of dis...

journal_title：Thrombosis research

authors： Wang Y,Ouyang Y,Liu B,Ma X,Ding R

更新日期：2018-06-01 00:00:00

abstract：:The protease inhibitor, aprotinin, has been examined for its ability to inhibit urokinase and tissue-type plasminogen activators at pH 7.4 in assays utilizing pyroGlu-Gly-Arg-p-nitroanilide and H-D-Ile-Pro-Arg-p-nitroanilide as substrates, respectively. Aprotinin inhibited both two-chain low molecular weight urokinase...

journal_title：Thrombosis research

authors： Lottenberg R,Sjak-Shie N,Fazleabas AT,Roberts RM

更新日期：1988-03-15 00:00:00

abstract：BACKGROUND:It has been previously shown that platelets of patients with diabetes are more reactive and less responsive to anti-platelet drugs compared with platelets from subjects without diabetes. Studies examining the effect of glycemic control on platelet reactivity have yielded conflicting data. Thus, in this study...

journal_title：Thrombosis research

authors： Singer J,Weissler Snir A,Leshem-Lev D,Rigler M,Kornowski R,Lev EI

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Microparticles (MPs) are small fragments of apoptotic or activated cells that may contribute to pathological processes in cardiovascular diseases. In studies of MPs in clinical cohorts, it is unclear if observed changes in MP composition are a cause or a result of the cardiovascular disease being studied. ...

journal_title：Thrombosis research

authors： Watts JA,Lee YY,Gellar MA,Fulkerson MB,Hwang SI,Kline JA

更新日期：2012-07-01 00:00:00

abstract：:Blackfoot disease is a unique endemic and chronic progressive arteriosclerotic vascular disease in southwest area of Taiwan. In this study, we determined the plasma levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI), urokinase plasminogen activator (uPA), and von Willebrand factor (vWF...

journal_title：Thrombosis research

authors： Wu HL,Yang WH,Wang MY,Shi GY

更新日期：1993-11-01 00:00:00

abstract：:Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. Using an immunostaining technique and electron microscopy, we investigated and compared the distribution of triflavin bind...

journal_title：Thrombosis research

authors： Chuang WJ,Wu CH,Huang HN,Chen SH,Hsiao G,Lin CH,Sheu JR

更新日期：2003-01-01 00:00:00

abstract：:Mice were implanted subcutaneously with a pellet containing 0.5 mg estradiol or with a placebo. Eight to 12 days later platelet aggregation was produced in mesenteric arterioles by injuring their endothelium in vivo with a noxious light/dye stimulus. The time between the onset of the noxious stimulus and the appearanc...

journal_title：Thrombosis research

authors： Rosenblum WI,el-Sabban F,Allen AD,Nelson GH,Bhatnagar AS,Choi S

更新日期：1985-08-01 00:00:00

abstract：:Seven compounds having varying affinities for peripheral benzodiazepine (p sites) were evaluated in vitro as inhibitors of arachidonic acid-induced rabbit platelet aggregation and thromboxane B2 (TXB2) synthesis. With the exception of flumazenil, all compounds inhibited both parameters with IC50 values ranging from 0....

journal_title：Thrombosis research

authors： Choppin A,Berry CN

更新日期：1995-05-15 00:00:00

abstract：INTRODUCTION:Colorectal cancer (CRC) is often complicated by thromboembolic episodes. It has been recognized that blood coagulation proteins play a role in cancer progression. An important inhibitory mechanism is provided by the protein C (PC) system consisting of PC, protein S (PS) and thrombomodulin (TM). Recently, n...

journal_title：Thrombosis research

authors： Sierko E,Wojtukiewicz MZ,Zawadzki R,Zimnoch L,Kisiel W

更新日期：2010-03-01 00:00:00

abstract：:Using the standard turbidimetric method of platelet aggregation and quantitation of platelet secretion with 14C-Serotonin, we have examined the responsiveness of the platelets of mongrel dogs to arachidonic acid (AA), and the thromboxane agonist U46619 in the presence and absence of a subthreshold concentration of epi...

journal_title：Thrombosis research

authors： McGoff MA,Allen BT,Der T,Sicard GA,Santoro SA

更新日期：1989-09-15 00:00:00

abstract：:The in vitro and in vivo pharmacological properties of two oversulfated dermatan sulfate (DS) derivatives, S-DS1 and S-DS2, containing 2 and 3.7 sulfate groups/disaccharide unit respectively were compared to those of the parent DS (1 sulfate group/disaccharide unit). In a purified system the ability of S-DS1 and of S-...

journal_title：Thrombosis research

authors： Dol F,Caranobe C,Dupouy D,Petitou M,Lormeau JC,Choay J,Sié P,Boneu B

更新日期：1988-10-15 00:00:00

abstract：:The placenta is the highly specialised organ of pregnancy that supports the normal growth and development of the fetus. Growth and function of the placenta are precisely regulated and coordinated to ensure the exchange of nutrients and waste products between the maternal and fetal circulatory systems operates at maxim...

journal_title：Thrombosis research

authors： Gude NM,Roberts CT,Kalionis B,King RG

更新日期：2004-01-01 00:00:00

abstract：:The levels of protein C (PC) and other coagulation factors were monitored during endotoxin-induced disseminated intravascular coagulation (DIC) in the dog. Initial evaluation of the effectiveness of intradermal administration of bolus endotoxin quantities into the dog, demonstrated induction of DIC in the canine, with...

journal_title：Thrombosis research

authors： Madden RM,Ward M,Marlar RA

更新日期：1989-08-01 00:00:00

abstract：:Endothelial cells from human umbilical vein were incubated in vitro with thrombin in the absence or presence of unfractionated heparin (UFH), low molecular weight heparin (LMWH) or dermatan sulfate (DS) to clarify the effect of these glycosaminoglycans on thrombin-stimulated prostaglandin I2 (PGI2) production. Althoug...

journal_title：Thrombosis research

authors： Itoh F,Kaji T,Hayakawa Y,Oguma Y,Sakuragawa N

更新日期：1990-02-15 00:00:00

abstract：:The association between blood coagulation and cancer growth and metastatic dissemination is not yet completely understood. In this study we demonstrate that thrombin is capable of enhancing tumor cell adhesive properties and thereby increases tumor cell metastatic potential. Following exposure to alpha-thrombin, Walke...

journal_title：Thrombosis research

authors： Wojtukiewicz MZ,Tang DG,Nelson KK,Walz DA,Diglio CA,Honn KV

更新日期：1992-11-01 00:00:00

abstract：:Platelet aggregation induced by ADP and collagen was monitored in 25 patients with increased serum levels of triglycerides (7 HLPs type IIb, 14 type IV, 4 type V patients) and compared with a group of 10 normolipidaemic control persons. Platelet aggregation was studied simultaneously in platelet rich plasma (PRP) by b...

journal_title：Thrombosis research

authors： Riess H,Merk W,Falkner C,Hiller E

更新日期：1986-02-01 00:00:00

abstract：INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...

journal_title：Thrombosis research

authors： Desai PC,Brittain JE,Jones SK,McDonald A,Wilson DR,Dominik R,Key NS,Parise LV,Ataga KI

更新日期：2013-09-01 00:00:00

abstract：:An insertion/deletion (4G/5G) polymorphism in what has been shown to be an enhancer/repressor binding site in the promoter region of the PAI-1 gene has been related to plasma PAI-1 activity. Transfection studies demonstrated increased interleukin-1 stimulated PAI-1 synthesis in cells containing the 4G sequence. To stu...

journal_title：Thrombosis research

authors： McCormack LJ,Semple JI,Stickland MH,Barrett JH,Grant PJ

更新日期：1998-12-01 00:00:00

abstract：INTRODUCTION:Coagulation factor XIII (FXIII) is a fibrin-stabilizing factor, which contributes to hemostasis, wound healing, and maintenance of pregnancy. Accordingly, patients with congenital FXIII deficiency manifest a life-long bleeding tendency, abnormal wound healing and recurrent miscarriage. In order to understa...

journal_title：Thrombosis research

authors： Souri M,Yee VC,Fujii N,Ichinose A

更新日期：2012-09-01 00:00:00

abstract：:Von Willebrand Factor is a multimer produced by endothelial cells and megakaryocytes, being stored in intracellular organelles, such as the Weibel-Palade bodies and alpha-granules in endothelial cells and platelets, respectively. This molecule acts as a carrier protein for factor VIIIc, involved in the intrinsic pathw...

journal_title：Thrombosis research

authors： Spadafora-Ferreira M,Lopes AA,Coelho V,Guilherme L,Kalil J

更新日期：2000-01-15 00:00:00

abstract：:The candidate-gene approach can be used to locate and identify genetic variations that are associated with a particular phenotype. This gene-centric approach assumes that there exists important genetic variation within genes that can influence health. Identifying known genes which are candidates for the phenotype of i...

journal_title：Thrombosis research

authors： Smith NL,Rice KM,Lumley T,Heckbert SR,Psaty BM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Unfractionated heparin (UFH) and low molecular weight heparin constitute fundamental anticoagulants during hemodialysis (HD). We aimed to investigate the effect of UFH and enoxaparin on plasma levels of prothrombin fragment 1+2 (PF 1+2) and thrombin/antithrombin complex (TAT) as markers of intravascular thro...

journal_title：Thrombosis research

authors： Naumnik B,Pawlak K,Myśliwiec M

更新日期：2009-02-01 00:00:00