Parallel characterization of bovine von Willebrand protein (factor VIII-associated protein) by light scattering and SDS gel electrophoresis.

abstract：PURPOSE:The study sought to synthesize anionic peptide-conjugated tissue plasminogen activator (tPA) for its targeted/triggered delivery, where tPA's activity would be masked in the circulation and regenerated at the thrombus site by a commonly used anticoagulant, heparin, to minimize tPA associated bleeding complicati...

journal_title：Thrombosis research

authors： Absar S,Choi S,Ahsan F,Cobos E,Yang VC,Kwon YM

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:There is a need to identify and develop novel thrombolytic agents that can directly digest fibrin clots from various biological resources. OBJECTIVE:To clone, express, purify, and characterize a recombinant protease named rvFMP capable of cleaving fibrinogen, fibrin polymer, and cross-linked fibrin in human...

journal_title：Thrombosis research

authors： Lim DS,Park JE,Park JW,Cho YH,Park JK,Lee JS

更新日期：2020-07-01 00:00:00

abstract：:Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disease after coronary artery disease and cerebrovascular disease and is responsible for significant morbidity and mortality in the general population. Full dose anticoagulation is th...

journal_title：Thrombosis research

authors： Imberti D,Ageno W,Manfredini R,Fabbian F,Salmi R,Duce R,Gallerani M

更新日期：2012-04-01 00:00:00

abstract：:The inability of the heparin-antithrombin complex to inhibit fibrin-bound thrombin limits the utility of heparin for treatment of arterial thrombosis. In contrast with heparin, melagatran, a direct thrombin inhibitor (DTI), is equally effective at inhibiting fluid-phase thrombin and thrombin bound to fibrin. This refl...

journal_title：Thrombosis research

authors： Weitz JI

更新日期：2003-07-15 00:00:00

abstract：:Tissue factor (TF) is a transmembrane protein which, in complex with factor (F)VIIa, initiates blood coagulation. Numerous studies have determined TF epitopes and individual amino acids which play an important role in the TF/FVIIa complex formation and its activity towards natural substrates. However the subject of ce...

journal_title：Thrombosis research

authors： Butenas S,Krudysz-Amblo J

更新日期：2012-05-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of tissue factor (thromboplastin), the initiating factor of the extrinsic clotting system, on angiogenesis in vivo and in vitro. In vivo angiogenesis was examined using a diffusion chamber assay in rats. After a week of implantation of the diffusion chambers con...

journal_title：Thrombosis research

authors： Watanabe T,Yasuda M,Yamamoto T

更新日期：1999-11-01 00:00:00

abstract：:von Willebrand Factor (vWF) is released from endothelial cells. Increased vWF in the coronary circulation during cardiac surgery could be a potential indicator of coronary endothelial injury or stimulation, and thus a possible tool to evaluate regimens of myocardial protection. Release of vWF was investigated in 12 pa...

journal_title：Thrombosis research

authors： Valen G,Blombäck M,Sellei P,Lindblom D,Vaage J

更新日期：1994-01-01 00:00:00

abstract：:We previously reported that the expression of thrombomodulin on the MEG-01, a cell line from human megakaryoblastic leukemia, was increased by agents that increase intracellular cAMP. In this paper we examine the effect of these agents on cultured human umbilical vein endothelial cells (HUVEC) and mouse hemangioma cel...

journal_title：Thrombosis research

authors： Maruyama I,Soejima Y,Osame M,Ito T,Ogawa K,Yamamoto S,Dittman WA,Saito H

更新日期：1991-02-01 00:00:00

abstract：:Some previous reports indicated that a minimal amount of anti-IIa is necessary for the optimal anti-Xa activity of low molecular weight heparin (LMW-H). To know if we could improve the prophylactic activity of LMW-H, providing a mild antithrombin effect, we conducted an experiment in which we administered subcutaneous...

journal_title：Thrombosis research

authors： Pèrez-Requejo JL,Lucena-Solano O,Pérez-García M,Santarelli MT

更新日期：1997-02-01 00:00:00

abstract：:Venous thromboembolism (VTE) affects approximately 1 per 1000 persons annually. Although patients are increasingly treated with direct oral anticoagulants, many patients continue to be anticoagulated with vitamin K antagonists (VKA). The most important adverse events during VKA treatment, bleeding and the risk of recu...

journal_title：Thrombosis research

authors： Schmidt DE,Chaireti R,Bruzelius M,Holmström M,Antovic J,Ågren A

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Time in therapeutic range (TTR) for international normalized ratio (INR) is an accepted quality measure of anticoagulation control in patient populations, but its usefulness for predicting stroke and bleeding in individuals is not well understood. MATERIALS AND METHODS:In a nested case control analysis am...

journal_title：Thrombosis research

authors： Nieuwlaat R,Connolly BJ,Hubers LM,Cuddy SM,Eikelboom JW,Yusuf S,Connolly SJ,ACTIVE Investigators.

更新日期：2012-06-01 00:00:00

abstract：:ZK-807834 (also known as CI-1031) is a small molecule that potently and selectively inhibits Factor Xa. Studies in animals have shown that ZK-807834 attenuates thrombosis and thrombus progression after fibrinolysis and exhibits an increased antithrombotic-to-bleeding risk ratio compared with conventional agents. The p...

journal_title：Thrombosis research

authors： Post JM,Sullivan ME,Abendschein D,Ewing J,Hinchman JW,Light DR

更新日期：2002-02-15 00:00:00

abstract：:A 79-year-old lean man with a height of 157cm and weight of 42kg (body mass index, 17.2kg/m(2)) receiving rivaroxaban developed an intracranial subdural hematoma and was treated conservatively. Because he had a reduced creatinine clearance of 44mL/min, his dosage of rivaroxaban was reduced from 15 to 10mg daily accord...

journal_title：Thrombosis research

authors： Yamaguchi Y,Koga M,Matsuki T,Hino T,Yokota C,Toyoda K

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The level of platelet reactivity (PR) inhibition obtained after P2Y12-ADP receptor antagonist loading dose (LD) is associated with the ischemic and bleeding risk following percutaneous coronary intervention (PCI) in acute coronary syndromes (ACS). OBJECTIVE:We aimed to evaluate the level of PR inhibition ac...

journal_title：Thrombosis research

authors： Laine M,Toesca R,Berbis J,Frere C,Barnay P,Pansieri M,Peyre JP,Michelet P,Bessereau J,Camilleri E,Helaf O,Camaleonte M,Paganelli F,Dignat-George F,Bonello L

更新日期：2013-07-01 00:00:00

abstract：:We have determined that pp60c-src, a protein tyrosine kinase abundant in normal platelets, is present at comparable levels in platelets that are deficient in dense granules (Hermansky-Pudlak syndrome). Relative quantitation of pp60c-src was performed by immunoblot analysis after protein separation by sodium dodecyl su...

journal_title：Thrombosis research

authors： Sorisky A,Lages B,Weiss HJ,Rittenhouse SE

更新日期：1992-01-01 00:00:00

abstract：:Protein C (PC) is the central protein in a major antithrombotic regulatory mechanism. Hereditary deficiencies of PC are associated with thrombosis. Therapeutic PC replacement may be an important treatment if pure functional human protein C is available in sufficient quantity. Human PC has been produced on a commercial...

journal_title：Thrombosis research

authors： Madden RM,Oppenheimer C,Wydro R,Marlar RA

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS:Patients with newly diagnosed cancer ...

journal_title：Thrombosis research

authors： El-Refai SM,Black EP,Adams VR,Talbert JC,Brown JD

更新日期：2017-10-01 00:00:00

abstract：:Blood was obtained from four patients envenomated by the Australian common brown snake, Pseudonaja textilis textilis. This elapid snake has one of the most toxic venoms in the world, containing extremely potent neurotoxic and coagulant components. The latter is a potent complete prothrombinase, converting prothrombin ...

journal_title：Thrombosis research

authors： Masci PP,Rowe EA,Whitaker AN,de Jersey J

更新日期：1990-09-01 00:00:00

abstract：INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...

journal_title：Thrombosis research

authors： Desai PC,Brittain JE,Jones SK,McDonald A,Wilson DR,Dominik R,Key NS,Parise LV,Ataga KI

更新日期：2013-09-01 00:00:00

abstract：:Human antithrombin III was demonstrated to bind plasminogen specifically in a time and concentration-dependent manner. The above binding was also confirmed using ligand western blot assays. The interaction of plasminogen was significantly (>90%) inhibited by lysine, indicating the involvement of kringles in binding an...

journal_title：Thrombosis research

authors： Dudani AK

更新日期：2000-09-15 00:00:00

abstract：:The potent inhibitor of platelet cAMP phosphodiesterase (PDE) HL 725 (9,10-Dimethoxy-2-mesitylimino-3-methyl-3, 4,6,7-tetrahydro-2H-pyrimido(6,1-A)-isoquinoline-4-one-hydrochloride), was examined for its effects on human and rat platelet aggregation. Strong inhibitory effects are seen on collagen-induced platelet aggr...

journal_title：Thrombosis research

authors： Agarwal KC,Buckley RS,Parks RE Jr

更新日期：1987-07-15 00:00:00

abstract：:In spite of numerous studies on the involvement of fibrinogen in transendothelial migration of leukocytes and thereby inflammation, there is still no clear understanding of which fibrin(ogen) species can stimulate leukocyte transmigration. Although we have previously proposed that interaction of fibrin with the VLDL r...

journal_title：Thrombosis research

authors： Yakovlev S,Medved L

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Early achievement of therapeutic INR leads to shorter hospital stay and lesser cost. Two warfarin initiation nomograms (10 mg nomogram and 5 mg nomogram) are widely used but it is not yet clear which one is better. They have been validated in the West but there are no studies from India. We undertook this ...

journal_title：Thrombosis research

authors： Naik D S,Pillai VM,Adole PS

更新日期：2019-04-01 00:00:00

abstract：:Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion...

journal_title：Thrombosis research

authors： Lawrence JB,Prevosti LG,Kramer WS,Lu DY,Leon MB

更新日期：1989-04-15 00:00:00

abstract：BACKGROUND:Tissue factor pathway inhibitor-2 (TFPI-2) regulates matrix metalloproteinases activation and extracellular matrix degradation. Over-expression of TFPI-2 enhances atherosclerotic plaque stability. The aim of this study is to investigate the effect of conditional knockout (KO) of TFPI-2 in vascular endothelia...

journal_title：Thrombosis research

authors： Hong J,Liu R,Chen L,Wu B,Yu J,Gao W,Pan J,Luo X,Shi H

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FI...

journal_title：Thrombosis research

authors： Sottilotta G,Oriana V,Latella C,Luise F,Piromalli A,Ramirez F,Mammì C,Santoro R,Iannaccaro P,Muleo G,Lombardo VT

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:D-dimer, a fibrin degradation product, is related to risk of cardiovascular disease and venous thromboembolism. Genetic determinants of D-dimer are not well characterized; notably, few data have been reported for African American (AA), Asian, and Hispanic populations. MATERIALS AND METHODS:We conducted a ...

journal_title：Thrombosis research

authors： Weng LC,Tang W,Rich SS,Smith NL,Redline S,O'Donnell CJ,Basu S,Reiner AP,Delaney JA,Tracy RP,Palmer CD,Young T,Yang Q,Folsom AR,Cushman M

更新日期：2014-08-01 00:00:00

abstract：:One of the major pathogens of periodontitis, Porphyromonas gingivalis (P. gingivalis), has the ability to aggregate human platelets. To investigate the interaction between P. gingivalis and human platelets in platelet rich plasma (PRP), platelet aggregation was measured by an aggregometer based on laser light scatteri...

journal_title：Thrombosis research

authors： Li X,Iwai T,Nakamura H,Inoue Y,Chen Y,Umeda M,Suzuki H

更新日期：2008-01-01 00:00:00

abstract：:The effect of dalteparin, a low molecular weight heparin, on severely antithrombin III (ATIII)-decreased disseminated intravascular coagulation (DIC) model was compared with that of unfractionated heparin (heparin). The DIC model in rabbits was produced by continuous infusion of thrombin in combination with bolus inje...

journal_title：Thrombosis research

authors： Tazawa S,Ichikawa K,Misawa K,Fukuyama J,Hamano S,Miyata H,Sakuragawa N

更新日期：1995-12-01 00:00:00

abstract：:The potency for the inhibition of 5-hydroxytryptamine (5-HT)-induced human platelet aggregation by ketanserin, pipamperone, spiperone, cyproheptadine and BW 501 in vitro decreased as the reaction pH increased progressively from 7.4 to 8.6, the largest shift (X 1125) in IC50 value (pH 7.4: 4 X 10(-9) M; pH 8.6: 4.5 X 1...

journal_title：Thrombosis research

authors： De Clerck F,Xhonneux B,Tollenaere JP,Janssen PA

更新日期：1985-12-01 00:00:00