Abstract:
INTRODUCTION:Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease. The aim of the study was to investigate the association of neutrophil activation with acute TTP, to assess whether neutrophil activation changes during plasma exchange therapy and to show if complement- and neutrophil activation are parallel, characteristic processes in acute TTP. MATERIALS AND METHODS:Altogether 49 EDTA-plasma samples of 21 TTP patients with acute disease and 17 in remission were investigated along with 20 healthy controls. A stable complex of PMNE-proteinase-inhibitor was measured by ELISA (Calbiochem, Merck-Millipore, Darmstadt, Germany). RESULTS:Acute disease was associated with significantly increased PMNE levels, the group medians were similarly low in TTP patients in remission and in healthy controls. Increased PMNE levels were characteristic for hematologically active and ADAMTS13 deficient form of TTP. PMNE concentration inversely correlated to disease activity markers platelet count (r=-0.349, p=0.032) and hemoglobin levels (p=-0.382 p=0.018). Achievement of remission was associated with significant reduction of plasma PMNE levels (p=0.031, Wilcoxon test). There was positive correlation between PMNE levels and complement activation markers C3a and Bb. CONCLUSIONS:We report increased PMNE levels in acute TTP and showed its association to activity markers of acute TTP and complement activation. Effective treatment of an acute TTP episode resulted in marked decrease in PMNE levels. Our data support and extend previous observations that neutrophil extracellular traps may be released in acute TTP and potentially contribute to the pathophysiology of this disease.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Mikes B,Sinkovits G,Farkas P,Csuka D,Schlammadinger A,Rázsó K,Demeter J,Domján G,Réti M,Prohászka Zdoi
10.1016/j.thromres.2014.01.034subject
Has Abstractpub_date
2014-04-01 00:00:00pages
616-21issue
4eissn
0049-3848issn
1879-2472pii
S0049-3848(14)00058-9journal_volume
133pub_type
杂志文章abstract:INTRODUCTION:This study aimed to determine the risk factors for subclinical umbilical catheter-related thrombosis (UCRT) and its association with clinical morbidities. MATERIALS AND METHODS:In infants without any symptoms associated with umbilical catheterization, the presence of thrombosis was monitored using abdomin...
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
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doi:10.1016/j.thromres.2012.11.030
更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2012.10.002
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Miniplasmin was a des-kringle variant of plasminogen with potential pharmacological application. We investigated the thrombolytic effect of miniplasmin in a canine model of femoral artery thrombosis. METHODS:In anesthetized dogs, a stable occlusive thrombus was formed by mechanical and electroly...
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pub_type: 杂志文章
doi:10.1016/j.thromres.2008.01.007
更新日期:2008-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2010.01.012
更新日期:2010-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.thromres.2008.07.012
更新日期:2009-03-01 00:00:00
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
doi:10.1016/j.thromres.2007.02.004
更新日期:2007-01-01 00:00:00
abstract::Addition of two commercial luciferin-luciferase reagents caused marked inhibition of the aggregatory response of washed human platelets to thrombin, ADP, vasopressin and platelet-activating factor (PAF). Analysis of the effects of the individual components of one of these reagents revealed that Mg2+, and to a lesser e...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90053-2
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(88)90277-0
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abstract::Tissue factor pathway inhibitor is the major potent physiologic inhibitor of tissue factor-induced coagulation. Several potential binding sites for transcription factors have been described in the 750 bp of the 5' flanking region of the human tissue factor pathway inhibitor gene reported earlier. To identify elements ...
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pub_type: 杂志文章
doi:10.1016/s0049-3848(99)00040-7
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doi:10.1016/j.thromres.2013.02.005
更新日期:2013-04-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2014.03.006
更新日期:2014-05-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90090-x
更新日期:1989-05-15 00:00:00
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doi:10.1016/j.thromres.2008.10.003
更新日期:2009-04-01 00:00:00
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journal_title:Thrombosis research
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doi:10.1016/0049-3848(94)90050-7
更新日期:1994-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(99)00002-x
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2013.11.011
更新日期:2014-02-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2020.09.036
更新日期:2020-12-01 00:00:00
abstract::Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failur...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2011.06.024
更新日期:2011-10-01 00:00:00