Abstract：
INTRODUCTION:Management of pregnant women at risk for venous thromboembolism (VTE) remains complex. Guidelines do not definitively fix optimal strategies due to limited trial data. Our objective was to build an easy-to-use tool allowing individualised, risk-adapted prophylaxis. MATERIALS AND METHODS:A Delphi exercise was conducted to collect 19 French experts' opinions on pregnancy-related VTE. RESULTS:Experts with an active interest in clinical research and care of VTE and placental vascular complications were selected. The risk score was classified by an anonymous computer vote. A scoring system for VTE risk in pregnant women was developed, each score being associated with a specific treatment: graduated elastic compression stockings, aspirin, prophylactic Low Molecular Weight Heparin (LMWH: variable durations), or adjusted-dose of LMWH through pregnancy and postpartum. CONCLUSIONS:Our simple consensual scoring system offers an individual estimation of thrombosis risk during pregnancy together with its related therapeutic strategy, in accordance with most of the new international recommendations. The accuracy of our individual risk score-based therapeutic guidance is currently being prospectively evaluated in a multicenter trial.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Chauleur C,Gris JC,Laporte S,Rancon F,Varlet MN,Decousus H,Mismetti P,STRATHEGE Group.doi
10.1016/j.thromres.2010.01.012subject
Has Abstractpub_date
2010-08-01 00:00:00pages
88-92issue
2eissn
0049-3848issn
1879-2472pii
S0049-3848(10)00040-Xjournal_volume
126pub_type
杂志文章abstract：:Megakaryocyte colony formation was increased in 13 patients with ITP. Out of splenectomized ITP patients Colony Forming Unit-Megakaryocyte (CFU-Mk) number normalized in four but was lower than normal in the remaining two. The proportion of immature megakaryocytes was higher in ITP than in normals or in ITP patients af...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90672-j
更新日期：1991-04-01 00:00:00
abstract：:The effects of hydrogen peroxide on factor Xa-catalyzed prothrombin activation on the surface of vascular endothelial cells, and the inhibitory effect of sphingosine on prothrombin activation were studied in cultured calf pulmonary artery endothelial cells (CPAEC). Hydrogen peroxide enhanced factor Xa-catalyzed prothr...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90263-a
更新日期：1992-07-01 00:00:00
abstract：:Dextran sulfate and polybrene were immobilized on polypropylene tubes with plastic adhesive. Serum albumin was also immobilized on the tube by heat-denaturation. In the those tubes thrombin was protected from inactivation in the presence of 0.1 M NaCl remarkably. Cholesterol coated on the tube also protected the enzym...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90277-0
更新日期：1988-07-01 00:00:00
abstract：INTRODUCTION:Cancer is a major risk factor for developing venous thromboembolism (VTE). Plasma hypercoagulability is an established risk factor for cancer-related VTE. In addition, thrombocytosis and hyperreactive platelets have been implicated in VTE and cancer progression. Cirrhosis is associated with changes in plat...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2014.11.016
更新日期：2015-02-01 00:00:00
abstract：:Plasma from patients with thrombotic thrombocytopenic purpura (TTP) caused the aggregation of washed human platelets, which was inhibited by preincubation with normal plasma. Using salt fractionation, ion exchange chromatography, and preparative agarose gel electrophoresis, we purified a protein from normal plasma whi...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90155-5
更新日期：1984-01-01 00:00:00
abstract：:Chronic immune thrombocytopenia purpura (ITP) is an autoimmune disease that exhibits an abnormally high Th1/Th2 ratio. Granulocyte colony-stimulating factor (G-CSF) has been shown to decrease the Th1/Th2 ratio in healthy donors. In this study, we investigated the effects of G-CSF treatment on the Th1/Th2 cells and the...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2016.10.028
更新日期：2016-12-01 00:00:00
abstract：:Venous thromboembolism remains an important cause of maternal mortality. For women at risk during pregnancy, the recommended venous thromboembolismprophylaxis is unfractionated heparin. Low molecular weight heparins, such as dalteparin, also may be suitable, but randomised trials have not been performed. Pregnant wome...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0049-3848(99)00110-3
更新日期：1999-11-15 00:00:00
abstract：INTRODUCTION:Global clotting assays may reflect an individual's net hemostatic balance and could contribute to prothrombotic and hemorrhagic risk assessment. In this research, a global assay that measures both coagulation and fibrinolytic capacities was developed and investigated. MATERIALS AND METHODS:In the Clot For...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2004.12.009
更新日期：2005-01-01 00:00:00
abstract：:The effect of dalteparin, a low molecular weight heparin, on severely antithrombin III (ATIII)-decreased disseminated intravascular coagulation (DIC) model was compared with that of unfractionated heparin (heparin). The DIC model in rabbits was produced by continuous infusion of thrombin in combination with bolus inje...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)00191-s
更新日期：1995-12-01 00:00:00
abstract：:Approximately one-fifth of all cases of venous thromboembolism (VTE) are related to cancer. VTE complications may have a substantial impact on prognosis, quality of life and care in patients with cancer. Patients with cancer-related VTE are at increased risk of developing recurrent VTE compared to patients without can...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/S0049-3848(20)30409-6
更新日期：2020-07-01 00:00:00
abstract：:The ability of the COA-SET Fibrin monomer (COA-SET FM) test to detect soluble fibrin was evaluated by comparing the results of the COA-SET FM test with fibrinopeptide A (FPA) determinations following thrombin incubation of plasma or whole blood. In addition, two semiquantitative tests (erythrocytes-agglutination test ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90066-l
更新日期：1990-02-15 00:00:00
abstract：INTRODUCTION:The Cilostazol Stroke Prevention Study found that cilostazol, a phosphodiesterase 3 inhibitor, can reduce the risk of subsequent stroke in Japanese patients with cerebral infarction. Here, we measured the effects of cilostazol in vitro on shear-induced platelet aggregation, an important mechanism of thromb...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2006.05.005
更新日期：2007-01-01 00:00:00
abstract：:A direct assay for plasminogen activator (PA) was developed. It employed polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and beta-mercaptoethanol to monitor PA-mediated conversion of single chain, 125I-plasminogen to two chain plasmin. By incorporating Triton X-100, albumin and trasylol in...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90008-2
更新日期：1984-05-01 00:00:00
abstract：BACKGROUND:Coagulopathy is a major cause of early death when arsenic trioxide (As(2)O(3)) therapy fails. In addition to the procoagulant properties of blast cells, the cytotoxic therapy may contribute to the coagulation disorders. The aim of the present study was to evaluate the possible impact of As(2)O(3) on membrane...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2011.01.003
更新日期：2011-05-01 00:00:00
abstract：:Two functional assays for protein C inhibitor (PCI) were evaluated in parallel for the same plasma samples. One assay is specific for active PCI and measures its ability to form complexes with activated protein C (APC) in the presence of heparin (España et al, Thromb Res 64, 309, 1991) (Method A). After incubation of ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90079-4
更新日期：1993-06-01 00:00:00
abstract：:There is now compelling evidence that use of oral contraceptives and postmenopausal hormonal therapies containing various estrogens is associated with a weak, but clinically relevant risk of both arterial and venous thrombosis. The increased risk is related to type and dose of both estrogen and combined progestagen an...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/S0049-3848(13)70009-4
更新日期：2013-01-01 00:00:00
abstract：:Coagulation is initiated by tissue factor (TF). Coagulant TF is constitutively expressed by extravascular cells, but there is increasing evidence that TF can also be present within the blood, in particular during pathological conditions. Such TF is exposed on circulating cell-derived vesicles, and its presence has bee...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2012.08.281
更新日期：2012-10-01 00:00:00
abstract：:The specific thromboxane A2/prostaglandin H2 (TXA2/PGH2) antagonist 13-azaprostanoic acid (13-APA) reverses platelet aggregation stimulated by TXA2/PGH2 and the prostaglandin endoperoxide analog U46619. The present report demonstrates that the deaggregatory properties of 13-APA are potentiated by prostacyclin (PGI2). ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(82)90097-4
更新日期：1982-12-15 00:00:00
abstract：:Patients with protamine allergy present a difficult dilemma when reversal of heparin is required for excessive bleeding. Premedication with steroids and antihistamines has not been shown to effectively prevent anaphylactic reactions in patients with hypersensitivity to protamine. Other heparin antagonists are either n...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(89)90132-1
更新日期：1989-06-15 00:00:00
abstract：:Anticoagulant properties of three sulfated compounds prepared from xylans isolated from corn cobs, larchwood and oatspelts were compared with heparin and sodium pentosan polysulfate (SP-54) by studying their effects on activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) using poo...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90148-4
更新日期：1987-08-01 00:00:00
abstract：PURPOSE:By using endovascular techniques, we set up an animal model of mesenteric venous thrombosis to avoid surgical laparotomy. MATERIALS AND METHODS:Ten pigs underwent percutaneous transhepatic puncture to create animal model of acute superior mesenteric venous thrombosis. Experimental animals were injected with th...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.10.028
更新日期：2015-12-01 00:00:00
abstract：:Platelet-neutrophil interactions play an important role in thrombotic and inflammatory responses. Although it is well known that adhesion of platelets to neutrophils requires interactions of adhesion molecules on platelets such as P-selectin, or GPIIb/IIIa with their counterparts on neutrophils, little is known on the...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(03)00413-4
更新日期：2003-06-15 00:00:00
abstract：:Although significant advances in hemophilia treatment have improved patient outcomes and quality of life, one of the greatest complications in severe hemophilia A is the development of anti-Factor VIII (FVIII) antibodies that inhibit FVIII activity in almost 30% of previously untreated patients (PUPs). Inhibitors make...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2018.05.027
更新日期：2018-08-01 00:00:00
abstract：:Fibrin film is prepared by compaction in one dimension of a fibrin clot (pH 6.3, ionic strength 0.15, fibrin concentration about 0.5%) by expulsion of fluid to reach a fibrin concentration of about 15%. Strips of film, equilibrated in the same buffer with very slowly increasing temperature, shrink in length in a narro...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90020-5
更新日期：1988-12-01 00:00:00
abstract：:The inhibition of one- and two-chain forms of tissue-type plasminogen activator by a series of peptide derivatives of arginine chloromethyl ketone was studied. Both forms of the enzyme were inhibited by such reagents at varying rates, dependent on the peptide sequence of the inhibitor. The order of relative effectiven...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(86)90133-7
更新日期：1986-10-15 00:00:00
abstract：INTRODUCTION:von Willebrand factor (VWF) is synthesised in vascular endothelial cells and released into the plasma as unusually large VWF multimers (UL-VWFMs). Sinusoidal endothelial cells are a major target of ischaemia-reperfusion injury due to liver surgery. This study aimed to clarify the effect of hepatectomy on U...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2019.09.005
更新日期：2019-11-01 00:00:00
abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90253-1
更新日期：1985-09-15 00:00:00
abstract：:Venous thromboembolism (VTE) is a common complication in patients with malignant disease. In addition to well-established acquired risk factors for VTE, several genetic risk factors, mainly related to the haemostatic system, are known to influence thrombotic risk. However, the contribution of gene abnormalities to thr...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(03)00179-8
更新日期：2003-02-15 00:00:00
abstract：:We have determined that pp60c-src, a protein tyrosine kinase abundant in normal platelets, is present at comparable levels in platelets that are deficient in dense granules (Hermansky-Pudlak syndrome). Relative quantitation of pp60c-src was performed by immunoblot analysis after protein separation by sodium dodecyl su...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90227-2
更新日期：1992-01-01 00:00:00
abstract：:Heparinase degraded heparin fragments (HDHF) are enriched with a UV chromophore and can be utilized as calibrators to determine the molecular weight profile of low molecular weight heparins (LMWH's). In a standard protocol (1), the second to the last peak is assumed to be a hexasaccharide with a molecular weight of 1....
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90222-a
更新日期：1993-04-01 00:00:00
