Abstract:
INTRODUCTION:Although the general improvement caused by recombinant human erythropoietin (rHuEPO) in the correction of uraemic anaemia cannot be questioned, some data suggest that the changes in the haemostasis, endothelial function and oxidative stress (SOX) are induced. The aim of the present study was to investigate the effect of one-year rHuEPO therapy on the coagulation activation, endothelial injury markers and SOX in haemodialysis (HD) patients. MATERIALS AND METHODS:Assessment of coagulation activation pathway: tissue factor (TF), its inhibitor (TFPI) and prothrombin fragment 1+2 (F1+2); endothelial injury markers: von Willebrand factor antigen (vWF:Ag) and thrombomodulin (TM); and several parameters related to SOX: total peroxide, Cu/Zn superoxide dismutase (Cu/Zn SOD) and autoantibodies to oxidized LDL (OxLDL-Ab) levels were performed in stable HD patients, treated for 12 months with rHuEPO (n=18; mean dose 113.5+/-41 U/kg/week) or not (with Hg<10 g/dl, n=8 and with Hg>10 g/dl, n=12), none of them on iron therapy. RESULTS:Patients with Hg<10 g/dl had a significantly lower erythrocytes count, Ht and Hg levels than those with Hg>10 g/dl and those on rHuEPO therapy. Long-term rHuEPO therapy does not affect coagulation pathway and SOX markers. Treatment with this hormone resulted in a tendency to decrease TM and vWF:Ag concentrations, however these changes did not reach a statistical significance. CONCLUSIONS:These results suggest that one-year rHuEPO therapy seems to exert no additional influence on coagulation activation, endothelial cell damage/activation markers and oxidative stress in patients undergoing regular HD in the absence of concomitant iron supplementation and irrespective from haemoglobin levels.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Pawlak K,Pawlak D,Mysliwiec Mdoi
10.1016/j.thromres.2007.02.004subject
Has Abstractpub_date
2007-01-01 00:00:00pages
797-803issue
6eissn
0049-3848issn
1879-2472pii
S0049-3848(07)00071-0journal_volume
120pub_type
临床试验,杂志文章abstract:INTRODUCTION:Inflammation and coagulation play important roles in the pathogenesis of sepsis. Anticoagulants with anti-inflammatory action draw attention as therapeutic agent in sepsis. OBJECTIVE:Whether cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2-(1H)-quinolinone), anticoagulant, protects m...
journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
abstract::The two objectives of the study were to determine whether a procedure could be developed for measuring cancer procoagulant (CP) activity in human serum and if this procedure provided a method for distinguishing people with cancer from those without cancer. A procedure was developed for processing human serum such that...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90256-9
更新日期:1989-11-01 00:00:00
abstract::Indirect genetic diagnosis using polymorphic DNA markers can be useful in large-scale screening programs, which is technically simpler, more rapid and amenable. The main objective of this study was to test the informativeness of two common intragenic markers (TaqI and XmnI) in Iranian haemophilia B families to detect ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2004.03.009
更新日期:2004-01-01 00:00:00
abstract::Arterial thrombosis and venous thromboembolism (VTE) are traditionally considered two different entities. However, patients with unprovoked VTE are at higher risk of developing subclinical and overt atherosclerosis compared to healthy controls challenging these distinctions. Obesity may explain the association between...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
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更新日期:2020-07-01 00:00:00
abstract:INTRODUCTION:Ticagrelor and prasugrel are recommended as first line therapy in patients with acute coronary syndromes (ACS). However, patients with anemia are commonly treated with clopidogrel in routine clinical practice. The RENAMI registry (REgistry of New Antiplatelet therapy in patients with acute Myocardial Infar...
journal_title:Thrombosis research
pub_type: 杂志文章,多中心研究
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更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:HELLP (Hemolysis, elevated liver enzymes and low platelets) syndrome is a severe and acute pregnancy-related disorder that occurs in approximately 2.5 per 1000 deliveries and represents a major cause of maternal and perinatal morbidity and mortality. This syndrome has been suggested to be a microangiopathy a...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2020.08.038
更新日期:2020-12-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90181-0
更新日期:1983-06-01 00:00:00
abstract::This study comprised 50 patients subjected to major abdominal surgery, of which 13 developed deep vein thrombosis (DVT) according to the 125I-fibrinogen test. Plasma was sampled preoperatively, for the specific analysis of tissue plasminogen activator (t-PA) before and during venous occlusion. The recently described f...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90103-3
更新日期:1985-07-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(98)00160-1
更新日期:1998-12-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(99)00013-4
更新日期:1999-06-15 00:00:00
abstract:BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.04.003
更新日期:2015-06-01 00:00:00
abstract::Clot adherence to peritoneal cavity mesothelium was studied in rats in an attempt to contribute to the problem of thrombus embolization. The adherence was decreased by platelets and the active constituent was identified as adenosine diphosphate which decreased the sticking of fibrin to cellular linings as well as to a...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90100-1
更新日期:1982-12-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2007.09.008
更新日期:2008-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00242-1
更新日期:1996-01-15 00:00:00
abstract::An abnormal prothrombin has been detected in a 26-year-old female, who had no history of excessive bleeding. Prothrombin activity was approximately 10% when measured using either the classical one-stage assay or the assay with Echis carinatus venom, whereas prothrombin antigen level was normal. In keeping with current...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(91)90373-5
更新日期:1991-06-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.10.027
更新日期:2012-04-01 00:00:00
abstract::In 51 shock patients with DIC Antithrombin III (AT III) substitution, heparin or a combination of both substances respectively was administered. In the two groups which had been given AT III substitution the concentration of AT III rose considerably higher than the activity. There was a drop of the platelet count in b...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90123-9
更新日期:1985-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0049-3848(03)00283-4
更新日期:2003-03-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00125-b
更新日期:1995-08-15 00:00:00
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pub_type: 杂志文章
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:1984-08-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90109-p
更新日期:1990-11-15 00:00:00
abstract::In order to choose the proper method for evaluating the antithrombin activity in samples of chitosan polysulphate (CP) with different polymerization degrees and sulphation degrees, we estimated the ability of direct anticoagulants to depress the coagulability of recalcified sheep blood using the third international he...
journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
abstract::Deep vein thrombosis and pulmonary embolism, collectively termed venous thromboembolism (VTE), affect over 1 million Americans each year. VTE is triggered by inflammation and blood stasis leading to the formation of thrombi rich in fibrin and red blood cells (RBCs). However, little is known about mechanisms regulating...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:Animal models of thrombosis and hemostasis are critical for target validation in pharmaceutical research. Guinea pig haemostatic mechanisms, such as the platelet thrombin receptor repertoire, resemble those of humans. Measuring the performance characteristics of marketed antithrombotic drugs in guinea pig ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2008.03.010
更新日期:2008-01-01 00:00:00
abstract::The fibrinogen molecule consists of two sets of Aalpha, Bbeta, and gamma chains assembled into a bilateral disulfide linked (Aalpha, Bbeta, gamma)2 structure. Cleavage of the two A-fibrinopeptides (FPA, Aalpha1-16) from normal Aalpha chains with arginine at position 16 (RFPA) by thrombin or the venom enzyme atroxin tr...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(00)00383-2
更新日期:2001-01-15 00:00:00
abstract::Atherothrombosis is the leading cause of morbidity and mortality in patients with diabetes mellitus. Several mechanisms contribute to the diabetic prothrombotic state, including endothelial dysfunction, coagulative activation and platelet hyper-reactivity. In particular, diabetic platelets are characterised by dysregu...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
abstract::Selective serotonin reuptake inhibitors (SSRIs) have been reported to reduce platelet aggregation induced by ADP. ADP induces platelet aggregation through two purinergic receptors P2Y1 and P2Y12. We characterized the inhibitory properties of SSRIs on ADP-induced platelet aggregation and investigated the effects of SSR...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.02.007
更新日期:2013-04-01 00:00:00
abstract::Cell lysates of the human monoblastic leukemia cell line, THP-1, have procoagulant activity (PCA) that is Ca++-dependent and not demonstrable in either Factor VII-, or Factor X-deficient plasma. The PCA of THP-1 cells was enhanced by human recombinant tumor necrosis factor-alpha (TNF-alpha) up to five fold. There was ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(89)90162-x
更新日期:1989-10-15 00:00:00
abstract::Human apolipoprotein B was purified by barium sulphate adsorption, subsequent delipidation and gel filtration. The protein was then reconstituted in soya bean lecithin and its inhibitory effect towards thromboplastin was assayed by incubation with rabbit brain thromboplastin. The use of an antibody against human apoli...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90033-7
更新日期:1992-10-15 00:00:00