Diabetes mellitus and thrombosis.

abstract：:Studies with animal models implicate the plasma proteases factor XIIa (FXIIa) and α-kallikrein in arterial and venous thrombosis. As congenital deficiencies of factor XII (FXII) or prekallikrein (PK), the zymogens of FXIIa and α-kallikrein respectively, do not cause bleeding disorders, inhibition of these enzymes may ...

journal_title：Thrombosis research

authors： Kokoye Y,Ivanov I,Cheng Q,Matafonov A,Dickeson SK,Mason S,Sexton DJ,Renné T,McCrae K,Feener EP,Gailani D

更新日期：2016-04-01 00:00:00

abstract：:Cilostazol is a newly developed antiplatelet drug that has been widely applied for clinical use. Its antiplatelet action appears to be mainly related to inhibition of intracellular phosphodiesterase activity. Our study was designed to investigate inhibitory effects of cilostazol on the expression of activation-depende...

journal_title：Thrombosis research

authors： Inoue T,Sohma R,Morooka S

更新日期：1999-02-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial, venous or small-vessel thrombotic events, and recurrent miscarriages or fetal loss. APS diagnosis is based on the repeated detection of anti-phospholipid (PL) antibodies (Ab), typically associated with anti-β2 glycoprotein I (β2GPI)-Ab...

journal_title：Thrombosis research

authors： Cañas F,Simonin L,Couturaud F,Renaudineau Y

更新日期：2015-02-01 00:00:00

abstract：:Nineteen patients, (2 adults, 17 children) with inherited bleeding disorders were infused with n-heptane-suspended-heated clotting factor concentrates. Twelve of the nineteen were previously untreated. Six patients were infused with Profilnine Heat-Treated and 13 with Profilate Heat-Treated. Five separate centers part...

journal_title：Thrombosis research

authors： Carnelli V,Gomperts ED,Friedman A,Aledort L,Hilgartner M,Dietrich S,Fedor EJ

更新日期：1987-06-15 00:00:00

abstract：:Pregnancy induces several haemostatic perturbations. Some authors described possible acquired activated protein C resistance (APCR) during normal pregnancy. We wanted to test this possibility and to evaluate if this acquired APCR might contribute to the known increased tendency to thrombosis associated with pregnancy....

journal_title：Thrombosis research

authors： Schlit AF,Col-De Beys C,Moriau M,Lavenne-Pardonge E

更新日期：1996-11-01 00:00:00

abstract：INTRODUCTION:Normal pregnancy is associated with hypercoagulable state. Elevated markers of coagulation and fibrinolytic system activation indicate increased thrombin activity and increased fibrinolysis following fibrin formation throughout pregnancy. These changes exceed the biological variability in most cases. Haemo...

journal_title：Thrombosis research

authors： Réger B,Péterfalvi A,Litter I,Pótó L,Mózes R,Tóth O,Kovács GL,Losonczy H

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:In the treatment of bleeds in haemophilia patients with inhibitors, a high initial dose of recombinant Factor VIIa (rFVIIa) provides at least equal efficacy and a similar safety profile to a standard initial dose. However, no pharmacoeconomic comparison between these dosing regimens has previously been per...

journal_title：Thrombosis research

authors： Salaj P,Kubes R,Cetkovsky P,Capova I,Penka M,Ovesná P,Mesterton J,Lindgren P

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Critical care patients are prone to venous thromboembolism (VTE) and, thus, pharmacological thromboprophylaxis is generally advised. Low-molecular weight heparins (LMWHs) have become the drug of choice in ICU patients, since their predictable and reproducible dose response. Monitoring their pharmacological e...

journal_title：Thrombosis research

authors： Vahtera A,Vaara S,Pettilä V,Kuitunen A

更新日期：2016-03-01 00:00:00

abstract：:Fibrinogen has been reported to interact with phospholipid; however, the properties of this binding interaction have not been characterized. Purified preparations of human fibrinogen bound to small unilamellar vesicles containing phosphatidylserine (PS) as measured by light scattering and radioisotope filtration. Bind...

journal_title：Thrombosis research

authors： Cunningham MT,Citron BA,Koerner TA

更新日期：1999-09-15 00:00:00

abstract：:Tissue factor pathway inhibitor is the major potent physiologic inhibitor of tissue factor-induced coagulation. Several potential binding sites for transcription factors have been described in the 750 bp of the 5' flanking region of the human tissue factor pathway inhibitor gene reported earlier. To identify elements ...

journal_title：Thrombosis research

authors： Petit L,Lesnik P,Dachet C,Hugou I,Moreau M,Chapman J,Rouis M

更新日期：1999-09-01 00:00:00

abstract：:D-dimer is an indicator for in vivo fibrin formation, reflecting the formation of fibrin crosslinked by factor XIIIa. D-dimer assays are frequently used in emergency situations, such as diagnosis of venous thrombosis and pulmonary embolism, or disseminated intravascular coagulation. In these conditions, short sample t...

journal_title：Thrombosis research

authors： Dempfle CE,Suvajac N,Elmas E,Borggrefe M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Upon platelet stimulation with agonists, reactive oxygen species (ROS) generation enhances platelet activation and granule release. Whether ROS generation during platelet storage could be directly correlated with the expression of proinflammatory molecules and granule release has been investigated in this st...

journal_title：Thrombosis research

authors： Ghasemzadeh M,Hosseini E

更新日期：2017-08-01 00:00:00

abstract：:Platelet-neutrophil interactions play an important role in thrombotic and inflammatory responses. Although it is well known that adhesion of platelets to neutrophils requires interactions of adhesion molecules on platelets such as P-selectin, or GPIIb/IIIa with their counterparts on neutrophils, little is known on the...

journal_title：Thrombosis research

authors： Chlopicki S,Lomnicka M,Gryglewski RJ

更新日期：2003-06-15 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is a transient hypercoagulability state initiated, paradoxically, by the anticoagulant, heparin. It is characterized by antibody-induced activation of platelets, leading to thrombin generation. Many patients with HIT develop thrombosis; even when heparin is stopped because of "is...

journal_title：Thrombosis research

authors： Warkentin TE

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...

journal_title：Thrombosis research

authors： Tabata N,Hokimoto S,Akasaka T,Arima Y,Kaikita K,Kumagae N,Morita K,Miyazaki H,Oniki K,Nakagawa K,Matsui K,Ogawa H

更新日期：2014-11-01 00:00:00

abstract：:Lipoprotein-associated coagulation inhibitor (LACI) is a plasma-derived protein that inhibits the tissue factor/factor VIIa/calcium/phospholipid complex in a factor Xa-dependent manner. Recombinant LACI (rLACI) added exogenously to plasma prolonged the activated partial thromboplastin time (APTT) and prothrombin time ...

journal_title：Thrombosis research

authors： Welsch DJ,Novotny WF,Wun TC

更新日期：1991-10-15 00:00:00

abstract：INTRODUCTION:Time in therapeutic range (TTR) for international normalized ratio (INR) is an accepted quality measure of anticoagulation control in patient populations, but its usefulness for predicting stroke and bleeding in individuals is not well understood. MATERIALS AND METHODS:In a nested case control analysis am...

journal_title：Thrombosis research

authors： Nieuwlaat R,Connolly BJ,Hubers LM,Cuddy SM,Eikelboom JW,Yusuf S,Connolly SJ,ACTIVE Investigators.

更新日期：2012-06-01 00:00:00

abstract：:Thrombus formation was electrically induced in the left common carotid artery of rats with preoccluded both vertebral and right carotid arteries. Following thrombus induction, animals became unresponsive and lost their righting reflex. The loss of righting reflex was observed when cortical tissular pO2 reached 55 +/- ...

journal_title：Thrombosis research

authors： Massad L,Plotkine M,Capdeville C,Boulu RG

更新日期：1987-10-01 00:00:00

abstract：:The effect of a low molecular weight heparin (Fragmin) (20-80 U/kg) was studied in 10 healthy male volunteers after intravenous administration. Clotting abnormalities are extensive shortly after injection, lasting for 1-2 hours depending on heparin dosage. Dilute thrombin time, showing a close correlation to anti-F-Xa...

journal_title：Thrombosis research

authors： Andrassy K,Mörike K,Koderisch J,Weber E

更新日期：1988-03-15 00:00:00

abstract：:The heparin-binding properties of human plasma apolipoproteins B-100 and E (apoB-100 and E) of low density lipoproteins (LDL), thrombin, and antithrombin-III (AT-III) were investigated. A highly reactive heparin (HRH) to apoB-100 was isolated by chromatography of crude heparin on a column of LDL immobilized to Affi-Ge...

journal_title：Thrombosis research

authors： Cardin AD,Barnhart RL,Witt KR,Jackson RL

更新日期：1984-06-15 00:00:00

abstract：INTRODUCTION:Von Willebrand Disease (VWD) is the most common inherited bleeding disorder. Measurement of von Willebrand factor (VWF) activity in plasma is often based on platelet agglutination stimulated by the ristocetin cofactor activity. Novel assays, based on latex beads with recombinant glycoprotein Ib instead of ...

journal_title：Thrombosis research

authors： Timm A,Hillarp A,Philips M,Goetze JP

更新日期：2015-04-01 00:00:00

abstract：:Diabetes is associated with multiple disorders including metabolic, cellular and blood disturbances leading to vascular complications. Increased circulating levels of platelet-leukocyte aggregates (PLA) have been described in several thrombotic diseases. In this study, we have evaluated circulating PLA in diabetic pat...

journal_title：Thrombosis research

authors： Elalamy I,Chakroun T,Gerotziafas GT,Petropoulou A,Robert F,Karroum A,Elgrably F,Samama MM,Hatmi M

更新日期：2008-01-01 00:00:00

abstract：:Endothelial cell activation or damage is believed to play a key role in preeclampsia (PE) and may underlie the hemostatic changes observed in this syndrome. The aim of this study was to evaluate a relationship between maternal and cord blood hemostatic disturbances in preeclamptic pregnancies. We measured the plasma l...

journal_title：Thrombosis research

authors： Catarino C,Rebelo I,Belo L,Rocha S,Castro EB,Patricio B,Quintanilha A,Santos-Silva A

更新日期：2008-01-01 00:00:00

abstract：:A frequent complication of venous access devices (VADs) is axillary-subclavian venous thrombosis. To study this problem we have compared blood drawn through VADs with peripheral blood samples in a group of oncology patients with venographically demonstrated venous damage (N = 14) and a group with normal venograms (N =...

journal_title：Thrombosis research

authors： Horne MK 3rd,Merryman PK,Mayo DJ,Gralnick HR,Chang RC,Alexander HR

更新日期：1995-08-15 00:00:00

abstract：:Hip joint replacement surgery, using acrylic cement for prosthesis fixation, is associated with intraoperative cardiorespiratory dysfunction, and a high frequency of postoperative proximal deep vein thrombosis (DVT). Levels of prothrombin fragments 1+2 (F1+2), tissue plasminogen activator antigen (t-PA), plasminogen a...

journal_title：Thrombosis research

authors： Dahl OE,Pedersen T,Kierulf P,Westvik AB,Lund P,Arnesen H,Seljeflot I,Abdelnoor M,Lyberg T

更新日期：1993-06-15 00:00:00

abstract：:A new model of arterial thrombosis in rats was based on a combination of a localizing hemodynamic factor /partial mechanical constriction of aorta/, generalized mild endothelial lesion /i.v.hypotonic saline/ and a humoral factor/i.v. serotonin/. The resulting aortic occlusion was indicated by measuring rectal temperat...

journal_title：Thrombosis research

authors： Hladovec J

更新日期：1986-03-01 00:00:00

abstract：:A simple and reproducible method to induce an occlusive thrombus in rabbit carotid artery is reported. Rabbits were anesthetized and prepared to record arterial pressure, heart rate, and carotid blood flow. A critical stenosis of a damaged carotid artery was obtained using an external plastic cylinder. Complete occlus...

journal_title：Thrombosis research

authors： Bevilacqua C,Finesso M,Prosdocimi M

更新日期：1991-05-15 00:00:00

abstract：:Three methods commonly used for isolation of blood platelets from plasma were compared. Platelets were isolated by: 1) a washing method; 2) a method of metrizamide-gradient centrifugation; 3) a modified method of gel-filtration. The last method employed BSA-Sepharose gel instead of routinely used Sepharose gel saturat...

journal_title：Thrombosis research

authors： Walkowiak B,Kralisz U,Michalec L,Majewska E,Koziolkiewicz W,Ligocka A,Cierniewski CS

更新日期：2000-09-01 00:00:00

abstract：:Surviving an embolism exposes patients to potential long-term complications, such as altered quality of life, persistent dyspnea, impaired exercise capacity or pulmonary hypertension. The common objective factor in most of these situations is the presence of residual pulmonary vascular obstruction (RPVO). Planar venti...

journal_title：Thrombosis research

authors： Bonnefoy PB,Margelidon-Cozzolino V,Catella-Chatron J,Ayoub E,Guichard JB,Murgier M,Bertoletti L

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:To measure the variations of different parameters in the hemostatic system and to analyze their roles in the development of hemostatic disorder in patients with orthotopic liver transplantation (OLT) procedures routinely performed without venovenous bypass. METHODS:The blood coagulation and fibrinolysis par...

journal_title：Thrombosis research

authors： Wang Y,Liu Y,Han R,Zhu Z,Zhang Y,Wang X,Wang L,Shen Z

更新日期：2008-01-01 00:00:00