Abstract:
INTRODUCTION:Time in therapeutic range (TTR) for international normalized ratio (INR) is an accepted quality measure of anticoagulation control in patient populations, but its usefulness for predicting stroke and bleeding in individuals is not well understood. MATERIALS AND METHODS:In a nested case control analysis among ACTIVE W study patients, cases with stroke and cases with bleeding were separately matched with controls. Several anticoagulation quality measures were compared, overall and in a time-dependent manner. RESULTS:32 cases with ischemic stroke and 234 cases with bleeding in the analysis were matched in a 4:1 ratio to 122 and 865 controls, respectively. Follow-up duration was 257±154days for the stroke analysis and 222±146days for the bleeding analysis. Compared with their respective controls, the study mean TTR of both stroke cases (53.9%±25.1 vs 63.4%±24.8; p=0.055) and bleeding cases (56.2%±25.4 vs 63.4%±26.8; p<0.001) was lower. Time below range for stroke and time above range for bleeding were only greater in the last month leading up to the event, not over the entire study period. Rather, over the entire study period bleeding cases spent more time below range than controls (26.8%±25.9 vs 20.8%±24.0; p=0.001). CONCLUSIONS:TTR was lower in individual AF patients with stroke or bleeding compared with matched controls in ACTIVE W. Maintaining a high TTR, with equal importance to avoid low and high INRs, is a relevant goal of individual patient treatment to prevent stroke and bleeding.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Nieuwlaat R,Connolly BJ,Hubers LM,Cuddy SM,Eikelboom JW,Yusuf S,Connolly SJ,ACTIVE Investigators.doi
10.1016/j.thromres.2011.08.024subject
Has Abstractpub_date
2012-06-01 00:00:00pages
715-9issue
6eissn
0049-3848issn
1879-2472pii
S0049-3848(11)00447-6journal_volume
129pub_type
杂志文章,随机对照试验abstract::Normal pregnancy is associated with an increasing state of activation of the haemostatic system. This activation state is excessive in women with placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE). Platelet activation plays a crucial pathophysiological role in PE. The very early activation ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/S0049-3848(19)30359-7
更新日期:2019-09-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.11.003
更新日期:2018-12-01 00:00:00
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2012.03.012
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2004.08.014
更新日期:2005-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
doi:10.1016/0049-3848(95)00041-0
更新日期:1995-04-15 00:00:00
abstract::Patients with essential hypertension (EH) and hyperhomocysteinemia (HHCY) suffer from more increased thrombotic events than those in EH alone. However, the underlying mechanisms for this effect are not well understood. This study hypothesized that neutrophil extracellular trap (NET) releasing may be triggered by HHCY ...
journal_title:Thrombosis research
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journal_title:Thrombosis research
pub_type: 杂志文章,评审
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90405-1
更新日期:1987-11-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1986-06-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(00)00268-1
更新日期:2000-09-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/0049-3848(94)90065-5
更新日期:1994-07-15 00:00:00
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pub_type: 杂志文章
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更新日期:1996-05-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90091-9
更新日期:1983-11-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0049-3848(03)00342-6
更新日期:2003-06-01 00:00:00
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doi:10.1016/j.thromres.2005.11.015
更新日期:2006-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章,多中心研究
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更新日期:2017-09-01 00:00:00
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2002-12-15 00:00:00
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pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90340-3
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Despite treatment, women with von Willebrand disease (VWD) have lower von Willebrand factor (VWF) levels and greater blood loss at delivery than controls. Current weight-based dosing does not account for the ~1.5-fold increase in blood volume in pregnancy. METHODS:To evaluate the feasibility of a trial to p...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.05.022
更新日期:2017-08-01 00:00:00
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更新日期:1983-03-15 00:00:00