当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonyl-meth oxy coumarin) inhibits the release of arachidonic acid in human platelets stimulated by thrombin.

AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonyl-meth oxy coumarin) inhibits the release of arachidonic acid in human platelets stimulated by thrombin.

Abstract：

:The coumarin derivative AD6 is known to inhibit platelet aggregation and release and it possesses vasodilatory properties on coronary arteries of laboratory animals. Furthermore, the inhibition of the production of TxB2 from endogenous substrates after stimulation of human platelets with collagen has been demonstrated. The present report demonstrates that AD6 inhibits the production of labeled arachidonic acid and diglycerides from phospholipids of platelets stimulated with thrombin. This effect is dose-dependent and is already evident at a concentration of the drug (25 microM) which is unable to prevent the aggregation. Apparently, AD6 inhibits the release of arachidonic acid from phosphatidylinositol and choline phosphoglycerides which are the main sources of the substrate for the synthesis of prostaglandins and thromboxanes.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Porcellati S,Costantini V,Prosdocimi M,Pistolesi R,Porrovecchio P,Nenci GG,Goracci G

doi

10.1016/0049-3848(87)90236-2

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

15-24

issue

1

eissn

0049-3848

issn

1879-2472

journal_volume

47

pub_type

杂志文章

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