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Effects of G-CSF on systemic inflammation, coagulation and platelet activation in patients with acute myocardial infarction.

Abstract：

INTRODUCTION:In the prospective, randomised, double-blind, placebo-controlled Regenerate Vital Myocardium by Vigorous Activation of Bone Marrow Stem Cells (REVIVAL)-2 trial patients with acute myocardial infarction (AMI) and successful mechanical reperfusion received granulocyte-colony stimulating factor (G-CSF, 10 μg/kg KG s.c.) or placebo for 5 days. Aim of this substudy was to assess the impact of G-CSF on systemic inflammatory and procoagulant responses and platelet activation. METHODS AND RESULTS:Before and five days after G-CSF (n=56) or placebo (n=58) circulating cytokine concentrations of interleukin (IL)-1ß, IL-6, IL-8, IL-10, IL-12 and Tumor-Necrosis Factor-α (TNF-α were measured. Prothrombin fragment F1+2 and Tissue Factor activity served as a measure for activated coagulation. Platelet activation was characterized by cell surface expression of the activated fibrinogen receptor (PAC-1), P-selectin and CD40L by flow cytometry. Administration of G-CSF was associated with elevated TNF-α and CRP concentrations compared to the placebo group after 5 days. Other cytokines (IL-1ß, IL-6, IL-8, IL-10, IL-12) were comparable after treatment with G-SCF or placebo. Similarly, circulating prothrombin fragments F1+2, TF activity and platelet activation did not differ in both groups. CONCLUSION:Treatment with G-CSF in patients with AMI was associated with enhanced proinflammatory TNF-α and CRP levels but no activation of coagulation.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Steppich BA,Demetz G,Schulz S,von Wedel J,Pogatsa-Murray G,Braun SL,Stein A,Kastrati A,Schömig A,Ott I

doi

10.1016/j.thromres.2010.11.004

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

119-21

issue

2

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(10)00600-6

journal_volume

127

pub_type

杂志文章,随机对照试验

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