Reductions in tissue plasminogen activator and thrombomodulin in blood draining veins damaged by venous access devices.

Abstract:

:A frequent complication of venous access devices (VADs) is axillary-subclavian venous thrombosis. To study this problem we have compared blood drawn through VADs with peripheral blood samples in a group of oncology patients with venographically demonstrated venous damage (N = 14) and a group with normal venograms (N = 21). The samples were assayed for a battery of proteins believed to be involved in thrombogenesis. After approximately six weeks of catheterization the venographically abnormal patients had significantly less thrombomodulin (P = 0.0055) and significantly higher PAI:tPA (P = 0.022) in catheter-drawn samples as compared with the venographically normal group. Although the data are inconclusive, it is hypothesized that these changes resulted from local endothelial injury.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Horne MK 3rd,Merryman PK,Mayo DJ,Gralnick HR,Chang RC,Alexander HR

doi

10.1016/0049-3848(95)00125-b

subject

Has Abstract

pub_date

1995-08-15 00:00:00

pages

369-76

issue

4

eissn

0049-3848

issn

1879-2472

pii

0049-3848(95)00125-B

journal_volume

79

pub_type

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