Heavy menstrual bleeding: An update on management.

abstract：:Adenosine is an endogenous antiaggregating substance that influences the platelet responses through specific A-type receptors that activate adenylate cyclase increasing the levels of 3',5'-cyclic adenosine monophosphate (cAMP). In this study, we investigated whether adenosine can also influence the levels of 3',5'-cyc...

journal_title：Thrombosis research

authors： Anfossi G,Russo I,Massucco P,Mattiello L,Cavalot F,Balbo A,Trovati M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Serious bleeding is a frequent and feared treatment complication in patients treated with oral anticoagulants (OACs). Levels of von Willebrand factor (VWF) antigen have been linked to the risk of bleeding complications, mortality, and cardiovascular events. OBJECTIVES:In this longitudinal cohort study of ev...

journal_title：Thrombosis research

authors： Lind M,Johansson L,Nilsson TK,Jansson JH,Hollestelle MJ

更新日期：2015-11-01 00:00:00

abstract：:Thirty-four derivatives of benzamidine were tested for their inhibitory activities on bovine and human thrombins using the chromogenic peptide substrate N-D-Phe-Pip-Arg-pNA. The inhibition constants of small molecular size inhibitors of comparatively low affinity as well as those of tight binding inhibitors did not di...

journal_title：Thrombosis research

authors： Stürzebecher J,Walsmann P,Voigt B,Wagner G

更新日期：1984-12-01 00:00:00

abstract：:Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...

journal_title：Thrombosis research

authors： Binnie C,Wagner RH,Cooper H,Hermans J

更新日期：1985-11-15 00:00:00

abstract：BACKGROUND:Immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder in children. Activated T cells have been shown to play important roles in ITP. The aims of this study were to evaluate whether these T cell activation markers could be used as indicators to differentiate ITP patients from controls, and to ...

journal_title：Thrombosis research

authors： Chen Y,Zhou Y,Chen P,Zhang P,Jia M,Tang Y

更新日期：2019-08-01 00:00:00

abstract：:Von Willebrand Factor is a multimer produced by endothelial cells and megakaryocytes, being stored in intracellular organelles, such as the Weibel-Palade bodies and alpha-granules in endothelial cells and platelets, respectively. This molecule acts as a carrier protein for factor VIIIc, involved in the intrinsic pathw...

journal_title：Thrombosis research

authors： Spadafora-Ferreira M,Lopes AA,Coelho V,Guilherme L,Kalil J

更新日期：2000-01-15 00:00:00

abstract：BACKGROUND:Muromonab-CD3 is a murine monoclonal antibody (MoAb) that is used in the prophylaxis and treatment of acute graft rejection. Activation of coagulation and fibrinolysis following anti-CD3 administration have been reported in some patients to lead to irreversible intragraft thrombosis. DESIGN AND METHODS:We h...

journal_title：Thrombosis research

authors： Lozano M,Oppenheimer F,Cofan F,Rosinyol L,Mazzara R,Escolar G,Ordinas A

更新日期：2001-12-15 00:00:00

abstract：:Fibrillar collagen endows the normal aortic wall with significant stiffness and strength and similarly plays important roles in many disease processes. For example, because of the marked loss of elastic fibers and functional smooth cells in aortic aneurysms, collagen plays a particularly important role in controlling ...

journal_title：Thrombosis research

authors： Schriefl AJ,Collins MJ,Pierce DM,Holzapfel GA,Niklason LE,Humphrey JD

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. MATERIALS AND METHODS:We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were in...

journal_title：Thrombosis research

authors： Rattazzi M,Villalta S,De Lucchi L,Sponchiado A,Galliazzo S,Faggin E,Pagliara V,Zilli C,Callegari E,Caberlotto L,Puato M,Pauletto P

更新日期：2017-12-01 00:00:00

abstract：:Resveratrol (3, 4', 5-trihydroxystilbene), a natural polyphenol, is found in some plants that are used in human nutrition. Grapes are a major source for resveratrol, and a significant amount can also be found in red wine. Several experimental studies have demonstrated biological properties of resveratrol, especially i...

journal_title：Thrombosis research

authors： Olas B,Wachowicz B,Saluk-Juszczak J,Zieliński T

更新日期：2002-08-15 00:00:00

abstract：:The effect of dalteparin, a low molecular weight heparin, on severely antithrombin III (ATIII)-decreased disseminated intravascular coagulation (DIC) model was compared with that of unfractionated heparin (heparin). The DIC model in rabbits was produced by continuous infusion of thrombin in combination with bolus inje...

journal_title：Thrombosis research

authors： Tazawa S,Ichikawa K,Misawa K,Fukuyama J,Hamano S,Miyata H,Sakuragawa N

更新日期：1995-12-01 00:00:00

abstract：INTRODUCTION:Low levels of plasminogen activator inhibitor type 1 (PAI-1) have been associated with increased risk for perioperative bleeding in some case reports. The aim of this study was to investigate prospectively whether low PAI-1 activity increases the risk for perioperative bleeding in patients undergoing trans...

journal_title：Thrombosis research

authors： Agren A,Kolmert T,Wiman B,Schulman S

更新日期：2007-01-01 00:00:00

abstract：:Reproducible disseminated intravascular coagulation in rabbits was provoked by two intravenous injections 24 hours apart of endotoxin from Salmonella enteritidis. There were mild symptoms of DIC before the second injection which considerably increased thereafter. In detail there was a sharp drop of the platelet count ...

journal_title：Thrombosis research

authors： Zawilska K,Zozulinska M,Turowiecka Z,Blahut M,Drobnik L,Vinazzer H

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Acquired von Willebrand Syndrome is a rare bleeding disorder, which arises in individuals with no personal or family history of bleeding, associated with lymphoproliferative and myeloproliferative disorders or other diseases. AIM:To develop a two-step approach assay to detect autoantibodies against VWF and ...

journal_title：Thrombosis research

authors： Franchi F,Biguzzi E,Stufano F,Siboni SM,Baronciani L,Peyvandi F

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Reports on the prevalence and risk factors of atherothrombotic events (AEs) are conflicting in persons with hemophilia (PWH). METHODS:This study evaluated the prevalence and risk factors of AEs among 1054 male hemophilia patients, using data collected from Taiwan's National Health Insurance Research Datab...

journal_title：Thrombosis research

authors： Wang JD,Chan WC,Fu YC,Tong KM,Chang ST,Hwang WL,Lin CH,Tsan YT

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Impaired endothelial-dependent flow-mediated dilatation (FMD) has been used to demonstrate endothelial dysfunction in a wide variety of cardiovascular disease, but previous studies have excluded patients with atrial fibrillation(AF). We therefore hypothesised that endothelial dysfunction exists in AF and tha...

journal_title：Thrombosis research

authors： Freestone B,Chong AY,Nuttall S,Lip GY

更新日期：2008-01-01 00:00:00

abstract：:In spite of numerous studies on the involvement of fibrinogen in transendothelial migration of leukocytes and thereby inflammation, there is still no clear understanding of which fibrin(ogen) species can stimulate leukocyte transmigration. Although we have previously proposed that interaction of fibrin with the VLDL r...

journal_title：Thrombosis research

authors： Yakovlev S,Medved L

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the eNOS3 gene on chromosome 7. The effects of the eNOS polymorphisms with the risk of coronary artery disease are conflicting. In this study, we investigated the association of the e...

journal_title：Thrombosis research

authors： Kim IJ,Bae J,Lim SW,Cha DH,Cho HJ,Kim S,Yang DH,Hwang SG,Oh D,Kim NK

更新日期：2007-01-01 00:00:00

abstract：:Severe rejection crises occurred in 13 out of 20 cadaver kidney recipients; removal of the graft was inevitable in 10 cases. The plasminogen levels were found to be lower (76.5 +/- 2.9%) in the 13 patients with impaired graft acceptance (group B) than in the 7 patients experiencing only moderate rejection (group A, 93...

journal_title：Thrombosis research

authors： Seitz R,Michalik R,Karges HE,Lange H,Egbring R

更新日期：1986-05-01 00:00:00

abstract：INTRODUCTION:Long-term dual antiplatelet therapy (DAPT) has substantially reduced the risk of post-percutaneous coronary intervention (PCI) myocardial infarction and stent thrombosis at the expense of major bleeding. We hypothesized that a short-term DAPT followed by extended P2Y12 inhibitor monotherapy might be approp...

journal_title：Thrombosis research

authors： Jin Y,Huang H,Shu X,Chen S,Lu L,Gao X,Wu Z

更新日期：2020-12-07 00:00:00

abstract：:Studies with animal models implicate the plasma proteases factor XIIa (FXIIa) and α-kallikrein in arterial and venous thrombosis. As congenital deficiencies of factor XII (FXII) or prekallikrein (PK), the zymogens of FXIIa and α-kallikrein respectively, do not cause bleeding disorders, inhibition of these enzymes may ...

journal_title：Thrombosis research

authors： Kokoye Y,Ivanov I,Cheng Q,Matafonov A,Dickeson SK,Mason S,Sexton DJ,Renné T,McCrae K,Feener EP,Gailani D

更新日期：2016-04-01 00:00:00

abstract：:Patients with Familial Hyperlipoproteinaemia Type II showed evidence of increased platelet aggregability when compared to normal controls. This abnormality was not influenced by oral therapy with probucol whether or not the serum cholesterol levels were lowered during the study period. Probucol assays indicated adequa...

journal_title：Thrombosis research

authors： Bradlow BA,Chetty N,Birnbaum M,Baker SG,Seftel HC

更新日期：1982-04-15 00:00:00

abstract：:The effect of suloctidil (600 mg/day) on platelet survival time (PST) and plasma and urine betathromboglobulin (BTG) was studied in a double-blind, placebo-controlled six-week crossover trial in 13 patients with shortened PST (less than 110 hrs, exponential model). Mean PST after suloctidil (110.6 hrs) was significant...

journal_title：Thrombosis research

authors： Turpie AG,Gent M,deBoer AC,Giroux M,Kinch D,Butt R,Gunstensen J,Saerens E,Genton E

更新日期：1984-08-15 00:00:00

abstract：:Tissue factor pathway inhibitor is the major potent physiologic inhibitor of tissue factor-induced coagulation. Several potential binding sites for transcription factors have been described in the 750 bp of the 5' flanking region of the human tissue factor pathway inhibitor gene reported earlier. To identify elements ...

journal_title：Thrombosis research

authors： Petit L,Lesnik P,Dachet C,Hugou I,Moreau M,Chapman J,Rouis M

更新日期：1999-09-01 00:00:00

abstract：:Hemorrhagic and thrombotic complications are common in the term and preterm infant. Limited information is currently available about neonatal platelet structure and function, and how these may predispose infants to bleeding problems. This study comparing platelet ultrastructure of 71 different term and preterm infants...

journal_title：Thrombosis research

authors： Saving KL,Jennings DE,Aldag JC,Caughey RC

更新日期：1994-03-15 00:00:00

abstract：:Because of a thrombasthenia-like platelet aggregation defect, platelets from dogs affected with Basset Hound Hereditary Thrombopathy were compared to normal control dog platelets by three different techniques in order to assess platelet membrane glycoprotein content. Crossed immunoelectrophoresis (CIE), two-dimensiona...

journal_title：Thrombosis research

authors： Patterson WR,Kunicki TJ,Bell TG

更新日期：1986-04-15 00:00:00

abstract：PURPOSE:The study sought to synthesize anionic peptide-conjugated tissue plasminogen activator (tPA) for its targeted/triggered delivery, where tPA's activity would be masked in the circulation and regenerated at the thrombus site by a commonly used anticoagulant, heparin, to minimize tPA associated bleeding complicati...

journal_title：Thrombosis research

authors： Absar S,Choi S,Ahsan F,Cobos E,Yang VC,Kwon YM

更新日期：2013-03-01 00:00:00

abstract：:Human tissue plasminogen activator (t-PA) was shown to bind specifically to human osteosarcoma cells (HOS), and human epidermoid carcinoma cells (A-431 cells). Crosslinking studies with DTSSP demonstrated high molecular weight complexes (130,000) between 125I-t-PA and cell membrane protein on human umbilical vein endo...

journal_title：Thrombosis research

authors： Beebe DP,Wood LL,Moos M

更新日期：1990-07-15 00:00:00

abstract：INTRODUCTION:Pelvic deep vein thrombosis (DVT) is difficult to diagnose during pregnancy. In a two-center trial, we evaluated the agreement between ultrasonography and magnetic resonance imaging (MRI) in diagnosing the extent of DVT into the pelvic veins during pregnancy. MATERIALS AND METHODS:Pregnant women with prox...

journal_title：Thrombosis research

authors： Torkzad MR,Bremme K,Hellgren M,Eriksson MJ,Hagman A,Jörgensen T,Lund K,Sandgren G,Blomqvist L,Kälebo P

更新日期：2010-08-01 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00