Abstract:
BACKGROUND:Serious bleeding is a frequent and feared treatment complication in patients treated with oral anticoagulants (OACs). Levels of von Willebrand factor (VWF) antigen have been linked to the risk of bleeding complications, mortality, and cardiovascular events. OBJECTIVES:In this longitudinal cohort study of evaluating patients treated with OACs, we aimed to evaluate the relationship between VWF displaying a glycoprotein Ib binding conformation (VWF activation factor) and the risk of cardiovascular events, bleeding complications, or all-cause mortality. MATERIALS AND METHODS:Blood samples were collected at baseline in 356 patients on OACs. Patients were followed for an average of 48 months and bleeding complications leading to admission to hospital or death, cardiovascular events (myocardial infarction, ischemic stroke, and peripheral arterial emboli), and all-cause mortality were recorded and classified. RESULTS:During the study period, 47 bleeding complications, 84 cardiovascular events, and 97 deaths occurred. In multivariate Cox regression analyses, VWF activation factor was significantly associated with all-cause mortality (HR 1.62; 95% CI: 1.25-2.08) and cardiovascular events (HR 1.28; 95% CI: 1.01-1.63). There was no association observed between VWF activation factor and bleeding complications. CONCLUSIONS:Patients with high levels of VWF activation factor had an increased risk of cardiovascular events and all-cause mortality during OAC treatment. The selectivity for thrombotic complications adds to the potential value of VWF activation factor as a biomarker or pharmacological target.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Lind M,Johansson L,Nilsson TK,Jansson JH,Hollestelle MJdoi
10.1016/j.thromres.2015.08.016subject
Has Abstractpub_date
2015-11-01 00:00:00pages
878-82issue
5eissn
0049-3848issn
1879-2472pii
S0049-3848(15)30099-2journal_volume
136pub_type
杂志文章abstract:INTRODUCTION:Edoxaban is an oral, once-daily direct factor Xa (FXa) inhibitor. Although rapidly cleared, strategies to reverse edoxaban-mediated effects on anticoagulation are needed in cases of excessive bleeding or emergency. This study evaluated the effect of two prohemostatic agents, recombinant factor VIIa (rFVIIa...
journal_title:Thrombosis research
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更新日期:2014-10-01 00:00:00
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更新日期:2002-12-15 00:00:00
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更新日期:2000-11-01 00:00:00
abstract::Thrombolysis is an effective but potential deleterious therapy and should therefore be limited to patients with acute intracerebral vessel occlusion and salvageable tissue. MRI currently develops towards the new diagnostic standard for the selection of stroke patients eligible for acute thrombolytic treatment and acut...
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pub_type: 杂志文章,评审
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abstract:INTRODUCTION:Profuse postpartum hemorrhage (PPH) and red blood cell (RBC) transfusion have been suggested to be associated with venous thromboembolic events (VTE). However, it is not fully clear if they are independent major risk factors. METHODS:Women who gave birth in the Stockholm area between 1999 and 2002 were th...
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更新日期:2018-05-01 00:00:00
abstract::We report an inbred family with two cases of homozygous protein C deficiency and review 11 other such cases. Both patients presented in the second half of their first year of life with recurrent rapidly disappearing ecchymotic skin lesions, disseminated intravascular coagulation, and venous thrombosis. Successful trea...
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pub_type: 杂志文章,评审
doi:10.1016/0049-3848(89)90202-8
更新日期:1989-03-01 00:00:00
abstract::The thrombolytic efficacy of recombinant tissue-type plasminogen activator (tPA) in the presence and absence of a thromboxane synthase inhibitor was studied in a model of femoral artery thrombosis in the anesthetized rabbit. The thrombus was formed by injection of thrombin and whole blood into an isolated segment of t...
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2014.06.002
更新日期:2014-08-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.05.020
更新日期:2017-08-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:1982-12-15 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0049-3848(82)90132-3
更新日期:1982-03-01 00:00:00
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更新日期:1997-10-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0049-3848(01)00342-5
更新日期:2001-10-01 00:00:00
abstract::Prothrombin time is a standard screening test to monitor patients treated with oral anticoagulants. We hypothesize that INR measurements will not vary a lot within a given day in a given patient. The present study was thus conducted to compare the change of the international normalized ratio (INR) of prothrombin time ...
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pub_type: 临床试验,杂志文章
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更新日期:2002-09-01 00:00:00
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更新日期:1988-10-15 00:00:00
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更新日期:1989-07-01 00:00:00
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更新日期:2018-11-01 00:00:00
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更新日期:1985-11-15 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-08-01 00:00:00