Abstract：
INTRODUCTION:Profuse postpartum hemorrhage (PPH) and red blood cell (RBC) transfusion have been suggested to be associated with venous thromboembolic events (VTE). However, it is not fully clear if they are independent major risk factors. METHODS:Women who gave birth in the Stockholm area between 1999 and 2002 were those studied, i.e., before the implementation of guidelines for thromboprophylaxis in pregnancy. In this population-based cohort study the Swedish Medical Birth Registry was linked to the National Discharge Registry and to the transfusion database. Cases with VTE were identified as well as the patient's transfusion history. The main outcome was an assessment of RBC transfusion and PPH as independent risk factors for postpartum thrombosis, analyzed in logistic regression models. RESULTS:Out of the 82,376 deliveries, 56 cases of postpartum VTE were identified (0.7‰). Compared to the control group, the risk of VTE increased with the number of RBC transfusions: 1 to 3 units (OR = 3.3, 95% CI 1.2-8.9) and >3 units (OR = 5.2, 95%CI 1.7-16.1), but PPH was not found to be a major risk factor (OR = 1.4, 95% CI 0.5-3.5). Surprisingly, the small group treated with plasma in addition to RBC transfusion were not at a significantly increased risk (OR = 1.8, 95% CI 0.2-14.0). Preeclampsia and placental abruption were major risk factors. CONCLUSION:We found RBC transfusion, but not PPH alone, to be an independent risk factor for postpartum VTE and propose that it should be included in the thromboprophylaxis algorithm for implementation during pregnancy.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Thurn L,Wikman A,Lindqvist PGdoi
10.1016/j.thromres.2018.03.002subject
Has Abstractpub_date
2018-05-01 00:00:00pages
54-60eissn
0049-3848issn
1879-2472pii
S0049-3848(18)30268-8journal_volume
165pub_type
杂志文章abstract：:Several single-nucleotide polymorphisms (SNPs) have been recognized as associated with ischemic heart disease (IHD) although the optimal set of risk genotypes has not be identified. This study aimed to examine whether identified high-risk SNPs are associated with early onset of IHD. In the GENOCOR study, 44 high-risk ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2014.03.006
更新日期：2014-05-01 00:00:00
abstract：:Factor IX Nagoya 3 (IX Nagoya 3) is a natural mutant of factor IX recognized in a patient with moderately severe hemophilia B. The patient had 0.60 units/ml of factor IX antigen and 2-5% of clotting activity. IX Nagoya 3 was purified from the patient's plasma by immunoaffinity chromatography with an anti-factor IX mon...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90109-p
更新日期：1990-11-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(99)00241-8
更新日期：2000-05-15 00:00:00
abstract：:Incubation of platelets with pronase or chymotrypsin results in the exposure of fibrinogen receptors. We determined that these enzymes did not affect the membrane fluidity as evaluated by the depolarization of the fluorescence of 1,6-diphenyl-1,3,5 hexatriene (DPH). There was no significant difference in either the de...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90124-0
更新日期：1985-07-01 00:00:00
abstract：BACKGROUND:Clauss fibrinogen assay (CFA) is widely used as a screening test to detect fibrinogen disorders. However, CFA alone cannot distinguish quantitative and qualitative defects because it depends on functional fibrinogen activity (Ac), and fibrinogen antigen (Ag) determination is required to classify fibrinogen d...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2018.12.018
更新日期：2019-02-01 00:00:00
abstract：:This work was designed to investigate the influence of rat platelet adrenoceptors on the early thrombin-induced serotonin release. In washed platelets prelabeled with [3H]-serotonin, adrenaline and isoproterenol both inhibited, in a dose-dependent manner, the early thrombin-induced secretion of serotonin. Inhibitory r...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90325-1
更新日期：1985-10-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(96)00004-7
更新日期：1996-02-01 00:00:00
abstract：INTRODUCTION:The recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) is undergoing clinical trials for prophylaxis and on-demand treatment of haemophilia B patients. The aim of this study was to investigate the pharmacokinetics, whole-body and knee joint distribution of rIX-FP following intra...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2014.02.010
更新日期：2014-05-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.thromres.2010.11.004
更新日期：2011-02-01 00:00:00
abstract：:Cardiovascular disease (CVD) includes a number of conditions such as myocardial infarction, coronary heart disease, stroke, and venous thromboembolism. CVD is a leading health problem worldwide and a major cause of mortality, morbidity, and disability; it is also associated with high healthcare costs. The incidence of...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2014.11.036
更新日期：2015-02-01 00:00:00
abstract：:In order to choose the proper method for evaluating the antithrombin activity in samples of chitosan polysulphate (CP) with different polymerization degrees and sulphation degrees, we estimated the ability of direct anticoagulants to depress the coagulability of recalcified sheep blood using the third international he...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(01)00266-3
更新日期：2001-06-01 00:00:00
abstract：:Central venous catheter-related thrombosis (CRT) is a complication seen in patients requiring long-term intravenous access. Treatment of CRT is not standardized and international guidelines for treatment are based on extrapolation of evidence from lower extremity thrombosis. We performed a systematic review of the lit...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2015.08.020
更新日期：2015-12-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2011.02.014
更新日期：2011-06-01 00:00:00
abstract：:Protein C has been measured by three different assays (antigenic, amidolytic and chronometric) in 27 end-stage renal insufficient patients before and after hemodialysis. Protein C levels have been compared with other coagulation inhibitors (antithrombin III, protein S) and fibrinolytic parameters. Baseline anticoagula...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90055-s
更新日期：1993-03-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(01)00412-1
更新日期：2002-01-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90211-7
更新日期：1985-06-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90376-1
更新日期：1984-10-01 00:00:00
abstract：:When single-chain pro-UK is activated by plasmin or kallikrein, the Lys158-Ile159 bond is cleaved, leaving a C-terminal lysine on the A-chain (Lys-UK). Two-chain, high molecular weight urokinase (UK) purified from urine, however, has been shown to contain a phenylalanine residue as the C-terminal of the A-chain (Phe-U...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90206-c
更新日期：1991-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00310-8
更新日期：2000-11-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章,多中心研究
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90299-4
更新日期：1987-04-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2007.01.012
更新日期：2007-01-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.10.024
更新日期：2013-01-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(03)00335-9
更新日期：2003-05-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2016.04.022
更新日期：2016-07-01 00:00:00
abstract：:Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90289-0
更新日期：1985-11-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(03)00288-3
更新日期：2003-04-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2009.07.014
更新日期：2010-05-01 00:00:00
abstract：:Venous thromboembolism (VTE) affects approximately 1 per 1000 persons annually. Although patients are increasingly treated with direct oral anticoagulants, many patients continue to be anticoagulated with vitamin K antagonists (VKA). The most important adverse events during VKA treatment, bleeding and the risk of recu...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2019.03.022
更新日期：2019-06-01 00:00:00
abstract：:Experimental disseminated intravascular coagulation (DIC) can be induced by 4-h sustained infusion of endotoxin in a dose of 100 mg/kg in rats. The experimental model of DIC in rats was used to study the preventive effect of dipyridamole against DIC. Before the infusion of endotoxin, 0.5, 5.0 or 50.0 mg/kg of dipyrida...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(83)90216-5
更新日期：1983-03-15 00:00:00
