Abstract：
:Antiphospholipid antibodies (APAs) are considered risk factors in patients with thromboembolic diseases. Although the incidence of such acquired coagulation disturbances in adults are well described, only few data exist for children. Therefore, in a first step to collect new data we analyzed the presence of different APAs in 202 consecutive children and compared them with two groups of adults. The children screened for APA were exclusively those who did not have any thromboembolic complications or a tendency for thrombophilia due to other underlying diseases such as systemic lupus or malignancy in their past or present medical history. Consecutive blood samples were evaluated from routine laboratory specimens. The two groups of adults comprised 200 patients after deep vein thrombosis and 200 patients without thromboembolic events that served as controls. Four lupus anticoagulant (LA) screening tests were determined: the dilute Russell's viper venom test; a lupus anticoagulant-sensitive activated partial thromboplastin time reagent; a second lupus-sensitive activated partial thromboplastin time; and the Kaolin clotting time. Furthermore, three different antiphospholipid antibodies ELISA assays against cardiolipin (ACA), beta2-glycoprotein I, and phosphatidyl-serine, were determined. The children had a much higher prevalence for LA than did the adults. On the other hand, their values for ACA were significantly lower than in adults with a history of thromboembolism. Findings in children were similar to the normal adult group. This has to be taken into account when evaluating children with thromboembolic diseases.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Siemens HJ,Gutsche S,Brückner S,Bucsky P,Katus HAdoi
10.1016/s0049-3848(99)00241-8subject
Has Abstractpub_date
2000-05-15 00:00:00pages
241-7issue
4eissn
0049-3848issn
1879-2472pii
S0049-3848(99)00241-8journal_volume
98pub_type
杂志文章abstract：:Endothelial cells in biopsied blood vessels from von Willebrand factor (vWf)-deficient Doberman pinscher dogs contain immunologically detectable vWf. These dogs and normal dogs were treated with DDAVP (0.6 microgram/kg) and epinephrine (0.5 microgram/kg/min for 30 minutes) and were exercised, using 5 different exercis...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90198-l
更新日期：1990-01-01 00:00:00
abstract：:Platelet aggregation in platelet-rich plasma (PRP) is more sensitive to agonists and more resistant to antagonists than that in whole blood. In this study, we show that the presence of neutrophils in whole blood accounts at least in part for diminished platelet aggregation in whole blood. The platelet-inhibitory effec...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90216-y
更新日期：1990-12-01 00:00:00
abstract：INTRODUCTION:Changes in platelet count and function contribute to thrombo-hemorrhagic episodes in chronic myeloproliferative syndromes (MPS). We used flow cytometry to study platelet-leukocyte conjugates and markers of platelet activation in patients with MPS. METHODS:Whole blood from patients with chronic myelogenous...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(02)00354-7
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND:The results of the EINSTEIN-DVT/PE and AMPLIFY trials, which compared rivaroxaban and apixaban with conventional anticoagulation therapy for acute venous thromboembolism (VTE), respectively, are often compared. However, the trials differed in duration of therapy (3-12 and 6months, respectively) and in patien...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
doi：10.1016/j.thromres.2016.11.014
更新日期：2017-01-01 00:00:00
abstract：:Recombinant factor IX (rFIX) is increasingly used to treat patients with hemophilia B. CHO (Chinese Hamster Ovary) cells are commonly used for the production of rFIX but they have a limited capacity for introducing post-translational modifications (PTM) leading to incomplete γ-carboxylation, low phosphorylation and su...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2012.08.313
更新日期：2012-11-01 00:00:00
abstract：:When single-chain pro-UK is activated by plasmin or kallikrein, the Lys158-Ile159 bond is cleaved, leaving a C-terminal lysine on the A-chain (Lys-UK). Two-chain, high molecular weight urokinase (UK) purified from urine, however, has been shown to contain a phenylalanine residue as the C-terminal of the A-chain (Phe-U...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90206-c
更新日期：1991-10-01 00:00:00
abstract：:We have investigated the role of platelet activating factor (PAF) in the pathogenesis of a murine model of traumatic shock using WEB 2086, a specific antagonist of PAF. WEB 2086 (0.5 mg/kg) significantly reversed the decrease in mean arterial blood pressure (MABP) induced by PAF (0.3 micrograms/kg) in anesthetized rat...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(89)90107-2
更新日期：1989-02-01 00:00:00
abstract：:Rabbit platelets pretreated with CV-3988 had reduced responsiveness to platelet activating factor(PAF) even after the platelets had been washed with a buffer. This was due to its tight binding to receptor sites for PAF, but not conformational changes of the receptor, because the platelets that were pretreated with CV-...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90215-5
更新日期：1987-04-01 00:00:00
abstract：:Heparin is known to exert its antithrombotic effects by accelerating the effect of antithrombin (AT) and by mobilizing tissue factor pathway inhibitor (TFPI) into the circulation from vascular endothelium. Heparin treatment has been reported to decrease FVIIa activity by 40%; this was suggested as a new antithrombotic...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00343-1
更新日期：2000-12-01 00:00:00
abstract：INTRODUCTION:Time in therapeutic range (TTR) for international normalized ratio (INR) is an accepted quality measure of anticoagulation control in patient populations, but its usefulness for predicting stroke and bleeding in individuals is not well understood. MATERIALS AND METHODS:In a nested case control analysis am...
journal_title：Thrombosis research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.thromres.2011.08.024
更新日期：2012-06-01 00:00:00
abstract：UNLABELLED:We undertook a survey of French university hospital hematological laboratories to ascertain the clinical characteristics of patients with suspected HIT, the laboratory tests performed, and the therapeutic strategy adopted in current practice. METHODS:A standardized medical records database for patients with...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2010.02.003
更新日期：2010-06-01 00:00:00
abstract：INTRODUCTION:Remote ischaemic conditioning (RIC) has been shown to prevent platelet activation during ablation for atrial fibrillation. RIC has also been associated with more postoperative transfusion in the off-pump coronary artery bypass graft surgery (OPCAB) patients. We evaluated the effects of RIC on coagulation f...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2020.01.004
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:To date, only a few case studies have reported occurrence of thrombosis in patients with VonWillebrand disease (VWD). No studies have looked at its incidence in this patient population. The aim of this study was to test our hypothesis that decreased VonWillebrand factor (VWF) levels confer a protective effect...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2012.09.005
更新日期：2012-11-01 00:00:00
abstract：:This study evaluates the role of neutrophil granulocytes in mediating acute phase stimulation of fibrinogen synthesis. Turpentine was administered to neutropenic and non-neutropenic rats and fibrinogen synthetic rates measured in an isolated liver perfusion system. Using the (14C) carbonate technique for the measureme...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(82)90032-9
更新日期：1982-10-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.thromres.2018.02.007
更新日期：2018-04-01 00:00:00
abstract：:To demonstrate that human alpha-thrombin is effectively inactivated by human antithrombin III (AT) during the production of a fibrin clot we measured the amount of alpha-thrombin activity which can be recovered from a clot generated from purified human proteins. We discovered that 0.05-0.07% of the original alpha-thro...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90234-f
更新日期：1993-03-01 00:00:00
abstract：INTRODUCTION:The TF-FVIIa complex is the primary activator of coagulation. Elevated levels of microvesicle (MV) bearing tissue factor (TF)-dependent procoagulant activity are detectable in patients with an increased risk of thrombosis. Several methods have been described to measure MV TF activity but they are hampered ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2019.07.011
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Anticoagulated patients are often seen unnecessarily in the emergency department (ED) for epistaxis, leading to increased healthcare costs. Patients are often unaware of preventative and management techniques for handling epistaxis in the home. METHODS:In 2016, the Michigan Anticoagulation Quality Improveme...
journal_title：Thrombosis research
pub_type： 信件
doi：10.1016/j.thromres.2021.01.007
更新日期：2021-01-16 00:00:00
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journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
doi：10.1016/j.thromres.2011.07.022
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:The "HERDOO2 rule" is a prospectively validated clinical decision rule used to identify low-risk women who can safely discontinue anticoagulants after completing 5-12 months of anticoagulant treatment for unprovoked venous thromboembolism. The VIDAS®d-Dimer (DD) assay, a component of the rule, was used in th...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2018.07.020
更新日期：2018-09-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2014.04.009
更新日期：2014-07-01 00:00:00
abstract：:The influence of red blood cells on platelet aggregation has recently been a subject of considerable interest. We have studied the effect of red cells on spontaneously formed platelet aggregates in rotating vials at 37 degrees C. Platelet aggregation was quantified by measuring the fall in number of single platelets w...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90150-1
更新日期：1985-05-01 00:00:00
abstract：:Mice were implanted subcutaneously with a pellet containing 0.5 mg estradiol or with a placebo. Eight to 12 days later platelet aggregation was produced in mesenteric arterioles by injuring their endothelium in vivo with a noxious light/dye stimulus. The time between the onset of the noxious stimulus and the appearanc...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90220-8
更新日期：1985-08-01 00:00:00
abstract：:In 51 shock patients with DIC Antithrombin III (AT III) substitution, heparin or a combination of both substances respectively was administered. In the two groups which had been given AT III substitution the concentration of AT III rose considerably higher than the activity. There was a drop of the platelet count in b...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90123-9
更新日期：1985-07-01 00:00:00
abstract：:The present investigation has used an aggregation-disaggregation-reaggregation model to determine if exposure to potent aggregating agents causing a refractory state in deaggregated platelets results in down-regulation and clearance of GPIb/IX, the receptor for von willebrand factor. Thrombin, the thrombin receptor ac...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(96)00185-5
更新日期：1996-11-15 00:00:00
abstract：:Normal pregnancy is associated with an increasing state of activation of the haemostatic system. This activation state is excessive in women with placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE). Platelet activation plays a crucial pathophysiological role in PE. The very early activation ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/S0049-3848(19)30359-7
更新日期：2019-09-01 00:00:00
abstract：:Human platelets synthesize nitric oxide (NO) through an endothelial-type NO synthase (ecNOS) activated also by substances enhancing 3',5'-cyclic adenosine monophosphate (cAMP) concentrations, such as catecholamines, beta-adrenoceptor agonists and adenosine. To verify whether cAMP directly activates ecNOS through the c...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2004.06.036
更新日期：2004-01-01 00:00:00
abstract：:This study focused on the clinical outcomes in multiple myeloma (MM) patients with venous thromboembolism (VTE) who received low-molecular-weight heparin (dalteparin) therapy. Changes in D-dimer levels before and after VTE were also evaluated. Among 549 patients treated with various chemotherapeutic agents, a total of...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.09.021
更新日期：2015-11-01 00:00:00
abstract：:Postoperative chylothorax is a frequently encountered pathology occurring in up to 4% of patients undergoing surgery for repair of congenital heart disease. Symptomatic thrombosis is associated with chylothorax and may contribute to its severity and duration. Furthermore, vessel thrombosis resulting in persistent vess...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.06.014
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:Aspirin is a common antiplatelet drug used in the prevention of ischemic stroke due to its inhibitory effect on platelet cyclooxygenase-1 (Cox-1). Patients can be categorized as either aspirin 'responders' or 'non-responders' depending on whether they are protected against a secondary stroke event or not. ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2003.12.005
更新日期：2003-01-01 00:00:00
