当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > CYP2C19*2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention.

CYP2C19*2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention.

Abstract：

INTRODUCTION:Information regarding any possible additional effect of genetic variants other than CYP2C19*2 on platelet reactivity in patients undergoing percutaneous coronary intervention (PCI), while on dual antiplatelet therapy, is sparse. MATERIALS AND METHODS:Genotyping for CYP2C19*2, CYP2C19*17, CYP2C9*3, CYP2B6*5, ABCB1 and P2RY12 (c.-217+2739T>C) variants was performed in 146 consecutive PCI patients receiving clopidogrel. Platelet reactivity was assessed by the Verify Now P2Y12 point-of-care assay and high on-treatment platelet reactivity (HTPR) was defined as a Platelet Reactivity Unit (PRU)≥235. RESULTS:We identified 65(44.5%) patients with HTPR and 38(26%) carriers of at least one CYP2C19*2 allele, which had higher platelet reactivity compared to non-carriers [least square (LS) mean difference 44.5, 95%CI 15.8-77.3, p=0.003]. In the entire study population, the presence of at least one CYP2C19*2 or P2RY12 allelic variant was independently associated with HTPR (OR=3.02, 95%CI 1.16-7.86, p=0.023 and OR=3.11, 95%CI 1.03-9.39, p=0.05 respectively). In CYP2C19*2 non-carriers, carriers of at least one CYP2B6*5 allelic variant had higher platelet reactivity compared to the remainders (LS mean difference 35.6, 95%CI 3.7-67.6, p=0.03) and the presence of at least one CYP2B6*5 or P2RY12 allelic variant was independently associated with HTPR (OR=3.26, 95%CI 1.08-9.86, p=0.04 and OR=4.27, 95%CI 1.11-16.4, p=0.04 respectively). CONCLUSIONS:Apart from the CYP2C19*2, other genetic variants involved in clopidogrel metabolism and action like CYP2B6*5 and P2RY12 seem to have an important association with HTPR.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Kassimis G,Davlouros P,Xanthopoulou I,Stavrou EF,Athanassiadou A,Alexopoulos D

doi

10.1016/j.thromres.2011.07.022

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

441-6

issue

4

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(11)00368-9

journal_volume

129

pub_type

临床试验,杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Arterial antithrombotic effects of aspirin, heparin, enoxaparin and clopidogrel alone, or in combination, in the rat.

    abstract：INTRODUCTION:Many antithrombotic drugs may have a deleterious effect on normal haemostasis leading to bleeding complications. The aim of this study was to determine if sub-therapeutic (low) doses of antithrombotic agents, when administered in combination, have enhanced efficacy without augmentation of bleeding time. M...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2005.11.015

    authors： Daykin HJ,Sturgeon SA,Jones C,Wright CE

    更新日期：2006-01-01 00:00:00

  • Procoagulant cellular activity (PCA) in the classification of acute leukemia.

    abstract：:The procoagulant cellular activity (PCA) of leukemic cells was evaluated, before and after endotoxin stimulation, in 38 patients with acute leukemia at presentation subdivided according to the FAB classification. In the M4 and M5 subgroups the stimulated leukemic cells showed a significant increase in the production o...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90317-3

    authors： Guarini A,Gugliotta L,Catani L,Chetti L,Macchi S,Tura S

    更新日期：1987-03-01 00:00:00

  • Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: a cohort study.

    abstract：BACKGROUND:While post thrombotic syndrome (PTS) is increasingly recognized as a frequent and potentially serious complication of deep vein thrombosis (DVT) in children, limited information is available regarding predictors of PTS. METHODS:Using the Mayo Clinic Master Diagnostic Index, all pediatric patients (age 0 to ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.12.005

    authors： Kumar R,Rodriguez V,Matsumoto JM,Khan SP,Weaver AL,McBane RD,Beebe TJ,Heit JA

    更新日期：2015-02-01 00:00:00

  • Factor XIII improves platelet adhesion to fibrinogen by protein disulfide isomerase-mediated activity.

    abstract：BACKGROUND:Factor XIII (FXIII), a plasma pro-transglutaminase, consists of two A subunits and two B subunits (FXIIIA2B2). Following activation by thrombin, it cross-links fibrin chains at the final step of coagulation. We previously reported that FXIII subunit A (FXIIIA) serves as a protein disulfide isomerase (PDI), a...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.12.003

    authors： Lahav J,Tvito A,Bagoly Z,Dardik R,Inbal A

    更新日期：2013-04-01 00:00:00

  • Amino acid substitutions of the P2 residue of human antithrombin that either enhance or impair function.

    abstract：:Recombinant forms of human antithrombin (AT) were expressed in COS-1 cells, and their interaction with human thrombin characterized by comparing the reactivity of two engineered mutant forms of AT with the wild-type recombinant. Both mutant forms contained single amino acid substitutions of Asp (G392D) or Pro (G392P) ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90240-2

    authors： Sheffield WP,Blajchman MA

    更新日期：1994-08-01 00:00:00

  • Clot waveform analysis in Clauss fibrinogen assay contributes to classification of fibrinogen disorders.

    abstract：BACKGROUND:Clauss fibrinogen assay (CFA) is widely used as a screening test to detect fibrinogen disorders. However, CFA alone cannot distinguish quantitative and qualitative defects because it depends on functional fibrinogen activity (Ac), and fibrinogen antigen (Ag) determination is required to classify fibrinogen d...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.12.018

    authors： Suzuki A,Suzuki N,Kanematsu T,Shinohara S,Arai N,Kikuchi R,Matsushita T

    更新日期：2019-02-01 00:00:00

  • The use of eConsults to improve access to specialty care in thrombosis medicine.

    abstract：INTRODUCTION:Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultat...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.11.002

    authors： Skeith L,Mohamed M,Karovitch A,Liddy C,Afkham A,Archibald D,Keely E

    更新日期：2017-12-01 00:00:00

  • Thrombin enhances tumor cell adhesive and metastatic properties via increased alpha IIb beta 3 expression on the cell surface.

    abstract：:The association between blood coagulation and cancer growth and metastatic dissemination is not yet completely understood. In this study we demonstrate that thrombin is capable of enhancing tumor cell adhesive properties and thereby increases tumor cell metastatic potential. Following exposure to alpha-thrombin, Walke...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90081-k

    authors： Wojtukiewicz MZ,Tang DG,Nelson KK,Walz DA,Diglio CA,Honn KV

    更新日期：1992-11-01 00:00:00

  • Role of red cells in preventing the growth of platelet aggregation.

    abstract：:Using high-resolution real-time two-dimensional ultrasound, we have investigated the role of red cells in the growth of already established platelet aggregates under controlled flow conditions. Platelet rich plasma (PRP) was circulated in vitro in horizontally and vertically arranged tubing at mean shear rate ranging ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90376-1

    authors： Machi J,Sigel B,Ramos JR,Justin JR,Feinberg H,LeBreton GC,Robertson AL Jr

    更新日期：1984-10-01 00:00:00

  • Antithrombotic and anticomplementary properties of a very low molecular mass dermatan sulfate.

    abstract：INTRODUCTION:Dermatan sulfate, a sulfated glycosaminoglycan, acts as an anticoagulant by accelerating the inhibition of thrombin by heparin cofactor II. MATERIALS AND METHODS:A low molecular mass dermatan sulfate was obtained by peroxy-radical depolymerization from a parent dermatan sulfate. Chemical characterization ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2007.09.001

    authors： Fabiana Alberto M,Giaquinta Romero D,Lazzari M,Calabrese GC

    更新日期：2008-01-01 00:00:00

  • Thrombomodulin alfa attenuates the procoagulant effect and cytotoxicity of extracellular histones through the promotion of protein C activation.

    abstract：INTRODUCTION:Extracellular histones are reported to increase thrombin generation in the plasma and induce endothelial cell death in vitro. These effects of histones were suggested to involve histone-induced inhibition of TM-dependent activated protein C (APC) generation. Therefore, we hypothesized that TM alfa, a recom...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.10.019

    authors： Osada K,Minami T,Arioka T,Sakai T,Tawara S,Kawasaki K,Fareed J,Matsuzaki O

    更新日期：2017-12-01 00:00:00

  • Monoclonal antibodies against plasminogen and alpha-2-antiplasmin: binding to native and modified antigens.

    abstract：:Two monoclonal antibodies against plasminogen and two against alpha-2-antiplasmin were characterized regarding their binding properties towards their respective native and modified antigens and towards the plasmin-alpha-2-antiplasmin complex. Using an ELISA system, the two monoclonal antibodies against plasminogen (MP...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90311-2

    authors： Hattey E,Wojta J,Binder BR

    更新日期：1987-03-01 00:00:00

  • Characterization of tissue plasminogen activator binding proteins isolated from endothelial cells and other cell types.

    abstract：:Human tissue plasminogen activator (t-PA) was shown to bind specifically to human osteosarcoma cells (HOS), and human epidermoid carcinoma cells (A-431 cells). Crosslinking studies with DTSSP demonstrated high molecular weight complexes (130,000) between 125I-t-PA and cell membrane protein on human umbilical vein endo...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90136-z

    authors： Beebe DP,Wood LL,Moos M

    更新日期：1990-07-15 00:00:00

  • Current insights into thrombotic microangiopathies: Thrombotic thrombocytopenic purpura and pregnancy.

    abstract：:The complex relation between thrombotic thrombocytopenic purpura (TTP) and pregnancy is concisely reviewed. Pregnancy is a very strong trigger for acute disease manifestation in patients with hereditary TTP caused by double heterozygous or homozygous mutations of ADAMTS13 (ADisintegrin And Metalloprotease with Thrombo...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/S0049-3848(15)50437-4

    authors： von Auer C,von Krogh AS,Kremer Hovinga JA,Lämmle B

    更新日期：2015-02-01 00:00:00

  • Incidence of venous thromboembolism in psychiatric units.

    abstract：INTRODUCTION:Incidence and risk factors of venous thromboembolism (VTE) are well established in surgical and medical settings, but data in psychiatric units are lacking. The aim of this study was to estimate the incidence of VTE in hospitalized psychiatric patients, and to assess the risk factors for VTE in this specif...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.10.002

    authors： Delluc A,Montavon S,Canceil O,Carpentier M,Nowak E,Mercier B,Bressollette L,Etienne S,Walter M,Mottier D,Lacut K

    更新日期：2012-12-01 00:00:00

  • Central thromboembolism is a possible predictor of right heart dysfunction in normotensive patients with acute pulmonary embolism.

    abstract：BACKGROUND:Right heart dysfunction is a crucial factor in risk stratification of normotensive patients with pulmonary embolism. Apart from biomarkers, determinants of right heart dysfunction in this group of patients are not yet well established. AIM AND METHOD:In order to identify such determinants, we analysed data ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2010.06.009

    authors： Berghaus TM,Haeckel T,Behr W,Wehler M,von Scheidt W,Schwaiblmair M

    更新日期：2010-09-01 00:00:00

  • Effects of heparin and a semi-synthetic heparin analogue on platelet aggregation, lipoprotein lipase and other laboratory tests in surgical patients.

    abstract：:Platelet aggregation, lipoprotein lipase activity, coagulation parameters and routine blood chemistry were measured in a randomised study of 21 surgical patients before, immediately after and 3 months after operation. Sodium heparin 5000 IU was given subcutaneously to 11 patients every 12 hours for 7 days, the first i...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0049-3848(83)90187-1

    authors： Törngren S,Norén I,Forsskåhl B,Sipilä H

    更新日期：1983-06-01 00:00:00

  • The anti-aggregation effects of ondansetron on platelets involve IP3 signaling and MAP kinase pathway, but not 5-HT3-dependent pathway.

    abstract：:Ondansetron is a 5-HT3 receptor antagonist with potent antiemetic, analgesic, and antiphlogistic effects. Literature concerning 5-HT3 antagonists on platelets is limited. In this report we examined the pharmacological effects of ondansetron on human washed platelets. Platelet aggregation induced by thrombin (0.1 U/mL)...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.06.003

    authors： Liu FC,Liou JT,Liao HR,Mao CC,Yang P,Day YJ

    更新日期：2012-09-01 00:00:00

  • Genetic prothrombotic risk factors in women with unexplained pregnancy loss.

    abstract：INTRODUCTION:Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FI...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2005.06.005

    authors： Sottilotta G,Oriana V,Latella C,Luise F,Piromalli A,Ramirez F,Mammì C,Santoro R,Iannaccaro P,Muleo G,Lombardo VT

    更新日期：2006-01-01 00:00:00

  • Iloprost and tissue-type plasminogen activator differentially affect platelet aggregation in platelet-rich plasma and in whole blood.

    abstract：:Platelet aggregation in platelet-rich plasma (PRP) is more sensitive to agonists and more resistant to antagonists than that in whole blood. In this study, we show that the presence of neutrophils in whole blood accounts at least in part for diminished platelet aggregation in whole blood. The platelet-inhibitory effec...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90216-y

    authors： Nicolini FA,Mehta JL

    更新日期：1990-12-01 00:00:00

  • Impact of clopidogrel resistance on thrombotic events after percutaneous coronary intervention with drug-eluting stent.

    abstract：OBJECTIVES:This study examines whether patient resistance to clopidogrel is associated with long-term thrombotic events after elective coronary drug-eluting stent (DES) implantation. METHODS:We prospectively enrolled 386 patients with stable angina who received elective percutaneous coronary intervention (PCI) with DE...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.10.007

    authors： Wang ZJ,Zhou YJ,Liu YY,Yu M,Shi DM,Zhao YX,Guo YH,Cheng WJ,Jia de A,Cao Z,Nie B,Ge HL,Yang SW,Yan ZX

    更新日期：2009-05-01 00:00:00

  • Residual perfusion defects in patients with pulmonary embolism are related to impaired fibrinolytic capacity.

    abstract：BACKGROUND:Few studies investigated the relationship between fibrinolysis abnormalities and residual pulmonary perfusion defects after acute pulmonary embolism (PE). OBJECTIVE:To assess the fibrinolytic profile in patients with prior PE in relation to the extent of scintigraphically detectable residual perfusion abnor...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.07.013

    authors： Lami D,Cellai AP,Antonucci E,Fiorillo C,Becatti M,Grifoni E,Cenci C,Marcucci R,Mannini L,Miniati M,Abbate R,Prisco D

    更新日期：2014-09-01 00:00:00

  • Adenosine increases human platelet levels of cGMP through nitric oxide: possible role in its antiaggregating effect.

    abstract：:Adenosine is an endogenous antiaggregating substance that influences the platelet responses through specific A-type receptors that activate adenylate cyclase increasing the levels of 3',5'-cyclic adenosine monophosphate (cAMP). In this study, we investigated whether adenosine can also influence the levels of 3',5'-cyc...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00412-1

    authors： Anfossi G,Russo I,Massucco P,Mattiello L,Cavalot F,Balbo A,Trovati M

    更新日期：2002-01-01 00:00:00

  • Methylene blue for neutralization of heparin.

    abstract：:Patients with protamine allergy present a difficult dilemma when reversal of heparin is required for excessive bleeding. Premedication with steroids and antihistamines has not been shown to effectively prevent anaphylactic reactions in patients with hypersensitivity to protamine. Other heparin antagonists are either n...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90132-1

    authors： Sloand EM,Kessler CM,McIntosh CL,Klein HG

    更新日期：1989-06-15 00:00:00

  • Pressure influences the rate of fibrin polymerization: decompression accelerates, compression decelerates.

    abstract：:We report here that the rate of fibrin polymerization is accelerated by decompression: the rate is essentially doubled by reducing the pressure by one-half (380 torr, 14.7 PSI or 1/2 ATM) and increased by 3.6 times with respect to the control at 25 torr (0.48 PSI or 1/30th ATM). We also report here that the rate of fi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(88)90251-4

    authors： Murayama M

    更新日期：1988-03-15 00:00:00

  • Detection of procoagulant phospholipid interfering in tests for lupus anticoagulant.

    abstract：:Excess platelets shorten most clotting tests for lupus anticoagulant (LA). Often it is not clear if a shortened, normal or slightly prolonged result in a test masks a weak LA in combination with activated platelets, which express procoagulant phospholipid (PPL). Our aim was to investigate a new LA-insensitive factor X...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2004.06.001

    authors： Exner T,Low J

    更新日期：2004-01-01 00:00:00

  • Thrombin-induced shape change in human megakaryoblastic leukemic cells, MEG-01, is mediated by protein kinase C.

    abstract：:We investigated the intracellular processes of the shape change in human megakaryoblastic leukemic cells, MEG-01, by platelet agonists. Thrombin induced the formation of many pseudopods. This shape change was also induced by phorbol 12-myristate 13 acetate (TPA) and weakly by Ca2+ ionophore, A23187, but not by ADP, co...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90130-3

    authors： Goto S,Kobayashi M,Murate T,Hotta T,Hagiwara M,Hoshino T,Hidaka H,Saito H

    更新日期：1992-10-01 00:00:00

  • Quality of individual INR control and the risk of stroke and bleeding events in atrial fibrillation patients: a nested case control analysis of the ACTIVE W study.

    abstract：INTRODUCTION:Time in therapeutic range (TTR) for international normalized ratio (INR) is an accepted quality measure of anticoagulation control in patient populations, but its usefulness for predicting stroke and bleeding in individuals is not well understood. MATERIALS AND METHODS:In a nested case control analysis am...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2011.08.024

    authors： Nieuwlaat R,Connolly BJ,Hubers LM,Cuddy SM,Eikelboom JW,Yusuf S,Connolly SJ,ACTIVE Investigators.

    更新日期：2012-06-01 00:00:00

  • Influence of exogenous and endogenous tissue-type plasminogen activator on the lysability of clots in a plasma milieu in vitro.

    abstract：:The fibrinolytic potential of tissue-type plasminogen activator (t-PA) either incorporated in a clot (endogenous) or added to the surrounding plasma (exogenous), was studied in an in vitro system consisting of 125I-labeled human plasma clots (200 microliters) immersed in human plasma (2 ml). Clot lysis was measured as...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90364-5

    authors： Zamarron C,Lijnen HR,Collen D

    更新日期：1984-08-01 00:00:00

  • eNOS genotype is without effect on circulating nitrite/nitrate level in healthy male population.

    abstract：INTRODUCTION:Nitric oxide (NO) plays an important role in the regulation of the cardiovascular system. It is produced by endothelial nitric oxide synthase (eNOS), which exhibits genetic polymorphisms. Although the clinically relevant polymorphism T(+IhI-786)C reduces eNOS-promoter activity, it is not clear whether circ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2004.09.003

    authors： Nagassaki S,Metzger IF,Souza-Costa DC,Marroni AS,Uzuelli JA,Tanus-Santos JE

    更新日期：2005-01-01 00:00:00