Abstract:
:This study focused on the clinical outcomes in multiple myeloma (MM) patients with venous thromboembolism (VTE) who received low-molecular-weight heparin (dalteparin) therapy. Changes in D-dimer levels before and after VTE were also evaluated. Among 549 patients treated with various chemotherapeutic agents, a total of 52 (9.47%) patients including 32 newly diagnosed with MM and 16 with relapsed/refractory MM developed VTE, 48 of whom received dalteparin. Among the 48 treated patients, 37 (77%) had proximal deep vein thrombosis (DVT), four had (8%) pulmonary embolism (PE), and seven (15%) had both DVT and PE. In 32 patients with available paired samples (at baseline and VTE occurrence), significant conversion of D-dimer levels from 2.2 ± 0.4 mg/L to 11.8 ± 1.6 mg/L (P < 0.001) was observed, which decreased from 10.9 ± 0.4 mg/L to 1.9 ± 0.6 mg/L one month after initiating dalteparin therapy. A total of 44 patients received dalteparin with a median duration of 4.2 months (range, 2.7-9.4), and four patients were discontinued early due to death (n = 3) and major bleeding (n = 1). After a median follow-up of 9.0 months (range, 0.7-35.8) since the first VTE episode, five patients showed recurrence of VTE with a cumulative incidence of 17.5 ± 7.9%. Major bleeding occurred in three patients. In summary, dalteparin seems to be a promising drug for the treatment of VTE in MM. In addition, the significant difference in D-dimer levels observed before occurrence of VTE and after dalteparin treatment may suggest the usefulness of D-dimer testing as a surrogate marker for VTE in MM patients.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Lee SE,Jeon YW,Yoon JH,Cho BS,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Kim DW,Lee JW,Min WS,Kim M,Min CKdoi
10.1016/j.thromres.2015.09.021subject
Has Abstractpub_date
2015-11-01 00:00:00pages
974-9issue
5eissn
0049-3848issn
1879-2472pii
S0049-3848(15)30132-8journal_volume
136pub_type
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(84)90189-0
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doi:10.1016/0049-3848(93)90087-5
更新日期:1993-06-15 00:00:00
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doi:10.1016/s0049-3848(03)00288-3
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journal_title:Thrombosis research
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90363-x
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journal_title:Thrombosis research
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doi:10.1016/0049-3848(82)90210-9
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90268-h
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journal_title:Thrombosis research
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2010.02.011
更新日期:2010-05-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(93)90200-8
更新日期:1993-08-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/S0049-3848(20)30409-6
更新日期:2020-07-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.02.004
更新日期:2015-04-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
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更新日期:2010-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(88)90278-2
更新日期:1988-07-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/S0049-3848(13)00023-6
更新日期:2013-01-01 00:00:00
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journal_title:Thrombosis research
pub_type:
doi:10.1016/j.thromres.2014.03.001
更新日期:2014-05-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90192-x
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pub_type: 杂志文章
doi:10.1016/0049-3848(94)90257-7
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journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2011.10.010
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(02)00096-8
更新日期:2002-04-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2014.07.013
更新日期:2014-09-01 00:00:00
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journal_title:Thrombosis research
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doi:10.1016/j.thromres.2015.06.017
更新日期:2015-08-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.03.002
更新日期:2013-06-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.02.004
更新日期:2013-04-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90008-8
更新日期:1985-04-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90376-8
更新日期:1987-07-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(01)00242-0
更新日期:2001-05-01 00:00:00
abstract::Heparin with low affinity (LA-heparin) to antithrombin III (AT III) enhanced the rate of inactivation of thrombin by AT III. The enhancement of the rate was saturable with AT III and was proportional to the LA-heparin concentration. Although the rate-enhancement in the presence of LA-heparin decreased with increase in...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90247-1
更新日期:1986-02-01 00:00:00