Abstract：
:The effect of the vasopressin analogue DDAVP on Factor VIII in plasma has been extensively studied in humans. To examine the effect of new and potentially better analogues a suitable animal model has to be established. In the present study trained Beagle dogs were injected with DDAVP and the time course of the Factor VIII response was monitored by a modification of the chromogenic substrate assay for Factor VIII. In most of the dogs DDAVP caused a biphasic increase of plasma concentrations of Factor VIII with an initial smaller increment within 10 min after the injection followed by a larger secondary rise after approximately 45 min. The average increase in Factor VIII was smaller than found in humans after comparable doses of DDAVP, and a few dogs responded very poorly. Despite these qualitative and quantitative differences it is concluded that trained dogs may serve as a useful model for testing the ability of other analogues than DDAVP to increase Factor VIII.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Vilhardt H,Barth T,Falch J,Nilsson IMdoi
10.1016/0049-3848(87)90363-xsubject
Has Abstractpub_date
1987-09-01 00:00:00pages
585-91issue
5eissn
0049-3848issn
1879-2472journal_volume
47pub_type
杂志文章abstract：:Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephad...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(83)90025-7
更新日期：1983-10-15 00:00:00
abstract：BACKGROUND:Rate of thalidomide-related VTE and risk factors in Japanese myeloma patients are not clear and effects of thromboprophylaxis remain controvertial. PATIENTS AND METHODS:We retrospectively analyzed a cohort data of registered Japanese myeloma patients treated with thalidomide-based regimens between 2009 and ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2012.11.014
更新日期：2013-02-01 00:00:00
abstract：:Whole blood electrical aggregometry (WBEA) has become an accepted method to gain quick information on platelet disorders. Compared to the optical method WBEA is closer to physiology and less complicated, but on the other hand more difficult to standardize. Different approaches have been attempted in the past to improv...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90232-2
更新日期：1990-12-15 00:00:00
abstract：:We characterized a platelet specific alloantigen (Yukb). In immunoblotting, anti-Yukb antibody was found to react with both 110 kDa and 96 kDa bands under nonreducing condition. Immunoblotting followed by separation by two-dimensional electrophoresis (isoelectric focusing/SDS-PAGE) showed that the 96 kDa band had a pI...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90136-x
更新日期：1992-07-15 00:00:00
abstract：:Intra-ventricular hemorrhage (IVH) occurs predominantly in very low birth weight premature infants. Survivors of severe IVH frequently experience long-term consequences including major neurological deficits. Advances in neonatal and obstetric care in the last decades, have led to a steady decline in mortality and in t...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/S0049-3848(11)70032-9
更新日期：2011-02-01 00:00:00
abstract：:The effects of locally deposited fibrin and of tranexamic acid-induced antifibrinolysis on forming granulation tissue were studied in the light of a recently developed method for treatment of postoperative fistulas by occlusion with a fibrin clot. Perforated teflon cylinders, either empty or fibrin-filled, were implan...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90152-x
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:Platelet microparticles (PMPs) possess proatherogenic and procoagulant properties which may play a role in atherogenesis and subsequent thromboembolic complications. The present study was conducted to investigate the possible relationship between carotid atherosclerosis and plasma concentrations of PMPs, and...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2008.10.016
更新日期：2009-04-01 00:00:00
abstract：:Using an ACL 300R coagulometer (Instrumentation Laboratory) we assessed the clinical usefulness of a new method to measure PS activity (PS:Act), based on the prolongation of prothrombin time of a mixture of diluted plasma sample, PS depleted plasma previously incubated with Protac for protein C activation, bovine thro...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90065-5
更新日期：1991-12-15 00:00:00
abstract：:PAF (1 ug/kg) injected intravenously (i.v.) into anesthetized rabbits resulted in marked loss of circulating platelets and leukocytes. Administration of FR-900452 1-methyl-3-(1-(5-methylthiomethyl-6-oxo-3-(2-oxo-3-cyclopenten-1-y lidene)- 2-piperazinyl) ethyl)-2-indolinone, a specific PAF inhibitor, at a dose of 10 mg...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(86)90344-0
更新日期：1986-06-01 00:00:00
abstract：INTRODUCTION:Endothelial dysfunction plays an essential role in the pathogenesis of sepsis. The study aimed to illustrate the associations between the dynamic change (from day 1 to day 7) in biomarker concentration of endothelial dysfunction and outcomes in severe sepsis and septic shock in the intensive care unit (ICU...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2018.09.059
更新日期：2018-11-01 00:00:00
abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90253-1
更新日期：1985-09-15 00:00:00
abstract：:The turnover of tissue plasminogen activator (tPA) was studied in rabbits using a double-label technique which allowed the comparison of various tPA derivatives with a standard tPA in individual animals. Purified recombinant tPA (Alteplase) was labelled with 125I and used as a standard for each experiment. Various tPA...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90278-2
更新日期：1988-07-01 00:00:00
abstract：:The purpose of this study was to determine whether plasma von Willebrand factor concentrations are correlated with the degree of intestinal ischaemia-reperfusion injury. Forty-six anaesthetised adult Wistar rats were divided into five groups. The sham-operated group (S, n=10) had laparotomy and isolation of the superi...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(99)00013-4
更新日期：1999-06-15 00:00:00
abstract：:From kinetic analysis on the initial stage of the fibrinogen-fibrin conversion catalyzed by thrombin, inhibition constants, Kip, of heparin and heparin analogues were obtained by the turbidimetrical method. The inhibitory effect per unit amount in weight of heparin and heparin analogues increased generally with decrea...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90235-x
更新日期：1985-09-01 00:00:00
abstract：BACKGROUND:Although patients undergoing coronary stenting routinely receive dual antiplatelet treatment to reduce the risk of stent thrombosis, this undesired event still occurs. A suboptimal response to clopidogrel treatment (low responders) has been suggested to contribute to stent thrombosis. In the present study, p...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2004.07.007
更新日期：2005-01-01 00:00:00
abstract：:We have studied the synthesis and subcellular distribution of the glycosylated membrane protein tissue factor (TF) in human blood monocytes and the inducible monocyte like cell line, HL-60. Following induction with endotoxin or the phorbol ester, TPA, tissue factor specific activity was measured in intact cells, sonic...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90405-1
更新日期：1987-11-15 00:00:00
abstract：BACKGROUND:The aim of this study was to describe platelet aggregation characteristics by multiple electrode aggregometry (MEA) and to evaluate MEA for its potential to detect platelet dysfunction and response to anti-aggregatory drugs in patients with myeloproliferative disorders (MPD). METHODS:We compared the platele...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2010.06.014
更新日期：2010-09-01 00:00:00
abstract：:Previous studies have indicated that the skin bleeding time test does not accurately reflect visceral bleeding time (BT). The present study examines the predictive value of the skin bleeding time for brain bleeding tendency. Sixteen Sprague-Dawley rats were divided into equal groups. The first group (controls) underwe...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(94)90282-8
更新日期：1994-12-15 00:00:00
abstract：:We have previously described a stimulus-specific defect in platelet aggregation in polycythaemia vera (PV) after stimulation with surface receptor dependent agonists such as platelet activating factor (PAF). In contrast, responses to phorbol myristate acetate (PMA) were normal. We now report that after PAF stimulation...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(98)00096-6
更新日期：1998-09-15 00:00:00
abstract：:In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfuncti...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.10.006
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Coronary collateral circulation (CCC) plays an important role in protecting myocardium from ischemic damage. The studies on factors which impact on CCC might be of great clinical interest. The aim of the present study was to evaluate endothelin-1 (ET-1) as a potential predictor for poor or good CCC in patien...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2016.04.007
更新日期：2016-06-01 00:00:00
abstract：:When single-chain pro-UK is activated by plasmin or kallikrein, the Lys158-Ile159 bond is cleaved, leaving a C-terminal lysine on the A-chain (Lys-UK). Two-chain, high molecular weight urokinase (UK) purified from urine, however, has been shown to contain a phenylalanine residue as the C-terminal of the A-chain (Phe-U...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90206-c
更新日期：1991-10-01 00:00:00
abstract：:Chloroquine inhibited aggregation of rat blood platelets in a dose-dependent way. The inhibitory effect decreased, depending on the aggregation stimulus used, in the rank order of potency: ADP > thrombin > A23187. Effect of 1 millimolar chloroquine on A23187-stimulated aggregation was significantly decreased or comple...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(94)90270-4
更新日期：1994-06-01 00:00:00
abstract：:The Fab fragment of a polyclonal antibody against platelet factor XIII inhibited the collagen-induced platelet aggregation in a dose-dependent manner. This inhibitory effect was specific for collagen, and it had no effect on arachidonic acid-, ADP-, and serotonin-induced aggregations. This finding strengthens our noti...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90226-5
更新日期：1988-04-15 00:00:00
abstract：:Five criteria for poor response to a 20 min venous occlusion test were applied to 58 patients 3 months or more after acute deep vein thrombosis (DVT). The criteria were arbitrarily defined as the last 5 percentiles of response distributions in an age- and sex-matched healthy control group of 51 subjects. The criteria ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90345-w
更新日期：1991-11-15 00:00:00
abstract：INTRODUCTION:Sepsis is frequently complicated by disseminated intravascular coagulation (DIC), which promotes multiple organ dysfunctions and significantly increase the mortality of patients with sepsis. How bacteria cause DIC is not fully understood. Outer membrane vesicles (OMVs) are membrane-enclosed microvesicles r...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2019.03.019
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:Medically ill, hospitalized patients are at increased risk for venous thromboembolism (VTE) after discharge. This study aimed to examine thromboprophylaxis patterns, risk factors, and post-discharge outcomes. METHODS:This was a retrospective claims analysis involving administrative claims data and in-pati...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.08.013
更新日期：2013-11-01 00:00:00
abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli ...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2016.12.026
更新日期：2017-03-01 00:00:00
abstract：:The aim was to describe the phlebographic pattern of asymptomatic and symptomatic deep vein thrombosis (DVT) after total hip replacement by the use of a scoring system in 102 consecutive patients (54 asymptomatic, 48 symptomatic). The DVTs were scored from 1 to 3, and registered in a scoring system dividing the deep v...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00274-7
更新日期：2000-09-01 00:00:00
abstract：:Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. Using an immunostaining technique and electron microscopy, we investigated and compared the distribution of triflavin bind...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(03)00104-x
更新日期：2003-01-01 00:00:00
