Turnover of tPA in rabbits: influence of carbohydrate moieties.

abstract：BACKGROUND/AIM:It is believed that the amniotic fluid-derived TF, in the case of amniotic fluid embolism (AFE), contributes to acute disseminated intravascular coagulation (DIC) and obstetric shock in the mother. However, the role of amniotic fluid-derived contact phase coagulation factors that irrupt into the bloodstr...

journal_title：Thrombosis research

authors： Uszyński W,Żekanowska E,Uszyński M,Kieszkowski P

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR). MATERIALS AND METHODS:To test the hypothesis of relative warfarin resistance i...

journal_title：Thrombosis research

authors： Ames PR,Margaglione M,Ciampa A,Colaizzo D,Ferrara F,Iannaccone L,Vincenzobrancaccio

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Blood flow induced shear stress plays an important role in platelet and endothelial cell functions. The goal of this study was to investigate the effect of physiologically relevant dynamic shear stress on platelet and endothelial cells. MATERIALS AND METHODS:Pulsatile shear stress waveforms mimicking the ...

journal_title：Thrombosis research

authors： Yin W,Shanmugavelayudam SK,Rubenstein DA

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Atherosclerosis occurs as a result of a chronic inflammatory response in the arterial wall associated with an increased uptake of low-density lipoprotein by macrophages and the subsequent transformation of this lipoprotein into foam cells. It has been found that miR-188-3p can suppress autophagy and myocardi...

journal_title：Thrombosis research

authors： Zhang XF,Yang Y,Yang XY,Tong Q

更新日期：2018-11-01 00:00:00

abstract：:Excess platelets shorten most clotting tests for lupus anticoagulant (LA). Often it is not clear if a shortened, normal or slightly prolonged result in a test masks a weak LA in combination with activated platelets, which express procoagulant phospholipid (PPL). Our aim was to investigate a new LA-insensitive factor X...

journal_title：Thrombosis research

authors： Exner T,Low J

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:A recent study suggested that the plasminogen activator inhibitor (PAI)-1 4G/5G genotype may play a role in the resolution of deep vein thrombosis (DVT) after surgery. In the present study, we investigated the association between PAI-1 4G/5G genotype and the persistence of venous occlusion after acute idiopa...

journal_title：Thrombosis research

authors： Giurgea GA,Brunner-Ziegler S,Jilma B,Sunder-Plassmann R,Koppensteiner R,Gremmel T

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the role of filter implantation in reducing the incidence of fatal pulmonary embolism during the endovascular treatment of thrombosis in the major tributary of the superior vena cava (SVC). METHODS:From October 2004 to October 2008, we conducted a cohort study of 40 patients with thrombosis of t...

journal_title：Thrombosis research

authors： Liang Z,Han R,Qu Y,Cao W,Cui J

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:It is well demonstrated that obesity is an independent risk factor for cardiovascular diseases. Recent studies have shown that obesity, insulin resistance and atherosclerosis are closely related phenomena in which low-grade inflammatory state and prothrombotic condition has pivotal roles. It has been shown t...

journal_title：Thrombosis research

authors： Guldiken S,Demir M,Arikan E,Turgut B,Azcan S,Gerenli M,Tugrul A

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR...

journal_title：Thrombosis research

authors： Schutte AE,Myburgh A,Olsen MH,Eugen-Olsen J,Schutte R

更新日期：2012-08-01 00:00:00

abstract：:The effect of several vitamin K (Vit K) analogues on the aggregation of human platelets was examined. The analogues were potent inhibitors of aggregation induced by ADP, thrombin, collagen and arachidonate but were less active against aggregation induced by the calcium ionophore A23187. Vit K3 also prevented platelet ...

journal_title：Thrombosis research

authors： Blackwell GJ,Radomski M,Moncada S

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:Avoiding intracranial hemorrhage (ICH) during warfarin therapy is critical but little is known about factors that affect warfarin-related ICH outcomes. We aimed to define the impact of warfarin on ICH incidence rates and to identify baseline clinical characteristics of patients who experienced ICH and fact...

journal_title：Thrombosis research

authors： Witt DM,Delate T,Hylek EM,Clark NP,Crowther MA,Dentali F,Ageno W,Martinez KD,Garcia DA

更新日期：2013-01-01 00:00:00

abstract：:The effects and mechanism of action of a phospholipase C (PLC) from Pseudomonas aeruginosa on human platelet rich plasma were examined to better understand the interaction of PLC with human platelets. PLC caused platelet aggregation in a concentration-dependent manner. Enzymatic activity of PLC was necessary for aggre...

journal_title：Thrombosis research

authors： Coutinho IR,Berk RS,Mammen E

更新日期：1988-09-01 00:00:00

abstract：:From kinetic analysis on the initial stage of the fibrinogen-fibrin conversion catalyzed by thrombin, inhibition constants, Kip, of heparin and heparin analogues were obtained by the turbidimetrical method. The inhibitory effect per unit amount in weight of heparin and heparin analogues increased generally with decrea...

journal_title：Thrombosis research

authors： Sato H,Nakajima A,Shimohira T

更新日期：1985-09-01 00:00:00

abstract：:We have recently demonstrated that contact activation of the intrinsic coagulation cascade in vitro is accompanied not only by thromboxane (TX) B2 generation but also by the formation of 5-lipoxygenase-derived cysteinyl-leukotrienes (LT). In our present study we have investigated the effects of the vascular wall on th...

journal_title：Thrombosis research

authors： Weide I,Winking M,Simmet T

更新日期：1993-10-01 00:00:00

abstract：:Human tissue plasminogen activator (t-PA) was shown to bind specifically to human osteosarcoma cells (HOS), and human epidermoid carcinoma cells (A-431 cells). Crosslinking studies with DTSSP demonstrated high molecular weight complexes (130,000) between 125I-t-PA and cell membrane protein on human umbilical vein endo...

journal_title：Thrombosis research

authors： Beebe DP,Wood LL,Moos M

更新日期：1990-07-15 00:00:00

abstract：:Tissue factor, the cofactor for factor VIIa-catalyzed activation of factors IX and X, plays an important role in the initiation of hemostasis. However, the distribution of tissue factor in the body has not been defined until recently. In the present study frozen sections of non-malignant human tissues were immunostain...

journal_title：Thrombosis research

authors： Fleck RA,Rao LV,Rapaport SI,Varki N

更新日期：1990-07-15 00:00:00

abstract：:Cilostazol is a newly developed antiplatelet drug that has been widely applied for clinical use. Its antiplatelet action appears to be mainly related to inhibition of intracellular phosphodiesterase activity. Our study was designed to investigate inhibitory effects of cilostazol on the expression of activation-depende...

journal_title：Thrombosis research

authors： Inoue T,Sohma R,Morooka S

更新日期：1999-02-01 00:00:00

abstract：INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...

journal_title：Thrombosis research

authors： Desai PC,Brittain JE,Jones SK,McDonald A,Wilson DR,Dominik R,Key NS,Parise LV,Ataga KI

更新日期：2013-09-01 00:00:00

abstract：:Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion...

journal_title：Thrombosis research

authors： Lawrence JB,Prevosti LG,Kramer WS,Lu DY,Leon MB

更新日期：1989-04-15 00:00:00

abstract：BACKGROUND:The quality of treatment with warfarin is mainly assessed by the time in therapeutic range (TTR) in patients with mechanical heart valve prosthesis (MHV). Our aim was to evaluate if International Normalized Ratio (INR) variability predicted a combined endpoint of thromboembolism, major bleeding and death bet...

journal_title：Thrombosis research

authors： Labaf A,Själander A,Stagmo M,Svensson PJ

更新日期：2015-12-01 00:00:00

abstract：:The heparin-derived oligosaccharide C3 (C3) is currently underdevelopment for the prevention and treatment of vascular dementia and senile dementia of Alzheimer's type. C3 exhibits a molecular weight of 2200-2500 Da with a narrow distribution. The objective of the present study was to assess the pharmacodynamics and p...

journal_title：Thrombosis research

authors： Ma Q,Schultz C,Neville B,Jeske W,Hoppensteadt D,Cornelli U,Lee J,Lorens S,Hanin I,Fareed J

更新日期：2003-01-01 00:00:00

abstract：:Disadvantages of current bleeding time methods include poor reproducibility, limited repeatability, and at times scar formation. We report a new, in vitro technique which circumvents these problems. Venous blood is collected in sodium citrate, stored capped in a siliconized tube at 37 degrees C until use, and made to ...

journal_title：Thrombosis research

authors： Uchiyama S,Stropp JQ,Claypool DA,Didisheim P,Dewanjee MK

更新日期：1983-07-01 00:00:00

abstract：:To demonstrate that human alpha-thrombin is effectively inactivated by human antithrombin III (AT) during the production of a fibrin clot we measured the amount of alpha-thrombin activity which can be recovered from a clot generated from purified human proteins. We discovered that 0.05-0.07% of the original alpha-thro...

journal_title：Thrombosis research

authors： Naski MC,Shafer JA

更新日期：1993-03-01 00:00:00

abstract：:Although effective therapies for haemophilia have been available for decades, the prevention and treatment of joint disease remain major clinical concerns for all haemophilia patients. Early identification of joint disease is vital to initiate or modify treatment, and prevent arthropathy. However, there remains a need...

journal_title：Thrombosis research

authors： Lambert T,Auerswald G,Benson G,Hedner U,Jiménez-Yuste V,Ljung R,Morfini M,Remor E,Santagostino E,Zupančić Šalek S

更新日期：2014-06-01 00:00:00

abstract：:The reunification of Germany in 1990 brought with it major challenges in terms of unifying the care offered to haemophilia patients. At that time, most of the treatment centres belonged to the largest regional hospitals. The centre for paediatric haemophilia patients in Leipzig was at the University Hospital. In this ...

journal_title：Thrombosis research

authors： Lenk H

更新日期：2014-11-01 00:00:00

abstract：:The brain and the placenta synthesize identical peptides and proteins, such as brain-derived neurotrophic factor, oxytocin, vascular endothelial growth factor, cortisol, and matrix metalloproteinases. Given the promiscuity between neurochemistry and the mechanism of placentation, it would be expected that mental disor...

journal_title：Thrombosis research

authors： Hoirisch-Clapauch S,Brenner B,Nardi AE

更新日期：2015-02-01 00:00:00

abstract：:Cross reactive antigens to factor VIII have been measured in a range of vertebrate phyla. VIII coagulant antigen (VIII:CAg) measured using a human antibody was in general, much lower than reported values of VIII coagulant activity (VIII:C) except in simians and the guinea pig. The dose response curve for the assay was...

journal_title：Thrombosis research

authors： Rotblat F,Hawkey C,O'Brien DP,Tuddenham EG

更新日期：1982-03-01 00:00:00

abstract：:To characterize the putative biochemical modifications induced by the Ser 460 to Pro (Heerlen) mutation in protein S (PS), we expressed both wild-type (wt) and mutated recombinant PS in HEK cells. In SDS-polyacrylamide gels, r-PS Heerlen migrated at 71 kDa whereas r-wt PS migrated at 73 kDa, a difference abolished aft...

journal_title：Thrombosis research

authors： Morboeuf O,Borgel D,Aiach M,Kaabache T,Gandrille S,Gaussem P

更新日期：2000-10-01 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) is a common cause of morbidity and mortality. In this study, we investigated patterns of morbidity and mortality from PE in Australia. MATERIALS & METHODS:Australian government databases were used to extract data on age and sex specific rates of mortality between 1997 and 2007, and...

journal_title：Thrombosis research

authors： Shiraev TP,Omari A,Rushworth RL

更新日期：2013-07-01 00:00:00

abstract：:Despite clear potential benefits of outpatient care, most patients suffering from pulmonary embolism (PE) are currently hospitalized due to the fear of possible adverse events. Nevertheless, some teams have increased or envisage to increase outpatient treatment or early discharge. We performed a narrative systematic r...

journal_title：Thrombosis research

authors： Roy PM,Moumneh T,Penaloza A,Sanchez O

更新日期：2017-07-01 00:00:00