Cilostazol inhibits the expression of activation-dependent membrane surface glycoprotein on the surface of platelets stimulated in vitro.

abstract：:The fibrinolytic system contains a proenzyme plasminogen (Plg) which is converted to plasmin (Plm) by the action of Plg activators. Physiological Plg activators are: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator. Plg was shown to be further cleaved by leukocyte elastase producing se...

journal_title：Thrombosis research

authors： Duboscq C,Genoud V,Parborell MF,Kordich LC

更新日期：1997-06-15 00:00:00

abstract：INTRODUCTION:Bleeding after cardiac surgery may be caused by surgical factors, impaired haemostasis, or a combination of both. Transfusion of blood products is used to improve haemostasis, but little is known about what combination is optimal. We hypothesized that addition of both fibrinogen and platelets to blood samp...

journal_title：Thrombosis research

authors： Shams Hakimi C,Fagerberg Blixter I,Hansson EC,Hesse C,Wallén H,Jeppsson A

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:SARS-CoV-2 infection has noted derangements in coagulation markers along with significant thrombotic complications. Post-mortem examinations show severe endothelial injury and widespread thrombotic microangiopathy in the pulmonary vasculature. Early reports describing the use of prophylactic anticoagulation ...

journal_title：Thrombosis research

authors： Hsu A,Liu Y,Zayac AS,Olszewski AJ,Reagan JL

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism (VTE) prophylaxis guidelines for non-surgical patients recommend VTE- and bleeding risk assessment to guide prophylactic strategies. These recommendations differ between guidelines and implementation is suboptimal. Assessing a guideline's implementability characteristics helps predic...

journal_title：Thrombosis research

authors： Moesker MJ,Damen NL,Volmeijer EE,Dreesens D,de Loos EM,Vink R,Coppens M,Kruip MJ,Meijer K,Langelaan M,de Bruijne MC,Wagner C

更新日期：2018-08-01 00:00:00

abstract：:The thrombin inhibitory role of antithrombin III (ATIII) and heparin cofactor II (HCII) was studied in vitro using intact and injured rabbit aortae. When intact vessels were loaded with thrombin and then exposed to either heat defibrinogenated human plasma (HDHP) or ATIII the same degree of thrombin inhibition was ach...

journal_title：Thrombosis research

authors： Pasche B,Swedenborg J,Frebelius S,Olsson P

更新日期：1991-06-01 00:00:00

abstract：:We previously reported that the expression of thrombomodulin on the MEG-01, a cell line from human megakaryoblastic leukemia, was increased by agents that increase intracellular cAMP. In this paper we examine the effect of these agents on cultured human umbilical vein endothelial cells (HUVEC) and mouse hemangioma cel...

journal_title：Thrombosis research

authors： Maruyama I,Soejima Y,Osame M,Ito T,Ogawa K,Yamamoto S,Dittman WA,Saito H

更新日期：1991-02-01 00:00:00

abstract：:Reproducible disseminated intravascular coagulation in rabbits was provoked by two intravenous injections 24 hours apart of endotoxin from Salmonella enteritidis. There were mild symptoms of DIC before the second injection which considerably increased thereafter. In detail there was a sharp drop of the platelet count ...

journal_title：Thrombosis research

authors： Zawilska K,Zozulinska M,Turowiecka Z,Blahut M,Drobnik L,Vinazzer H

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Our goal is to develop a vascular targeting treatment for brain arteriovenous malformations (AVMs). Externalized phosphatidylserine has been established as a potential biomarker on the endothelium of irradiated AVM blood vessels. We hypothesize that phosphatidylserine could be selectively targeted after AVM ...

journal_title：Thrombosis research

authors： Subramanian S,Ugoya SO,Zhao Z,McRobb LS,Grau GE,Combes V,Inglis DW,Gauden AJ,Lee VS,Moutrie V,Santos ED,Stoodley MA

更新日期：2018-07-01 00:00:00

abstract：:Preanalytical and biological variability both have strong influences on test results of coagulation. Beyond age and gender, increasing emphasis is now being given to a variety of demographic and lifestyle variables, including ethnicity, smoking, diet, and exercise, which should be taken into account when interpreting ...

journal_title：Thrombosis research

authors： Lippi G,Favaloro EJ,Franchini M,Guidi GC

更新日期：2008-01-01 00:00:00

abstract：:A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...

journal_title：Thrombosis research

authors： Contant G,Martinoli JL

更新日期：1989-11-01 00:00:00

abstract：:SK, t-PA or APSAC were incubated in human plasma (adjusted to 300,000 platelets/mm3), in vitro, for up to 90 minutes using concentrations which were equivalent to those achieved in the treatment of AMI patients. Aggregation was measured in response to ADP and collagen. SK inhibited platelet aggregation after a 60 minu...

journal_title：Thrombosis research

authors： Fears R,Ferres H,Greenwood HC

更新日期：1990-11-15 00:00:00

abstract：:Blackfoot disease is a unique endemic and chronic progressive arteriosclerotic vascular disease in southwest area of Taiwan. In this study, we determined the plasma levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI), urokinase plasminogen activator (uPA), and von Willebrand factor (vWF...

journal_title：Thrombosis research

authors： Wu HL,Yang WH,Wang MY,Shi GY

更新日期：1993-11-01 00:00:00

abstract：:The proteinase, brinase (Mr approximately 35000), from Aspergillus oryzae, which has been used in therapeutic attempts as a thrombolytic agent in arterial thrombosis, binds to purified human alpha 2-macroglobulin (alpha 2M) with a stoichiometry of 1.7-1.9 mol of enzyme/mol inhibitor. This binding leads to quantitative...

journal_title：Thrombosis research

authors： Larsson LJ,Frisch EP,Törneke K,Lindblom T,Björk I

更新日期：1988-01-01 00:00:00

abstract：:Clinical and epidemiological trials often involve central laboratory analyses of coagulation tests, including fibrinogen, which requires freezing of the plasma samples. Although rapid freezing by immersion of sample tubes in liquid nitrogen and storage at -70 degrees C is recommended, plasma samples are often transfer...

journal_title：Thrombosis research

authors： Alesci S,Borggrefe M,Dempfle CE

更新日期：2009-05-01 00:00:00

abstract：INTRODUCTION:In the prospective, randomised, double-blind, placebo-controlled Regenerate Vital Myocardium by Vigorous Activation of Bone Marrow Stem Cells (REVIVAL)-2 trial patients with acute myocardial infarction (AMI) and successful mechanical reperfusion received granulocyte-colony stimulating factor (G-CSF, 10 μg/...

journal_title：Thrombosis research

authors： Steppich BA,Demetz G,Schulz S,von Wedel J,Pogatsa-Murray G,Braun SL,Stein A,Kastrati A,Schömig A,Ott I

更新日期：2011-02-01 00:00:00

abstract：:In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfuncti...

journal_title：Thrombosis research

authors： van der Land V,Peters M,Biemond BJ,Heijboer H,Harteveld CL,Fijnvandraat K

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Use of antiplatelet therapy in combination with oral anticoagulants remains controversial. The purpose of this article is to review current consensus recommendations for antithrombotic therapy, to evaluate risks for bleeding among patients taking combination antithrombotic therapy, and lastly to review singl...

journal_title：Thrombosis research

authors： Johnson S

更新日期：2008-01-01 00:00:00

abstract：:Resveratrol (3, 4', 5-trihydroxystilbene), a natural polyphenol, is found in some plants that are used in human nutrition. Grapes are a major source for resveratrol, and a significant amount can also be found in red wine. Several experimental studies have demonstrated biological properties of resveratrol, especially i...

journal_title：Thrombosis research

authors： Olas B,Wachowicz B,Saluk-Juszczak J,Zieliński T

更新日期：2002-08-15 00:00:00

abstract：:Platelet concentrates (PC) were prepared by platelet apheresis to obtain a low (< 0.1 x 10(9)/l, PC A) and high (2-9 x 10(9)/l, PC B) concentration of white cells from the same donor. The mean platelet count (+/- SD) of the PC were 1000 +/- 50 x 10(9)/l. During storage 71-96% of the white cells were mononuclear. A por...

journal_title：Thrombosis research

authors： Wallvik J,Suontaka AM

更新日期：1993-05-01 00:00:00

abstract：:Prothrombin time is a standard screening test to monitor patients treated with oral anticoagulants. We hypothesize that INR measurements will not vary a lot within a given day in a given patient. The present study was thus conducted to compare the change of the international normalized ratio (INR) of prothrombin time ...

journal_title：Thrombosis research

authors： Ho CH,Lin MW,You JY,Chen CC,Yu TJ

更新日期：2002-09-01 00:00:00

abstract：:We tested whether inhibition of platelet activation by nitric oxide (NO) might be altered by strenuous exercise. Sixteen healthy male non-smokers, aged 20-26 years, underwent treadmill testing. All subjects reached Bruce stage IV without chest pain or abnormal ST-T wave changes. Platelet aggregation by Born's method a...

journal_title：Thrombosis research

authors： Sakita S,Kishi Y,Numano F

更新日期：1997-09-01 00:00:00

abstract：:Binding of 3H-labeled 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor; PAF) to the intact, washed canine platelet has been defined and characterized as being specific and receptor-mediated. Under the conditions described, specific binding to 2 X 10(7) canine platelets reached saturation with...

journal_title：Thrombosis research

authors： Janero DR,Burghardt B,Burghardt C

更新日期：1988-06-15 00:00:00

abstract：:The placenta is the highly specialised organ of pregnancy that supports the normal growth and development of the fetus. Growth and function of the placenta are precisely regulated and coordinated to ensure the exchange of nutrients and waste products between the maternal and fetal circulatory systems operates at maxim...

journal_title：Thrombosis research

authors： Gude NM,Roberts CT,Kalionis B,King RG

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:The first aim of this study is to evaluate the biological effect of doubling the maintenance dose of clopidogrel in pre-defined clopidogrel "low responders", compared to the biological effect of the standard dose in "responders". The second aim is to test the influence of the CYP 2C19*2 allele on clopidogr...

journal_title：Thrombosis research

authors： Fontana P,Senouf D,Mach F

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:The prevalence and etiology of occult bleeding among patients on warfarin who are screened systematically for new anemia is largely unknown. We aimed to estimate the usefulness of following hemoglobin and mean red cell volume (MCV) with INR in order to screen for developing anemia as an indicator of occult...

journal_title：Thrombosis research

authors： Johannsdottir GA,Onundarson PT,Gudmundsdottir BR,Bjornsson ES

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Although patients with idiopathic VTE are at higher than normal risk of asymptomatic atherosclerosis and of cardiovascular events, the impact of cardiovascular risk factors on VTE is poorly understood. OBJECTIVE:To assess the prevalence of the metabolic syndrome and of its components in patients with early-...

journal_title：Thrombosis research

authors： Di Minno MN,Tufano A,Guida A,Di Capua M,De Gregorio AM,Cerbone AM,Tarantino G,Di Minno G

更新日期：2011-03-01 00:00:00

abstract：:Defibrotide (D) is a natural polydeoxyribonucleotide from mammalian lungs with profibrinolytic and antithrombotic activities. D also has PGI2-stimulating and tissue plasminogen activator (TPA)-releasing activities, but has no anticoagulant properties. The protective effects of D were demonstrated very recently in a mo...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1986-05-01 00:00:00

abstract：:Severe prekallikrein (Fletcher factor) deficiency was diagnosed in a 49-year-old woman and in 3 of her siblings. Functional prekallikrein (PKK) activity was found below 1% by clotting assay and 20% by amidolytic assay in all the affected subjects; PKK cross-reacting material (CRM) was present in all the patients (anti...

journal_title：Thrombosis research

authors： De Stefano V,Leone G,Teofili L,De Marinis L,Micalizzi P,Fiumara C,Bizzi B

更新日期：1990-12-01 00:00:00

abstract：:Five criteria for poor response to a 20 min venous occlusion test were applied to 58 patients 3 months or more after acute deep vein thrombosis (DVT). The criteria were arbitrarily defined as the last 5 percentiles of response distributions in an age- and sex-matched healthy control group of 51 subjects. The criteria ...

journal_title：Thrombosis research

authors： Stegnar M,Peternel P,Keber D,Vene N

更新日期：1991-11-15 00:00:00

abstract：:A quantitative assessment was made of the distribution of arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) among the individual sub-classes (diacyl, alkylacyl, alkenylacyl) of the various platelet phospholipids of human subjects consuming a fish oil concen...

journal_title：Thrombosis research

authors： Holub BJ,Celi B,Skeaff CM

更新日期：1988-04-01 00:00:00