当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Association of Graves' disease and prekallikrein congenital deficiency in a patient belonging to the first CRM+ prekallikrein-deficient Italian family.

Association of Graves' disease and prekallikrein congenital deficiency in a patient belonging to the first CRM+ prekallikrein-deficient Italian family.

Abstract：

:Severe prekallikrein (Fletcher factor) deficiency was diagnosed in a 49-year-old woman and in 3 of her siblings. Functional prekallikrein (PKK) activity was found below 1% by clotting assay and 20% by amidolytic assay in all the affected subjects; PKK cross-reacting material (CRM) was present in all the patients (antigen levels from 34% to 54%). This is the first CRM+ PKK-deficient family identified in Italy. The index patient was affected from Graves' disease: such association was previously reported in another patient with PKK congenital defect.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

De Stefano V,Leone G,Teofili L,De Marinis L,Micalizzi P,Fiumara C,Bizzi B

doi

10.1016/0049-3848(90)90222-x

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

397-404

issue

5

eissn

0049-3848

issn

1879-2472

pii

0049-3848(90)90222-X

journal_volume

60

pub_type

杂志文章

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