Adverse obstetric and neonatal outcomes in women with mental disorders.

abstract：:We have recently demonstrated that contact activation of the intrinsic coagulation cascade in vitro is accompanied not only by thromboxane (TX) B2 generation but also by the formation of 5-lipoxygenase-derived cysteinyl-leukotrienes (LT). In our present study we have investigated the effects of the vascular wall on th...

journal_title：Thrombosis research

authors： Weide I,Winking M,Simmet T

更新日期：1993-10-01 00:00:00

abstract：:Anticoagulant fucoidan fractions of different molecular weight and sulfate content were prepared and investigated for their effects on platelet function in vitro. The fucoidan fractions were incubated with human platelet rich plasma (PRP) at concentrations of 5, 10 and 50 micrograms/ml. Platelet activation was subsequ...

journal_title：Thrombosis research

authors： Dürig J,Bruhn T,Zurborn KH,Gutensohn K,Bruhn HD,Béress L

更新日期：1997-03-15 00:00:00

abstract：:Ca2+ influx and efflux in unstimulated platelets and Ca2+ uptake by simultaneously isolated two membrane fractions of platelets from patients with myeloproliferative disorders (MPD) have been investigated. In MPD, Ca2+ influx and efflux across the plasma membrane in unstimulated platelets were in equilibrium at signif...

journal_title：Thrombosis research

authors： Fujimoto T,Fujimura K,Kuramoto A

更新日期：1989-01-15 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect of CYP2C19 polymorphism and co-therapy with esomeprazole on the antiplatelet efficacy of clopidogrel. BACKGROUND:The antiplatelet efficacy of clopidogrel depends on CYP2C19 polymorphism or the co-administration of some kind of proton pump inhibitor (PPI). ...

journal_title：Thrombosis research

authors： Hokimoto S,Akasaka T,Tabata N,Arima Y,Tsujita K,Sakamoto K,Kaikita K,Morita K,Kumagae N,Yamamoto E,Oniki K,Nakagawa K,Ogawa H

更新日期：2015-06-01 00:00:00

abstract：:The protease inhibitor, aprotinin, has been examined for its ability to inhibit urokinase and tissue-type plasminogen activators at pH 7.4 in assays utilizing pyroGlu-Gly-Arg-p-nitroanilide and H-D-Ile-Pro-Arg-p-nitroanilide as substrates, respectively. Aprotinin inhibited both two-chain low molecular weight urokinase...

journal_title：Thrombosis research

authors： Lottenberg R,Sjak-Shie N,Fazleabas AT,Roberts RM

更新日期：1988-03-15 00:00:00

abstract：:Adenosine is an endogenous antiaggregating substance that influences the platelet responses through specific A-type receptors that activate adenylate cyclase increasing the levels of 3',5'-cyclic adenosine monophosphate (cAMP). In this study, we investigated whether adenosine can also influence the levels of 3',5'-cyc...

journal_title：Thrombosis research

authors： Anfossi G,Russo I,Massucco P,Mattiello L,Cavalot F,Balbo A,Trovati M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:It has been previously shown that platelets of patients with diabetes are more reactive and less responsive to anti-platelet drugs compared with platelets from subjects without diabetes. Studies examining the effect of glycemic control on platelet reactivity have yielded conflicting data. Thus, in this study...

journal_title：Thrombosis research

authors： Singer J,Weissler Snir A,Leshem-Lev D,Rigler M,Kornowski R,Lev EI

更新日期：2014-07-01 00:00:00

abstract：:Incubation of recombinant human tissue factor apoprotein (Apo-TF) with human plasma decreased the recalcified clotting time of this plasma in a time-and dose-dependent manner suggesting relipidation of the Apo-TF by plasma lipoproteins. Incubation of Apo-TF with purified preparations of human very low density, low den...

journal_title：Thrombosis research

authors： Sakai T,Kisiel W

更新日期：1990-11-01 00:00:00

abstract：:Mice were implanted subcutaneously with a pellet containing 0.5 mg estradiol or with a placebo. Eight to 12 days later platelet aggregation was produced in mesenteric arterioles by injuring their endothelium in vivo with a noxious light/dye stimulus. The time between the onset of the noxious stimulus and the appearanc...

journal_title：Thrombosis research

authors： Rosenblum WI,el-Sabban F,Allen AD,Nelson GH,Bhatnagar AS,Choi S

更新日期：1985-08-01 00:00:00

abstract：INTRODUCTION:Systemic embolism is the most serious complication of cardioversion of atrial fibrillation (AF) and the immediate post-cardioversion period is associated with increased risk for thrombus formation. For this reason, treatment with vitamin K antagonist (VKA) is recommended for patients with AF. No informatio...

journal_title：Thrombosis research

authors： Poli D,Antonucci E,Grifoni E,Paoletti O,Rancan E,Dentali F,Testa S

更新日期：2012-05-01 00:00:00

abstract：:Clot dissolution using enzymes from the human fibrinolytic system has long been a goal of physicians and scientists. While recent focus has been on activators of the fibrinolytic system, new data support the use of plasmin itself. This supplement reviews the role of plasmin in fibrinolysis and locally administered pla...

journal_title：Thrombosis research

authors： White GC 2nd

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Non-vitamin K antagonist oral anticoagulants (NOACs) do not need routine laboratory monitoring but measurement of drug concentration is important in emergency conditions. Specific laboratory tests are not readily available or not implemented in every hospital. Point-of-Care Tests (POCT) may bridge this gap a...

journal_title：Thrombosis research

authors： Padayattil Jose S,Banzato A,Carraro P,Haleh A,Rossi K,Nante G,Denas G,Zoppellaro G,Pengo V

更新日期：2018-03-01 00:00:00

abstract：:When a purified myeloma protein with the ability to inhibit fibrin polymerization was preincubated with sheep anti-human F(ab')2 antibodies, there was a marked reduction of the ability to prolong the thrombin clotting time, while anti-Fc antibodies had only a slight effect. A monoclonal immunoglobulin which shortens t...

journal_title：Thrombosis research

authors： Wisløff F,Michaelsen TE,Kierulf P,Godal HC

更新日期：1985-11-15 00:00:00

abstract：INTRODUCTION:Uremic bleeding frequently occurs in dialysis patients. Although its mechanism is not well characterized, acquired platelet dysfunction has been implicated in its pathogenesis. Skin bleeding time has been used to characterize platelet dysfunction in this population. However, the bleeding time is prone to e...

journal_title：Thrombosis research

authors： Brophy DF,Martin EJ,Carr SL,Kirschbaum B,Carr ME Jr

更新日期：2007-01-01 00:00:00

abstract：:A direct assay for plasminogen activator (PA) was developed. It employed polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and beta-mercaptoethanol to monitor PA-mediated conversion of single chain, 125I-plasminogen to two chain plasmin. By incorporating Triton X-100, albumin and trasylol in...

journal_title：Thrombosis research

authors： Mussoni L,Lawrence D,Loskutoff DJ

更新日期：1984-05-01 00:00:00

abstract：:Since the 19(th) century an association between cancer and thromboembolic events has been described, with a poorer survival prognosis. Production and secretion of procoagulant factors affect tumor biology and cancer-associated thrombosis. Tissue factor (TF) exerts coagulant and protease activated receptor (PAR)-depend...

journal_title：Thrombosis research

authors： Ünlü B,Versteeg HH

更新日期：2014-05-01 00:00:00

abstract：:Sulfation of the natural polysaccharide curdlan results in anticoagulantly active beta-1,3-glucan sulfates whose activity depends on various structural parameters. In this study the anticoagulant and antithrombotic effects of one of these beta-1,3-glucan sulfates (GS) were compared with those of a porcine mucosal hepa...

journal_title：Thrombosis research

authors： Alban S,Jeske W,Welzel D,Franz G,Fareed J

更新日期：1995-05-01 00:00:00

abstract：:Concentration-response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: hADP = hL-EPINEPHRINE = hPAF = hPGH2 = hU46619 le...

journal_title：Thrombosis research

authors： Vrzheshch PV,Tatarintsev AV,Yershov DE,Varfolomeyev SD

更新日期：1992-06-01 00:00:00

abstract：:Platelet and clotting abnormalities have been described in diabetes, but little is known about their relationship to daily stresses. In order to evaluate whether states of abnormal carbohydrate metabolism modify the hemostatic response to stress, 12 subjects with type I diabetes mellitus, 9 with type II, 7 with impair...

journal_title：Thrombosis research

authors： Maiello M,Boeri D,Bonadonna R,Odetti P,Saccarello A,Adezati L

更新日期：1988-06-15 00:00:00

abstract：:Hemostasis, the system of generation and degradation of thrombi, consists of coagulation and fibrinolysis. Whereas global assays to study coagulation have existed for many years, there has been no simple, rapid, and economic routine test for the plasmatic fibrinolysis parameters plasminogen activator inhibitor-1, alph...

journal_title：Thrombosis research

authors： Stief TW,Hinz F,Kurz J,Doss MO,Kretschmer V

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:Abdominal obesity has been found to be associated with an increased risk of deep vein thrombosis (DVT). Whether patients with abdominal obesity have an increased risk of recurrence is currently unknown. METHODS:Patients with objective diagnosis of DVT and a life expectancy of greater than 6 months underwent...

journal_title：Thrombosis research

authors： Romualdi E,Squizzato A,Ageno W

更新日期：2007-01-01 00:00:00

abstract：:Ondansetron is a 5-HT3 receptor antagonist with potent antiemetic, analgesic, and antiphlogistic effects. Literature concerning 5-HT3 antagonists on platelets is limited. In this report we examined the pharmacological effects of ondansetron on human washed platelets. Platelet aggregation induced by thrombin (0.1 U/mL)...

journal_title：Thrombosis research

authors： Liu FC,Liou JT,Liao HR,Mao CC,Yang P,Day YJ

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:Tissue Factor Pathway Inhibitor-2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor whose expression is up-regulated by VEGF in microvascular and umbilical vein endothelial cells (EC). Despite this, TFPI-2 has been suggested as anti-angiogenic molecule, due to its ability to inhibit the migration/proli...

journal_title：Thrombosis research

authors： Ghilardi C,Anastasia A,Avigni R,Lupi M,Giavazzi R,Bani MR

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:The activated partial thromboplastin time (APTT) is commonly used to monitor unfractionated heparin (UFH) but may not accurately measure the amount of heparin present. The anti-Xa assay is less susceptible to confounding factors and may be a better assay for this purpose. MATERIALS AND METHODS:The validit...

journal_title：Thrombosis research

authors： Arachchillage DRJ,Kamani F,Deplano S,Banya W,Laffan M

更新日期：2017-09-01 00:00:00

abstract：:An electron transport system regulates the initiation of thrombus formation through the activation of critical receptors involved in hemostasis and thrombosis. Protein disulfide isomerase along with other thiol isomerases, important for intracellular protein synthesis, are responsible for this extracellular activity d...

journal_title：Thrombosis research

authors： Furie B,Furie BC

更新日期：2012-10-01 00:00:00

abstract：:Clot adherence to peritoneal cavity mesothelium was studied in rats in an attempt to contribute to the problem of thrombus embolization. The adherence was decreased by platelets and the active constituent was identified as adenosine diphosphate which decreased the sticking of fibrin to cellular linings as well as to a...

journal_title：Thrombosis research

authors： Hladovec J

更新日期：1982-12-15 00:00:00

abstract：:Tissue factor is an ubiquitous membrane-anchored glycoprotein that initiates blood coagulation by forming a complex with circulating factors VII and VIIa. Under normal circumstances, endothelial cells do not express tissue factor but, in some pathological situations, when the endothelium or the monocytes are exposed t...

journal_title：Thrombosis research

authors： Savi P,Bernat A,Dumas A,Aït-Chek L,Herbert JM

更新日期：1994-01-15 00:00:00

abstract：:The activity of tissue plasminogen activator-plasminogen activator inhibitor-1 (t-PA-PAI-1) complex to convert plasminogen to plasmin was examined by using fibrin autography and casein zymography where plasminogen was added or removed for casein layer. Fibrin autography was more sensitive to the activity of t-PA even ...

journal_title：Thrombosis research

authors： Takada Y,Takada A

更新日期：1991-07-01 00:00:00

abstract：:This study compares selected properties of purified tryptic fragments of human von Willebrand (vW) protein in order to better understand how the M(r) 116,000 fragment retains activity in ristocetin-induced platelet agglutination. Wheat germ agglutinin (WGA) aggregation of platelet-rich plasma was potentiated by preinc...

journal_title：Thrombosis research

authors： Martin SE,Francis CW,Marder VJ

更新日期：1983-08-01 00:00:00

abstract：:The effect of a low molecular weight heparin (Fragmin) (20-80 U/kg) was studied in 10 healthy male volunteers after intravenous administration. Clotting abnormalities are extensive shortly after injection, lasting for 1-2 hours depending on heparin dosage. Dilute thrombin time, showing a close correlation to anti-F-Xa...

journal_title：Thrombosis research

authors： Andrassy K,Mörike K,Koderisch J,Weber E

更新日期：1988-03-15 00:00:00