Abstract：
:When a purified myeloma protein with the ability to inhibit fibrin polymerization was preincubated with sheep anti-human F(ab')2 antibodies, there was a marked reduction of the ability to prolong the thrombin clotting time, while anti-Fc antibodies had only a slight effect. A monoclonal immunoglobulin which shortens the thrombin time was uninfluenced by anti-F (ab')2 as well as by anti-Fc antibodies. Partial reduction and alkylation of the immunoglobulins did not modify their effect on the thrombin time. None of the immunoglobulins bound to fibrinogen or fibrin monomer that had been linked to CNBr-activated agarose. Myeloma proteins may interfere with fibrin polymerization in two ways: some proteins inhibit polymerization in a reaction that depends on the Fab (antigen binding) part of the molecule; however, antibody binding activity against fibrinogen or fibrin monomer has not been demonstrated. Other (rare) myeloma proteins accelerate fibrin polymerization; this effect cannot be ascribed to any particular portion of the molecule and is probably of an unspecific nature.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Wisløff F,Michaelsen TE,Kierulf P,Godal HCdoi
10.1016/0049-3848(85)90284-1subject
Has Abstractpub_date
1985-11-15 00:00:00pages
473-82issue
4eissn
0049-3848issn
1879-2472journal_volume
40pub_type
杂志文章abstract：INTRODUCTION:Although the procoagulant reactivity of monocytes largely depends on expression and cell surface presentation of tissue factor (TF), little is known about the impact of tissue factor pathway inhibitor (TFPI) on regulation of TF function on the monocyte surface. MATERIALS AND METHODS:Peripheral blood monon...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2010.07.014
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:The AMPLIFY trial found significantly lower major bleeding (MB) and similar recurrent venous thromboembolism (VTE) risks associated with apixaban vs warfarin among patients with VTE. OBJECTIVES:To compare MB, clinically-relevant non-major (CRNM) bleeding, and recurrent VTE risks among clinically-relevant su...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2020.11.039
更新日期：2020-12-08 00:00:00
abstract：:Changes in the plasma thrombomodulin (TM) level were examined in endotoxin-infused rabbits. The plasma TM level in normal rabbits was 143.8 +/- 8.4 ng/ml (n = 67) and the molecular weight of the major TM was about 55 kd. Endotoxin (lipopolysaccharide, LPS, E. Coli B8:0127) was intravenously infused. LPS infusion incre...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90240-b
更新日期：1992-01-15 00:00:00
abstract：:Cooperative effects of PAF-acether and arachidonic acid in blood platelet activation were studied in human platelet-rich plasma. Using a combination of low concentrations of PAF-acether and subthreshold amounts of exogenous arachidonic acid an enhancement of aggregation and an increased formation of malondialdehyde ar...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90080-x
更新日期：1984-02-15 00:00:00
abstract：:Platelet activation plays an important role in the development of sepsis. During sepsis, platelet activation leads to endothelial cell injury and promotes neutrophil extracellular trap and microthrombus formation, exacerbating septic coagulation and inflammatory reactions. The resultant induction or aggravation of dis...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2018.04.007
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Histamine is classified as an inflammatory mediator and has been reported to have anti- as well as pro-inflammatory properties. The aim of this study was to explore the role of histamine on the production of LPS-induced tissue factor (TF) activity and TNFα in monocytes of whole blood in the absence and prese...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.12.022
更新日期：2014-03-01 00:00:00
abstract：:The association between blood coagulation and cancer growth and metastatic dissemination is not yet completely understood. In this study we demonstrate that thrombin is capable of enhancing tumor cell adhesive properties and thereby increases tumor cell metastatic potential. Following exposure to alpha-thrombin, Walke...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90081-k
更新日期：1992-11-01 00:00:00
abstract：:The hemolytic uremic syndrome involves the presence of Shiga toxin producing strains of Escherichia coli and is associated with thrombocytopenia, platelet activation, and microthrombi formation. We have, therefore, investigated the ability of Shiga toxin isotypes 1 and 2 to cause or enhance platelet aggregation under ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00191-2
更新日期：2000-06-01 00:00:00
abstract：:The anticoagulant properties of myxalin, a glycopeptide secreted by a Gram negative bacterium strain (Myxococcus xanthus) are studied and compared to those of heparin. This soluble material exhibits an anticoagulant activity which implies the inhibition of some serine proteases, thrombin and factor Xa. In the presence...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90335-a
更新日期：1990-10-01 00:00:00
abstract：:An in vitro model of platelet adhesion, the annular perfusion chamber, was utilized to test the effects of Interleukin 1 on vascular thrombogenicity for platelets. De-endothelialized, everted human umbilical arteries were placed in cell culture media with or without Interleukin 1. The arteries were later perfused with...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(89)90235-1
更新日期：1989-11-15 00:00:00
abstract：:Lipoprotein(a) [Lp(a)] has been demonstrated to be an independent risk factor for coronary heart disease. However, the precise mechanism by which it contributes to the development of atherosclerosis remains unclear. P-selectin is one of the major adhesion molecules to mediate the interaction between monocytes, platele...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00363-7
更新日期：2000-12-15 00:00:00
abstract：INTRODUCTION:Patients with stable coronary artery disease (CAD) are at risk of arterial thrombosis causing myocardial infarction. Detection of global haemostatic markers of hypercoagulability and hypofibrinolysis may be important for risk stratification and individualised treatment. We examined overall haemostatic pote...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.03.015
更新日期：2013-05-01 00:00:00
abstract：:Anticoagulants are effective for preventing both venous and arterial thrombosis. Although antithrombotic agents have been reported to reduce thrombin formation, to our knowledge, the relation between blood viscosity (BV) and antithrombotic agents has not been examined. We examined the effects on whole BV of various do...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(01)00359-0
更新日期：2001-12-01 00:00:00
abstract：:To investigate the effects of new drugs on the prevention of venous thrombosis, the Wessler stasis model is extensively employed usually in the rabbit. In this model, a hypercoagulable state is achieved by the administration of either heterologous serum (often human serum) or an activated coagulation factor followed b...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(96)00023-0
更新日期：1996-02-15 00:00:00
abstract：:Defibrotide both "in vitro" and "ex vivo" decreases PMN adhesion to nylon columns. This activity is blunted by 8-phenyltheophylline, a known blocker of adenosine A1/A2 receptors, suggesting that Defibrotide acts on that kind of receptors. Indomethacin, a blocker of PGI2 synthesis, did not cancel DFT's activity, sugges...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)00178-t
更新日期：1995-11-15 00:00:00
abstract：INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2014.07.039
更新日期：2014-11-01 00:00:00
abstract：:Prothrombin time is a standard screening test to monitor patients treated with oral anticoagulants. We hypothesize that INR measurements will not vary a lot within a given day in a given patient. The present study was thus conducted to compare the change of the international normalized ratio (INR) of prothrombin time ...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
doi：10.1016/s0049-3848(02)00339-0
更新日期：2002-09-01 00:00:00
abstract：:Four calcium channel blockers (nimodipine, nifedipine, verapamil and diltiazem) of three chemical classes were tested in vitro for inhibition of platelet aggregation using heparinized human platelet rich plasma. Both ADP- and thrombin-induced aggregation were inhibited as was the biosynthesis of thromboxane A2 in resp...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90241-x
更新日期：1984-06-01 00:00:00
abstract：UNLABELLED:We undertook a survey of French university hospital hematological laboratories to ascertain the clinical characteristics of patients with suspected HIT, the laboratory tests performed, and the therapeutic strategy adopted in current practice. METHODS:A standardized medical records database for patients with...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2010.02.003
更新日期：2010-06-01 00:00:00
abstract：:The thrombolytic efficacy of recombinant tissue-type plasminogen activator (tPA) in the presence and absence of a thromboxane synthase inhibitor was studied in a model of femoral artery thrombosis in the anesthetized rabbit. The thrombus was formed by injection of thrombin and whole blood into an isolated segment of t...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90022-9
更新日期：1988-12-01 00:00:00
abstract：CONTEXT:Recently, there has been an increasing number of reports of incidental pulmonary embolism (PE) in patients undergoing chest computer tomography (CT) for reasons other than the research of suspected PE. Natural history of incidental PE remains unclear. OBJECTIVES:To estimate the prevalence of incidental PE, to ...
journal_title：Thrombosis research
pub_type： 杂志文章,meta分析
doi：10.1016/j.thromres.2010.03.016
更新日期：2010-06-01 00:00:00
abstract：:Binding of 3H-labeled 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor; PAF) to the intact, washed canine platelet has been defined and characterized as being specific and receptor-mediated. Under the conditions described, specific binding to 2 X 10(7) canine platelets reached saturation with...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90339-8
更新日期：1988-06-15 00:00:00
abstract：BACKGROUND:The immediate administration of oral antiplatelet therapy in the form of aspirin plus a P2Y12 inhibitor is the universally recognised standard of care for patients who present with acute myocardial infarction. Despite strong recommendations for their use, there are a paucity of data describing their onset of...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2016.05.019
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:A recent study suggested that the plasminogen activator inhibitor (PAI)-1 4G/5G genotype may play a role in the resolution of deep vein thrombosis (DVT) after surgery. In the present study, we investigated the association between PAI-1 4G/5G genotype and the persistence of venous occlusion after acute idiopa...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2017.03.017
更新日期：2017-05-01 00:00:00
abstract：:The cerebral vascular supply is constructed to protect the cerebral hemispheres and brainstem from the consequences of blood flow cessation. Reversal of blood flow around local obstructions is a feature of the microvascular beds of the striatum and cerebral cortex. Cerebral capillaries of these beds consist of endothe...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/s0049-3848(00)00218-8
更新日期：2000-05-01 00:00:00
abstract：:Arthral, abdominal and renal symptoms in Henoch-Schönlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0049-3848(89)90284-3
更新日期：1989-12-15 00:00:00
abstract：:Clot lysis induced by streptokinase has been studied and the influences of pH and the concentrations of plasminogen, fibrinogen and buffer composition investigated. Variations in the concentrations of plasminogen strongly effect the SK apparent activity, maxima being obtained at different plasminogen concentrations li...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90071-4
更新日期：1991-12-15 00:00:00
abstract：:The effect of alpha-tocopherol on various endothelial cell functions was evaluated in vitro using cultures of human umbilical vein endothelial cells. Prostacyclin synthesis, plasminogen activator activity and von Willebrand factor activity were evaluated in control and alpha-tocopherol supplemented cultures. Alpha-toc...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90203-4
更新日期：1988-05-15 00:00:00
abstract：INTRODUCTION:Pregnancy has recently been described as a generalized intravascular inflammatory response to the conceptus. Total fibrinogen concentrations increase during pregnancy. The percentage high molecular weight fibrinogen (HMW-Fg) of the concentration total fibrinogen is known to increase during acute-phase cond...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
doi：10.1016/j.thromres.2004.04.008
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:Cancer associated thrombosis is a well-recognized phenomenon that results in considerable patient morbidity and mortality. Malignancy conveys an increased risk for thrombosis and chemotherapy further elevates this risk. The pathophysiological mechanisms underlying this process remain poorly defined. MATER...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2011.06.022
更新日期：2012-02-01 00:00:00
