Fibrinogen and high molecular weight fibrinogen during and after normal pregnancy.


INTRODUCTION:Pregnancy has recently been described as a generalized intravascular inflammatory response to the conceptus. Total fibrinogen concentrations increase during pregnancy. The percentage high molecular weight fibrinogen (HMW-Fg) of the concentration total fibrinogen is known to increase during acute-phase conditions like inflammation. Therefore, we investigated whether the percentage high molecular weight fibrinogen increases during normal pregnancy. MATERIALS AND METHODS:Eighteen healthy nulliparous women with uncomplicated pregnancies with normal course and outcome participated in this study. Five blood samples were drawn from every woman in the gestational age periods 9 to 16, 17 to 24, 25 to 33 and 34 to 42 weeks and at 12 to 20 weeks after delivery. Total fibrinogen concentrations were determined according to Clauss and the percentage high molecular weight fibrinogen was assessed by SDS-electrophoresis and densitometry after isolation of fibrinogen by precipitation. One-way analysis of variance (ANOVA) was used to evaluate differences between gestational age periods and correlation coefficients were calculated by Pearson's method. RESULTS:Total fibrinogen concentrations increased with advancing gestational age and decreased after delivery. The percentage high molecular weight fibrinogen of the total fibrinogen remained unaltered during and after pregnancy. CONCLUSIONS:During normal pregnancy, there is an increase of total fibrinogen concentrations with advancing gestational age, without a rise in percentage high molecular weight fibrinogen. After delivery, the total fibrinogen returns to baseline concentrations.


Thromb Res


Thrombosis research


Manten GT,Franx A,Sikkema JM,Hameeteman TM,Visser GH,de Groot PG,Voorbij HA




Has Abstract


2004-01-01 00:00:00














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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Ettelaie C,Howell RM

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  • Characterization of tissue plasminogen activator binding proteins isolated from endothelial cells and other cell types.

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Beebe DP,Wood LL,Moos M

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  • Methylene blue for neutralization of heparin.

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Sloand EM,Kessler CM,McIntosh CL,Klein HG

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Chauleur C,Gris JC,Laporte S,Rancon F,Varlet MN,Decousus H,Mismetti P,STRATHEGE Group.

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    journal_title:Thrombosis research

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    authors: Nakano T,Hanasaki K,Arita H

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  • Ischaemia-reperfusion injury with Pringle's maneuver induces unusually large von Willebrand factor multimers after hepatectomy.

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    journal_title:Thrombosis research

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    authors: Yoshikawa T,Nomi T,Sakai K,Hayakawa M,Hokuto D,Matsuo Y,Sho M,Matsumoto M

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Gando S,Kameue T,Nanzaki S,Nakanishi Y

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  • Autoimmune hemolytic anemia and venous thromboembolism: A systematic review and meta-analysis.

    abstract:OBJECTIVE:To investigate the risk of venous thromboembolism (VTE) among patients with autoimmune hemolytic anemia (AIHA). METHODS:We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing the risk of VTE i...

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    更新日期:2019-07-01 00:00:00

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: White GC 2nd,Knupp CL

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    pub_type: 杂志文章


    authors: Rut W,Nielsen NV,Czarna J,Poreba M,Kanse SM,Drag M

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    pub_type: 杂志文章


    authors: Andrassy K,Mörike K,Koderisch J,Weber E

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Valles J,Aznar J,Santos MT,Fernandez MA

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Shlansky-Goldberg R

    更新日期:2008-01-01 00:00:00

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    更新日期:2004-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


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  • Blood clotting factor IX Nagoya 3: the molecular defect of zymogen activation caused by an arginine-145 to histidine substitution.

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    pub_type: 杂志文章


    authors: Suehiro K,Miyata T,Takeya H,Takamatsu J,Saito H,Murakawa M,Okamura T,Niho Y,Iwanaga S

    更新日期:1990-11-15 00:00:00

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    authors: Newall F,Bauman M

    更新日期:2006-01-01 00:00:00

  • The effect of sulphinpyrazone on whole blood thromboxane and prostacyclin generation in man.

    abstract::A new method, based on the observation that leukocytes contain PGI2-synthetase activity, was used to measure the effect of pharmacological levels of sulphinpyrazone on the TXA2 and PGI2 production in whole blood. Four human volunteers took 400 mg sulphinpyrazone twice daily for 5 1/2 days. Blood was drawn before the s...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Badenhorst PN,Deckmyn H,Vermylen J

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  • Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis.

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    pub_type: 杂志文章


    authors: Knoll B,Hach-Wunderle V,Rieger S,Häring D,Mannhalter C

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Nilsson TK,Johnson O

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  • Immunologic studies of factor VIII coagulant activity (VIII:C). 2. Factor VIII in selected vertebrates.

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    pub_type: 杂志文章


    authors: Rotblat F,Hawkey C,O'Brien DP,Tuddenham EG

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  • Fatal pulmonary embolism or bleeding in patients with venous thromboembolism: implications of real-life data.

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    journal_title:Thrombosis research

    pub_type: 杂志文章,评审


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    更新日期:2019-09-01 00:00:00

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Stegnar M,Peternel P,Chen JP

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    pub_type: 杂志文章


    authors: Nagashima M,Werner M,Wang M,Zhao L,Light DR,Pagila R,Morser J,Verhallen P

    更新日期:2000-05-15 00:00:00

  • Rivaroxaban for the treatment of venous thromboembolism. A "real-life" perspective in 103 patients.

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    pub_type: 杂志文章


    authors: Jara-Palomares L,Sanchez-Oro-Gomez R,Elias-Hernandez T,Morillo-Guerrero R,Ferrer-Galvan M,Asensio-Cruz MI,Barrot-Cortes E,Otero-Candelera R

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Pettersen AÅ,Arnesen H,Opstad TB,Bratseth V,Seljeflot I

    更新日期:2012-09-01 00:00:00

  • Production of a recombinant antithrombotic and fibrinolytic protein, PLATSAK, in Escherichia coli.

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: van Zyl WB,Pretorius GH,Hartmann M,Kotzé HF

    更新日期:1997-12-01 00:00:00

  • Microsomal CA2+ uptake in human platelets is stimulated by calmodulin.

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Salimath BP,Mittelholzer E,Muggli R,Dieter P,Marmé D

    更新日期:1986-02-15 00:00:00

  • Release of tissue-type plasminogen activator (t-PA) in the splanchnic circulation of the anaesthetised pig during high sympathetic tone.

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    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Björkman JA,Ilebekk A,Jern C

    更新日期:2010-03-01 00:00:00