Anti-human factor IX monoclonal antibodies specific for calcium ion-induced conformations.

abstract：BACKGROUND:Despite treatment, women with von Willebrand disease (VWD) have lower von Willebrand factor (VWF) levels and greater blood loss at delivery than controls. Current weight-based dosing does not account for the ~1.5-fold increase in blood volume in pregnancy. METHODS:To evaluate the feasibility of a trial to p...

journal_title：Thrombosis research

authors： Ragni MV,Machin N,James AH,Seaman CD,Malec LM,Kessler CM,Konkle BA,Kouides PA,Neff AT,Philipp CS,Brooks MM

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Blood flow induced shear stress plays an important role in platelet and endothelial cell functions. The goal of this study was to investigate the effect of physiologically relevant dynamic shear stress on platelet and endothelial cells. MATERIALS AND METHODS:Pulsatile shear stress waveforms mimicking the ...

journal_title：Thrombosis research

authors： Yin W,Shanmugavelayudam SK,Rubenstein DA

更新日期：2011-03-01 00:00:00

abstract：:Patients with active cancer have a heightened risk of venous thromboembolism (VTE). This risk is further increased by the initiation of chemotherapy. Although previous studies have suggested that the use of parenteral thromboprophylaxis in all ambulatory cancer patients receiving chemotherapy significantly decreases t...

journal_title：Thrombosis research

authors： Kimpton M,Wells PS,Carrier M

更新日期：2018-04-01 00:00:00

abstract：:Urokinase-type plasminogen activator (uPA) plays a central role in many aspects of cellular regulation, such as fibrinolysis, cell migration, and metastasis. The uPA induction by inflammatory stimuli such as IL-1, TNFalpha, and lipopolysaccharide (LPS) has been reported in a number of human cells. We examined the effe...

journal_title：Thrombosis research

authors： Ohta S,Niiya K,Sakuragawa N,Fuse H

更新日期：2000-03-01 00:00:00

abstract：:The extrinsic fibrinolytic system was assessed among 124 consecutive survivors of acute myocardial infarction below 70 years of age. In samples drawn 3 months after discharge from hospital, the PAI-1 levels were higher and the tPA activities were lower than among elderly healthy controls. In contrast, the AMI survivor...

journal_title：Thrombosis research

authors： Nilsson TK,Johnson O

更新日期：1987-12-15 00:00:00

abstract：:The use of oral contraceptives (OCs) has been associated with vascular complications. The mechanism(s) by which OCs predispose to thrombotic events remains unclear. Recent studies have demonstrated that postmenopausal (PM) women who take estrogen replacement therapy (ERT) have a decreased incidence of myocardial infar...

journal_title：Thrombosis research

authors： Dores GM,Miller ME,Thorpe SL

更新日期：1993-01-15 00:00:00

abstract：:ACS patients undergoing percutaneous coronary intervention (PCI) when treated with bivalirudin and clopidogrel had increased frequency of early stent thrombosis. 24 patients referred for intervention with planned bivalirudin therapy, not previously treated with a P2Y12 inhibitor and not receiving heparins or αIIbβ3 in...

journal_title：Thrombosis research

authors： Kimmelstiel C,Stevenson R,Nguyen N,Van Doren L,Zhang P,Perkins J,Kapur NK,Weintraub A,Castaneda V,Kuliopulos A,Covic L

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:A higher level of health insurance coverage may be related to better quality of care and outcomes. Whether insurance status is associated with anticoagulation quality and clinical outcomes in patients with venous thromboembolism (VTE) is unknown. METHODS:We studied 819 elderly patients treated with vitami...

journal_title：Thrombosis research

authors： Zumbrunn B,Stalder O,Méan M,Limacher A,Tritschler T,Rodondi N,Aujesky D

更新日期：2019-01-01 00:00:00

abstract：:The effect of the major acute phase protein serum amyloid A (SAA) on collagen induced platelet aggregation was investigated. A truncated version of SAA, SAA25-76 was tested for inhibitory capacity of collagen induced platelet aggregation in platelet-rich plasma (PRP) and whole blood (WB). The tetrapeptide RGDV, a know...

journal_title：Thrombosis research

authors： Syversen PV,Saeter U,Cunha-Ribeiro L,Orvim U,Sletten K,Husby G,Sakariassen KS

更新日期：1994-11-01 00:00:00

abstract：INTRODUCTION:Viscoelastometry enables rapid evaluation of coagulopathy in settings such as cardiac surgery but may be influenced by red cell concentration. METHODS:In order to study the effects of supra-physiological red cell concentrations on viscoelastometry, we compared ROTEM® viscoelastometry and plasma coagulatio...

journal_title：Thrombosis research

authors： Westbury SK,Lee K,Reilly-Stitt C,Tulloh R,Mumford AD

更新日期：2013-08-01 00:00:00

abstract：:This study investigates the effect on human platelet function of two sesquiterpene lactones from Arnica montana L., helenalin (H) and 11 alpha,13-dihydrohelenalin (DH). Both compounds inhibited collagen-induced platelet aggregation, thromboxane formation and 5-hydroxytryptamine secretion in a concentration-dependent m...

journal_title：Thrombosis research

authors： Schröder H,Lösche W,Strobach H,Leven W,Willuhn G,Till U,Schrör K

更新日期：1990-03-15 00:00:00

abstract：INTRODUCTION:Inflammation and coagulation play important roles in the pathogenesis of sepsis. Anticoagulants with anti-inflammatory action draw attention as therapeutic agent in sepsis. OBJECTIVE:Whether cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2-(1H)-quinolinone), anticoagulant, protects m...

journal_title：Thrombosis research

authors： Chang KC

更新日期：2015-08-01 00:00:00

abstract：:Chronic immune thrombocytopenia purpura (ITP) is an autoimmune disease that exhibits an abnormally high Th1/Th2 ratio. Granulocyte colony-stimulating factor (G-CSF) has been shown to decrease the Th1/Th2 ratio in healthy donors. In this study, we investigated the effects of G-CSF treatment on the Th1/Th2 cells and the...

journal_title：Thrombosis research

authors： Ge F,Zhang Z,Hou J,Cao F,Zhang Y,Wang P,Wei H,Zhou J

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Thrombosis is one of the most frequent adverse events after cardiac catheterization, which can be reduced by anticoagulation with unfractionated heparin (UFH) in both children and adults. Low molecular weight heparin (LMWH) might possibly offer advantages. Laboratory signs of thrombin generation during ped...

journal_title：Thrombosis research

authors： Roschitz B,Beitzke A,Gamillscheg A,Sudi K,Koestenberger M,Leschnik B,Muntean W

更新日期：2003-01-01 00:00:00

abstract：:Human saphenous veins were analyzed for presence of plasminogen activators (t-PA) in the endothelium of the vessel walls by immunohistochemical techniques. We used a polyclonal rabbit antihuman t-PA antibody, a monoclonal mouse-antihuman t-PA and a goat antibody to low molecular weight urokinase. To demonstrate presen...

journal_title：Thrombosis research

authors： Risberg B,Eriksson E,Björk S,Hansson GK

更新日期：1986-02-01 00:00:00

abstract：:Hemorrhagic and thrombotic complications are common in the term and preterm infant. Limited information is currently available about neonatal platelet structure and function, and how these may predispose infants to bleeding problems. This study comparing platelet ultrastructure of 71 different term and preterm infants...

journal_title：Thrombosis research

authors： Saving KL,Jennings DE,Aldag JC,Caughey RC

更新日期：1994-03-15 00:00:00

abstract：INTRODUCTION:Flow cytometry (FCM) is the most commonly used method for detection of platelet-derived microparticles (PDMPs), but it is poorly standardized and mainly used for "bedside" analyses in fresh samples. If PDMPs could be analyzed in previously frozen samples it would increase the usefulness of the method. Howe...

journal_title：Thrombosis research

authors： Mobarrez F,Antovic J,Egberg N,Hansson M,Jörneskog G,Hultenby K,Wallén H

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Hydrogen sulfide (H2S) known as a gasotransmitter is increasingly recognized for its anti-adhesive, anti-inflammatory and vasoactive properties. Due to these properties, we analysed anti-thrombotic effects of H2S and the participation of the nitric oxide synthase (NOS)-pathway. MATERIALS AND METHODS:In in...

journal_title：Thrombosis research

authors： Kram L,Grambow E,Mueller-Graf F,Sorg H,Vollmar B

更新日期：2013-08-01 00:00:00

abstract：:It has previously been observed that aspirin diminishes the increase in blood fibrinolytic activity during arm venous occlusion. We studied the duration of this inhibitory effect on fibrinolytic response during 20 minutes arm venous occlusion and its effect on fibrinolytic response during acute physical activity (stan...

journal_title：Thrombosis research

authors： Keber I,Jereb M,Keber D

更新日期：1987-04-15 00:00:00

abstract：:The anticoagulant (U.S.P., APTT; "in vitro" and "in vivo") antithrombotic (aXa; Yin and Wessler and chromogenic), antilipemic (LPL) activities of heparin, heparin fractions and fragments, heparinoids, heparan sulfate and other sulfated glycosaminoglycans were compared with the activities of these compounds as antithro...

journal_title：Thrombosis research

authors： Bianchini P,Osima B,Parma B,Nader HB,Dietrich CP

更新日期：1985-12-01 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00

abstract：:Defibrotide (D) is a natural polydeoxyribonucleotide from mammalian lungs with profibrinolytic and antithrombotic activities. D also has PGI2-stimulating and tissue plasminogen activator (TPA)-releasing activities, but has no anticoagulant properties. The protective effects of D were demonstrated very recently in a mo...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1986-05-01 00:00:00

abstract：INTRODUCTION:In the prospective, randomised, double-blind, placebo-controlled Regenerate Vital Myocardium by Vigorous Activation of Bone Marrow Stem Cells (REVIVAL)-2 trial patients with acute myocardial infarction (AMI) and successful mechanical reperfusion received granulocyte-colony stimulating factor (G-CSF, 10 μg/...

journal_title：Thrombosis research

authors： Steppich BA,Demetz G,Schulz S,von Wedel J,Pogatsa-Murray G,Braun SL,Stein A,Kastrati A,Schömig A,Ott I

更新日期：2011-02-01 00:00:00

abstract：:Patients with essential hypertension (EH) and hyperhomocysteinemia (HHCY) suffer from more increased thrombotic events than those in EH alone. However, the underlying mechanisms for this effect are not well understood. This study hypothesized that neutrophil extracellular trap (NET) releasing may be triggered by HHCY ...

journal_title：Thrombosis research

authors： Li JH,Tong DX,Wang Y,Gao L,Liu Y,Zhang XH,Chen WJ,Chi JY,Liu N,Yang K,Wang SP,Xu Y,Li Y,Yin XH,Liu WX

更新日期：2021-01-01 00:00:00

abstract：:We investigated on how to effectively administer orally factor VIII preparation to two patients with von Willebrand's disease as volunteers, and the following results were obtained: Bleeding time and aPTT were shortened, but no change of PT was observed. Factor VIII:C increased slightly, but no significant increase wa...

journal_title：Thrombosis research

authors： Sakuragawa N,Niiya K,Kondo S

更新日期：1985-06-15 00:00:00

abstract：:Binding of 3H-labeled 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor; PAF) to the intact, washed canine platelet has been defined and characterized as being specific and receptor-mediated. Under the conditions described, specific binding to 2 X 10(7) canine platelets reached saturation with...

journal_title：Thrombosis research

authors： Janero DR,Burghardt B,Burghardt C

更新日期：1988-06-15 00:00:00

abstract：:A new model of arterial thrombosis in rats was based on a combination of a localizing hemodynamic factor /partial mechanical constriction of aorta/, generalized mild endothelial lesion /i.v.hypotonic saline/ and a humoral factor/i.v. serotonin/. The resulting aortic occlusion was indicated by measuring rectal temperat...

journal_title：Thrombosis research

authors： Hladovec J

更新日期：1986-03-01 00:00:00

abstract：:Stent implantation after balloon dilation of coronary arteries has improved clinical prognosis in patients undergoing transluminal coronary angioplasty (PTCA), but late restenosis remains a relevant problem. A previous study has indicated that PAI-1 activity changes immediately after PTCA without stent implantation ar...

journal_title：Thrombosis research

authors： Prisco D,Fedi S,Antonucci E,Capanni M,Chiarugi L,Chioccioli M,Falai M,Giglioli C,Abbate R,Gensini GF

更新日期：2001-11-01 00:00:00

abstract：INTRODUCTION:Randomized clinical trials have demonstrated non-inferiority of rivaroxaban compared with vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE). Our objective was to analyze in real life, tolerance, recurrence, bleeding and adverse events of rivaroxaban in patients with acute sympto...

journal_title：Thrombosis research

authors： Jara-Palomares L,Sanchez-Oro-Gomez R,Elias-Hernandez T,Morillo-Guerrero R,Ferrer-Galvan M,Asensio-Cruz MI,Barrot-Cortes E,Otero-Candelera R

更新日期：2014-09-01 00:00:00

abstract：:Therapeutic developments have seen significant improvement in mortality over the past thirty years for breast, colorectal and prostate cancer. Lung cancer is the commonest cancer in the world, but has seen little improvement in survival figures. The role of low-molecular-weight heparin (LMWH) in improving cancer survi...

journal_title：Thrombosis research

authors： Noble S

更新日期：2012-04-01 00:00:00