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Induction of urokinase-type plasminogen activator by lipopolysaccharide in PC-3 human prostatic cancer cells.

Abstract：

:Urokinase-type plasminogen activator (uPA) plays a central role in many aspects of cellular regulation, such as fibrinolysis, cell migration, and metastasis. The uPA induction by inflammatory stimuli such as IL-1, TNFalpha, and lipopolysaccharide (LPS) has been reported in a number of human cells. We examined the effects of LPS on uPA expression in human PC-3 prostatic cancer cells that express uPA in a conditioned medium. LPS increased the uPA accumulation in PC-3 cells, whereas IL-1, IL-6, and TNFalpha did not. Northern blot analysis revealed that the peak induction of uPA mRNA occurred 5 hours after LPS stimulation. A protein synthesis inhibitor, cycloheximide, amplified the LPS-induced uPA mRNA, suggesting that LPS induces uPA by activating the gene expression in which de novo protein synthesis is not necessary.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Ohta S,Niiya K,Sakuragawa N,Fuse H

doi

10.1016/s0049-3848(99)00174-7

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

343-7

issue

5

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(99)00174-7

journal_volume

97

pub_type

杂志文章

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