Low-molecular-weight heparin and survival in lung cancer.

abstract：BACKGROUND:Impaired endothelial-dependent flow-mediated dilatation (FMD) has been used to demonstrate endothelial dysfunction in a wide variety of cardiovascular disease, but previous studies have excluded patients with atrial fibrillation(AF). We therefore hypothesised that endothelial dysfunction exists in AF and tha...

journal_title：Thrombosis research

authors： Freestone B,Chong AY,Nuttall S,Lip GY

更新日期：2008-01-01 00:00:00

abstract：:The effect of the major acute phase protein serum amyloid A (SAA) on collagen induced platelet aggregation was investigated. A truncated version of SAA, SAA25-76 was tested for inhibitory capacity of collagen induced platelet aggregation in platelet-rich plasma (PRP) and whole blood (WB). The tetrapeptide RGDV, a know...

journal_title：Thrombosis research

authors： Syversen PV,Saeter U,Cunha-Ribeiro L,Orvim U,Sletten K,Husby G,Sakariassen KS

更新日期：1994-11-01 00:00:00

abstract：:Advances in antithrombotic therapy began when traditional anticoagulant agents such as heparin and the vitamin K antagonists like Coumadin became commercially available in the 1940s and 1950s. Inherent limitations of these compounds, including the need for monitoring and multiple food and drug interactions (with couma...

journal_title：Thrombosis research

authors： Spyropoulos AC

更新日期：2008-01-01 00:00:00

abstract：:HC II functional assays are generally preferred with respect to immunochemical assays. Nevertheless functional assays can be biased by the antithrombin III (AT III)-heparin complex activity; in fact trace amounts of heparin generally contaminate dermatan sulfate (DS) commercial preparations used as HC II reaction acti...

journal_title：Thrombosis research

authors： Ruzzenente O,Ghidini R,Poli G,Schiavon R,Guidi GC

更新日期：1992-01-15 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor-alpha (TNF-α) exerts a critical role in inflammatory events through two distinct receptors, TNFR1 and TNFR2. Platelets have been recognized as important inflammatory cells, but little is known about the effects of TNF-α on the platelet activity. OBJECTIVES:In the present study we hav...

journal_title：Thrombosis research

authors： Bonfitto PHL,Naime ACA,Lopes-Pires ME,Goulart G,Mendes-Silverio CB,Bueno PI,Castilho RF,Antunes E,Marcondes S

更新日期：2018-12-01 00:00:00

abstract：:The ultrastructure of the platelet contacts with collagen fibrils (CF) as well as the course taken by CF on the platelet surface were studied on ultrathin sections of platelets and CF. Platelets from normal donors and from a patient with thrombasthenia were incubated in citrated plasma with collagen. For electron micr...

journal_title：Thrombosis research

authors： Ruf A,Morgenstern E,Janzarik H,Lüscher EF

更新日期：1986-11-15 00:00:00

abstract：:Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failur...

journal_title：Thrombosis research

authors： Stevic I,Chan HH,Chan AK

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Although recurrent venous thromboembolism is a known risk factor for chronic thromboembolic pulmonary hypertension (CTEPH), the prevalence of CTEPH after recurrent pulmonary embolism (PE) is not clear. MATERIALS AND METHODS:A cohort screening study was performed to clarify the prevalence of echocardiograp...

journal_title：Thrombosis research

authors： Berghaus TM,Barac M,von Scheidt W,Schwaiblmair M

更新日期：2011-12-01 00:00:00

abstract：:Vascular endothelial injury (VEI) triggers pathological processes in various cardiovascular diseases, such as coronary heart disease and hypertension. To further elucidate the in vivo pathological mechanisms of VEI, many animal models have been established. For the easiness of genetic manipulation and feeding, murine ...

journal_title：Thrombosis research

authors： Wu Y,Su SA,Xie Y,Shen J,Zhu W,Xiang M

更新日期：2018-09-01 00:00:00

abstract：:Thirty-four derivatives of benzamidine were tested for their inhibitory activities on bovine and human thrombins using the chromogenic peptide substrate N-D-Phe-Pip-Arg-pNA. The inhibition constants of small molecular size inhibitors of comparatively low affinity as well as those of tight binding inhibitors did not di...

journal_title：Thrombosis research

authors： Stürzebecher J,Walsmann P,Voigt B,Wagner G

更新日期：1984-12-01 00:00:00

abstract：:A platelet storage pool deficiency (SPD) is present in platelets from cattle with the Chediak-Higashi syndrome (CHS). The most plausible hypothesis for the SPD is that dense granule precursors are simply not formed in CHS megakaryocytes. There is, however, evidence that some recently acquired 5-hydroxytryptamine (5HT)...

journal_title：Thrombosis research

authors： Meyers KM,Costa JL,Magnuson J

更新日期：1990-05-01 00:00:00

abstract：INTRODUCTION:Monocyte- and microparticle (MP)-associated tissue factor (TF) is upregulated in diabetes. Lipopolysaccharide (LPS) induces expression of TF and alternatively spliced TF (asTF) and increases MP release from monocytes. Using LPS-stimulated TF-bearing human monocytes, we examined whether glibenclamide, a sul...

journal_title：Thrombosis research

authors： Henriksson CE,Hellum M,Haug KB,Aass HC,Joø GB,Øvstebø R,Trøseid AM,Klingenberg O,Kierulf P

更新日期：2011-11-01 00:00:00

abstract：:Excess platelets shorten most clotting tests for lupus anticoagulant (LA). Often it is not clear if a shortened, normal or slightly prolonged result in a test masks a weak LA in combination with activated platelets, which express procoagulant phospholipid (PPL). Our aim was to investigate a new LA-insensitive factor X...

journal_title：Thrombosis research

authors： Exner T,Low J

更新日期：2004-01-01 00:00:00

abstract：:Red blood cells have historically been viewed as innocent bystanders in the process of blood coagulation and thrombin generation; however a century of clinical evidence linking red blood cells to thrombosis suggests the contrary. In this brief review, the biochemical evidence for red blood cell involvement in thrombin...

journal_title：Thrombosis research

authors： Whelihan MF,Mann KG

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Deep vein thrombosis (DVT) is a common complication of acute stroke, but the new incidence in the era of improved specialist input in stroke care is yet unknown. The models for VTE diagnosis is well established, but prediction models to target at-risk patients for pharmacological prophylaxis is lacking and r...

journal_title：Thrombosis research

authors： Balogun IO,Roberts LN,Patel R,Pathansali R,Kalra L,Arya R

更新日期：2016-06-01 00:00:00

abstract：:Several sex-related differences in the incidence rate, clinical presentation and outcomes of VTE were recently investigated. Gender-related risk factors, such as the use of oral contraceptives (OC) and pregnancy, in particular in women with a thrombophilic state, are associated with an increased risk of venous thrombo...

journal_title：Thrombosis research

authors： Romualdi E,Ageno W

更新日期：2011-02-01 00:00:00

abstract：:We previously found evidence (based on the use of 5HT as a marker) that i.v. injection of a lipopolysaccharide (LPS) into mice induces a rapid accumulation of platelets in liver and lung. Our previous studies lacked measurement of the platelet count itself, but we have now compared the LPS-induced changes in 5HT level...

journal_title：Thrombosis research

authors： Ohtaki Y,Shimauchi H,Yokochi T,Takada H,Endo Y

更新日期：2002-12-15 00:00:00

abstract：INTRODUCTION:The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI). MATERIALS AND METHODS:Patients with an AMI (n=202) randomly assigned to aspirin 160 ...

journal_title：Thrombosis research

authors： Andersen K,Hurlen M,Arnesen H,Seljeflot I

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:Information regarding any possible additional effect of genetic variants other than CYP2C19*2 on platelet reactivity in patients undergoing percutaneous coronary intervention (PCI), while on dual antiplatelet therapy, is sparse. MATERIALS AND METHODS:Genotyping for CYP2C19*2, CYP2C19*17, CYP2C9*3, CYP2B6*...

journal_title：Thrombosis research

authors： Kassimis G,Davlouros P,Xanthopoulou I,Stavrou EF,Athanassiadou A,Alexopoulos D

更新日期：2012-04-01 00:00:00

abstract：:Numerous factors affect the response to vitamin K antagonists (VKA) including age, dietary vitamin K, other drugs, pharmacogenetics, and disease states. In antithrombotic guidelines, fever is mentioned as a factor that may increase response to VKA. The purpose of this article is to review the available evidence regard...

journal_title：Thrombosis research

authors： Self TH,Oliphant CS,Reaves AB,Richardson AM,Sands CW

更新日期：2015-01-01 00:00:00

abstract：:Patients with active cancer have a heightened risk of venous thromboembolism (VTE). This risk is further increased by the initiation of chemotherapy. Although previous studies have suggested that the use of parenteral thromboprophylaxis in all ambulatory cancer patients receiving chemotherapy significantly decreases t...

journal_title：Thrombosis research

authors： Kimpton M,Wells PS,Carrier M

更新日期：2018-04-01 00:00:00

abstract：:Patients with the nephrotic syndrome are at increased risk of developing venous and arterial thromboembolism, the most common of which is renal vein thrombosis. There are several unanswered or controversial issues relating to the nephrotic syndrome and thromboembolism, which include the mechanism of thromboembolism, a...

journal_title：Thrombosis research

authors： Singhal R,Brimble KS

更新日期：2006-01-01 00:00:00

abstract：:Using the standard turbidimetric method of platelet aggregation and quantitation of platelet secretion with 14C-Serotonin, we have examined the responsiveness of the platelets of mongrel dogs to arachidonic acid (AA), and the thromboxane agonist U46619 in the presence and absence of a subthreshold concentration of epi...

journal_title：Thrombosis research

authors： McGoff MA,Allen BT,Der T,Sicard GA,Santoro SA

更新日期：1989-09-15 00:00:00

abstract：BACKGROUND:Advances in medical and surgical therapy in children have resulted in increased survival in children with primary illnesses. However, thrombosis is a serious complication of this success and results in mortality and morbidity. Prevention or treatment of thrombosis using warfarin is challenging in children du...

journal_title：Thrombosis research

authors： Bauman ME,Black K,Kuhle S,Wang L,Legge L,Callen-Wicks D,Mitchell L,Bajzar L,Massicotte MP,Western Canadian Children's Heart Network WCCHN.

更新日期：2009-03-01 00:00:00

abstract：:The time course and degree of collagen induced platelet shape change, aggregation and ATP-secretion in citrated human platelet rich plasma was monitored with a lumi-aggregometer. Onset of ATP-secretion was measurable within seconds after collagen challenge and always distinctly before onset of shape change. In absence...

journal_title：Thrombosis research

authors： Malmgren R

更新日期：1986-08-15 00:00:00

abstract：:Three methods commonly used for isolation of blood platelets from plasma were compared. Platelets were isolated by: 1) a washing method; 2) a method of metrizamide-gradient centrifugation; 3) a modified method of gel-filtration. The last method employed BSA-Sepharose gel instead of routinely used Sepharose gel saturat...

journal_title：Thrombosis research

authors： Walkowiak B,Kralisz U,Michalec L,Majewska E,Koziolkiewicz W,Ligocka A,Cierniewski CS

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the role of filter implantation in reducing the incidence of fatal pulmonary embolism during the endovascular treatment of thrombosis in the major tributary of the superior vena cava (SVC). METHODS:From October 2004 to October 2008, we conducted a cohort study of 40 patients with thrombosis of t...

journal_title：Thrombosis research

authors： Liang Z,Han R,Qu Y,Cao W,Cui J

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Rate of thalidomide-related VTE and risk factors in Japanese myeloma patients are not clear and effects of thromboprophylaxis remain controvertial. PATIENTS AND METHODS:We retrospectively analyzed a cohort data of registered Japanese myeloma patients treated with thalidomide-based regimens between 2009 and ...

journal_title：Thrombosis research

authors： Kato A,Takano H,Ichikawa A,Koshino M,Igarashi A,Hattori K,Nagata K

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:Available data on fibrin clot properties and fibrinolysis in hyperthyroidism and hypothyroidism are inconsistent. Our objective was to assess the impact of effective treatment of hyper- and hypothyroidism on fibrin clot characteristics. MATERIAL AND METHODS:In a case-control study, ex vivo plasma fibrin c...

journal_title：Thrombosis research

authors： Mazur P,Sokołowski G,Hubalewska-Dydejczyk A,Płaczkiewicz-Jankowska E,Undas A

更新日期：2014-08-01 00:00:00

abstract：:The candidate-gene approach can be used to locate and identify genetic variations that are associated with a particular phenotype. This gene-centric approach assumes that there exists important genetic variation within genes that can influence health. Identifying known genes which are candidates for the phenotype of i...

journal_title：Thrombosis research

authors： Smith NL,Rice KM,Lumley T,Heckbert SR,Psaty BM

更新日期：2009-01-01 00:00:00