Oral administration of factor VIII concentrate preparation in von Willebrand's disease.

abstract：:The anticoagulant (U.S.P., APTT; "in vitro" and "in vivo") antithrombotic (aXa; Yin and Wessler and chromogenic), antilipemic (LPL) activities of heparin, heparin fractions and fragments, heparinoids, heparan sulfate and other sulfated glycosaminoglycans were compared with the activities of these compounds as antithro...

journal_title：Thrombosis research

authors： Bianchini P,Osima B,Parma B,Nader HB,Dietrich CP

更新日期：1985-12-01 00:00:00

abstract：:We evaluate the anti-platelet and anti-thrombotic effects of cilostazol using Multiplate® and PFA-100® in vitro and ex vivo with freshly isolated rat whole blood and in vivo venous and arterial thrombosis models in the same species, in an effort to assess the sensitivity of the whole blood aggregometer assays without ...

journal_title：Thrombosis research

authors： Kim CW,Yun JW,Bae IH,Park YH,Jeong YS,Park JW,Chung JH,Park YH,Lim KM

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Inherited abnormalities of fibrinogen (FG) are rare coagulation disorders divided into two types: quantitative abnormalities (afibrinogenemia and hypofibrinogenemia) or qualitative abnormalities (dysfibrinogenemia and hypo-dysfibrinogenemia) of circulating fibrinogen. In particular, congenital afibrinogene...

journal_title：Thrombosis research

authors： Amri Y,Toumi Nel H,Hadj Fredj S,de Moerloose P

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. METHODS:Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenect...

journal_title：Thrombosis research

authors： Comerota AJ,Oostra C,Fayad Z,Gunning W,Henke P,Luke C,Lynn A,Lurie F

更新日期：2015-05-01 00:00:00

abstract：:Acute coronary syndromes (ACS) represent the main clinical manifestation of atherosclerotic progression in the coronary district. Thrombosis plays a critical role in the patho-anatomical of ACS, as disruption of an atherosclerotic plaque exposes flowing blood to subendothelial collagen, tissue factor, and other procoa...

journal_title：Thrombosis research

authors： Abbate R,Cioni G,Ricci I,Miranda M,Gori AM

更新日期：2012-03-01 00:00:00

abstract：:The efficacy and the safety of a new urokinase dosage regimen (loading dose 250,000 IU, initial maintenance dosage 2,000 IU/kg/h in combination with heparin) was studied in ten cases of deep vein thrombosis with regard to the changes of the blood coagulation and fibrinolytic enzyme system. The coagulation analyses dem...

journal_title：Thrombosis research

authors： Schöffel G,Zimmermann R,Harenberg J,Mörl H

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS:Patients with newly diagnosed cancer ...

journal_title：Thrombosis research

authors： El-Refai SM,Black EP,Adams VR,Talbert JC,Brown JD

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Impaired endothelial-dependent flow-mediated dilatation (FMD) has been used to demonstrate endothelial dysfunction in a wide variety of cardiovascular disease, but previous studies have excluded patients with atrial fibrillation(AF). We therefore hypothesised that endothelial dysfunction exists in AF and tha...

journal_title：Thrombosis research

authors： Freestone B,Chong AY,Nuttall S,Lip GY

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus f...

journal_title：Thrombosis research

authors： Nakamura Y,Nakamura K,Fukushima-Kusano K,Ohta K,Matsubara H,Hamuro T,Yutani C,Ohe T

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanism underlying the hypercoagulable state in severe pre-eclampsia. METHODS:Plasma tissue factor (TF) and tissue factor pathway inhibitor (TFPI) expression from pre-eclampsia patients and healthy pregnant controls were determined by ELISA. Placental TF and TFPI gene and protein express...

journal_title：Thrombosis research

authors： Teng Y,Jiang R,Lin Q,Ding C,Ye Z

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Guidelines recommend the assessment of stroke and bleeding risk before initiating warfarin anticoagulation in patients with atrial fibrillation. Many of the elements used to predict stroke also overlap with bleeding risk in atrial fibrillation patients and it is tempting to use stroke risk scores to effici...

journal_title：Thrombosis research

authors： Barnes GD,Gu X,Haymart B,Kline-Rogers E,Almany S,Kozlowski J,Besley D,Krol GD,Froehlich JB,Kaatz S

更新日期：2014-08-01 00:00:00

abstract：:This paper continues our study (see Part I) where we modeled the spatio-temporal dynamics of the intrinsic pathway of blood coagulation. Here, we analyzed this model and showed that it describes the threshold behavior of coagulation. When activation is subthreshold (which produces not more than 0.07 nM factor XIa at s...

journal_title：Thrombosis research

authors： Zarnitsina VI,Pokhilko AV,Ataullakhanov FI

更新日期：1996-12-01 00:00:00

abstract：INTRODUCTION:Platelets and the coagulation system may be involved in the pathogenesis of pre-eclampsia. We investigated whether platelet and coagulation activation markers, are elevated in pre-eclampsia. MATERIALS/METHODS:Case-control study in which activated platelets, platelet-monocyte/ neutrophil aggregates, platel...

journal_title：Thrombosis research

authors： Macey MG,Bevan S,Alam S,Verghese L,Agrawal S,Beski S,Thuraisingham R,MacCallum PK

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:The effects of multiple inherited and acquired thrombophilic defects on the outcome of in-vitro fertilization (IVF) remain unexplored. The aim of this study was to evaluate the association between multiple thrombophilia and clinical outcomes in a large prospective cohort of women undergoing IVF. MATERIALS...

journal_title：Thrombosis research

authors： Di Nisio M,Ponzano A,Tiboni GM,Guglielmi MD,Rutjes AWS,Porreca E

更新日期：2018-07-01 00:00:00

abstract：:Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...

journal_title：Thrombosis research

authors： Binnie C,Wagner RH,Cooper H,Hermans J

更新日期：1985-11-15 00:00:00

abstract：INTRODUCTION:Long-term dual antiplatelet therapy (DAPT) has substantially reduced the risk of post-percutaneous coronary intervention (PCI) myocardial infarction and stent thrombosis at the expense of major bleeding. We hypothesized that a short-term DAPT followed by extended P2Y12 inhibitor monotherapy might be approp...

journal_title：Thrombosis research

authors： Jin Y,Huang H,Shu X,Chen S,Lu L,Gao X,Wu Z

更新日期：2020-12-07 00:00:00

abstract：:The extrinsic pathway of coagulation is initiated when zymogen factor VII binds to its cell surface receptor tissue factor. Recently recombinant human tissue factor has become available and therefore in this study the direct binding of human factor VII in plasma to recombinant tissue factor was explored. Factor VII bi...

journal_title：Thrombosis research

authors： Sridhara S,Clarke BJ,Ofosu FA,High KA,Blajchman MA

更新日期：1993-05-15 00:00:00

abstract：:Factor Xa-catalyzed prothrombin activation occurs on cellular surfaces, including those of vascular endothelial cells. In a reconstituted model, endothelial cells and platelets acted synergistically to maximally activate prothrombin in the presence of Factor Xa. Synergism was observed at platelet concentrations less t...

journal_title：Thrombosis research

authors： Rodgers GM,Shuman MA

更新日期：1987-01-15 00:00:00

abstract：INTRODUCTION:Nitric oxide (NO) plays an important role in the regulation of the cardiovascular system. It is produced by endothelial nitric oxide synthase (eNOS), which exhibits genetic polymorphisms. Although the clinically relevant polymorphism T(+IhI-786)C reduces eNOS-promoter activity, it is not clear whether circ...

journal_title：Thrombosis research

authors： Nagassaki S,Metzger IF,Souza-Costa DC,Marroni AS,Uzuelli JA,Tanus-Santos JE

更新日期：2005-01-01 00:00:00

abstract：:The effect of dalteparin, a low molecular weight heparin, on severely antithrombin III (ATIII)-decreased disseminated intravascular coagulation (DIC) model was compared with that of unfractionated heparin (heparin). The DIC model in rabbits was produced by continuous infusion of thrombin in combination with bolus inje...

journal_title：Thrombosis research

authors： Tazawa S,Ichikawa K,Misawa K,Fukuyama J,Hamano S,Miyata H,Sakuragawa N

更新日期：1995-12-01 00:00:00

abstract：INTRODUCTION:The standard dabigatran etexilate dosage for prevention of venous thromboembolism (VTE) after elective total hip or knee replacement (THR/TKR) is 220mg once daily (qd), with 150mg qd for patients with moderate renal impairment. As clinical trial experience in patients with moderate renal impairment was lim...

journal_title：Thrombosis research

authors： Samama CM,Rosencher N,Kleine E,Feuring M,Brueckmann M,Clemens A,Gullberg J,Frostick SP

更新日期：2016-07-01 00:00:00

abstract：:To determine whether homocysteine, a risk factor for possible endothelial cell dysfunction, procoagulant effects and premature vascular disease but with a potential nutritional role for fetal and neonatal metabolism and development, is elevated in women at time of elective caesarean section with nitrous oxide general ...

journal_title：Thrombosis research

authors： Zanardo V,Caroni G,Burlina A

更新日期：2003-01-01 00:00:00

abstract：:The three main components involved in thrombosis and haemostasis are thrombin, platelets, and plasmin. Almost all inhibitors of thrombosis are focused either on the inhibition of thrombin or on the inhibition of platelets. We designed a construct using the fibrinolytic activity of staphylokinase, fused via a cleavable...

journal_title：Thrombosis research

authors： van Zyl WB,Pretorius GH,Hartmann M,Kotzé HF

更新日期：1997-12-01 00:00:00

abstract：:Thromboangiitis obliterans (TAO), or Buerger's disease, is a segmental occlusive inflammatory disorder of the arteries and veins, and etiopathogenesis is still obscure. In the present study we investigated the prevalence of prothrombin 20210 G-->A, factor V 1691 G-->A (Factor V Leiden), and factor V 4070 A-->G (His 12...

journal_title：Thrombosis research

authors： Avcu F,Akar E,Demirkiliç U,Yilmaz E,Akar N,Yalçin A

更新日期：2000-11-01 00:00:00

abstract：INTRODUCTION:Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo gamma-carboxylation system in stable cell lines used for transfection has a limited capacity of ...

journal_title：Thrombosis research

authors： Wajih N,Owen J,Wallin R

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To investigate the risk of venous thromboembolism (VTE) among patients with autoimmune hemolytic anemia (AIHA). METHODS:We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing the risk of VTE i...

journal_title：Thrombosis research

authors： Ungprasert P,Tanratana P,Srivali N

更新日期：2015-11-01 00:00:00

abstract：:The sequel of survivors after hospitalisation for an acute myocardial infarction was studied during the following 15 years in 48 patients treated with streptokinase and in 41 controls. No significant difference was seen in the morbidity or mortality during the first 6 months nor in the mortality thereafter. ...

journal_title：Thrombosis research

authors： Heikinheimo R,Leskinen O,Siitonen L

更新日期：1984-08-15 00:00:00

abstract：INTRODUCTION:Thrombotic storm (TS) presents as a severe, acute thrombotic phenotype, characterized by multiple clotting events and frequently affecting younger adults. Understanding the extensive hypercoagulation of an extreme phenotype as TS will also provide insight into the pathogenesis of a wider spectrum of thromb...

journal_title：Thrombosis research

authors： Nuytemans K,Ortel TL,Gomez L,Hofmann N,Alves N,Dueker N,Beecham A,Whitehead P,Hahn Estabrooks S,Kitchens CS,Erkan D,Brandão LR,James AH,Kulkarni R,Manco-Johnson MJ,Pericak-Vance MA,Vance JM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Muromonab-CD3 is a murine monoclonal antibody (MoAb) that is used in the prophylaxis and treatment of acute graft rejection. Activation of coagulation and fibrinolysis following anti-CD3 administration have been reported in some patients to lead to irreversible intragraft thrombosis. DESIGN AND METHODS:We h...

journal_title：Thrombosis research

authors： Lozano M,Oppenheimer F,Cofan F,Rosinyol L,Mazzara R,Escolar G,Ordinas A

更新日期：2001-12-15 00:00:00

abstract：INTRODUCTION:The TF-FVIIa complex is the primary activator of coagulation. Elevated levels of microvesicle (MV) bearing tissue factor (TF)-dependent procoagulant activity are detectable in patients with an increased risk of thrombosis. Several methods have been described to measure MV TF activity but they are hampered ...

journal_title：Thrombosis research

authors： Vallier L,Bouriche T,Bonifay A,Judicone C,Bez J,Franco C,Guervilly C,Hisada Y,Mackman N,Houston R,Poncelet P,Dignat-George F,Lacroix R

更新日期：2019-10-01 00:00:00