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Enhancement of prothrombin activation on platelets by endothelial cells and mechanism of activation of factor V.

Abstract：

:Factor Xa-catalyzed prothrombin activation occurs on cellular surfaces, including those of vascular endothelial cells. In a reconstituted model, endothelial cells and platelets acted synergistically to maximally activate prothrombin in the presence of Factor Xa. Synergism was observed at platelet concentrations less than 1 X 10(8)/ml. Thrombin formation was required for optimal prothrombin activation by endothelial cells and Factor Xa, with thrombin serving as an activator of Factor V. These data provide additional support for the hypothesis that vascular endothelium is a physiologic surface for hemostasis.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Rodgers GM,Shuman MA

doi

10.1016/0049-3848(87)90168-x

subject

Has Abstract

pub_date

1987-01-15 00:00:00

pages

145-52

issue

2

eissn

0049-3848

issn

1879-2472

journal_volume

45

pub_type

杂志文章

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