The protein C pathway in cancer metastasis.

abstract：:A new method, based on the observation that leukocytes contain PGI2-synthetase activity, was used to measure the effect of pharmacological levels of sulphinpyrazone on the TXA2 and PGI2 production in whole blood. Four human volunteers took 400 mg sulphinpyrazone twice daily for 5 1/2 days. Blood was drawn before the s...

journal_title：Thrombosis research

authors： Badenhorst PN,Deckmyn H,Vermylen J

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:Muromonab-CD3 is a murine monoclonal antibody (MoAb) that is used in the prophylaxis and treatment of acute graft rejection. Activation of coagulation and fibrinolysis following anti-CD3 administration have been reported in some patients to lead to irreversible intragraft thrombosis. DESIGN AND METHODS:We h...

journal_title：Thrombosis research

authors： Lozano M,Oppenheimer F,Cofan F,Rosinyol L,Mazzara R,Escolar G,Ordinas A

更新日期：2001-12-15 00:00:00

abstract：BACKGROUND:Although excess platelet activation, as indicated by increased plasma beta thromboglobulin (beta-TG), has been shown in pregnancy-induced hypertension (PIH), platelet adhesion, platelet morphology and a comparison of platelet and soluble (plasma) levels of the adhesion molecules P-selectin (pPsel and sPsel, ...

journal_title：Thrombosis research

authors： Karalis I,Nadar SK,Al Yemeni E,Blann AD,Lip GY

更新日期：2005-01-01 00:00:00

abstract：:When activated in vitro, thrombin-activatable fibrinolysis inhibitor (TAFI) slows clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin. An inhibitor of carboxypeptidase isolated from potato (CPI) reverses prolongation of clot lysis by inhibiting activated TAFI. We investiga...

journal_title：Thrombosis research

authors： Nagashima M,Werner M,Wang M,Zhao L,Light DR,Pagila R,Morser J,Verhallen P

更新日期：2000-05-15 00:00:00

abstract：:125I-fibronectin is incorporated into fibrin when blood plasma is clotted with thrombin. This process is dependent upon fibronectin concentration, temperature, and the presence of calcium ions. Fibronectin appears to be a very strong inhibitor of fibrin formation and influences both the thrombin clotting time and fibr...

journal_title：Thrombosis research

authors： Niewiarowska J,Cierniewski CS

更新日期：1982-09-01 00:00:00

abstract：:Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...

journal_title：Thrombosis research

authors： Binnie C,Wagner RH,Cooper H,Hermans J

更新日期：1985-11-15 00:00:00

abstract：:Activated factor X (FXa) and thrombin can up-regulate gene expression of connective tissue growth factor (CTGF/CCN2) on fibroblasts. Since tissue factor (TF) is expressed on these cells, we hypothesized that they may assemble the prothrombinase complex leading to CTGF/CCN2 upregulation. In addition, the effect of thro...

journal_title：Thrombosis research

authors： Rico MC,Rough JJ,Manns JM,Del Carpio-Cano F,Safadi FF,Kunapuli SP,DeLa Cadena RA

更新日期：2012-06-01 00:00:00

abstract：:In this study, we investigated the effects of a 3-min insulin incubation both at physiological and at supraphysiological concentrations on platelet aggregation and intraplatelet cyclic guanosine monophosphate (cGMP) levels both in the absence and in the presence of phosphodiesterase inhibition. We observed that insuli...

journal_title：Thrombosis research

authors： Anfossi G,Massucco P,Mattiello L,Piretto V,Mularoni E,Cavalot F,Paoletti G,Trovati M

更新日期：1996-04-01 00:00:00

abstract：:Pharmacovigilance is an essential element of any drug treatment and considering the history of adverse events due to products used to treat inherited bleeding disorders, it should be an integral component of modern haemophilia treatment. Because inherited bleeding disorders and adverse events are rare, a multicentre, ...

journal_title：Thrombosis research

authors： Makris M,Calizzani G,Fischer K,Gilman EA,Hay CR,Lassila R,Lambert T,Ludlam CA,Mannucci PM

更新日期：2011-01-01 00:00:00

abstract：:Indirect genetic diagnosis using polymorphic DNA markers can be useful in large-scale screening programs, which is technically simpler, more rapid and amenable. The main objective of this study was to test the informativeness of two common intragenic markers (TaqI and XmnI) in Iranian haemophilia B families to detect ...

journal_title：Thrombosis research

authors： Ghandil P,Ghadiri A,Farhud D,Zeinali S

更新日期：2004-01-01 00:00:00

abstract：:Human antithrombin III was demonstrated to bind plasminogen specifically in a time and concentration-dependent manner. The above binding was also confirmed using ligand western blot assays. The interaction of plasminogen was significantly (>90%) inhibited by lysine, indicating the involvement of kringles in binding an...

journal_title：Thrombosis research

authors： Dudani AK

更新日期：2000-09-15 00:00:00

abstract：:Four calcium channel blockers (nimodipine, nifedipine, verapamil and diltiazem) of three chemical classes were tested in vitro for inhibition of platelet aggregation using heparinized human platelet rich plasma. Both ADP- and thrombin-induced aggregation were inhibited as was the biosynthesis of thromboxane A2 in resp...

journal_title：Thrombosis research

authors： Onoda JM,Sloane BF,Honn KV

更新日期：1984-06-01 00:00:00

abstract：:Platelet aggregation induced by ADP and collagen was monitored in 25 patients with increased serum levels of triglycerides (7 HLPs type IIb, 14 type IV, 4 type V patients) and compared with a group of 10 normolipidaemic control persons. Platelet aggregation was studied simultaneously in platelet rich plasma (PRP) by b...

journal_title：Thrombosis research

authors： Riess H,Merk W,Falkner C,Hiller E

更新日期：1986-02-01 00:00:00

abstract：:Nineteen patients, (2 adults, 17 children) with inherited bleeding disorders were infused with n-heptane-suspended-heated clotting factor concentrates. Twelve of the nineteen were previously untreated. Six patients were infused with Profilnine Heat-Treated and 13 with Profilate Heat-Treated. Five separate centers part...

journal_title：Thrombosis research

authors： Carnelli V,Gomperts ED,Friedman A,Aledort L,Hilgartner M,Dietrich S,Fedor EJ

更新日期：1987-06-15 00:00:00

abstract：:Von Willebrand Factor is a multimer produced by endothelial cells and megakaryocytes, being stored in intracellular organelles, such as the Weibel-Palade bodies and alpha-granules in endothelial cells and platelets, respectively. This molecule acts as a carrier protein for factor VIIIc, involved in the intrinsic pathw...

journal_title：Thrombosis research

authors： Spadafora-Ferreira M,Lopes AA,Coelho V,Guilherme L,Kalil J

更新日期：2000-01-15 00:00:00

abstract：:Low circulating protein C (PC) levels have been observed in sepsis, especially in patients with Neisseriae Meningitides infections. Poor clinical outcome and high limb amputation rates have been associated in infected patients with low circulating PC levels. Published studies using activated PC replacement therapy pat...

journal_title：Thrombosis research

authors： Piccin A,O' Marcaigh A,Mc Mahon C,Murphy C,Okafor I,Marcheselli L,Casey W,Claffey L,Smith OP

更新日期：2014-07-01 00:00:00

abstract：:Cell based models of coagulation (CBM) have provided mechanistic insight into numerous hematological issues for nearly two decades. This review discusses another coagulation model system--the clot lifespan model (CLSM)--that has been designed to compliment the CBM-based approach to elucidating the mechanisms responsib...

journal_title：Thrombosis research

authors： Nielsen VG

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Cerebral vein thrombosis (CVT) is a rare, life-threatening disease affecting one adult per 100,000 per year. Genetic risk factors are deficiencies of the natural anticoagulant proteins antithrombin, protein C, protein S or single nucleotide polymorphisms such as factor V Leiden and prothrombin 20210A. In 20%...

journal_title：Thrombosis research

authors： Gorski MM,de Haan HG,Mancini I,Lotta LA,Bucciarelli P,Passamonti SM,Cairo A,Pappalardo E,van Hylckama Vlieg A,Martinelli I,Rosendaal FR,Peyvandi F

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Systemic thrombolysis rapidly improves right ventricular (RV) dysfunction in patients with acute pulmonary embolism (PE) but is associated with major bleeding complications in up to 20%. The efficacy of low-dose, catheter-directed ultrasound-accelerated thrombolysis (USAT) on the reversal of RV dysfunction i...

journal_title：Thrombosis research

authors： Engelhardt TC,Taylor AJ,Simprini LA,Kucher N

更新日期：2011-08-01 00:00:00

abstract：:A variant of type II von Willebrand disease (vWd) is described in a young woman and her mother with severe lifelong bleeding histories. On electrophoresis with low-resolution agarose gels the plasma of the proband lacked large and intermediate-size multimers of von Willebrand factor (vWF) but the platelet multimeric s...

journal_title：Thrombosis research

authors： Castaman G,Rodeghiero F,Lattuada A,Mannucci PM

更新日期：1992-02-01 00:00:00

abstract：:Heparin cofactor II (HCII) is a specific thrombin inhibitor; its inhibitory activity is stimulated by heparin (Hep) and dermatan sulfate (DS). Vitronectin (VN), a heparin binding adhesive glycoprotein present in plasma and extracellular matrix, has been shown to decrease the stimulatory effect of Hep but not of DS on ...

journal_title：Thrombosis research

authors： Petzelbauer E,Seiffert D,Beckmann R,Pusch B,Geiger M,Binder BR

更新日期：1992-06-01 00:00:00

abstract：:The three polypeptide chains of fibrinogen, A alpha, B beta and gamma chain, are synthesized on separate polysomes. Fully formed fibrinogen is a six chain, disulfide-linked, dimeric molecule with a molecular weight of 340kDa. Previous pulse-chase studies with L-35 S methionine using the human hepatocellular carcinoma ...

journal_title：Thrombosis research

authors： Yu S,Kong V,Kudryk B,Redman C

更新日期：1987-04-15 00:00:00

abstract：:Heat treatment is employed to diminish the transmission of hepatitis when blood products are administered. It is possible that such a procedure could reduce the biological activity of the proteins and induce changes in structure and aggregation state. We have therefore made in vitro and pharmacokinetic studies of heat...

journal_title：Thrombosis research

authors： Tengborn L,Frohm B,Nilsson LE,Johansson L,Andersson LO

更新日期：1987-12-15 00:00:00

abstract：:Current therapies for treatment of hemophilia A involve infusion of factor VIII, but are ineffective for patients who develop inhibitory antibodies. We have previously proposed that bypassing the intrinsic pathway (VIIIa/IXa) with reversibly acylated factor Xa offers an improvement on existing therapies as it provides...

journal_title：Thrombosis research

authors： Lin PH,Laibelman AM,Sinha U

更新日期：1997-11-15 00:00:00

abstract：:We report here that the rate of fibrin polymerization is accelerated by decompression: the rate is essentially doubled by reducing the pressure by one-half (380 torr, 14.7 PSI or 1/2 ATM) and increased by 3.6 times with respect to the control at 25 torr (0.48 PSI or 1/30th ATM). We also report here that the rate of fi...

journal_title：Thrombosis research

authors： Murayama M

更新日期：1988-03-15 00:00:00

abstract：OBJECTIVES:To measure the variations of different parameters in the hemostatic system and to analyze their roles in the development of hemostatic disorder in patients with orthotopic liver transplantation (OLT) procedures routinely performed without venovenous bypass. METHODS:The blood coagulation and fibrinolysis par...

journal_title：Thrombosis research

authors： Wang Y,Liu Y,Han R,Zhu Z,Zhang Y,Wang X,Wang L,Shen Z

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus f...

journal_title：Thrombosis research

authors： Nakamura Y,Nakamura K,Fukushima-Kusano K,Ohta K,Matsubara H,Hamuro T,Yutani C,Ohe T

更新日期：2003-01-01 00:00:00

abstract：:Clot lysis induced by streptokinase has been studied and the influences of pH and the concentrations of plasminogen, fibrinogen and buffer composition investigated. Variations in the concentrations of plasminogen strongly effect the SK apparent activity, maxima being obtained at different plasminogen concentrations li...

journal_title：Thrombosis research

authors： Westlund LE,Andersson LO

更新日期：1991-12-15 00:00:00

abstract：:Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPG) on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis. Evidence was provided that heparanase over-expression in canc...

journal_title：Thrombosis research

authors： Nadir Y,Brenner B

更新日期：2010-04-01 00:00:00

abstract：:Anticoagulant properties of three sulfated compounds prepared from xylans isolated from corn cobs, larchwood and oatspelts were compared with heparin and sodium pentosan polysulfate (SP-54) by studying their effects on activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) using poo...

journal_title：Thrombosis research

authors： Campbell A,Nesheim ME,Doctor VM

更新日期：1987-08-01 00:00:00