Evidence of a phospholipid binding species within human fibrinogen preparations.

abstract：BACKGROUND:Whether antibodies directed to β2-Glycoprotein I (aβ2GPI) are responsible for LA activity is not well defined. However, in the absence of such antibodies the molecule responsible for LA phenomenon is unknown. OBJECTIVE:The aim of this study was the biochemical identification of the target antigen epitope of...

journal_title：Thrombosis research

authors： Pengo V,Del Ross T,Ruffatti A,Bison E,Cattini MG,Pontara E,Testa S,Legnani C,Pozzi N,Peterle D,Acquasaliente L,De Filippis V,Denas G

更新日期：2018-12-01 00:00:00

abstract：:PAF (1 ug/kg) injected intravenously (i.v.) into anesthetized rabbits resulted in marked loss of circulating platelets and leukocytes. Administration of FR-900452 1-methyl-3-(1-(5-methylthiomethyl-6-oxo-3-(2-oxo-3-cyclopenten-1-y lidene)- 2-piperazinyl) ethyl)-2-indolinone, a specific PAF inhibitor, at a dose of 10 mg...

journal_title：Thrombosis research

authors： Okamoto M,Yoshida K,Nishikawa M,Kohsaka M,Aoki H

更新日期：1986-06-01 00:00:00

abstract：INTRODUCTION:The activation of coagulation is recognized as a universal event in severe sepsis. Both antithrombin and thrombomodulin play pivotal roles as suppressors of coagulation. Since the levels of both anticoagulants decrease significantly, we hypothesized that a combination therapy would be beneficial. METHODS:...

journal_title：Thrombosis research

authors： Iba T,Miki T,Hashiguchi N,Tabe Y,Nagaoka I

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Edoxaban is an oral, once-daily direct factor Xa (FXa) inhibitor. Although rapidly cleared, strategies to reverse edoxaban-mediated effects on anticoagulation are needed in cases of excessive bleeding or emergency. This study evaluated the effect of two prohemostatic agents, recombinant factor VIIa (rFVIIa...

journal_title：Thrombosis research

authors： Halim AB,Samama MM,Mendell J

更新日期：2014-10-01 00:00:00

abstract：:The effects of desmopressin and dextran on haemostasis and fibrinolysis were studied in four healthy volunteers. Both drugs were compared to placebo, each volunteer being subject to four experiments. Dextran 70 (30 g i.v.) moderately decreased VIII:C and vWF:Ag and slightly increased antithrombin III, also when haemod...

journal_title：Thrombosis research

authors： Flordal PA,Svensson J,Ljungström KG

更新日期：1991-06-01 00:00:00

abstract：INTRODUCTION:Medically ill, hospitalized patients are at increased risk for venous thromboembolism (VTE) after discharge. This study aimed to examine thromboprophylaxis patterns, risk factors, and post-discharge outcomes. METHODS:This was a retrospective claims analysis involving administrative claims data and in-pati...

journal_title：Thrombosis research

authors： Mahan CE,Fisher MD,Mills RM,Fields LE,Stephenson JJ,Fu AC,Spyropoulos AC

更新日期：2013-11-01 00:00:00

abstract：:Fibrin is found in most solid tumours, and there is speculation regarding its role in tumour invasion and metastasis. An assay to quantitate fibrin levels in tissues would be a useful preliminary tool in assessing the above. Such an assay to quantitatively detect levels of fibrin in various types of canine tumour was ...

journal_title：Thrombosis research

authors： Raut S,McEvoy F,Gaffney PJ

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor type-1 (PAI-1) is considered to be the main inhibitor of fibrinolysis in sepsis. However, the contribution of TAFI to the inhibition of fibrinolysis in sepsis is currently unknown. METHODS:TAFI antigen and PAI-1 levels were measured in severe sepsis (n = 32) and septic shock ...

journal_title：Thrombosis research

authors： Zeerleder S,Schroeder V,Hack CE,Kohler HP,Wuillemin WA

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) is undergoing clinical trials for prophylaxis and on-demand treatment of haemophilia B patients. The aim of this study was to investigate the pharmacokinetics, whole-body and knee joint distribution of rIX-FP following intra...

journal_title：Thrombosis research

authors： Herzog E,Harris S,Henson C,McEwen A,Schenk S,Nolte MW,Pragst I,Dickneite G,Schulte S,Zollner S

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Uremic bleeding frequently occurs in dialysis patients. Although its mechanism is not well characterized, acquired platelet dysfunction has been implicated in its pathogenesis. Skin bleeding time has been used to characterize platelet dysfunction in this population. However, the bleeding time is prone to e...

journal_title：Thrombosis research

authors： Brophy DF,Martin EJ,Carr SL,Kirschbaum B,Carr ME Jr

更新日期：2007-01-01 00:00:00

abstract：:Changes in the plasma thrombomodulin (TM) level were examined in endotoxin-infused rabbits. The plasma TM level in normal rabbits was 143.8 +/- 8.4 ng/ml (n = 67) and the molecular weight of the major TM was about 55 kd. Endotoxin (lipopolysaccharide, LPS, E. Coli B8:0127) was intravenously infused. LPS infusion incre...

journal_title：Thrombosis research

authors： Sawada K,Yamamoto H,Matsumoto K,Yago H,Suehiro S,Tahara C,Ishii H,Kazama M,Abe T

更新日期：1992-01-15 00:00:00

abstract：INTRODUCTION:Patients with type 1 diabetes have high risk of developing microvascular complications, and microangiopathy contributes to premature cardiovascular disease in this population. The role that microvesicles (MVs) may play in the development of microangiopathy in type 1 diabetes remains unclear. MATERIALS AND...

journal_title：Thrombosis research

authors： Bergen K,Mobarrez F,Jörneskog G,Wallén H,Tehrani S

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Colorectal cancer (CRC) is often complicated by thromboembolic episodes. It has been recognized that blood coagulation proteins play a role in cancer progression. An important inhibitory mechanism is provided by the protein C (PC) system consisting of PC, protein S (PS) and thrombomodulin (TM). Recently, n...

journal_title：Thrombosis research

authors： Sierko E,Wojtukiewicz MZ,Zawadzki R,Zimnoch L,Kisiel W

更新日期：2010-03-01 00:00:00

abstract：:Hemostasis, the system of generation and degradation of thrombi, consists of coagulation and fibrinolysis. Whereas global assays to study coagulation have existed for many years, there has been no simple, rapid, and economic routine test for the plasmatic fibrinolysis parameters plasminogen activator inhibitor-1, alph...

journal_title：Thrombosis research

authors： Stief TW,Hinz F,Kurz J,Doss MO,Kretschmer V

更新日期：2000-02-15 00:00:00

abstract：:The coumarin derivative AD6 is known to inhibit platelet aggregation and release and it possesses vasodilatory properties on coronary arteries of laboratory animals. Furthermore, the inhibition of the production of TxB2 from endogenous substrates after stimulation of human platelets with collagen has been demonstrated...

journal_title：Thrombosis research

authors： Porcellati S,Costantini V,Prosdocimi M,Pistolesi R,Porrovecchio P,Nenci GG,Goracci G

更新日期：1987-07-01 00:00:00

abstract：:Blood was obtained from four patients envenomated by the Australian common brown snake, Pseudonaja textilis textilis. This elapid snake has one of the most toxic venoms in the world, containing extremely potent neurotoxic and coagulant components. The latter is a potent complete prothrombinase, converting prothrombin ...

journal_title：Thrombosis research

authors： Masci PP,Rowe EA,Whitaker AN,de Jersey J

更新日期：1990-09-01 00:00:00

abstract：:Homocystinuria due to cystathionine-beta-synthase deficiency (CBS-def-HOCY) initially often presents with vascular disorders, e.g. thromboembolic events. The measurement of vascular endothelial markers in plasma could help to assess endothelial damage. We determined von Willebrand factor (measured as Ristocetincofacto...

journal_title：Thrombosis research

authors： Schienle HW,Seitz R,Nawroth P,Rohner I,Lerch L,Krumpholz B,Krauss G,Fowler B,Baumgartner R,Willenbockel U

更新日期：1995-01-01 00:00:00

abstract：:The potent inhibitor of platelet cAMP phosphodiesterase (PDE) HL 725 (9,10-Dimethoxy-2-mesitylimino-3-methyl-3, 4,6,7-tetrahydro-2H-pyrimido(6,1-A)-isoquinoline-4-one-hydrochloride), was examined for its effects on human and rat platelet aggregation. Strong inhibitory effects are seen on collagen-induced platelet aggr...

journal_title：Thrombosis research

authors： Agarwal KC,Buckley RS,Parks RE Jr

更新日期：1987-07-15 00:00:00

abstract：BACKGROUND:Although risk of hospital-associated venous thromboembolism (HA-VTE) differs between critically and non-critically ill children, studies to date have not led to distinct, pragmatic risk scores. OBJECTIVE:To determine risk factors for HA-VTE in critically ill children not undergoing cardiothoracic surgery, i...

journal_title：Thrombosis research

authors： Arlikar SJ,Atchison CM,Amankwah EK,Ayala IA,Barrett LA,Branchford BR,Streiff MB,Takemoto CM,Goldenberg NA

更新日期：2015-10-01 00:00:00

abstract：:Experience with tranexamic acid, an indirect fibrinolytic inhibitor, started as soon as it was released from Shosuke Okamoto's lab in the early 1960s. It was first prescribed to females with heavy menstrual blood loss and to patients with hereditary bleeding disorders. Soon the indications were widened to elective sur...

journal_title：Thrombosis research

authors： Tengborn L,Blombäck M,Berntorp E

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism is a common cause of morbidity and mortality. Although cirrhosis has classically been considered as an acquired bleeding diathesis, there is increasing evidence that rejects the traditional belief that these patients are naturally protected against venous thromboembolism. However, an...

journal_title：Thrombosis research

authors： Gómez Cuervo C,Bisbal Pardo O,Pérez-Jacoiste Asín MA

更新日期：2013-10-01 00:00:00

abstract：:Blackfoot disease is a unique endemic and chronic progressive arteriosclerotic vascular disease in southwest area of Taiwan. In this study, we determined the plasma levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI), urokinase plasminogen activator (uPA), and von Willebrand factor (vWF...

journal_title：Thrombosis research

authors： Wu HL,Yang WH,Wang MY,Shi GY

更新日期：1993-11-01 00:00:00

abstract：:Owing to the beneficial health effects on human cardiovascular system, soybeans and soy-related products have been a focus of intensive research. Soy isoflavones are known to be primarily responsible for the soy-related biological effects including anti-platelet activity but its in vivo relevancy has not been fully ve...

journal_title：Thrombosis research

authors： Kim K,Lim KM,Shin HJ,Seo DB,Noh JY,Kang S,Chung HY,Shin S,Chung JH,Bae ON

更新日期：2013-03-01 00:00:00

abstract：:The enzymatic activities of uPA, and a collagenase-like proteinase in the post-nuclear fraction of cell homogenates of a metastatic carcinomatous cell line following X-ray irradiation were examined by the use of chromogenic substrates and by casein- or gelatin-containing zymographies and electrophoretic gel stained wi...

journal_title：Thrombosis research

authors： Uchida N,Takahashi K,Kasai T,Ishida T,Kwaan HC

更新日期：1994-06-15 00:00:00

abstract：:Some previous reports indicated that a minimal amount of anti-IIa is necessary for the optimal anti-Xa activity of low molecular weight heparin (LMW-H). To know if we could improve the prophylactic activity of LMW-H, providing a mild antithrombin effect, we conducted an experiment in which we administered subcutaneous...

journal_title：Thrombosis research

authors： Pèrez-Requejo JL,Lucena-Solano O,Pérez-García M,Santarelli MT

更新日期：1997-02-01 00:00:00

abstract：INTRODUCTION:Although investigation for JAK2 V617F mutation is recommended in patients presenting with splanchnic venous thrombosis (SVT), no specific clinical advice is given to SVT patients presenting without myeloproliferative neoplasms (MPN) and JAK2 V617F mutation. In MPN-free SVT patients, to investigate the clin...

journal_title：Thrombosis research

authors： Colaizzo D,Amitrano L,Guardascione MA,Tiscia GL,D'Andrea G,Longo VA,Grandone E,Margaglione M

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Reports on the prevalence and risk factors of atherothrombotic events (AEs) are conflicting in persons with hemophilia (PWH). METHODS:This study evaluated the prevalence and risk factors of AEs among 1054 male hemophilia patients, using data collected from Taiwan's National Health Insurance Research Datab...

journal_title：Thrombosis research

authors： Wang JD,Chan WC,Fu YC,Tong KM,Chang ST,Hwang WL,Lin CH,Tsan YT

更新日期：2015-03-01 00:00:00

abstract：:The fibrin sleeve of venous catheters (VC) and parietal thrombi represent frequent and dangerous side-effects of central venous catheterization (CVC), due to the risk of embolism. Reduced levels of coagulation clotting factors inhibitors (such as Antithrombin III) are known to be associated with increased thrombogenic...

journal_title：Thrombosis research

authors： De Cicco M,Matovic M,Balestreri L,De Angelis V,Fracasso A,Morassut S,Coran F,Babare R,Buonadonna A,Testa V

更新日期：1995-04-15 00:00:00

abstract：BACKGROUND:Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. METHODS:Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenect...

journal_title：Thrombosis research

authors： Comerota AJ,Oostra C,Fayad Z,Gunning W,Henke P,Luke C,Lynn A,Lurie F

更新日期：2015-05-01 00:00:00

abstract：:Evidence is presented for in vitro high affinity binding of serotonin (5-HT) by beta-thromboglobulin (beta TG) and platelet factor 4 (PF4) from human blood. Results include: 1) identification by radioimmunoassay of PF4 in specifically bound material obtained by 5-HT affinity chromatography of human platelet extracts; ...

journal_title：Thrombosis research

authors： Heemstra VL

更新日期：1983-02-01 00:00:00