Fibrinolysis as a feature of disseminated intravascular coagulation (DIC) after Pseudonaja textilis textilis envenomation.

abstract：:A recently developed platelet aggregometer using a laser light scattering method is capable of monitoring the increase in size of small-sized platelet aggregates (diameter 9-25 microm), which cannot be detected with the conventional methods. Whether coronary spasm can cause platelet aggregation in the coronary circula...

journal_title：Thrombosis research

authors： Miyamoto S,Ogawa H,Soejima H,Takazoe K,Kajiwara I,Shimomura H,Sakamoto T,Yoshimura M,Kugiyama K,Yasue H,Ozaki Y

更新日期：2001-09-01 00:00:00

abstract：:Capsaicin was found to be a potent inhibitor of platelet aggregation and release reaction. It inhibited the aggregation of rat platelet induced by collagen and thrombin, but only slightly reduced those of AA and A23187. The IC50 on collagen-induced platelet aggregation was about 85 micrograms/ml. Less inhibition was o...

journal_title：Thrombosis research

authors： Wang JP,Hsu MF,Teng CM

更新日期：1984-12-15 00:00:00

abstract：BACKGROUND:Thrombin is the most potent platelet activator, and achieves rapid platelet activation even in the presence of antiplatelet therapy. Since activated platelets respond stronger to additional stimuli, the extent of endogenous thrombin generation may in part be responsible for the reported response variability ...

journal_title：Thrombosis research

authors： Gremmel T,Panzer S,Steiner S,Seidinger D,Koppensteiner R,Pabinger I,Kopp CW,Ay C

更新日期：2013-07-01 00:00:00

abstract：:Activation of human plasminogen by human tissue-type plasminogen activator (t-PA) is accelerated in the presence of cyanogen bromide digests of human fibrin(ogen). In the present study a possible species specificity of this phenomenon was investigated. All combinations of the plasminogens, fibrin monomers and cyanogen...

journal_title：Thrombosis research

authors： Nieuwenhuizen W,Keyser J

更新日期：1985-06-15 00:00:00

abstract：BACKGROUND:Bypassing agents are the first line therapy in patients with acquired haemophilia A (AHA). Activated prothrombin complex concentrate (aPCC) proved to be effective as initial treatment, but 20% of patients (pts) had relapses. aPCC as short-term prophylaxis to reduce subsequent bleeds is still not clear. AIM:...

journal_title：Thrombosis research

authors： Zanon E,Pasca S,Siragusa S,Napolitano M,Santoro C,Mameli L,Rocino A,FAIR Study Group.

更新日期：2019-02-01 00:00:00

abstract：:The interaction of platelets with collagen involves short aminoacid sequences which recur along the fibres. Platelet aggregation by collagen and serotonin release is inhibited by a synthetic octapeptide LYS-PRO-GLY-GLU- PRO-GLY-PRO-LYS- derived from type III collagen. In contrast, this octapeptide inhibits only weakly...

journal_title：Thrombosis research

authors： Karniguian A,Legrand YJ,Lefrancier P,Caen JP

更新日期：1983-12-15 00:00:00

abstract：INTRODUCTION:High concentrations of N-terminal-pro-brain natriuretic peptide (NT-proBNP) are found in patients with right ventricular overload. Right ventricular overload may be the result of large perfusion defects in patients with pulmonary embolism (PE). NT-proBNP levels are associated with poorer outcome in patient...

journal_title：Thrombosis research

authors： Agterof MJ,Schutgens RE,Verzijlbergen JF,van Buul MM,Tromp EA,Eijkemans MJ,van der Griend R,Biesma DH

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Right heart dysfunction is a crucial factor in risk stratification of normotensive patients with pulmonary embolism. Apart from biomarkers, determinants of right heart dysfunction in this group of patients are not yet well established. AIM AND METHOD:In order to identify such determinants, we analysed data ...

journal_title：Thrombosis research

authors： Berghaus TM,Haeckel T,Behr W,Wehler M,von Scheidt W,Schwaiblmair M

更新日期：2010-09-01 00:00:00

abstract：:Eight patients with femoro-popliteal or sural DVT, confirmed by phlebography, were treated with intravenous Desmin (LMW-dermatan sulphate): on the first day, after an initial i.v. injection of 400 mg, all patients received an infusion of 800 mg in 500 ml of saline, during 24 hours; this infusion was repeated in each o...

journal_title：Thrombosis research

authors： Kretz JG,Chakfe N,Wiesel ML,Grunebaum L,Zamboni V,Palazzini E,Cazenave JP

更新日期：1996-12-15 00:00:00

abstract：INTRODUCTION:Thrombosis and coagulation abnormalities are thought to be involved in disease progression of pulmonary hypertension. Platelet-derived microparticles (PDMP) are released from platelets following stimulation and have recently been demonstrated to play an important role in pathogenesis of various diseases. T...

journal_title：Thrombosis research

authors： Ogawa A,Matsubara H

更新日期：2020-11-01 00:00:00

abstract：:In-vitro determinations of purified kallikrein on the one hand, of human plasma and whole blood prekallikrein on the other hand have been conducted with the S-2648 electrogenic substrate using the electroanalytical technique. Plasmatic evaluations have been checked photometrically for assessing the reliability of the ...

journal_title：Thrombosis research

authors： Corretge E,Nigretto JM

更新日期：1984-12-15 00:00:00

abstract：:The influence of red blood cells on platelet aggregation has recently been a subject of considerable interest. We have studied the effect of red cells on spontaneously formed platelet aggregates in rotating vials at 37 degrees C. Platelet aggregation was quantified by measuring the fall in number of single platelets w...

journal_title：Thrombosis research

authors： Saniabadi AR,Lowe GD,Barbenel JC,Forbes CD

更新日期：1985-05-01 00:00:00

abstract：INTRODUCTION:Inherited abnormalities of fibrinogen (FG) are rare coagulation disorders divided into two types: quantitative abnormalities (afibrinogenemia and hypofibrinogenemia) or qualitative abnormalities (dysfibrinogenemia and hypo-dysfibrinogenemia) of circulating fibrinogen. In particular, congenital afibrinogene...

journal_title：Thrombosis research

authors： Amri Y,Toumi Nel H,Hadj Fredj S,de Moerloose P

更新日期：2016-07-01 00:00:00

abstract：:Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephad...

journal_title：Thrombosis research

authors： Sanders KD,Fuller GM

更新日期：1983-10-15 00:00:00

abstract：INTRODUCTION:The A-subunit of blood coagulation factor XIII is a pro-transglutaminase, which cross-links α- and γ-fibrin-chains in its activated form. Selective inhibitors against FXIII-A may be desirable drugs to prevent the development of thromboses. Animal models are generally used for proof of principle and for tox...

journal_title：Thrombosis research

authors： Heil A,Weber J,Büchold C,Pasternack R,Hils M

更新日期：2013-05-01 00:00:00

abstract：:Intra-ventricular hemorrhage (IVH) occurs predominantly in very low birth weight premature infants. Survivors of severe IVH frequently experience long-term consequences including major neurological deficits. Advances in neonatal and obstetric care in the last decades, have led to a steady decline in mortality and in t...

journal_title：Thrombosis research

authors： Kenet G,Kuperman AA,Strauss T,Brenner B

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Cytomegalovirus (CMV)-associated thrombosis has been reported sporadically in the medical literature until now. However, thrombosis incidence and its risk factors have never been studied in a cohort of patients with acute CMV infection. MATERIALS AND METHODS:A retrospective case-control study. Medical cha...

journal_title：Thrombosis research

authors： Atzmony L,Halutz O,Avidor B,Finn T,Zimmerman O,Steinvil A,Zeltser D,Giladi M,Justo D

更新日期：2010-12-01 00:00:00

abstract：:Changes in cytoplasmic free calcium in response to epinephrine in combination with other agonists were studied in human platelets loaded with the fluorescent calcium indicator, quin 2. In the presence of 1mM external calcium, epinephrine augmented the increase in cytoplasmic free calcium in response to collagen or thr...

journal_title：Thrombosis research

authors： Ardlie NG,Bell LK,McGuiness JA

更新日期：1987-05-15 00:00:00

abstract：:HC II functional assays are generally preferred with respect to immunochemical assays. Nevertheless functional assays can be biased by the antithrombin III (AT III)-heparin complex activity; in fact trace amounts of heparin generally contaminate dermatan sulfate (DS) commercial preparations used as HC II reaction acti...

journal_title：Thrombosis research

authors： Ruzzenente O,Ghidini R,Poli G,Schiavon R,Guidi GC

更新日期：1992-01-15 00:00:00

abstract：INTRODUCTION:The safety and efficacy of low-molecular-weight heparin (LMWH) treatment in patients with cancer-associated thrombosis (CAT) beyond 6months are unknown. Our aim was to determine the safety of long-term tinzaparin use in patients with CAT. METHODS:We performed a prospective, open, single arm, multicentre s...

journal_title：Thrombosis research

authors： Jara-Palomares L,Solier-Lopez A,Elias-Hernandez T,Asensio-Cruz M,Blasco-Esquivias I,Marin-Barrera L,de la Borbolla-Artacho MR,Praena-Fernandez JM,Montero-Romero E,Navarro-Herrero S,Serrano-Gotarredona MP,Sánchez-Díaz JM,Palacios

更新日期：2017-09-01 00:00:00

abstract：:A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents in preclinical animal models and in patients with inherited bleeding disorders, such as von Willebrand disease (VWD) and hemophilia A, or with acquired bleeding disorders such as those resulting fr...

journal_title：Thrombosis research

authors： Scola MR,Baggesen LM,Nichols TC,Key NS,Gallippi CM

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:This study determines the impact of tissue factor (TF)-signaling on the extrinsic pathway of apoptosis in cancer cells and propose death associated protein kinase-1 (DAPK1) as a novel key regulator. MATERIALS AND METHODS:In MDA-MB-231 breast and PC3 prostate cancer cells, mRNA levels were analyzed by real...

journal_title：Thrombosis research

authors： Aberg M,Johnell M,Wickström M,Siegbahn A

更新日期：2011-02-01 00:00:00

abstract：:Seven males with atherosclerotic disease received daily 1.6 g of the thromboxane antagonist BM 13.177 in two separate oral dosages over a period of four days. The drug significantly reduced elevated plasma levels of thromboxane B2, beta-thromboglobulin and platelet factor 4, whereas thromboxane B2 generation was only ...

journal_title：Thrombosis research

authors： Riess H,Hiller E,Reinhardt B,Bräuning C

更新日期：1984-08-15 00:00:00

abstract：:Effects of vascular constriction on thrombotic occlusion was evaluated using rat mesenteric arteries and video-recording system attached to the microscope. Topical application of norepinephrine of 1, 10 and 100 micrograms/ml reduced the arterial diameter dose dependently from 297 +/- 41 mu to 166 +/- 50, 87 +/- 18 and...

journal_title：Thrombosis research

authors： Araki H,Nishi K

更新日期：1986-10-01 00:00:00

abstract：:Clot lysis induced by streptokinase has been studied and the influences of pH and the concentrations of plasminogen, fibrinogen and buffer composition investigated. Variations in the concentrations of plasminogen strongly effect the SK apparent activity, maxima being obtained at different plasminogen concentrations li...

journal_title：Thrombosis research

authors： Westlund LE,Andersson LO

更新日期：1991-12-15 00:00:00

abstract：:Severe rejection crises occurred in 13 out of 20 cadaver kidney recipients; removal of the graft was inevitable in 10 cases. The plasminogen levels were found to be lower (76.5 +/- 2.9%) in the 13 patients with impaired graft acceptance (group B) than in the 7 patients experiencing only moderate rejection (group A, 93...

journal_title：Thrombosis research

authors： Seitz R,Michalik R,Karges HE,Lange H,Egbring R

更新日期：1986-05-01 00:00:00

abstract：:We have investigated fibrinolytic parameters in 33 patients with peripheral arterial occlusive disease (PAOD) before and 6, 24, and 48 hours after percutaneous transluminal angioplasty (PTA) as well as in 35 gender-matched healthy controls, whose mean age was not significantly different from the mean age of the patien...

journal_title：Thrombosis research

authors： Roller RE,Janisch S,Carroll V,Kvas E,Pilger E,Binder BR,Wojta J

更新日期：1999-05-15 00:00:00

abstract：:Low circulating protein C (PC) levels have been observed in sepsis, especially in patients with Neisseriae Meningitides infections. Poor clinical outcome and high limb amputation rates have been associated in infected patients with low circulating PC levels. Published studies using activated PC replacement therapy pat...

journal_title：Thrombosis research

authors： Piccin A,O' Marcaigh A,Mc Mahon C,Murphy C,Okafor I,Marcheselli L,Casey W,Claffey L,Smith OP

更新日期：2014-07-01 00:00:00

abstract：:Prothrombin time is a standard screening test to monitor patients treated with oral anticoagulants. We hypothesize that INR measurements will not vary a lot within a given day in a given patient. The present study was thus conducted to compare the change of the international normalized ratio (INR) of prothrombin time ...

journal_title：Thrombosis research

authors： Ho CH,Lin MW,You JY,Chen CC,Yu TJ

更新日期：2002-09-01 00:00:00

abstract：:Antithrombin (AT) is a serpin capable of trapping thrombin (IIa) in a stable and covalent complex. Complex formation is prevented by leukocyte elastase (LE) cleavage near the AT reactive centre. We mutated the known LE cleavage sites of AT to explore the possibility of producing an LE-resistant AT molecule. Initially,...

journal_title：Thrombosis research

authors： Cunningham MA,Blajchman MA,Sheffield WP

更新日期：1997-10-15 00:00:00