当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Outcome of patients with splanchnic venous thrombosis presenting without overt MPN: a role for the JAK2 V617F mutation re-evaluation.

Outcome of patients with splanchnic venous thrombosis presenting without overt MPN: a role for the JAK2 V617F mutation re-evaluation.

Abstract：

INTRODUCTION:Although investigation for JAK2 V617F mutation is recommended in patients presenting with splanchnic venous thrombosis (SVT), no specific clinical advice is given to SVT patients presenting without myeloproliferative neoplasms (MPN) and JAK2 V617F mutation. In MPN-free SVT patients, to investigate the clinical outcome, the clinical impact of re-evaluation for the JAK2 V617F mutation, and relationships with the occurrence and time to diagnosis of MPN. MATERIALS AND METHODS:A cohort of non-cirrhotic SVT patients, enrolled at a single centre and prospectively analyzed. RESULTS:In 121 SVT patients prospectively followed from 1994 to 2012, a MPN was present in 28 (23.1%). Additional 13 patients (10.7%) showed only the JAK2 V617F mutation. During the follow-up, the JAK2 V617F mutation and/or MPN were identified in 8 patients (median time of development: 21 months, range 6-120), whereas 72 remained (MPN and JAK2 V617F)-free until the end of the observation. The mortality rate was higher among patients presenting with MPN and/or the JAK2 V617F mutation than in patients who developed later or remained disease-free (p=0.032). The thrombosis-free survival was lower in patients with (p=0.04) or developing later MPN and the JAK2 V617F mutation (p=0.005) than in patients (MPN and JAK2 V617F)-free. The incidence of bleeding was similar among groups. CONCLUSIONS:MPN with or without circulating positive clones for JAK2 V617F mutation can occur long after a SVT, identifying at risk patients for new thrombotic events. If confirmed in other studies, re-evaluation for JAK2 V617F mutation may be of help in early MPN detection and clinical management of SVT patients.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Colaizzo D,Amitrano L,Guardascione MA,Tiscia GL,D'Andrea G,Longo VA,Grandone E,Margaglione M

doi

10.1016/j.thromres.2013.07.014

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

e99-e104

issue

2

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(13)00292-2

journal_volume

132

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody.

    abstract：:Tissue factor, the cofactor for factor VIIa-catalyzed activation of factors IX and X, plays an important role in the initiation of hemostasis. However, the distribution of tissue factor in the body has not been defined until recently. In the present study frozen sections of non-malignant human tissues were immunostain...

    journal_title：Thrombosis research

    pub_type： 更正并重新发布的文章,杂志文章

    doi：10.1016/0049-3848(90)90148-6

    authors： Fleck RA,Rao LV,Rapaport SI,Varki N

    更新日期：1990-07-15 00:00:00

  • The use of prothrombin complex concentrates in the treatment of hemorrhages induced by oral anticoagulation.

    abstract：:Bleeding events are a common adverse effect in oral anticoagulation that frequently depend on the duration and intensity of treatment. Major bleeding events, particularly intracerebral hemorrhages, are a serious complication in cases that require the rapid reversal of anticoagulation. Urgent correction of the coagulat...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/s0049-3848(99)00085-7

    authors： Pindur G,Mörsdorf S

    更新日期：1999-08-15 00:00:00

  • Disulfide bond exchanges in integrins αIIbβ3 and αvβ3 are required for activation and post-ligation signaling during clot retraction.

    abstract：BACKGROUND:Integrin αIIbβ3 mediates platelet adhesion, aggregation and fibrin clot retraction. These processes require activation of αIIbβ3 and post-ligation signaling. Disulfide bond exchanges are involved in αIIbβ3 and αvβ3 activation. METHODS:In order to investigate the role of integrin activation and disulfide bon...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.02.001

    authors： Mor-Cohen R,Rosenberg N,Averbukh Y,Seligsohn U,Lahav J

    更新日期：2014-05-01 00:00:00

  • The relationship between heparanase levels, thrombus burden and thromboembolism in patients receiving unfractionated heparin treatment for prosthetic valve thrombosis.

    abstract：INTRODUCTION:Procoagulant activity of heparanase has been recently described in several arterial and venous thrombotic disorders. In this study, we aimed to investigate the role of heparanase with regard to thrombus burden, thromboembolism, and treatment success with unfractionated heparin (UFH) in patients with prosth...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.09.061

    authors： Bayam E,Kalçık M,Gürbüz AS,Yesin M,Güner A,Gündüz S,Gürsoy MO,Karakoyun S,Cerşit S,Kılıçgedik A,Candan Ö,Yaman A,Özkan M

    更新日期：2018-11-01 00:00:00

  • Assessing the clinical and cost impact of on-demand immunoassay testing for the diagnosis of heparin induced thrombocytopenia.

    abstract：BACKGROUND:The diagnostic work-up for heparin induced thrombocytopenia (HIT) can take several days. Consequently patients may be speculatively switched onto replacement anticoagulant therapy before a diagnosis is confirmed. On-demand immunoassay diagnostic testing enables timely treatment decisions, based on test resul...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2016.01.025

    authors： Caton S,O'Brien E,Pannelay AJ,Cook RG

    更新日期：2016-04-01 00:00:00

  • Thromboprophylaxis patterns, risk factors, and outcomes of care in the medically ill patient population.

    abstract：INTRODUCTION:Medically ill, hospitalized patients are at increased risk for venous thromboembolism (VTE) after discharge. This study aimed to examine thromboprophylaxis patterns, risk factors, and post-discharge outcomes. METHODS:This was a retrospective claims analysis involving administrative claims data and in-pati...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.08.013

    authors： Mahan CE,Fisher MD,Mills RM,Fields LE,Stephenson JJ,Fu AC,Spyropoulos AC

    更新日期：2013-11-01 00:00:00

  • Specific binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the intact canine platelet.

    abstract：:Binding of 3H-labeled 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor; PAF) to the intact, washed canine platelet has been defined and characterized as being specific and receptor-mediated. Under the conditions described, specific binding to 2 X 10(7) canine platelets reached saturation with...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(88)90339-8

    authors： Janero DR,Burghardt B,Burghardt C

    更新日期：1988-06-15 00:00:00

  • Clinical relevance of pulmonary infarction in patients with pulmonary embolism.

    abstract：INTRODUCTION:Data regarding the clinical relevance of pulmonary infarction (PI) in patients with pulmonary embolism (PE) are lacking. The aim of this study was to investigate the clinical features of PE patients with PI and the prognostic role of PI for PE patients. MATERIALS AND METHODS:Based on computed tomography s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.03.012

    authors： Cha SI,Shin KM,Lee J,Hwangbo Y,Yoo SS,Lee J,Lee SY,Kim CH,Park JY,Jung TH

    更新日期：2012-09-01 00:00:00

  • Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients.

    abstract：BACKGROUND:Cancer patients have an increased risk of thrombosis. Tissue factor (TF) antigen and TF activity associated with microparticles in plasma are elevated in patients with various types of cancer. Of these two measurements, TF activity is considered superior to TF antigen levels because the activity more closely...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2007.12.023

    authors： Tilley RE,Holscher T,Belani R,Nieva J,Mackman N

    更新日期：2008-01-01 00:00:00

  • Incidence of venous thromboembolism in psychiatric units.

    abstract：INTRODUCTION:Incidence and risk factors of venous thromboembolism (VTE) are well established in surgical and medical settings, but data in psychiatric units are lacking. The aim of this study was to estimate the incidence of VTE in hospitalized psychiatric patients, and to assess the risk factors for VTE in this specif...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2012.10.002

    authors： Delluc A,Montavon S,Canceil O,Carpentier M,Nowak E,Mercier B,Bressollette L,Etienne S,Walter M,Mottier D,Lacut K

    更新日期：2012-12-01 00:00:00

  • Tissue factor expression in atrial endothelia associated with nonvalvular atrial fibrillation: possible involvement in intracardiac thrombogenesis.

    abstract：INTRODUCTION:Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus f...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(03)00405-5

    authors： Nakamura Y,Nakamura K,Fukushima-Kusano K,Ohta K,Matsubara H,Hamuro T,Yutani C,Ohe T

    更新日期：2003-01-01 00:00:00

  • Dilute prothrombin time-based lupus ratio test. Integrated LA testing with recombinant tissue thromboplastin.

    abstract：:The lupus ratio (LR) test is a normalized ratio of the clotting times obtained with low and high phospholipid (PL) concentrations, where the test plasma is mixed 1:1 with normal pooled plasma (NP). As an integrated, automated, and computer-assisted assay, this principle has been applied to the dilute activated partial...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00420-0

    authors： Liestøl S,Jacobsen EM,Wisløff F

    更新日期：2002-01-15 00:00:00

  • No evidence for increased platelet activation in patients with hepatitis B- or C-related cirrhosis and hepatocellular carcinoma.

    abstract：INTRODUCTION:Cancer is a major risk factor for developing venous thromboembolism (VTE). Plasma hypercoagulability is an established risk factor for cancer-related VTE. In addition, thrombocytosis and hyperreactive platelets have been implicated in VTE and cancer progression. Cirrhosis is associated with changes in plat...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.11.016

    authors： Alkozai EM,Porte RJ,Adelmeijer J,Zanetto A,Simioni P,Senzolo M,Lisman T

    更新日期：2015-02-01 00:00:00

  • Recurrent thrombosis in antiphospholipid syndrome may be associated with cardiovascular risk factors and inflammatory response.

    abstract：INTRODUCTION:Antiphospholipid syndrome (APS) is a pro-thrombotic autoimmune disease that affects different vascular beds, with potential risk for recurrence. Systemic lupus erythematosus (SLE), specific autoantibodies profile and atherogenic disorders have been described as risk factors for the occurrence of first thro...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2015.10.029

    authors： Saraiva Sda S,Custódio IF,Mazetto Bde M,Collela MP,de Paula EV,Appenzeller S,Annichino-Bizzachi J,Orsi FA

    更新日期：2015-12-01 00:00:00

  • Anticoagulant effects of two types of low molecular weight heparin administered subcutaneously.

    abstract：:Two types of LMW heparin were prepared by gel filtration of standard heparin (LMW fraction) and by degradation of heparin by nitrous acid (LMW fragment), respectively. The effects on factor Xa inhibition (XaI), APTT, platelet aggregation and AT III level of these preparations were studied after subcutaneous administra...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90091-9

    authors： Bergqvist D,Hedner U,Sjörin E,Holmer E

    更新日期：1983-11-15 00:00:00

  • Coagulation markers in healthy human subjects exposed to diesel exhaust.

    abstract：BACKGROUND:Ambient particulate matter (PM) is associated with cardiovascular morbidity and mortality. It has been proposed that PM induces a pro-thrombotic process, increasing the risk of cardiovascular events, with some support from epidemiological and laboratory-based models. Diesel exhaust is a major contributor to ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2007.01.005

    authors： Carlsten C,Kaufman JD,Peretz A,Trenga CA,Sheppard L,Sullivan JH

    更新日期：2007-01-01 00:00:00

  • Clot waveform analysis in Clauss fibrinogen assay contributes to classification of fibrinogen disorders.

    abstract：BACKGROUND:Clauss fibrinogen assay (CFA) is widely used as a screening test to detect fibrinogen disorders. However, CFA alone cannot distinguish quantitative and qualitative defects because it depends on functional fibrinogen activity (Ac), and fibrinogen antigen (Ag) determination is required to classify fibrinogen d...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.12.018

    authors： Suzuki A,Suzuki N,Kanematsu T,Shinohara S,Arai N,Kikuchi R,Matsushita T

    更新日期：2019-02-01 00:00:00

  • Mechanism of potentiation of antithrombin III [AT-III] inhibition by sulfated xylans.

    abstract：:Anticoagulant properties of three sulfated compounds prepared from xylans isolated from corn cobs, larchwood and oatspelts were compared with heparin and sodium pentosan polysulfate (SP-54) by studying their effects on activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) using poo...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90148-4

    authors： Campbell A,Nesheim ME,Doctor VM

    更新日期：1987-08-01 00:00:00

  • Activators and inhibitors of coagulation and fibrinolysis in patients with prostatic cancer treated with oestrogen or orchidectomy.

    abstract：:The treatment of prostatic cancer with oestrogen has been reported to be associated with cardiovascular side effects. Twenty patients with recently diagnosed prostatic cancer were randomly allocated to oestrogen therapy or orchidectomy. As compared to healthy age matched controls the patients with prostatic cancer had...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0049-3848(86)90024-1

    authors： Henriksson P,Blombäck M,Bratt G,Edhag O,Eriksson A

    更新日期：1986-12-15 00:00:00

  • Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: a cohort study.

    abstract：BACKGROUND:While post thrombotic syndrome (PTS) is increasingly recognized as a frequent and potentially serious complication of deep vein thrombosis (DVT) in children, limited information is available regarding predictors of PTS. METHODS:Using the Mayo Clinic Master Diagnostic Index, all pediatric patients (age 0 to ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.12.005

    authors： Kumar R,Rodriguez V,Matsumoto JM,Khan SP,Weaver AL,McBane RD,Beebe TJ,Heit JA

    更新日期：2015-02-01 00:00:00

  • Validation of a novel tissue factor assay in experimental human endotoxemia.

    abstract：BACKGROUND:Nuclear factor kappa B (NF-kappa B) activation and tissue factor (TF) expression may contribute to lethality in sepsis. Inappropriate in vivo expression of TF is likely responsible for fibrin deposition in sepsis-associated disseminated intravascular coagulation (DIC). Clinical assessment of TF expression ha...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.thromres.2003.09.017

    authors： Marsik C,Quehenberger P,Mackman N,Osterud B,Luther T,Jilma B

    更新日期：2003-01-01 00:00:00

  • Experimental model of thrombus adherence to the vessel wall.

    abstract：:Clot adherence to peritoneal cavity mesothelium was studied in rats in an attempt to contribute to the problem of thrombus embolization. The adherence was decreased by platelets and the active constituent was identified as adenosine diphosphate which decreased the sticking of fibrin to cellular linings as well as to a...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90100-1

    authors： Hladovec J

    更新日期：1982-12-15 00:00:00

  • Excessive expressions of T cell activation markers in pediatric immune thrombocytopenia.

    abstract：BACKGROUND:Immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder in children. Activated T cells have been shown to play important roles in ITP. The aims of this study were to evaluate whether these T cell activation markers could be used as indicators to differentiate ITP patients from controls, and to ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2019.05.010

    authors： Chen Y,Zhou Y,Chen P,Zhang P,Jia M,Tang Y

    更新日期：2019-08-01 00:00:00

  • Comparison of 10-mg and 5-mg warfarin initiation nomograms in a South Indian population - An open label trial.

    abstract：INTRODUCTION:Early achievement of therapeutic INR leads to shorter hospital stay and lesser cost. Two warfarin initiation nomograms (10 mg nomogram and 5 mg nomogram) are widely used but it is not yet clear which one is better. They have been validated in the West but there are no studies from India. We undertook this ...

    journal_title：Thrombosis research

    pub_type： 临床试验,信件

    doi：10.1016/j.thromres.2018.12.026

    authors： Naik D S,Pillai VM,Adole PS

    更新日期：2019-04-01 00:00:00

  • Analysis of antithrombin III microheterogeneity by isoelectric focusing in polyacrylamide gels and immunoblotting.

    abstract：:Microheterogeneity of antithrombin III (ATIII) was examined in pooled normal human plasma and serum by IEF/PA and immunoblotting techniques. A pattern consisting of 8 bands varying in isoelectric point from 4.7 to 5.2 was observed in citrated plasma following IEF in a pH range of 4-6. A similar pattern was observed in...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90331-7

    authors： Daly M,Hallinan F

    更新日期：1985-10-15 00:00:00

  • Low PAI-1 activity in relation to the risk for perioperative bleeding complications in transurethral resection of the prostate.

    abstract：INTRODUCTION:Low levels of plasminogen activator inhibitor type 1 (PAI-1) have been associated with increased risk for perioperative bleeding in some case reports. The aim of this study was to investigate prospectively whether low PAI-1 activity increases the risk for perioperative bleeding in patients undergoing trans...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2006.06.014

    authors： Agren A,Kolmert T,Wiman B,Schulman S

    更新日期：2007-01-01 00:00:00

  • Platelet adhesion at low shear rate: study of a normal population.

    abstract：:The use of oral contraceptives (OCs) has been associated with vascular complications. The mechanism(s) by which OCs predispose to thrombotic events remains unclear. Recent studies have demonstrated that postmenopausal (PM) women who take estrogen replacement therapy (ERT) have a decreased incidence of myocardial infar...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(93)90043-n

    authors： Dores GM,Miller ME,Thorpe SL

    更新日期：1993-01-15 00:00:00

  • Treatment of patients with acute deep vein thrombosis and/or pulmonary embolism: efficacy and safety of non-VKA oral anticoagulants in selected populations.

    abstract：:Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), presents a large clinical burden. Prompt, effective and sustained anticoagulation is vital because of the risk of recurrent events, including life-threatening PE, and complications such as post-thrombotic syndrome and chro...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2014.05.013

    authors： Prandoni P

    更新日期：2014-08-01 00:00:00

  • Translocation and phosphorylation of cytosolic phospholipase A2 in activated platelets.

    abstract：:The release of arachidonic acid, and its subsequent conversion to thromboxane A2, is an important component of platelet activation. The precise mechanism of arachidonic acid release is unknown although cytosolic phospholipase A2 (cPLA2) has been implicated. In the present study the effects of three agonists, the serin...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(98)00097-8

    authors： McNicol A,Shibou TS

    更新日期：1998-10-01 00:00:00

  • A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect.

    abstract：INTRODUCTION:Peden et al. have revealed a significant association between four new risk loci and coronary heart disease (CHD) in Europeans and South Asians. The goal of this study is to evaluate the contribution of these genetic loci to CHD risk in Han Chinese. METHODS:We recruited 161 CHD patients and 112 controls pr...

    journal_title：Thrombosis research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.thromres.2012.05.023

    authors： Zhou J,Huang Y,Huang RS,Wang F,Xu L,Le Y,Yang X,Xu W,Huang X,Lian J,Duan S

    更新日期：2012-10-01 00:00:00