Abstract:
INTRODUCTION:Procoagulant activity of heparanase has been recently described in several arterial and venous thrombotic disorders. In this study, we aimed to investigate the role of heparanase with regard to thrombus burden, thromboembolism, and treatment success with unfractionated heparin (UFH) in patients with prosthetic valve thrombosis (PVT). METHODS:This study enrolled 79 PVT patients who received UFH for PVT and 82 controls. Plasma samples which were collected from patients both at baseline and after the UFH treatment and from controls at baseline only, were tested for heparanase levels by heparanase enzyme-linked immunosorbent assay. RESULTS:The PVT group included 18 obstructive and 61 non-obstructive PVT patients who received UFH infusions for a median duration of 15 (7-20) days. The UFH treatment was successful in 37 (46.8%) patients. Baseline heparanase levels were significantly higher in the patient group than in the controls [0.29 (0.21-0.71) vs. 0.25 (0.17-0.33) ng/mL; p = 0.002]. Baseline heparanase levels were significantly higher in obstructive PVT patients. There was a significant increase in heparanase levels after UFH treatment. Post-UFH heparanase levels were higher in patients who experienced treatment failure compared to successfully treated group. Baseline and post-UFH heparanase levels were significantly higher in patients with a thrombus area ≥1 cm2 and with a recent history of thromboembolism. CONCLUSIONS:Increased heparanase levels may be one of the esoteric causes for PVT. UFH treatment may trigger an increase in heparanase levels which may affect the treatment success. Increased heparanase levels may be associated with high risk of thromboembolism and increased thrombus burden in PVT patients.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Bayam E,Kalçık M,Gürbüz AS,Yesin M,Güner A,Gündüz S,Gürsoy MO,Karakoyun S,Cerşit S,Kılıçgedik A,Candan Ö,Yaman A,Özkan Mdoi
10.1016/j.thromres.2018.09.061subject
Has Abstractpub_date
2018-11-01 00:00:00pages
103-110eissn
0049-3848issn
1879-2472pii
S0049-3848(18)30552-8journal_volume
171pub_type
杂志文章abstract:INTRODUCTION:Unfractionated heparin (UFH) does not cross the placenta and has demonstrated utility in the prevention and treatment of thrombosis during pregnancy. Limited information is available to guide initiation and monitoring of therapeutic UFH targeting an anti-Xa concentration of 0.3-0.7 u/ml during pregnancy. T...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2009.07.014
更新日期:2010-05-01 00:00:00
abstract::Tissue factor pathway inhibitor is the major potent physiologic inhibitor of tissue factor-induced coagulation. Several potential binding sites for transcription factors have been described in the 750 bp of the 5' flanking region of the human tissue factor pathway inhibitor gene reported earlier. To identify elements ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(99)00040-7
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Troponin I (cTnI), myoglobin, heart-type fatty acid binding protein (H-FABP), and natriuretic peptides (BNP, NTproBNP) were all reported to be elevated in patients with pulmonary embolism (PE). METHODS:To assess the correlation between the aforementioned markers and helical computed tomography (hCT) right v...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2007.07.003
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Antithrombin (AT), protein C (PC) and protein S (PS) deficiencies are risk factors for venous thromboembolism. Overlapping values between heterozygous carriers and normal individuals often make a correct classification of a deficiency difficult. The aim of this study was to investigate the effect of sex, a...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.07.003
更新日期:2013-08-01 00:00:00
abstract::One of the major pathogens of periodontitis, Porphyromonas gingivalis (P. gingivalis), has the ability to aggregate human platelets. To investigate the interaction between P. gingivalis and human platelets in platelet rich plasma (PRP), platelet aggregation was measured by an aggregometer based on laser light scatteri...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2008.03.011
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Even though thrombocytopenia following transcatheter aortic valve implantation (TAVI) has been described, further investigation of this phenomenon is needed. AIMS:To determine which factors may explain the fall in platelet count that occurs after implantation of a TAVI device, including markers of platele...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.05.020
更新日期:2017-08-01 00:00:00
abstract::The role of protein kinase C (PKC) in platelet activation by thrombin was assessed using a PKC inhibitor Ro 31-7549/001 (R2) which, in vitro, shows more selectivity for PKC than other kinase inhibitors. During early (1.5 s) thrombin-induced platelet activation, when phosphorylation of 47 kDa protein (pleckstrin) and m...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(93)90008-c
更新日期:1993-01-01 00:00:00
abstract::Increased fibrinolytic activity is a well recognized constant finding observed during cardiopulmonary bypass (CPB). The purpose of the present work was to study and estimate the factors involved in the plasminogen activation and prekallikrein-kallikrein systems in a population of adult patients undergoing open heart s...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90018-6
更新日期:1992-09-01 00:00:00
abstract:INTRODUCTION:Although recurrent venous thromboembolism is a known risk factor for chronic thromboembolic pulmonary hypertension (CTEPH), the prevalence of CTEPH after recurrent pulmonary embolism (PE) is not clear. MATERIALS AND METHODS:A cohort screening study was performed to clarify the prevalence of echocardiograp...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.07.045
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:Monocyte- and microparticle (MP)-associated tissue factor (TF) is upregulated in diabetes. Lipopolysaccharide (LPS) induces expression of TF and alternatively spliced TF (asTF) and increases MP release from monocytes. Using LPS-stimulated TF-bearing human monocytes, we examined whether glibenclamide, a sul...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2011.07.007
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND/AIMS:The plasminogen activator (PA)-plasmin system is primarily involved in fibrinolysis, but is also in the patho/physiological events in which breakdown of extracellular matrices is evoked topically. In this present study, we examined the expression of fibrinolytic factors, tissue-type PA (t-PA) and Type 1...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(01)00370-x
更新日期:2001-11-15 00:00:00
abstract:INTRODUCTION:We recently proposed a scale for assessment of patient-relevant functional limitations following an episode of venous thromboembolism (VTE). Further development of this post-VTE functional status (PVFS) scale is still needed. METHODS:Guided by the input of VTE experts and patients, we refined the PVFS sca...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2020.03.020
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The immediate administration of oral antiplatelet therapy in the form of aspirin plus a P2Y12 inhibitor is the universally recognised standard of care for patients who present with acute myocardial infarction. Despite strong recommendations for their use, there are a paucity of data describing their onset of...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2016.05.019
更新日期:2016-07-01 00:00:00
abstract::The loss of sialic acid was determined in human platelets stored during a seven day period in their homologous plasma. Approximately 30% of the sialic acid was lost during the first three days of incubation at room temperature and a total of 73% was lost after seven days. The rapid in vitro loss of sialic acid may mim...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(82)90316-4
更新日期:1982-06-15 00:00:00
abstract::Patients with active cancer have a heightened risk of venous thromboembolism (VTE). This risk is further increased by the initiation of chemotherapy. Although previous studies have suggested that the use of parenteral thromboprophylaxis in all ambulatory cancer patients receiving chemotherapy significantly decreases t...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.01.018
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION:Tumor necrosis factor-alpha (TNF-α) exerts a critical role in inflammatory events through two distinct receptors, TNFR1 and TNFR2. Platelets have been recognized as important inflammatory cells, but little is known about the effects of TNF-α on the platelet activity. OBJECTIVES:In the present study we hav...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.10.008
更新日期:2018-12-01 00:00:00
abstract::Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failur...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2011.06.024
更新日期:2011-10-01 00:00:00
abstract:INTRODUCTION:Coagulation factor XIII (FXIII) is a fibrin-stabilizing factor, which contributes to hemostasis, wound healing, and maintenance of pregnancy. Accordingly, patients with congenital FXIII deficiency manifest a life-long bleeding tendency, abnormal wound healing and recurrent miscarriage. In order to understa...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2012.05.003
更新日期:2012-09-01 00:00:00
abstract::The present study was designed to find out whether the synthetic pentasaccharide SR 90107A/Org 31540, which is presently being evaluated in clinical trials as an antithrombotic agent, influences lipoprotein metabolism in rats as determined by plasma triglyceride (TG) lipase activity. A comparison with three clinically...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(97)00075-3
更新日期:1997-05-15 00:00:00
abstract:OBJECTIVE:To compare rates of VTE occurrence in obese versus non-obese hospitalized patients who received UFH 5000 units subcutaneously q8 h. MATERIALS AND METHODS:This was a retrospective cohort study conducted in an academic medical center in the United States. Consecutive adult patients who were hospitalized during...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.07.027
更新日期:2018-09-01 00:00:00
abstract::Blood was obtained from four patients envenomated by the Australian common brown snake, Pseudonaja textilis textilis. This elapid snake has one of the most toxic venoms in the world, containing extremely potent neurotoxic and coagulant components. The latter is a potent complete prothrombinase, converting prothrombin ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90399-w
更新日期:1990-09-01 00:00:00
abstract::In 51 shock patients with DIC Antithrombin III (AT III) substitution, heparin or a combination of both substances respectively was administered. In the two groups which had been given AT III substitution the concentration of AT III rose considerably higher than the activity. There was a drop of the platelet count in b...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90123-9
更新日期:1985-07-01 00:00:00
abstract:INTRODUCTION:High RDW values are associated with adverse prognosis in many clinical conditions including short and medium term outcome of patients with ST Elevation Myocardial Infarction (STEMI). The aim of the present study was to evaluate the association between RDW and long term mortality in STEMI patients undergoin...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2014.08.016
更新日期:2014-11-01 00:00:00
abstract::Acute coronary syndromes (ACS) represent the main clinical manifestation of atherosclerotic progression in the coronary district. Thrombosis plays a critical role in the patho-anatomical of ACS, as disruption of an atherosclerotic plaque exposes flowing blood to subendothelial collagen, tissue factor, and other procoa...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/j.thromres.2011.12.026
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Cerebral vein thrombosis (CVT) is a rare, life-threatening disease affecting one adult per 100,000 per year. Genetic risk factors are deficiencies of the natural anticoagulant proteins antithrombin, protein C, protein S or single nucleotide polymorphisms such as factor V Leiden and prothrombin 20210A. In 20%...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.06.011
更新日期:2018-09-01 00:00:00
abstract::Activation of human platelets by PAF was augmented by C-reactive protein, an acute phase plasma protein. The concentration of PAF required for irreversible activation (secondary aggregation of platelet and release of serotonin) was decreased to 1/10 in the presence of C-reactive protein (CRP). The presence of CRP stim...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90361-0
更新日期:1986-03-01 00:00:00
abstract:INTRODUCTION:Whether clinical prediction rules for pulmonary embolism are accepted and used among general internal medicine residents remains uncertain. We therefore evaluated the frequency of use and acceptability of the Revised Geneva Score (RGS) and the Pulmonary Embolism Severity Index (PESI), and explored which fa...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.09.028
更新日期:2017-12-01 00:00:00
abstract::A recently developed platelet aggregometer using a laser light scattering method is capable of monitoring the increase in size of small-sized platelet aggregates (diameter 9-25 microm), which cannot be detected with the conventional methods. Whether coronary spasm can cause platelet aggregation in the coronary circula...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
doi:10.1016/s0049-3848(01)00333-4
更新日期:2001-09-01 00:00:00
abstract::The pharmacokinetics of a low molecular weight heparin (LMWH) with a mean mw of 4000-6000 D (KABI 2165, Fragmin) was studied in 6 healthy volunteers after intravenous (iv) and subcutaneous (sc) administration of 120 U (anti FXa)/kg. The half-life in plasma of the anti FXa activity after iv injection was 119 +/- 17 min...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90340-3
更新日期:1986-06-01 00:00:00
abstract::The perfusion technique to measure the relative adhesive and thrombogenic indices of vascular prostheses by a quantitative scanning electron microscopy has been described. To normalize the experiments with different samples of plasma we compared the adhesive and thrombogenic properties of the analyzed prostheses with ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90038-5
更新日期:1983-02-01 00:00:00