Thrombosis and acute coronary syndrome.

abstract：:We characterized a platelet specific alloantigen (Yukb). In immunoblotting, anti-Yukb antibody was found to react with both 110 kDa and 96 kDa bands under nonreducing condition. Immunoblotting followed by separation by two-dimensional electrophoresis (isoelectric focusing/SDS-PAGE) showed that the 96 kDa band had a pI...

journal_title：Thrombosis research

authors： Sugano W,Ryo R,Yamaguchi N,Shibata Y

更新日期：1992-07-15 00:00:00

abstract：:Properties of a new concentrate of FVII/FVIIa, obtained by adsorption onto an inorganic adsorbent followed by a chromatographic step onto Q-Sepharose using a by-product of routine fractionation as starting material, are described. This fraction contains only small amounts of the other components of the prothrombin com...

journal_title：Thrombosis research

authors： Chabbat J,Hampikian-Lenin S,Toully V,Gaillandre A,Péjaudier L,Steinbuch M

更新日期：1989-06-15 00:00:00

abstract：:Understanding the intracellular events triggered by antiphospholipid (aPL) antibodies in platelets and endothelial cells (ECs) is important in designing new modalities of targeted therapies for the treatment of thrombosis in Antiphospholipid Syndrome (APS). A recent study showed a significant increase in the expressio...

journal_title：Thrombosis research

authors： Pierangeli SS,Vega-Ostertag M,Harris EN

更新日期：2004-01-01 00:00:00

abstract：:VKORC1 and VKORC1L1 are enzymes that both catalyze the reduction of vitamin K2,3-epoxide via vitamin K quinone to vitamin K hydroquinone. VKORC1 is the key enzyme of the classical vitamin K cycle by which vitamin K-dependent (VKD) proteins are γ-carboxylated by the hepatic γ-glutamyl carboxylase (GGCX). In contrast, t...

journal_title：Thrombosis research

authors： Caspers M,Czogalla KJ,Liphardt K,Müller J,Westhofen P,Watzka M,Oldenburg J

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:A close association exists between oral health and cardiovascular disease. Periodontal disease induces early vascular changes while oral pathogens have been detected in sub gingival and atheromatous plaques. We examined the interrelationship between Periodontal disease, oral bacteria, surrogate sub-clinica...

journal_title：Thrombosis research

authors： Shanker J,Setty P,Arvind P,Nair J,Bhasker D,Balakrishna G,Kakkar VV

更新日期：2013-07-01 00:00:00

abstract：:While the role of platelets in hemostasis is well characterized from a biological perspective, the biophysical interactions between platelets and their mechanical microenvironment are relatively unstudied. The field of cellular mechanics has developed a number of approaches to study the effects of extracellular matrix...

journal_title：Thrombosis research

authors： Ciciliano JC,Tran R,Sakurai Y,Lam WA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Systemic thrombolysis rapidly improves right ventricular (RV) dysfunction in patients with acute pulmonary embolism (PE) but is associated with major bleeding complications in up to 20%. The efficacy of low-dose, catheter-directed ultrasound-accelerated thrombolysis (USAT) on the reversal of RV dysfunction i...

journal_title：Thrombosis research

authors： Engelhardt TC,Taylor AJ,Simprini LA,Kucher N

更新日期：2011-08-01 00:00:00

abstract：:The enzymatic and fibrinolytic properties of glycosylated and nonglycosylated recombinant human pro-urokinase (pro-UK) produced in yeast Pichia pastoris were characterized and compared with those of Escherichia coli and mammalian cell-derived pro-UK. Among the five different forms of pro-UK, the yeast glycosylated pro...

journal_title：Thrombosis research

authors： Wang P,Zhang J,Sun Z,Chen Y,Gurewich V,Liu JN

更新日期：2000-12-01 00:00:00

abstract：:Low circulating protein C (PC) levels have been observed in sepsis, especially in patients with Neisseriae Meningitides infections. Poor clinical outcome and high limb amputation rates have been associated in infected patients with low circulating PC levels. Published studies using activated PC replacement therapy pat...

journal_title：Thrombosis research

authors： Piccin A,O' Marcaigh A,Mc Mahon C,Murphy C,Okafor I,Marcheselli L,Casey W,Claffey L,Smith OP

更新日期：2014-07-01 00:00:00

abstract：:Envenomation caused by Lonomia obliqua caterpillars is an increasing problem in Southern Brazil. The clinical profile is characterized by a profound hemorrhagic disorder. In the present study, we describe the characterization of a fibrin(ogen)olytic factor (lonofibrase) isolated from a venomous secretion of the caterp...

journal_title：Thrombosis research

authors： Pinto AF,Dobrovolski R,Veiga AB,Guimarães JA

更新日期：2004-01-01 00:00:00

abstract：:This prospective randomized study investigated the influence of normotensive and hypotensive general anesthesia on platelet aggregability, intraoperative blood loss and parameters of plasmatic coagulation during extensive orthognathic surgery. A total of 30 patients were randomly allocated for either normotensive anes...

journal_title：Thrombosis research

authors： Felfernig-Boehm D,Salat A,Kinstner C,Fleck T,Felfernig M,Kimberger O,Andel H,Mueller MR

更新日期：2001-08-01 00:00:00

abstract：:Severe prekallikrein (Fletcher factor) deficiency was diagnosed in a 49-year-old woman and in 3 of her siblings. Functional prekallikrein (PKK) activity was found below 1% by clotting assay and 20% by amidolytic assay in all the affected subjects; PKK cross-reacting material (CRM) was present in all the patients (anti...

journal_title：Thrombosis research

authors： De Stefano V,Leone G,Teofili L,De Marinis L,Micalizzi P,Fiumara C,Bizzi B

更新日期：1990-12-01 00:00:00

abstract：INTRODUCTION:Preterm infants often require assisted ventilation, however ventilation when applied to the immature lung can initiate ventilator-induced lung injury (VILI). The biotrauma which underscores VILI is largely undefined, and is likely to involve vascular injury responses, including hemostasis. We aimed to use ...

journal_title：Thrombosis research

authors： Schmid C,Ignjatovic V,Pang B,Nie S,Williamson NA,Tingay DG,Pereira-Fantini PM

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. METHODS:Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenect...

journal_title：Thrombosis research

authors： Comerota AJ,Oostra C,Fayad Z,Gunning W,Henke P,Luke C,Lynn A,Lurie F

更新日期：2015-05-01 00:00:00

abstract：:The effect of suloctidil (600 mg/day) on platelet survival time (PST) and plasma and urine betathromboglobulin (BTG) was studied in a double-blind, placebo-controlled six-week crossover trial in 13 patients with shortened PST (less than 110 hrs, exponential model). Mean PST after suloctidil (110.6 hrs) was significant...

journal_title：Thrombosis research

authors： Turpie AG,Gent M,deBoer AC,Giroux M,Kinch D,Butt R,Gunstensen J,Saerens E,Genton E

更新日期：1984-08-15 00:00:00

abstract：:A B S T R A C T Thrombotic events are a major cause of morbidity and mortality in cancer. While the association of venous thromboembolic events with cancer is well documented, in recent years arterial events (i.e. acute myocardial infarction and ischemic strokes) have also emerged as relatively common complications am...

journal_title：Thrombosis research

authors： Horowitz NA,Brenner B

更新日期：2020-07-01 00:00:00

abstract：:The placental transfer of Org 10172, a low-molecular weight heparinoid, was determined in 12 awake late-pregnant guinea pigs. Nine animals receiving placebo served as controls. After 5 days i.v. treatment with Org 10172 (2 x 300 anti-Xa U/kg/day), anti-Xa activity in fetal plasma amounted to 2.4% of the maternal conce...

journal_title：Thrombosis research

authors： Peeters LL,Hobbelen PM,Verkeste CM,Vogel GM,Hasenack HG,Meuleman DG,Wallenburg HC

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Few studies investigated the relationship between fibrinolysis abnormalities and residual pulmonary perfusion defects after acute pulmonary embolism (PE). OBJECTIVE:To assess the fibrinolytic profile in patients with prior PE in relation to the extent of scintigraphically detectable residual perfusion abnor...

journal_title：Thrombosis research

authors： Lami D,Cellai AP,Antonucci E,Fiorillo C,Becatti M,Grifoni E,Cenci C,Marcucci R,Mannini L,Miniati M,Abbate R,Prisco D

更新日期：2014-09-01 00:00:00

abstract：:The effect of activated protein C (APC) on agonist-induced platelet activation and on thrombin generation after intrinsic (IA) and extrinsic (EA) activation of the coagulation system was studied by flow cytometry and by measuring levels of prothrombin fragment F1+2. In platelet activation studies blood drawn from heal...

journal_title：Thrombosis research

authors： Kaiser B,Jeske W,Hoppensteadt DH,Walenga JM,Drohan W,Fareed J

更新日期：1997-07-15 00:00:00

abstract：:Heat treatment is employed to diminish the transmission of hepatitis when blood products are administered. It is possible that such a procedure could reduce the biological activity of the proteins and induce changes in structure and aggregation state. We have therefore made in vitro and pharmacokinetic studies of heat...

journal_title：Thrombosis research

authors： Tengborn L,Frohm B,Nilsson LE,Johansson L,Andersson LO

更新日期：1987-12-15 00:00:00

abstract：:Prothrombin fragments (F1+2), thrombin-antithrombin complexes (TAT) and D-dimers, markers of hemostatic system activation, were measured in 59 consecutive patients with deep vein thrombosis (DVT). Patients were randomly treated either with subcutaneous unfractionated heparin (UH) administered in two to three subcutane...

journal_title：Thrombosis research

authors： Peternel P,Terbizan M,Tratar G,Bozic M,Horvat D,Salobir B,Stegnar M

更新日期：2002-02-01 00:00:00

abstract：:Cardiovascular diseases are one of the leading causes of morbidity and mortality in industrialized countries, and although many processes play a role in the development of vascular disease, thrombosis is the primary event that precipitates stroke and acute coronary syndromes. The blood platelets are of significant imp...

journal_title：Thrombosis research

authors： Alexandru N,Popov D,Georgescu A

更新日期：2012-02-01 00:00:00

abstract：:The in vitro and in vivo pharmacological properties of two oversulfated dermatan sulfate (DS) derivatives, S-DS1 and S-DS2, containing 2 and 3.7 sulfate groups/disaccharide unit respectively were compared to those of the parent DS (1 sulfate group/disaccharide unit). In a purified system the ability of S-DS1 and of S-...

journal_title：Thrombosis research

authors： Dol F,Caranobe C,Dupouy D,Petitou M,Lormeau JC,Choay J,Sié P,Boneu B

更新日期：1988-10-15 00:00:00

abstract：:Endothelial cells from human umbilical vein were incubated in vitro with thrombin in the absence or presence of unfractionated heparin (UFH), low molecular weight heparin (LMWH) or dermatan sulfate (DS) to clarify the effect of these glycosaminoglycans on thrombin-stimulated prostaglandin I2 (PGI2) production. Althoug...

journal_title：Thrombosis research

authors： Itoh F,Kaji T,Hayakawa Y,Oguma Y,Sakuragawa N

更新日期：1990-02-15 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli ...

journal_title：Thrombosis research

authors： Ende-Verhaar YM,Huisman MV,Klok FA

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Administrative data can be used to identify venous thromboembolism (VTE) and major bleeding (MB) events. However, the validity of this data in emergency room discharge records in Canada is unknown. METHODS:We conducted a single-institution retrospective chart re-abstraction study in London, Canada. We ident...

journal_title：Thrombosis research

authors： Al-Ani F,Shariff S,Siqueira L,Seyam A,Lazo-Langner A

更新日期：2015-12-01 00:00:00

abstract：:An in vitro model of platelet adhesion, the annular perfusion chamber, was utilized to test the effects of Interleukin 1 on vascular thrombogenicity for platelets. De-endothelialized, everted human umbilical arteries were placed in cell culture media with or without Interleukin 1. The arteries were later perfused with...

journal_title：Thrombosis research

authors： Schorer AE,White JG

更新日期：1989-11-15 00:00:00

abstract：:The behavior of hemostatic system activation during protracted physical exercise is well known, but the duration of its modification is not yet defined. In order to evaluate the time of hemostatic system activation after prolonged strenuous endurance physical exercise (typical marathon race: 42.195 km, v=15.35 km/h; m...

journal_title：Thrombosis research

authors： Prisco D,Paniccia R,Bandinelli B,Fedi S,Cellai AP,Liotta AA,Gatteschi L,Giusti B,Colella A,Abbate R,Gensini GF

更新日期：1998-01-15 00:00:00

abstract：BACKGROUND:Rate of thalidomide-related VTE and risk factors in Japanese myeloma patients are not clear and effects of thromboprophylaxis remain controvertial. PATIENTS AND METHODS:We retrospectively analyzed a cohort data of registered Japanese myeloma patients treated with thalidomide-based regimens between 2009 and ...

journal_title：Thrombosis research

authors： Kato A,Takano H,Ichikawa A,Koshino M,Igarashi A,Hattori K,Nagata K

更新日期：2013-02-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) is a severe complication of septic shock. Polymorphonuclear neutrophils (PMNs) may play a key role in septic shock-induced DIC via the release of neutrophils extracellular traps (NETs). NETs capture invading pathogens, but also act as a pro-coagulant surface at the interfac...

journal_title：Thrombosis research

authors： Stiel L,Mayeur-Rousse C,Helms J,Meziani F,Mauvieux L

更新日期：2019-11-01 00:00:00