Placental transfer of Org 10172, a low-molecular weight heparinoid, in the awake late-pregnant guinea pig.

abstract：INTRODUCTION:Circulating microparticles support thrombin generation. The aim of this study is to determine the indirect microparticle activity and the parameters of thrombin generation in healthy infants. MATERIALS AND METHODS:A total of 85 infants who were brought to follow-up visits were taken into the study. Blood ...

journal_title：Thrombosis research

authors： Orhon FS,Egin Y,Ulukol B,Baskan S,Akar N

更新日期：2014-02-01 00:00:00

abstract：:Human and bovine alpha-thrombins (greater than 90% alpha form) with high fibrinogen clotting activities (approximately 3,000 U.S. units/mg protein) exhibit similar Michaelis menten kinetics with the p-nitroanilide tripeptide substrates Tos-Gly-Pro-arg-pNA (Chromozym-TH) and D-Phe-Pip-Arg-pNA (S-2238). The kinetic para...

journal_title：Thrombosis research

authors： Lottenberg R,Hall JA,Fenton JW 2nd,Jackson CM

更新日期：1982-11-01 00:00:00

abstract：:Since the first description by Dahlbäck et al (1) of a hereditary defect in the plasma of three unrelated thrombophilic patients characterized by a poor anticoagulant response to activated protein C (APC), many reports have shown a high prevalence of the APC resistance in both the general and thrombophilic populations...

journal_title：Thrombosis research

authors： Gouault-Heilmann M,Leroy-Matheron C

更新日期：1997-02-15 00:00:00

abstract：:von Willebrand Factor (vWF) is released from endothelial cells. Increased vWF in the coronary circulation during cardiac surgery could be a potential indicator of coronary endothelial injury or stimulation, and thus a possible tool to evaluate regimens of myocardial protection. Release of vWF was investigated in 12 pa...

journal_title：Thrombosis research

authors： Valen G,Blombäck M,Sellei P,Lindblom D,Vaage J

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Atherosclerosis, the underlying disorder of coronary artery disease (CAD), is an inflammatory process involving multiple molecular pathways. Chemokine-mediated mechanisms are potent regulators of atherosclerosis. Genetic variations that alter such signaling pathways could affect susceptibility to CAD. We i...

journal_title：Thrombosis research

authors： Apostolakis S,Baritaki S,Kochiadakis GE,Igoumenidis NE,Panutsopulos D,Spandidos DA

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:This study determines the impact of tissue factor (TF)-signaling on the extrinsic pathway of apoptosis in cancer cells and propose death associated protein kinase-1 (DAPK1) as a novel key regulator. MATERIALS AND METHODS:In MDA-MB-231 breast and PC3 prostate cancer cells, mRNA levels were analyzed by real...

journal_title：Thrombosis research

authors： Aberg M,Johnell M,Wickström M,Siegbahn A

更新日期：2011-02-01 00:00:00

abstract：:Calcium accumulating vesicles were prepared from washed human platelets. Ca2+ uptake could be stimulated with calmodulin. The stimulation of Ca2+ uptake was not abolished by the adenylate cyclase inhibitor 2',5'-dideoxyadenosine, thus excluding enhanced cAMP formation as a possible cause for the calmodulin effect. Our...

journal_title：Thrombosis research

authors： Salimath BP,Mittelholzer E,Muggli R,Dieter P,Marmé D

更新日期：1986-02-15 00:00:00

abstract：OBJECTIVE:The present cohort study was performed to investigate the impact of the factor 5 rs6025 [F5] and the factor 2 rs1799963 [F2] mutations on high-titer inhibitor development [HRI] in patients with severe/moderate-severe hemophilia A [HA]. PATIENTS AND METHODS:216 patients with F8<2% born between 1980 and 2011 w...

journal_title：Thrombosis research

authors： Kenet G,Bidlingmaier C,Bogdanova N,Ettingshausen CE,Goldenberg N,Gutsche S,Halimeh S,Holzhauer S,Kurnik K,Limperger V,Junker R,Nowak-Göttl U

更新日期：2014-04-01 00:00:00

abstract：:Patients with protamine allergy present a difficult dilemma when reversal of heparin is required for excessive bleeding. Premedication with steroids and antihistamines has not been shown to effectively prevent anaphylactic reactions in patients with hypersensitivity to protamine. Other heparin antagonists are either n...

journal_title：Thrombosis research

authors： Sloand EM,Kessler CM,McIntosh CL,Klein HG

更新日期：1989-06-15 00:00:00

abstract：:Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephad...

journal_title：Thrombosis research

authors： Sanders KD,Fuller GM

更新日期：1983-10-15 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00

abstract：INTRODUCTION:Unfractionated heparin (UFH) potentiates platelet aggregation induced by some agonists. P2Y12 and P2Y1 receptors play a major role in amplifying platelet aggregation. We assessed the ability of cangrelor, a selective P2Y12 antagonist, A2P5P, a selective P2Y1 antagonist, and aspirin to block the potentiatin...

journal_title：Thrombosis research

authors： Storey RF,May JA,Heptinstall S

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To compare rates of VTE occurrence in obese versus non-obese hospitalized patients who received UFH 5000 units subcutaneously q8 h. MATERIALS AND METHODS:This was a retrospective cohort study conducted in an academic medical center in the United States. Consecutive adult patients who were hospitalized during...

journal_title：Thrombosis research

authors： Patanwala AE,Seaman SM,Kopp BJ,Erstad BL

更新日期：2018-09-01 00:00:00

abstract：:This study compared the responses of canine and human platelets to various aggregating agonists in the presence or absence of extracellular ATP and ATP analogues. Canine and human platelets were approximately equally reactive with ADP or collagen while the canine platelets were about 10 fold more sensitive to thrombin...

journal_title：Thrombosis research

authors： Soslau G,Arabe L,Parker J,Pelleg A

更新日期：1993-10-15 00:00:00

abstract：:Heparin is an effective, relatively safe, inexpensive parenteral antithrombotic agent widely used in the prevention and treatment of thromboembolic disorders, but it has several limitations such as the marked intra- and inter-patient variability in its anticoagulant response, its poor bioavailability at low doses and ...

journal_title：Thrombosis research

authors： Cosmi B,Palareti G

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. METHODS:Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenect...

journal_title：Thrombosis research

authors： Comerota AJ,Oostra C,Fayad Z,Gunning W,Henke P,Luke C,Lynn A,Lurie F

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Quercetin is widely distributed in plants and has been reported to have effects of anti-inflammation and anti-thrombosis. In this study, we evaluated the protective effect of quercetin on LPS-induced experimental DIC in rabbits, and tried to clarify its mechanism against DIC. MATERIALS AND METHODS:LPS-ind...

journal_title：Thrombosis research

authors： Yu PX,Zhou QJ,Zhu WW,Wu YH,Wu LC,Lin X,Chen MH,Qiu BT

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Association between ADAMTS13 levels and cardiovascular events has been described recently. However, no genetic study of ADAMTS13 in coronary patients has been described. MATERIALS AND METHODS:Based on related populations frequencies and functional studies, we tested three ADAMTS13 polymorphisms: C1342G (Q...

journal_title：Thrombosis research

authors： Schettert IT,Pereira AC,Lopes NH,Hueb WA,Krieger JE

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:In this randomized management study, we examined the safety of withholding anticoagulation on the basis of negative impedance plethysmography (IPG) compared to negative contrast venography (CV) in symptomatic patients with a first episode of clinically suspected deep vein thrombosis (DVT), and we determined ...

journal_title：Thrombosis research

authors： Kahn SR,Joseph L,Grover SA,Leclerc JR

更新日期：2001-04-01 00:00:00

abstract：:Tissue factor (TF) is a transmembrane protein which, in complex with factor (F)VIIa, initiates blood coagulation. Numerous studies have determined TF epitopes and individual amino acids which play an important role in the TF/FVIIa complex formation and its activity towards natural substrates. However the subject of ce...

journal_title：Thrombosis research

authors： Butenas S,Krudysz-Amblo J

更新日期：2012-05-01 00:00:00

abstract：:Two types of LMW heparin were prepared by gel filtration of standard heparin (LMW fraction) and by degradation of heparin by nitrous acid (LMW fragment), respectively. The effects on factor Xa inhibition (XaI), APTT, platelet aggregation and AT III level of these preparations were studied after subcutaneous administra...

journal_title：Thrombosis research

authors： Bergqvist D,Hedner U,Sjörin E,Holmer E

更新日期：1983-11-15 00:00:00

abstract：:Normal haemostasis requires maintenance of a careful equilibrium between the necessity to clot when bleeding and the retention of fluid phase at all other times. Disruption of this equilibrium can result in catastrophic outcomes, e.g. acute myocardial infarction and pulmonary embolism. However, despite the significant...

journal_title：Thrombosis research

authors： Lim HY,O'Malley C,Donnan G,Nandurkar H,Ho P

更新日期：2019-07-01 00:00:00

abstract：:The brain and the placenta synthesize identical peptides and proteins, such as brain-derived neurotrophic factor, oxytocin, vascular endothelial growth factor, cortisol, and matrix metalloproteinases. Given the promiscuity between neurochemistry and the mechanism of placentation, it would be expected that mental disor...

journal_title：Thrombosis research

authors： Hoirisch-Clapauch S,Brenner B,Nardi AE

更新日期：2015-02-01 00:00:00

abstract：:The time course and degree of collagen induced platelet shape change, aggregation and ATP-secretion in citrated human platelet rich plasma was monitored with a lumi-aggregometer. Onset of ATP-secretion was measurable within seconds after collagen challenge and always distinctly before onset of shape change. In absence...

journal_title：Thrombosis research

authors： Malmgren R

更新日期：1986-08-15 00:00:00

abstract：:Resveratrol (3, 4', 5-trihydroxystilbene), a natural polyphenol, is found in some plants that are used in human nutrition. Grapes are a major source for resveratrol, and a significant amount can also be found in red wine. Several experimental studies have demonstrated biological properties of resveratrol, especially i...

journal_title：Thrombosis research

authors： Olas B,Wachowicz B,Saluk-Juszczak J,Zieliński T

更新日期：2002-08-15 00:00:00

abstract：INTRODUCTION:Patients with nonvalvular atrial fibrillation are at increased risk for systemic embolism, predominantly disabling stroke. To study how stroke and mortality rates vary with different degrees of anticoagulation reflected by the international normalised ratio (INR) we critically assess information from diffe...

journal_title：Thrombosis research

authors： Odén A,Fahlén M,Hart RG

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Clinical parameters, biomarkers and imaging-based risk stratification are widely accepted in pulmonary embolism(PE). The present study has investigated the prognostic role of simplified Pulmonary Embolism Severity Index (sPESI) score and the European Society of Cardiology (ESC) model. METHODS:This prospecti...

journal_title：Thrombosis research

authors： Ozsu S,Ozlu T,Sentürk A,Uçar EY,Kırkıl G,Kadıoğlu EE,Altınsoy B,Saylan B,Selimoğlu HŞ,Dabak G,Tutar N,Uysal A,TUPEG Study Investigators.

更新日期：2014-06-01 00:00:00

abstract：:Heparin with low affinity (LA-heparin) to antithrombin III (AT III) enhanced the rate of inactivation of thrombin by AT III. The enhancement of the rate was saturable with AT III and was proportional to the LA-heparin concentration. Although the rate-enhancement in the presence of LA-heparin decreased with increase in...

journal_title：Thrombosis research

authors： Oshima G,Nagasawa K

更新日期：1986-02-01 00:00:00

abstract：INTRODUCTION:Warfarin is the most widely used oral anticoagulant. It has been suggested that anticoagulation effect of warfarin is significantly associated with the polymorphism of certain genes, including Cytochrome P450 complex subunit 2C9 (CYP2C9), Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1), Gamma-Glutam...

journal_title：Thrombosis research

authors： Yang L,Ge W,Yu F,Zhu H

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Treatment of deep-vein thrombosis (DVT) with a once-daily regimen of enoxaparin, rather than a continuous infusion of unfractionated heparin (UFH) is more convenient and allows for home care in some patients. This study was designed to compare the efficacy and safety of these two regimens for the treatment o...

journal_title：Thrombosis research

authors： Ramacciotti E,Araújo GR,Lastoria S,Maffei FH,Karaoglan de Moura L,Michaelis W,Sandri JL,Dietrich-Neto F,CLETRAT Investigators.

更新日期：2004-01-01 00:00:00