Microsomal CA2+ uptake in human platelets is stimulated by calmodulin.

abstract：INTRODUCTION:Clinical trials have provided evidence about efficacy and safety of extended thromboprophylaxis among total hip replacement (THR) patients. There is a lack of evidence on effectiveness and safety of extended treatment in unselected patients from routine clinical practice. We examined the effectiveness and ...

journal_title：Thrombosis research

authors： Pedersen AB,Sorensen HT,Mehnert F,Johnsen SP,Overgaard S

更新日期：2015-02-01 00:00:00

abstract：:Human saphenous veins were analyzed for presence of plasminogen activators (t-PA) in the endothelium of the vessel walls by immunohistochemical techniques. We used a polyclonal rabbit antihuman t-PA antibody, a monoclonal mouse-antihuman t-PA and a goat antibody to low molecular weight urokinase. To demonstrate presen...

journal_title：Thrombosis research

authors： Risberg B,Eriksson E,Björk S,Hansson GK

更新日期：1986-02-01 00:00:00

abstract：:The fibrinolytic system contains a proenzyme plasminogen (Plg) which is converted to plasmin (Plm) by the action of Plg activators. Physiological Plg activators are: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator. Plg was shown to be further cleaved by leukocyte elastase producing se...

journal_title：Thrombosis research

authors： Duboscq C,Genoud V,Parborell MF,Kordich LC

更新日期：1997-06-15 00:00:00

abstract：:Severe rejection crises occurred in 13 out of 20 cadaver kidney recipients; removal of the graft was inevitable in 10 cases. The plasminogen levels were found to be lower (76.5 +/- 2.9%) in the 13 patients with impaired graft acceptance (group B) than in the 7 patients experiencing only moderate rejection (group A, 93...

journal_title：Thrombosis research

authors： Seitz R,Michalik R,Karges HE,Lange H,Egbring R

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Clinical parameters, biomarkers and imaging-based risk stratification are widely accepted in pulmonary embolism(PE). The present study has investigated the prognostic role of simplified Pulmonary Embolism Severity Index (sPESI) score and the European Society of Cardiology (ESC) model. METHODS:This prospecti...

journal_title：Thrombosis research

authors： Ozsu S,Ozlu T,Sentürk A,Uçar EY,Kırkıl G,Kadıoğlu EE,Altınsoy B,Saylan B,Selimoğlu HŞ,Dabak G,Tutar N,Uysal A,TUPEG Study Investigators.

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether the administration of multiple boluses of oral and intravenous tranexamic acid (TXA) postoperatively was equivalent in reducing blood loss in primary THA. METHODS:A total of 108 patients were randomized into two groups: oral TXA group (54 patients receiving...

journal_title：Thrombosis research

authors： Cao G,Huang Z,Xie J,Huang Q,Xu B,Zhang S,Pei F

更新日期：2018-04-01 00:00:00

abstract：:To examine whether moderate hyperhomocyst(e)inemia is associated with coronary artery disease and the number of diseased coronary vessels in Koreans, we investigated 201 patients with angiographically documented coronary artery disease and 187 healthy subjects without evidence of stroke and coronary artery disease. Th...

journal_title：Thrombosis research

authors： Yoo JH,Park JE,Hong KP,Lee SH,Kim DK,Lee WR,Park SC

更新日期：1999-04-01 00:00:00

abstract：INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...

journal_title：Thrombosis research

authors： Desai PC,Brittain JE,Jones SK,McDonald A,Wilson DR,Dominik R,Key NS,Parise LV,Ataga KI

更新日期：2013-09-01 00:00:00

abstract：:A nephelometric method is described for determination of plasminogen and two types of plasmin inhibitors in human plasma having different affinity toward plasmin. This method is based on the kinetic analysis of effects of whole plasma and plasmin inhibitor fraction obtained from plasma on the activity of exogenously a...

journal_title：Thrombosis research

authors： Saito Y,Takabayashi K,Tsukada T,Inada Y

更新日期：1983-04-01 00:00:00

abstract：:Von Willebrand disease (VWD) is classified into three primary subtypes; type 1 includes partial quantitative deficiency, type 2 (A, B, M and N) includes qualitative defects and type 3 includes virtually complete deficiency of von Willebrand factor (VWF). Type 2A includes variants with decreased platelet adhesion cause...

journal_title：Thrombosis research

authors： Lillicrap D

更新日期：2007-01-01 00:00:00

abstract：:A frequent complication of venous access devices (VADs) is axillary-subclavian venous thrombosis. To study this problem we have compared blood drawn through VADs with peripheral blood samples in a group of oncology patients with venographically demonstrated venous damage (N = 14) and a group with normal venograms (N =...

journal_title：Thrombosis research

authors： Horne MK 3rd,Merryman PK,Mayo DJ,Gralnick HR,Chang RC,Alexander HR

更新日期：1995-08-15 00:00:00

abstract：:This paper continues our study (see Part I) where we modeled the spatio-temporal dynamics of the intrinsic pathway of blood coagulation. Here, we analyzed this model and showed that it describes the threshold behavior of coagulation. When activation is subthreshold (which produces not more than 0.07 nM factor XIa at s...

journal_title：Thrombosis research

authors： Zarnitsina VI,Pokhilko AV,Ataullakhanov FI

更新日期：1996-12-01 00:00:00

abstract：:Antithrombin (AT) is a serpin capable of trapping thrombin (IIa) in a stable and covalent complex. Complex formation is prevented by leukocyte elastase (LE) cleavage near the AT reactive centre. We mutated the known LE cleavage sites of AT to explore the possibility of producing an LE-resistant AT molecule. Initially,...

journal_title：Thrombosis research

authors： Cunningham MA,Blajchman MA,Sheffield WP

更新日期：1997-10-15 00:00:00

abstract：:To demonstrate that human alpha-thrombin is effectively inactivated by human antithrombin III (AT) during the production of a fibrin clot we measured the amount of alpha-thrombin activity which can be recovered from a clot generated from purified human proteins. We discovered that 0.05-0.07% of the original alpha-thro...

journal_title：Thrombosis research

authors： Naski MC,Shafer JA

更新日期：1993-03-01 00:00:00

abstract：INTRODUCTION:Retinal vein occlusion is a major cause of ocular morbidity. The precise mechanism leading to thrombosis in retinal vein occlusion has not yet been clearly elucidated. Several risk factors have been identified, including hypertension diabetes, history of cardiovascular disease, hypercholesterolemia, hyperh...

journal_title：Thrombosis research

authors： Leoncini G,Signorello MG,Segantin A,Giacobbe E,Armani U,Piana A,Camicione P

更新日期：2009-12-01 00:00:00

abstract：:In a double-blind, placebo-controlled trial of 40 patients requiring aortocoronary vene transplant surgery, prostacyclin (PGI2) was infused in a dose of 8 ng/kg/min throughout cardiopulmonary bypass. When compared with the placebo-group, the patients treated with PGI2 were found to have significantly higher platelet c...

journal_title：Thrombosis research

authors： Heinrich D,Schleussner E,Wagner WL,Sellmann-Richter R,Hehrlein FW

更新日期：1983-11-15 00:00:00

abstract：BACKGROUND:The quality of treatment with warfarin is mainly assessed by the time in therapeutic range (TTR) in patients with mechanical heart valve prosthesis (MHV). Our aim was to evaluate if International Normalized Ratio (INR) variability predicted a combined endpoint of thromboembolism, major bleeding and death bet...

journal_title：Thrombosis research

authors： Labaf A,Själander A,Stagmo M,Svensson PJ

更新日期：2015-12-01 00:00:00

abstract：:The role of free radical generation and its scavenging enzymes in circulating mice polymorphonuclear leukocytes (PMNLs) has been studied following pulmonary thromboembolism. Levels of malonaldehyde (MDA), 02- radical generation, activity of superoxide dismutase (SOD), catalase (CAT), lactate dehydrogenase (LDH), myelo...

journal_title：Thrombosis research

authors： Dikshit M,Kumari R,Srimal RC

更新日期：1992-05-01 00:00:00

abstract：UNLABELLED:We undertook a survey of French university hospital hematological laboratories to ascertain the clinical characteristics of patients with suspected HIT, the laboratory tests performed, and the therapeutic strategy adopted in current practice. METHODS:A standardized medical records database for patients with...

journal_title：Thrombosis research

authors： Bidet A,Tardy Poncet B,Desprez D,de Maistre E,Presles E,Lecompte T,Lavenu-Bombled C,Huisse MG,Wolf M,Morange P,Racadot E,Mouton C,Grunebaum L,Pouplard C,Tardy B,GEHT-HIT study group.

更新日期：2010-06-01 00:00:00

abstract：:Surviving an embolism exposes patients to potential long-term complications, such as altered quality of life, persistent dyspnea, impaired exercise capacity or pulmonary hypertension. The common objective factor in most of these situations is the presence of residual pulmonary vascular obstruction (RPVO). Planar venti...

journal_title：Thrombosis research

authors： Bonnefoy PB,Margelidon-Cozzolino V,Catella-Chatron J,Ayoub E,Guichard JB,Murgier M,Bertoletti L

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. The inhibition of P2Y12 is used pharmacologically to suppress aggregation underlining the physiological significance of this receptor. Since the regulation of...

journal_title：Thrombosis research

authors： Koessler J,Trulley VN,Bosch A,Weber K,Koessler A,Boeck M,Kobsar A

更新日期：2018-08-01 00:00:00

abstract：:A variant of type II von Willebrand disease (vWd) is described in a young woman and her mother with severe lifelong bleeding histories. On electrophoresis with low-resolution agarose gels the plasma of the proband lacked large and intermediate-size multimers of von Willebrand factor (vWF) but the platelet multimeric s...

journal_title：Thrombosis research

authors： Castaman G,Rodeghiero F,Lattuada A,Mannucci PM

更新日期：1992-02-01 00:00:00

abstract：:Heparin and other antithrombotic drugs besides their anticoagulant action could have a profibrinolytic effect. We have analyzed the effect of unfractionated heparin (UFH) and hirudin on PAI-1 gene expression in human umbilical vein endothelial cells (HUVEC). Cells were stimulated with UFH (1 and 10 IU/ml) and hirudin ...

journal_title：Thrombosis research

authors： Orbe J,Montes R,Zabalegui N,Pérez-Ruiz A,Páramo JA

更新日期：1999-05-01 00:00:00

abstract：:Antithrombin III (AT III) is increased in situations where there is increased platelet turnover. Plasma AT III levels measured in 39 renal transplant recipients were significantly higher than in 20 healthy subjects (p less than 0.001) and 20 patient controls (p less than 0.025). AT III levels were significantly correl...

journal_title：Thrombosis research

authors： Woo KT,Lee EJ,Lau YK,Lim CH

更新日期：1985-05-01 00:00:00

abstract：:When a purified myeloma protein with the ability to inhibit fibrin polymerization was preincubated with sheep anti-human F(ab')2 antibodies, there was a marked reduction of the ability to prolong the thrombin clotting time, while anti-Fc antibodies had only a slight effect. A monoclonal immunoglobulin which shortens t...

journal_title：Thrombosis research

authors： Wisløff F,Michaelsen TE,Kierulf P,Godal HC

更新日期：1985-11-15 00:00:00

abstract：:We examined the effects of verapamil on platelet function. Verapamil (0.5 micrograms/ml) in this study inhibited platelet aggregation induced by threshold amounts of ADP, AA, and epinephrine. With higher concentrations of aggregating stimuli, verapamil caused a dose-dependent inhibition of aggregation. Verapamil reduc...

journal_title：Thrombosis research

authors： Mehta J,Mehta P,Ostrowski N,Crews F

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Cardiovascular mortality is especially low in southwest France (the French Paradox). In previous experimental studies, we found that alcohol-free extracts of armagnac could inhibit human platelet function in vitro and experimental thrombosis in vivo. To test the possible relevance of these findings, we teste...

journal_title：Thrombosis research

authors： Umar A,Depont F,Jacquet A,Lignot S,Segur MC,Boisseau M,Bégaud B,Moore N

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Early aspirin treatment is widely used to inhibit platelet activity and to reduce morbidity and mortality in patients presenting with an acute myocardial infarction or a stroke. A number of different aspirin formulations have been used for this purpose; however, a comparison of their effectiveness in inhibit...

journal_title：Thrombosis research

authors： Schwertner HA,McGlasson D,Christopher M,Bush AC

更新日期：2006-01-01 00:00:00

abstract：:The efficacy and the safety of a new urokinase dosage regimen (loading dose 250,000 IU, initial maintenance dosage 2,000 IU/kg/h in combination with heparin) was studied in ten cases of deep vein thrombosis with regard to the changes of the blood coagulation and fibrinolytic enzyme system. The coagulation analyses dem...

journal_title：Thrombosis research

authors： Schöffel G,Zimmermann R,Harenberg J,Mörl H

更新日期：1982-01-01 00:00:00

abstract：INTRODUCTION:Incidence and risk factors of venous thromboembolism (VTE) are well established in surgical and medical settings, but data in psychiatric units are lacking. The aim of this study was to estimate the incidence of VTE in hospitalized psychiatric patients, and to assess the risk factors for VTE in this specif...

journal_title：Thrombosis research

authors： Delluc A,Montavon S,Canceil O,Carpentier M,Nowak E,Mercier B,Bressollette L,Etienne S,Walter M,Mottier D,Lacut K

更新日期：2012-12-01 00:00:00