Abstract：
OBJECTIVE:The present cohort study was performed to investigate the impact of the factor 5 rs6025 [F5] and the factor 2 rs1799963 [F2] mutations on high-titer inhibitor development [HRI] in patients with severe/moderate-severe hemophilia A [HA]. PATIENTS AND METHODS:216 patients with F8<2% born between 1980 and 2011 were followed after initial HA diagnosis over the first 200 exposure days. The first HA patient per family who presented for diagnosis was included in the present study. RESULTS:32 of 216 children [14.8%] tested for F5/F2 carried either the F5 or the F2 variant. HRI occurred in 14 out of 32F5/F2-carriers compared with 40 of 184 without F5/F2. Multivariate analysis adjusted for F8 genotype, treatment intensity, first-line use of plasma derived FVIII versus recombinant FVIII concentrates revealed that the presence of F5/F2 independently increases the risk of HRI development to odds [OR] of 3.4. Large deletions in the F8 gene [OR: 5.10], patients from Israel [OR: 4.0], the increase of FVIII per one IU/kgbw [OR: 1.05] and birth year [OR: 1.12] were significantly associated with the risk to develop HRI. CONCLUSION:Data presented here suggest that HRI development is of multifactorial origin and that F5 and F2 mutations may contribute to this risk.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Kenet G,Bidlingmaier C,Bogdanova N,Ettingshausen CE,Goldenberg N,Gutsche S,Halimeh S,Holzhauer S,Kurnik K,Limperger V,Junker R,Nowak-Göttl Udoi
10.1016/j.thromres.2014.01.005subject
Has Abstractpub_date
2014-04-01 00:00:00pages
544-9issue
4eissn
0049-3848issn
1879-2472pii
S0049-3848(14)00014-0journal_volume
133pub_type
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