Abstract：
:While the role of platelets in hemostasis is well characterized from a biological perspective, the biophysical interactions between platelets and their mechanical microenvironment are relatively unstudied. The field of cellular mechanics has developed a number of approaches to study the effects of extracellular matrix (ECM)-derived mechanical forces on various cells, and has elucidated that integrin-cytoskeleton-mediated force transduction governs many cellular processes. As platelets adhere and spread via molecular machinery that is similar to that which enables other cells to mechanosense and mechanotransduce forces from their biophysical microenvironment, platelets too are likely governed by the same overarching mechanisms. Indeed, recent platelet mechanobiology studies have revealed that key aspects of platelet physiology and activation are regulated by the mechanical and spatial properties of the ECM microenvironment. At the same time, there are also key differences that make platelets unique in the world of cells-- their size, origin as megakaryocyte fragments, and unique αIIbβ3 integrin-- render their mechanosensing activities particularly interesting. The structurally "simple," anucleate nature of platelets coupled with their high actin concentration (20% of total protein) and integrin density [1] seem to make them ideal for mechanical force generation and transmission. Further studies will enhance our understanding of the role of platelet mechanobiology in hemostasis and thrombosis, potentially leading to new categories of diagnostics that investigate the mechanical properties of clots to determine bleeding risk, as well as therapies that target the mechanotransduction signaling pathway to alter the stability of clots.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Ciciliano JC,Tran R,Sakurai Y,Lam WAdoi
10.1016/j.thromres.2013.12.037subject
Has Abstractpub_date
2014-04-01 00:00:00pages
532-7issue
4eissn
0049-3848issn
1879-2472pii
S0049-3848(13)00623-3journal_volume
133pub_type
杂志文章,评审abstract：:Liquid permeation studies of fibrin gels, which were formed in the presence of thrombin (Fibrin II) and in the presence of Batroxobin (Fibrin I), showed that those gels have distinctly different flow properties. For both gels the permeability coefficient (Ks) and average pore size varied depending on the conditions fo...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(82)90214-6
更新日期：1982-01-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(89)90196-5
更新日期：1989-03-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/S0049-3848(10)70005-0
更新日期：2010-04-01 00:00:00
abstract：:Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failur...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2011.06.024
更新日期：2011-10-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/S0049-3848(12)70013-0
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journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2012.08.262
更新日期：2012-10-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2016.02.020
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2008.11.010
更新日期：2009-05-01 00:00:00
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journal_title：Thrombosis research
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Thrombosis research
pub_type： 杂志文章,评审
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更新日期：2000-05-01 00:00:00
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journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00383-2
更新日期：2001-01-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
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更新日期：2002-09-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2010.06.009
更新日期：2010-09-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(83)90238-4
更新日期：1983-04-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章,meta分析
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更新日期：2006-01-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章,评审
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(89)90250-8
更新日期：1989-11-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90233-z
更新日期：1992-01-15 00:00:00
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更新日期：2007-01-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(89)90113-8
更新日期：1989-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Thrombosis research
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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pub_type： 杂志文章
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(97)00104-7
更新日期：1997-07-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90283-g
更新日期：1992-05-15 00:00:00
abstract：INTRODUCTION:Global clotting assays may reflect an individual's net hemostatic balance and could contribute to prothrombotic and hemorrhagic risk assessment. In this research, a global assay that measures both coagulation and fibrinolytic capacities was developed and investigated. MATERIALS AND METHODS:In the Clot For...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2004.12.009
更新日期：2005-01-01 00:00:00
