Tests predictive of thrombosis in cancer.

abstract：BACKGROUND:Coagulopathy is a major cause of early death when arsenic trioxide (As(2)O(3)) therapy fails. In addition to the procoagulant properties of blast cells, the cytotoxic therapy may contribute to the coagulation disorders. The aim of the present study was to evaluate the possible impact of As(2)O(3) on membrane...

journal_title：Thrombosis research

authors： Zhou J,Li H,Fu Y,Shi J,Hou J,Zhang Y,Liu X,Song P

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the eNOS3 gene on chromosome 7. The effects of the eNOS polymorphisms with the risk of coronary artery disease are conflicting. In this study, we investigated the association of the e...

journal_title：Thrombosis research

authors： Kim IJ,Bae J,Lim SW,Cha DH,Cho HJ,Kim S,Yang DH,Hwang SG,Oh D,Kim NK

更新日期：2007-01-01 00:00:00

abstract：:Activated factor X (FXa) and thrombin can up-regulate gene expression of connective tissue growth factor (CTGF/CCN2) on fibroblasts. Since tissue factor (TF) is expressed on these cells, we hypothesized that they may assemble the prothrombinase complex leading to CTGF/CCN2 upregulation. In addition, the effect of thro...

journal_title：Thrombosis research

authors： Rico MC,Rough JJ,Manns JM,Del Carpio-Cano F,Safadi FF,Kunapuli SP,DeLa Cadena RA

更新日期：2012-06-01 00:00:00

abstract：:Cancer is frequently associated with activation of blood coagulation, which in turn has been suggested to promote tumor growth and metastasis. Indeed, low molecular weight heparin treatment significantly prolongs the survival of a wide variety of patients with cancer. Based on this notion that anticoagulant treatment ...

journal_title：Thrombosis research

authors： Spek CA,Arruda VR

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Viscoelastometry enables rapid evaluation of coagulopathy in settings such as cardiac surgery but may be influenced by red cell concentration. METHODS:In order to study the effects of supra-physiological red cell concentrations on viscoelastometry, we compared ROTEM® viscoelastometry and plasma coagulatio...

journal_title：Thrombosis research

authors： Westbury SK,Lee K,Reilly-Stitt C,Tulloh R,Mumford AD

更新日期：2013-08-01 00:00:00

abstract：:To estimate the effect of dilazep in preventing restenosis after a transluminal angioplasty, we have attempted an animal experiment in which the efficacy of drug was tested on an angioplastic injury superimposed on to atherosclerotic lesions. Using a modification of Block's method, atherosclerotic lesions first were m...

journal_title：Thrombosis research

authors： Nobuyoshi M,Tanaka M,Fujii M,Asanuma A,Takimoto M

更新日期：1989-06-15 00:00:00

abstract：INTRODUCTION:Changes in platelet count and function contribute to thrombo-hemorrhagic episodes in chronic myeloproliferative syndromes (MPS). We used flow cytometry to study platelet-leukocyte conjugates and markers of platelet activation in patients with MPS. METHODS:Whole blood from patients with chronic myelogenous...

journal_title：Thrombosis research

authors： Villmow T,Kemkes-Matthes B,Matzdorff AC

更新日期：2002-11-01 00:00:00

abstract：:Anticoagulant therapy for the typical venous thromboembolism patient is straightforward with predictably favorable outcomes. However, for certain patients with venous thromboembolism, there remains uncertainty and controversy about optimal treatment. These controversial areas include venous thromboembolism patients wi...

journal_title：Thrombosis research

authors： Rondina MT,Pendleton RC,Wheeler M,Rodgers GM

更新日期：2007-01-01 00:00:00

abstract：:Thirty-four derivatives of benzamidine were tested for their inhibitory activities on bovine and human thrombins using the chromogenic peptide substrate N-D-Phe-Pip-Arg-pNA. The inhibition constants of small molecular size inhibitors of comparatively low affinity as well as those of tight binding inhibitors did not di...

journal_title：Thrombosis research

authors： Stürzebecher J,Walsmann P,Voigt B,Wagner G

更新日期：1984-12-01 00:00:00

abstract：:A rapid method is described for the production of a human marrow cell suspension highly enriched in megakaryocytes. These concentrates were incubated with radiolabelled amino-acids, and cell lysates were then analysed for fibrinogen synthesis. Neosynthesized proteins were detected by immunoprecipitation, immuno-affini...

journal_title：Thrombosis research

authors： Belloc F,Hourdille P,Fialon P,Boisseau MR,Soria J

更新日期：1985-05-15 00:00:00

abstract：:The present investigation has used an aggregation-disaggregation-reaggregation model to determine if exposure to potent aggregating agents causing a refractory state in deaggregated platelets results in down-regulation and clearance of GPIb/IX, the receptor for von willebrand factor. Thrombin, the thrombin receptor ac...

journal_title：Thrombosis research

authors： White JG,Rao GH

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:Deep vein thrombosis (DVT) is a common multi-factorial disease with a partially understood aetiology. Although the roles of high factor (F)VIII and von Willebrand factor (VWF) levels are recognized, that of ADAMTS13 is still unclear. AIM:To assess the association between ADAMTS13 activity levels, VWF antige...

journal_title：Thrombosis research

authors： Pagliari MT,Boscarino M,Cairo A,Mancini I,Martinelli I,Bucciarelli P,Rossi F,Rosendaal FR,Peyvandi F

更新日期：2021-01-01 00:00:00

abstract：:Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failur...

journal_title：Thrombosis research

authors： Stevic I,Chan HH,Chan AK

更新日期：2011-10-01 00:00:00

abstract：:Endothelial cells from human umbilical vein were incubated in vitro with thrombin in the absence or presence of unfractionated heparin (UFH), low molecular weight heparin (LMWH) or dermatan sulfate (DS) to clarify the effect of these glycosaminoglycans on thrombin-stimulated prostaglandin I2 (PGI2) production. Althoug...

journal_title：Thrombosis research

authors： Itoh F,Kaji T,Hayakawa Y,Oguma Y,Sakuragawa N

更新日期：1990-02-15 00:00:00

abstract：OBJECTIVES:Elevated plasma homocysteine has been implicated as a risk factor for hypertension. C677T polymorphism in methylenetetrahydrofolate reductase gene (MTHFR) is a major determinant of hyperhomocysteinemia, which results in endothelial dysfunction. Angiotensin-converting enzyme (ACE) inhibitors appear to remedy ...

journal_title：Thrombosis research

authors： Jiang S,Hsu YH,Xu X,Xing H,Chen C,Niu T,Zhang Y,Peng S,Xu X

更新日期：2004-01-01 00:00:00

abstract：:Normal haemostasis requires maintenance of a careful equilibrium between the necessity to clot when bleeding and the retention of fluid phase at all other times. Disruption of this equilibrium can result in catastrophic outcomes, e.g. acute myocardial infarction and pulmonary embolism. However, despite the significant...

journal_title：Thrombosis research

authors： Lim HY,O'Malley C,Donnan G,Nandurkar H,Ho P

更新日期：2019-07-01 00:00:00

abstract：:In this paper, we demonstrated that the procoagulant action of Lonomia achelous (Cramer) is due in part to a component that activates prothrombin. The activation by crude venom and Fractions obtained by gel filtration on Sephadex G-75 is not dependent of phospholipid, Ca++ or Factor V. The activation of prothrombin by...

journal_title：Thrombosis research

authors： Guerrero B,Arocha-Piñango CL

更新日期：1992-05-01 00:00:00

abstract：:Antithrombin (AT) is a serpin capable of trapping thrombin (IIa) in a stable and covalent complex. Complex formation is prevented by leukocyte elastase (LE) cleavage near the AT reactive centre. We mutated the known LE cleavage sites of AT to explore the possibility of producing an LE-resistant AT molecule. Initially,...

journal_title：Thrombosis research

authors： Cunningham MA,Blajchman MA,Sheffield WP

更新日期：1997-10-15 00:00:00

abstract：INTRODUCTION:Pregnancy has recently been described as a generalized intravascular inflammatory response to the conceptus. Total fibrinogen concentrations increase during pregnancy. The percentage high molecular weight fibrinogen (HMW-Fg) of the concentration total fibrinogen is known to increase during acute-phase cond...

journal_title：Thrombosis research

authors： Manten GT,Franx A,Sikkema JM,Hameeteman TM,Visser GH,de Groot PG,Voorbij HA

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Time in therapeutic range (TTR) for international normalized ratio (INR) is an accepted quality measure of anticoagulation control in patient populations, but its usefulness for predicting stroke and bleeding in individuals is not well understood. MATERIALS AND METHODS:In a nested case control analysis am...

journal_title：Thrombosis research

authors： Nieuwlaat R,Connolly BJ,Hubers LM,Cuddy SM,Eikelboom JW,Yusuf S,Connolly SJ,ACTIVE Investigators.

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Clauss fibrinogen assay (CFA) is widely used as a screening test to detect fibrinogen disorders. However, CFA alone cannot distinguish quantitative and qualitative defects because it depends on functional fibrinogen activity (Ac), and fibrinogen antigen (Ag) determination is required to classify fibrinogen d...

journal_title：Thrombosis research

authors： Suzuki A,Suzuki N,Kanematsu T,Shinohara S,Arai N,Kikuchi R,Matsushita T

更新日期：2019-02-01 00:00:00

abstract：:We characterized the antithrombotic, haemorrhagic, and ex vivo anticoagulant effects of a recently identified depolymerized holothurian glycosaminoglycan (DHG), and compared these effects with those of unfractionated heparin (UFH), low molecular weight heparin (LMWH), and dermatan sulfate (DS). In thrombin-induced ven...

journal_title：Thrombosis research

authors： Kitazato K,Kitazato KT,Nagase H,Minamiguchi K

更新日期：1996-10-15 00:00:00

abstract：PURPOSE:Due to its specific pharmacokinetic profile, tinzaparin, a low-molecular-weight heparin (LMWH), appears not to be associated with anti-factor Xa accumulation. Our meta-analysis aimed at determining whether long-term curative doses of tinzaparin is a valuable alternative to vitamin K antagonists (VKA) for the tr...

journal_title：Thrombosis research

authors： Laporte S,Bertoletti L,Romera A,Mismetti P,Pérez de Llano LA,Meyer G

更新日期：2012-12-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of tissue factor (thromboplastin), the initiating factor of the extrinsic clotting system, on angiogenesis in vivo and in vitro. In vivo angiogenesis was examined using a diffusion chamber assay in rats. After a week of implantation of the diffusion chambers con...

journal_title：Thrombosis research

authors： Watanabe T,Yasuda M,Yamamoto T

更新日期：1999-11-01 00:00:00

abstract：:Ethanol (88-880 mmol/l) inhibited the formation of proaggregatory, vasoconstricting thromboxane A2 (TxA2) during whole blood clotting and during thrombin-induced aggregation of platelet rich plasma. This inhibition was counteracted by the addition of exogenous arachidonic acid, which suggested that ethanol suppressed ...

journal_title：Thrombosis research

authors： Toivanen J,Ylikorkala O,Viinikka L

更新日期：1984-01-01 00:00:00

abstract：:Effects of Ca2+ on phospholipid methylation in rabbit platelet membranes were studied using S-adenosyl-L-[3H-methyl]methionine as a substrate. The methylation was inhibited to 30% of the basal activity with 100 microM Ca2+. The inhibition was completely counteracted by various calmodulin antagonists. Their concentrati...

journal_title：Thrombosis research

authors： Taniguchi S,Mori K,Hayashi H,Fujiwara M,Fujiwara M

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Use of antiplatelet therapy in combination with oral anticoagulants remains controversial. The purpose of this article is to review current consensus recommendations for antithrombotic therapy, to evaluate risks for bleeding among patients taking combination antithrombotic therapy, and lastly to review singl...

journal_title：Thrombosis research

authors： Johnson S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Brain tumor patients have an increased risk of venous thromboembolism (VTE). An important role in cancer-related VTE has been suggested for tissue factor (TF), the main initiator of the coagulation cascade. We conducted a prospective cohort study to determine whether expression levels of TF in brain tumors a...

journal_title：Thrombosis research

authors： Thaler J,Preusser M,Ay C,Kaider A,Marosi C,Zielinski C,Pabinger I,Hainfellner JA

更新日期：2013-02-01 00:00:00

abstract：:Heparin cofactor II (HCII) is a specific thrombin inhibitor; its inhibitory activity is stimulated by heparin (Hep) and dermatan sulfate (DS). Vitronectin (VN), a heparin binding adhesive glycoprotein present in plasma and extracellular matrix, has been shown to decrease the stimulatory effect of Hep but not of DS on ...

journal_title：Thrombosis research

authors： Petzelbauer E,Seiffert D,Beckmann R,Pusch B,Geiger M,Binder BR

更新日期：1992-06-01 00:00:00

abstract：:Pulmonary embolism (PE) is a common, lethal yet treatable disease. The clinical diagnosis of PE remains to be a problem due to the nonspecific presenting signs, symptoms, electrocardiographic findings, arterial blood gas abnormalities and chest X-ray changes. Despite these nonspecific clinical findings, clinicians are...

journal_title：Thrombosis research

authors： Rodger M,Wells PS

更新日期：2001-09-15 00:00:00