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Activation of human prothrombin by the venom of Lonomia achelous (Cramer) caterpillars.

Abstract：

:In this paper, we demonstrated that the procoagulant action of Lonomia achelous (Cramer) is due in part to a component that activates prothrombin. The activation by crude venom and Fractions obtained by gel filtration on Sephadex G-75 is not dependent of phospholipid, Ca++ or Factor V. The activation of prothrombin by Fraction I is greatly stimulated by Factor V in the presence of phospholipid and Ca++; in presence of SBTI, we found that the Fraction I and Factor Xa act in a similar manner. These results suggest that the Fraction I is a Factor Xa - like prothrombin activator.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Guerrero B,Arocha-Piñango CL

doi

10.1016/0049-3848(92)90187-f

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

169-77

issue

2-3

eissn

0049-3848

issn

1879-2472

pii

0049-3848(92)90187-F

journal_volume

66

pub_type

杂志文章

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