当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Antithrombotic actions of selective inhibitors of blood coagulation factor Xa in rat models of thrombosis.

Antithrombotic actions of selective inhibitors of blood coagulation factor Xa in rat models of thrombosis.

Abstract：

:The antithrombotic actions of selective factor Xa (FXa) inhibitors, recombinant tick anticoagulant peptide (rTAP) and DX-9065a, were evaluated in experimental thrombosis models in anesthetized rats. In the first model, thrombosis was induced by exposing flowing blood to a silk thread anchored in an arteriovenous (AV) shunt. rTAP, DX-9065a and heparin, given as an iv infusion 1 hr before blood was circulated in the AV shunt, had ID50s of 0.007, 0.6 mumol/kg/hr and 16 U/kg/hr, respectively. In the model of venous thrombosis which was induced by hypotonic saline (0.225%) followed by 15-min stasis of abdominal vena cava, rTAP and heparin had ID50s of 0.007 mumol/kg/hr and 3.5 U/kg/hr, respectively. In both models, full inhibition of thrombus formation was achieved with FXa inhibition at doses which only modestly increased ex vivo plasma clotting time APTT (1.26 to 1.82 over the baseline). By contrast, the maximum antithrombotic effect of heparin was associated with high and significant APTT prolongation (> 5 fold over the baseline). Therefore, our study suggests that FXa inhibitors are effective agents in preventing thrombosis in both rat thrombosis models and may have therapeutic antithrombotic potential.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Wong PC,Crain EJ Jr,Nguan O,Watson CA,Racanelli A

doi

10.1016/0049-3848(96)00112-0

subject

Has Abstract

pub_date

1996-07-15 00:00:00

pages

117-26

issue

2

eissn

0049-3848

issn

1879-2472

pii

0049-3848(96)00112-0

journal_volume

83

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Rho-kinase inhibitor treatment prevents pulmonary inflammation and coagulation in lipopolysaccharide-induced lung injury.

    abstract：INTRODUCTION:In the pathogenesis of sepsis-induced acute lung injury (ALI), the crosstalk between inflammation and coagulation plays a pivotal role. The aim of this study was to investigate the role of Rho kinase (ROCK) inhibitor in alleviating pulmonary inflammation and coagulation in lipopolysaccharide (LPS)-induced ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2016.12.020

    authors： Ding R,Zhao D,Li X,Liu B,Ma X

    更新日期：2017-02-01 00:00:00

  • Autoimmune hemolytic anemia and venous thromboembolism: A systematic review and meta-analysis.

    abstract：OBJECTIVE:To investigate the risk of venous thromboembolism (VTE) among patients with autoimmune hemolytic anemia (AIHA). METHODS:We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing the risk of VTE i...

    journal_title：Thrombosis research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.thromres.2015.09.004

    authors： Ungprasert P,Tanratana P,Srivali N

    更新日期：2015-11-01 00:00:00

  • Hyperhomocysteinemia and venous thromboembolism: a risk factor more prevalent in the elderly and in idiopathic cases.

    abstract：:Fasting plasma homocysteine level and the related clinical findings were analysed in 240 consecutive patients with venous thromboembolism. Hyperhomocysteinemia, defined as a plasma level above 20 micromol/l (corresponding to the percentile 95th in the controls), was present in 11.2% of the patients. Plasma homocystein...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(02)00096-8

    authors： Hainaut P,Jaumotte C,Verhelst D,Wallemacq P,Gala JL,Lavenne E,Heusterspreute M,Zech F,Moriau M

    更新日期：2002-04-15 00:00:00

  • Alloxan-induced hyperglycemia in rabbits and the response of platelets to aggregating agents in vitro and to exposed subendothelium in vivo.

    abstract：:Many patients with diabetes mellitus show increased platelet aggregation and prostaglandin synthesis in response to physiological agents such as ADP and collagen when their platelets are tested in platelet-rich plasma or washed platelet suspensions. However, the relationship between increased platelet aggregation in v...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90265-9

    authors： Ingerman-Wojenski CM,Smith M,Silver MJ

    更新日期：1987-06-01 00:00:00

  • Thrombin-activatable fibrinolysis inhibitor antigen and TAFI activity in patients with APC resistance caused by factor V Leiden mutation.

    abstract：:Thrombin-activatable fibrinolysis inhibitor (TAFI), also known as procarboxypeptidase U or plasma procarboxypeptidase B, is a relatively recently described plasma glycoprotein synthesised in the liver. It can be activated into active enzyme TAFIa (carboxypeptidase U or plasma carboxypeptidase B) by a complex of thromb...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(02)00072-5

    authors： Antovic JP,Blombäck M

    更新日期：2002-04-01 00:00:00

  • Increased expression of thrombomodulin on the cultured human umbilical vein endothelial cells and mouse hemangioma cells by cyclic AMP.

    abstract：:We previously reported that the expression of thrombomodulin on the MEG-01, a cell line from human megakaryoblastic leukemia, was increased by agents that increase intracellular cAMP. In this paper we examine the effect of these agents on cultured human umbilical vein endothelial cells (HUVEC) and mouse hemangioma cel...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(91)90107-8

    authors： Maruyama I,Soejima Y,Osame M,Ito T,Ogawa K,Yamamoto S,Dittman WA,Saito H

    更新日期：1991-02-01 00:00:00

  • Effects of low molecular weight heparin on a severely antithrombin III-decreased disseminated intravascular coagulation model in rabbits.

    abstract：:The effect of dalteparin, a low molecular weight heparin, on severely antithrombin III (ATIII)-decreased disseminated intravascular coagulation (DIC) model was compared with that of unfractionated heparin (heparin). The DIC model in rabbits was produced by continuous infusion of thrombin in combination with bolus inje...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)00191-s

    authors： Tazawa S,Ichikawa K,Misawa K,Fukuyama J,Hamano S,Miyata H,Sakuragawa N

    更新日期：1995-12-01 00:00:00

  • Production of a recombinant antithrombotic and fibrinolytic protein, PLATSAK, in Escherichia coli.

    abstract：:The three main components involved in thrombosis and haemostasis are thrombin, platelets, and plasmin. Almost all inhibitors of thrombosis are focused either on the inhibition of thrombin or on the inhibition of platelets. We designed a construct using the fibrinolytic activity of staphylokinase, fused via a cleavable...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(97)00277-6

    authors： van Zyl WB,Pretorius GH,Hartmann M,Kotzé HF

    更新日期：1997-12-01 00:00:00

  • Subcutaneous treatment of deep venous thrombosis with low molecular weight heparin. A dose finding study with LMWH-Novo.

    abstract：:Treatment of deep venous thrombosis with low molecular weight heparin (LMWH-Novo, Logiparin) was carried out with two different doses of Logiparin, 75 XaI U/kg b.w. twice daily and 150 XaI U/kg b.w. once daily subcutaneously for 5 days. Simultaneously warfarin was given from the first day of heparin treatment. Mean ag...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0049-3848(89)90307-1

    authors： Siegbahn A,Y-Hassan S,Boberg J,Bylund H,Neerstrand HS,Ostergaard P,Hedner U

    更新日期：1989-09-15 00:00:00

  • Fluorescent labeling of blood platelets in vivo.

    abstract：:In rabbits, a clear microscopic image of individual, fluorescent blood platelets flowing in a mesenteric microvessel could be obtained over the whole cross-sectional area of the vessel, following an intravenous injection of a solution containing 5-15 mg of the fluorochrome Acridine Red. Most of the circulating platele...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90106-2

    authors： Tangelder GJ,Slaaf DW,Reneman RS

    更新日期：1982-12-15 00:00:00

  • Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways.

    abstract：:This study investigates the effect on human platelet function of two sesquiterpene lactones from Arnica montana L., helenalin (H) and 11 alpha,13-dihydrohelenalin (DH). Both compounds inhibited collagen-induced platelet aggregation, thromboxane formation and 5-hydroxytryptamine secretion in a concentration-dependent m...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90151-2

    authors： Schröder H,Lösche W,Strobach H,Leven W,Willuhn G,Till U,Schrör K

    更新日期：1990-03-15 00:00:00

  • Knockdown of liver-derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function.

    abstract：BACKGROUND:Plasma coagulation Factor XII (FXII) plays a crucial role in contact activation, ultimately regulating both the kinin-kallikrein system and the intrinsic pathway of coagulation. A growing body of evidence suggests that inhibition of FXII can prevent thrombosis. Given FXII does not appear to modulate hemostas...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2020.08.040

    authors： Liu J,Cooley BC,Akinc A,Butler J,Borodovsky A

    更新日期：2020-12-01 00:00:00

  • Effectiveness of alternative treatments for reducing potential viral contaminants from plasma-derived products.

    abstract：:An issue of great importance and continuing concern with regard to all products derived from human plasma is their safety from potential contaminants in the source material from which they are purified. Since viral contaminants are a major safety consideration with these products, a number of different methods, includ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/s0049-3848(02)00044-0

    authors： Chandra S,Groener A,Feldman F

    更新日期：2002-03-01 00:00:00

  • Intercellular transport through a partially denuded arterial endothelial monolayer. Effect of platelets and PGI2.

    abstract：:Fluorescein Dextran (FD) was shown to be transported at increased rates through partially denuded endothelial monolayer. Platelet binding to the partially denuded monolayer lowered transport rates to those comparable with intact endothelium. Inhibition of transport by platelet binding was not affected by the addition ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90191-c

    authors： Yagyu Y,Mineo C,Imanaka T,Ikegami S,Takano T

    更新日期：1992-05-01 00:00:00

  • Laboratory evaluation of the Coasys® Plus C coagulation analyzer.

    abstract：INTRODUCTION:The Coasys® Plus C (Behnk Elektronik, distributed by Roche Diagnostics) is a coagulation analyzer for small to midsize clinical chemistry laboratories. We performed a laboratory evaluation. MATERIALS AND METHODS:After a familiarization period the dead volume, carry-over, capacity, within-assay reproducibi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.02.004

    authors： de Bie P,Schornagel WJ,van den Dool EJ,Bakker B,van Dam W,Heckman M,Ağar C,Sturk A,Stroobants AK

    更新日期：2013-04-01 00:00:00

  • Real-world incidence of cancer following a first unprovoked venous thrombosis: Results from the EPIGETBO study.

    abstract：BACKGROUND:Venous thromboembolism (VTE) can be the first manifestation of cancer; however, the current incidence of malignancy in unselected patients with first unprovoked VTE needs to be confirmed. MATERIAL AND METHODS:Between March 1st, 2013 and February 28th, 2015 we included and followed-up all patients living in ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.02.151

    authors： Delluc A,Ianotto JC,Tromeur C,De Moreuil C,Couturaud F,Lacut K,Le Moigne E,Louis P,Thereaux J,Metges JP,Mottier D

    更新日期：2018-04-01 00:00:00

  • Inhibition of red blood cell-induced platelet aggregation in whole blood by a nonionic surfactant, poloxamer 188 (RheothRx injection).

    abstract：:RheothRx Injection, an aqueous solution of a nonionic block copolymer (poloxamer 188) formulated for intravenous administration, was investigated as an inhibitor of red blood cell (RBC)-induced platelet aggregation at plasma concentrations of 0.05-5mgmL-1. Platelet aggregation was determined by measuring the fall in s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)00134-d

    authors： Armstrong JK,Meiselman HJ,Fisher TC

    更新日期：1995-09-15 00:00:00

  • Effect of warfarin on intracranial hemorrhage incidence and fatal outcomes.

    abstract：INTRODUCTION:Avoiding intracranial hemorrhage (ICH) during warfarin therapy is critical but little is known about factors that affect warfarin-related ICH outcomes. We aimed to define the impact of warfarin on ICH incidence rates and to identify baseline clinical characteristics of patients who experienced ICH and fact...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.10.024

    authors： Witt DM,Delate T,Hylek EM,Clark NP,Crowther MA,Dentali F,Ageno W,Martinez KD,Garcia DA

    更新日期：2013-01-01 00:00:00

  • Stable thrombus formation on irradiated microvascular endothelial cells under pulsatile flow: Pre-testing annexin V-thrombin conjugate for treatment of brain arteriovenous malformations.

    abstract：BACKGROUND:Our goal is to develop a vascular targeting treatment for brain arteriovenous malformations (AVMs). Externalized phosphatidylserine has been established as a potential biomarker on the endothelium of irradiated AVM blood vessels. We hypothesize that phosphatidylserine could be selectively targeted after AVM ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.05.016

    authors： Subramanian S,Ugoya SO,Zhao Z,McRobb LS,Grau GE,Combes V,Inglis DW,Gauden AJ,Lee VS,Moutrie V,Santos ED,Stoodley MA

    更新日期：2018-07-01 00:00:00

  • Effectiveness of vitamin K in anticoagulation reversal for hip fracture surgery--a prospective observational study.

    abstract：INTRODUCTION:Vitamin K antagonists are often used for anticoagulant treatment in hip fracture patients. The optimal handling with such anticoagulants is unclear. We aimed to determine when anticoagulation reversal occurred after vitamin K administration and how often prothrombin complex concentrates (PCCs) were adminis...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.10.031

    authors： Buecking B,Eschbach D,Bliemel C,Oberkircher L,Struewer J,Ruchholtz S,Sachs UJ

    更新日期：2014-01-01 00:00:00

  • A review of global coagulation assays - Is there a role in thrombosis risk prediction?

    abstract：:Normal haemostasis requires maintenance of a careful equilibrium between the necessity to clot when bleeding and the retention of fluid phase at all other times. Disruption of this equilibrium can result in catastrophic outcomes, e.g. acute myocardial infarction and pulmonary embolism. However, despite the significant...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2019.04.033

    authors： Lim HY,O'Malley C,Donnan G,Nandurkar H,Ho P

    更新日期：2019-07-01 00:00:00

  • Markers of hemostatic system activation during treatment of deep vein thrombosis with subcutaneous unfractionated or low-molecular weight heparin.

    abstract：:Prothrombin fragments (F1+2), thrombin-antithrombin complexes (TAT) and D-dimers, markers of hemostatic system activation, were measured in 59 consecutive patients with deep vein thrombosis (DVT). Patients were randomly treated either with subcutaneous unfractionated heparin (UH) administered in two to three subcutane...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0049-3848(02)00023-3

    authors： Peternel P,Terbizan M,Tratar G,Bozic M,Horvat D,Salobir B,Stegnar M

    更新日期：2002-02-01 00:00:00

  • Identification of the 1.4 kb and 4.0 kb messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein.

    abstract：:Lipoprotein-Associated Coagulation Inhibitor (LACI) is a factor Xa dependent inhibitor of the factor VII(a)/Tissue Factor catalytic complex. Deduced from partial cDNA sequence, LACI's amino acid sequence has recently been reported. Northern blot analysis showed LACI cDNA hybridizes to RNAs of 1.4 and 4.0 kb in size. T...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90454-4

    authors： Girard TJ,Warren LA,Novotny WF,Bejcek BE,Miletich JP,Broze GJ Jr

    更新日期：1989-07-01 00:00:00

  • Clinical evaluation of a pasteurized factor XIII concentrate administration in Henoch-Schönlein purpura. Japanese Pediatric Group.

    abstract：:Arthral, abdominal and renal symptoms in Henoch-Schönlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/0049-3848(89)90284-3

    authors： Fukui H,Kamitsuji H,Nagao T,Yamada K,Akatsuka J,Inagaki M,Shike S,Kobayashi Y,Yoshioka K,Maki S

    更新日期：1989-12-15 00:00:00

  • Stable expression of native Coagulation factor VIII using the 2A self-processing sequence and furin cleavage site.

    abstract：:Hemophilia A is an X-linked recessive bleeding disorder, widely prevalent throughout the world, for which, replacement therapy is the current treatment done by infusion of either recombinant FVIII or human plasma derived FVIII. The expression of FVIII is limited by many aspects, bioengineered FVIII with increased the ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2011.07.015

    authors： He B,Pan Y,Chen L,Xu Y,Chen N,Gu L,Nie Z,Wang S,Liu Z

    更新日期：2011-12-01 00:00:00

  • Blood rheology during chemotherapy in patients with ovarian cancer.

    abstract：:The use of platinum based chemotherapy in ovarian malignancy and other cancer types is known to be associated with deep vein thrombosis. In a prospective study of 47 patients with ovarian cancer of International Federation of Gynecology and Obstetrics stage Ib-IV, serial rheological parameters were determined (plasma ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(98)00022-x

    authors： von Tempelhoff GF,Niemann F,Schneider DM,Kirkpatrick CJ,Hommel G,Heilmann L

    更新日期：1998-04-15 00:00:00

  • Studies on the anticoagulant action of Aspilia africana.

    abstract：:An anticoagulant activity was identified and isolated from the leaves of a West African plant, Aspilia africana by gel filtration on Sephadex G-100. The anticoagulant factor had an apparent molecular weight of approximately 60,000 d. Upon incubation with plasma, it prolonged the partial thromboplastin time, prothrombi...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90455-5

    authors： Hanna MM,Niemetz J

    更新日期：1987-08-15 00:00:00

  • Tests predictive of thrombosis in cancer.

    abstract：:There is a close interrelation between cancer and haemostasis, which is characterized by changes in the haemostatic system, mostly an activation of coagulation in cancer patients. Venous thromboembolism (VTE) is a frequent complication of cancer and in particular of anticancer therapy and is associated with significan...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/S0049-3848(10)70005-0

    authors： Ay C,Pabinger I

    更新日期：2010-04-01 00:00:00

  • New families with von Willebrand disease type 2M (Vicenza).

    abstract：:The variant von Willebrand disease (vWd) variant type 2M (Vicenza) was identified in 13 patients of 7 unrelated families. 11 patients were from different parts of germany and 2 patients from Turkey. Hitherto this variant of vWd has been described only in two families originating from the province of Vicenza in Norther...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(97)00104-7

    authors： Zieger B,Budde U,Jessat U,Zimmermann R,Simon M,Kätzel R,Sutor AH

    更新日期：1997-07-01 00:00:00

  • Determinants of left atrial thrombus or spontaneous echo contrast in nonvalvular atrial fibrillation.

    abstract：BACKGROUND:The CHADS2 and CHA2DS2-VASc scores are well-established clinical scales to estimate the risk of stroke in patients with atrial fibrillation (AF). However, the predictive power of the two scales concerning left atrial thrombus (LAT) or spontaneous echo contrast (SEC) has not been well investigated. Therefore,...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2020.07.055

    authors： Han D,Chu Y,Wu Y,Wang X

    更新日期：2020-11-01 00:00:00