当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Laboratory evaluation of the Coasys® Plus C coagulation analyzer.

Laboratory evaluation of the Coasys® Plus C coagulation analyzer.

Abstract：

INTRODUCTION:The Coasys® Plus C (Behnk Elektronik, distributed by Roche Diagnostics) is a coagulation analyzer for small to midsize clinical chemistry laboratories. We performed a laboratory evaluation. MATERIALS AND METHODS:After a familiarization period the dead volume, carry-over, capacity, within-assay reproducibility and imprecision were determined for the tests aPTT (STA APTT en STA Cephascreen), PT (STA Neoplastin Plus, STA Neoplastin R), INR (Hepato Quick), fibrinogen (STA Fibrinogen), antithrombin (Antithrombin III) and D-Dimer (Tina-quant D-Dimer Gen.2). A precision test and patient comparison with a STA-R Evolution® system were performed for aPTT (STA Cephascreen), PT (STA Neoplastin R), fibrinogen, antithrombin and D-Dimer. RESULTS:No carry-over was detected. The analyzer performed on average 66 measurements per hour. Within-assay reproducibility (% with normal/abnormal/extreme result): STA APTT 2.4/1.7/2.7; aPTT Cephascreen 1.4/3.1/1.8; PT Neoplastin Plus 1.2/2.1/1.7; PT Neoplastin R 2.3/-/3.1; INR Hepato Quick 0.6/0.9/1.9; fibrinogen 4.8/3.0/4.5; antithrombin 1.3/4.1/3.8; D-Dimer 19.9/4.3/4.3. Total imprecision (% with control 1/control 2/human pooled plasma): STA APTT 3.1/1.4/2.1; APTT Cephascreen 2.3/2.6/2.0; PT Neoplastin Plus 3.3/1.3/4.1; PT Neoplastin R 3.7/4.0/3.5; INR Hepato Quick 1.5/4.3/1.4; fibrinogen 3.4/5.8/8.1; antithrombin 3.0/6.4/2.4; D-Dimer 4.6/2.2/30.3. The correlation between the Coasys® Plus C and the STA-R Evolution® was good for aPTT, PT, antithrombin and fibrinogen. Some differences were observed for extreme deviant results for fibrinogen. For the analysis of D-Dimer, no sufficient correlation was found between the two analyzers. CONCLUSIONS:The Coasys® Plus C analyzer is fast, easy to handle and safe for the personnel. Its analytical performance makes it suitable for use in a clinical chemistry laboratory.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

de Bie P,Schornagel WJ,van den Dool EJ,Bakker B,van Dam W,Heckman M,Ağar C,Sturk A,Stroobants AK

doi

10.1016/j.thromres.2013.02.004

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

357-62

issue

4

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(13)00047-9

journal_volume

131

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • The effect of calcium ionophore A23187 on tissue factor activity and mRNA in endothelial cells.

    abstract：:Tissue factor (TF) is an integral membrane glycoprotein that serves as a cofactor for blood coagulation factor VIIa. The induction of TF on the surface of endothelial cells is initiated by various kinds of stimuli including lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90002-7

    authors： Wakita K,Stearns-Kurosawa DJ,Marumoto Y

    更新日期：1994-04-15 00:00:00

  • Effect of pulmonary thromboembolism on circulating neutrophils in mice.

    abstract：:The role of free radical generation and its scavenging enzymes in circulating mice polymorphonuclear leukocytes (PMNLs) has been studied following pulmonary thromboembolism. Levels of malonaldehyde (MDA), 02- radical generation, activity of superoxide dismutase (SOD), catalase (CAT), lactate dehydrogenase (LDH), myelo...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90183-b

    authors： Dikshit M,Kumari R,Srimal RC

    更新日期：1992-05-01 00:00:00

  • Fibrinolysis as a feature of disseminated intravascular coagulation (DIC) after Pseudonaja textilis textilis envenomation.

    abstract：:Blood was obtained from four patients envenomated by the Australian common brown snake, Pseudonaja textilis textilis. This elapid snake has one of the most toxic venoms in the world, containing extremely potent neurotoxic and coagulant components. The latter is a potent complete prothrombinase, converting prothrombin ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90399-w

    authors： Masci PP,Rowe EA,Whitaker AN,de Jersey J

    更新日期：1990-09-01 00:00:00

  • Adenosine increases human platelet levels of cGMP through nitric oxide: possible role in its antiaggregating effect.

    abstract：:Adenosine is an endogenous antiaggregating substance that influences the platelet responses through specific A-type receptors that activate adenylate cyclase increasing the levels of 3',5'-cyclic adenosine monophosphate (cAMP). In this study, we investigated whether adenosine can also influence the levels of 3',5'-cyc...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00412-1

    authors： Anfossi G,Russo I,Massucco P,Mattiello L,Cavalot F,Balbo A,Trovati M

    更新日期：2002-01-01 00:00:00

  • No evidence for increased platelet activation in patients with hepatitis B- or C-related cirrhosis and hepatocellular carcinoma.

    abstract：INTRODUCTION:Cancer is a major risk factor for developing venous thromboembolism (VTE). Plasma hypercoagulability is an established risk factor for cancer-related VTE. In addition, thrombocytosis and hyperreactive platelets have been implicated in VTE and cancer progression. Cirrhosis is associated with changes in plat...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.11.016

    authors： Alkozai EM,Porte RJ,Adelmeijer J,Zanetto A,Simioni P,Senzolo M,Lisman T

    更新日期：2015-02-01 00:00:00

  • Feasibility of the Von Willebrand disease PREVENT trial.

    abstract：BACKGROUND:Despite treatment, women with von Willebrand disease (VWD) have lower von Willebrand factor (VWF) levels and greater blood loss at delivery than controls. Current weight-based dosing does not account for the ~1.5-fold increase in blood volume in pregnancy. METHODS:To evaluate the feasibility of a trial to p...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.05.022

    authors： Ragni MV,Machin N,James AH,Seaman CD,Malec LM,Kessler CM,Konkle BA,Kouides PA,Neff AT,Philipp CS,Brooks MM

    更新日期：2017-08-01 00:00:00

  • Inhibition by luciferin-luciferase reagents of aggregatory responses to excitatory agonists in washed platelet suspensions.

    abstract：:Addition of two commercial luciferin-luciferase reagents caused marked inhibition of the aggregatory response of washed human platelets to thrombin, ADP, vasopressin and platelet-activating factor (PAF). Analysis of the effects of the individual components of one of these reagents revealed that Mg2+, and to a lesser e...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90053-2

    authors： Thompson NT,Scrutton MC

    更新日期：1985-04-15 00:00:00

  • Antithrombin III deficiency as a risk factor for catheter-related central vein thrombosis in cancer patients.

    abstract：:The fibrin sleeve of venous catheters (VC) and parietal thrombi represent frequent and dangerous side-effects of central venous catheterization (CVC), due to the risk of embolism. Reduced levels of coagulation clotting factors inhibitors (such as Antithrombin III) are known to be associated with increased thrombogenic...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0049-3848(95)00041-0

    authors： De Cicco M,Matovic M,Balestreri L,De Angelis V,Fracasso A,Morassut S,Coran F,Babare R,Buonadonna A,Testa V

    更新日期：1995-04-15 00:00:00

  • Inhibition of human platelet aggregation by vitamin K.

    abstract：:The effect of several vitamin K (Vit K) analogues on the aggregation of human platelets was examined. The analogues were potent inhibitors of aggregation induced by ADP, thrombin, collagen and arachidonate but were less active against aggregation induced by the calcium ionophore A23187. Vit K3 also prevented platelet ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90037-4

    authors： Blackwell GJ,Radomski M,Moncada S

    更新日期：1985-01-01 00:00:00

  • On the inhibitory effect of chloroquine on blood platelet aggregation.

    abstract：:Chloroquine inhibited aggregation of rat blood platelets in a dose-dependent way. The inhibitory effect decreased, depending on the aggregation stimulus used, in the rank order of potency: ADP > thrombin > A23187. Effect of 1 millimolar chloroquine on A23187-stimulated aggregation was significantly decreased or comple...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90270-4

    authors： Jancinová V,Nosál R,Petríková M

    更新日期：1994-06-01 00:00:00

  • Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease.

    abstract：INTRODUCTION:The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI). MATERIALS AND METHODS:Patients with an AMI (n=202) randomly assigned to aspirin 160 ...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0049-3848(02)00405-x

    authors： Andersen K,Hurlen M,Arnesen H,Seljeflot I

    更新日期：2002-10-01 00:00:00

  • Inflammatory particles stimulate thromboplastin production by human monocytes.

    abstract：:Several inflammatory particles (zymosan, two forms of asbestos, carrageenan) and the soluble inflammatory agent dextran sulphate induced a dose- and time-dependent increase in thromboplastin activity of cultured human monocytes. Two weakly inflammatory particles (latex and anatase) had little effect. The increase larg...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90227-x

    authors： Dean RT,Prydz H

    更新日期：1983-05-15 00:00:00

  • Effect of dipyridamole on experimental disseminated intravascular coagulation in rats.

    abstract：:Experimental disseminated intravascular coagulation (DIC) can be induced by 4-h sustained infusion of endotoxin in a dose of 100 mg/kg in rats. The experimental model of DIC in rats was used to study the preventive effect of dipyridamole against DIC. Before the infusion of endotoxin, 0.5, 5.0 or 50.0 mg/kg of dipyrida...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90216-5

    authors： Yoshikawa T,Murakami M,Furukawa Y,Takemura S,Kondo M

    更新日期：1983-03-15 00:00:00

  • Are the antiplatelet and profibrinolytic properties of selective serotonin-reuptake inhibitors relevant to their brain effects?

    abstract：:The serotonin transporter (SERT) is found in neuron and platelet membranes. Selective serotonin-reuptake inhibitors (SSRIs) are widely prescribed for severe depression. They may at least partly counteract the effects of serotonin on the vascular biology system, can lower agonists-induced platelet activation, aggregati...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2014.02.028

    authors： Hoirisch-Clapauch S,Nardi AE,Gris JC,Brenner B

    更新日期：2014-07-01 00:00:00

  • Chronic kidney disease status modifies the association of CYP2C19 polymorphism in predicting clinical outcomes following coronary stent implantation.

    abstract：INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.07.039

    authors： Tabata N,Hokimoto S,Akasaka T,Arima Y,Kaikita K,Kumagae N,Morita K,Miyazaki H,Oniki K,Nakagawa K,Matsui K,Ogawa H

    更新日期：2014-11-01 00:00:00

  • A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women.

    abstract：BACKGROUND:Postmenopausal hormone therapy is associated with many diseases and conditions, e.g., cardiovascular diseases and asthma, but the underlying molecular mechanisms are incompletely understood. The aim of the current study was to investigate the effect of four different postmenopausal hormone therapy regimens o...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2011.12.009

    authors： Dahm AE,Eilertsen AL,Goeman J,Olstad OK,Ovstebø R,Kierulf P,Mowinckel MC,Skretting G,Sandset PM

    更新日期：2012-07-01 00:00:00

  • D-dimer specific monoclonal antibodies react with fibrinogen aggregates.

    abstract：:Human fibrinogen exposed to 46.5 degrees C was subjected to gel permeation chromatography. The protein eluted in two distinct peaks. The first peak appeared in the void volume containing soluble fibrinogen aggregates, while the other peak represented monomeric fibrinogen. In contrast to the monomeric peak material, th...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(96)00063-1

    authors： Bennick A,Haddeland U,Brosstad F

    更新日期：1996-04-15 00:00:00

  • Evaluation of platelet function and pharmacological platelet inhibition in patients with myeloproliferative disorders using multiple electrode aggregometry.

    abstract：BACKGROUND:The aim of this study was to describe platelet aggregation characteristics by multiple electrode aggregometry (MEA) and to evaluate MEA for its potential to detect platelet dysfunction and response to anti-aggregatory drugs in patients with myeloproliferative disorders (MPD). METHODS:We compared the platele...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2010.06.014

    authors： Robier C,Neubauer M,Sternad H,Quehenberger F,Rainer F,Neumeister P

    更新日期：2010-09-01 00:00:00

  • Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin.

    abstract：:Resveratrol (3, 4', 5-trihydroxystilbene), a natural polyphenol, is found in some plants that are used in human nutrition. Grapes are a major source for resveratrol, and a significant amount can also be found in red wine. Several experimental studies have demonstrated biological properties of resveratrol, especially i...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(02)00273-6

    authors： Olas B,Wachowicz B,Saluk-Juszczak J,Zieliński T

    更新日期：2002-08-15 00:00:00

  • Current status of thrombolytics-the need for better, especially safer, agents.

    abstract：:Clot dissolution using enzymes from the human fibrinolytic system has long been a goal of physicians and scientists. While recent focus has been on activators of the fibrinolytic system, new data support the use of plasmin itself. This supplement reviews the role of plasmin in fibrinolysis and locally administered pla...

    journal_title：Thrombosis research

    pub_type：

    doi：10.1016/j.thromres.2008.06.008

    authors： White GC 2nd

    更新日期：2008-01-01 00:00:00

  • Naproxen treatment prevents periprocedural inflammatory response but not myocardial injury after percutaneous coronary intervention.

    abstract：BACKGROUND AND AIM:Recent studies have documented that elevation of C-reactive protein (CRP) levels after percutaneous coronary intervention (PCI) have been predictive of adverse outcome. This study was performed to test the hypothesis that preprocedural use of naproxen sodium is associated with a reduction in the exte...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2006.11.003

    authors： Ozdol C,Gulec S,Rahimov U,Atmaca Y,Turhan S,Erol C

    更新日期：2007-01-01 00:00:00

  • Prior simvastatin treatment is associated with reduced thrombin generation and platelet activation in patients with acute ST-segment elevation myocardial infarction.

    abstract：BACKGROUND:It has been reported that statin therapy produces additional effects including impaired activation of blood coagulation. It is not clear whether statins can affect hemostasis in patients with acute coronary syndrome. The aim of this study was to investigate the effect of prior statin treatment on thrombin ge...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2009.06.021

    authors： Pastuszczak M,Kotlarz A,Mostowik M,Zalewski J,Zmudka K,Undas A

    更新日期：2010-05-01 00:00:00

  • CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators.

    abstract：:Fractalkine/CX3CR1 pathway is considered a major modulator of atherosclerosis. In the present study, expression of CX3CR1 on PBMCs/monocytes of healthy individuals and coronary artery diseased patients was initially assessed by flow cytometry. Effects of pre-inflammatory cytokines interferon (INF)-gamma and tumor necr...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2007.04.005

    authors： Apostolakis S,Krambovitis E,Vlata Z,Kochiadakis GE,Baritaki S,Spandidos DA

    更新日期：2007-01-01 00:00:00

  • Rho-kinase inhibitor treatment prevents pulmonary inflammation and coagulation in lipopolysaccharide-induced lung injury.

    abstract：INTRODUCTION:In the pathogenesis of sepsis-induced acute lung injury (ALI), the crosstalk between inflammation and coagulation plays a pivotal role. The aim of this study was to investigate the role of Rho kinase (ROCK) inhibitor in alleviating pulmonary inflammation and coagulation in lipopolysaccharide (LPS)-induced ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2016.12.020

    authors： Ding R,Zhao D,Li X,Liu B,Ma X

    更新日期：2017-02-01 00:00:00

  • Glycoprotein IIb-IIIa complex in platelets of patients and heterozygotes of Glanzmann's thrombasthenia.

    abstract：:The concentration of the glycoprotein (GP) IIb-IIIa complex in thrombasthenic platelets of 8 patients of 6 families has been estimated. In the thrombasthenic platelets of 3 patients this complex is absent (thrombasthenia type I and subtype I). In 2 patients only traces are detectable and in 3 patients GP IIb-IIIa comp...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90063-4

    authors： Herrmann FH,Meyer M,Gogstad GO,Solum NO

    更新日期：1983-12-15 00:00:00

  • Aggregation of platelets from monocrotaline pyrrole-treated rats.

    abstract：:Aggregation responses of platelet-rich plasma (PRP) from monocrotaline pyrrole (MCTP)-treated rats were examined to help elucidate the role of platelets in MCTP-induced pulmonary hypertension. PRP from rats treated one or four days earlier with MCTP (5 mg/kg, i.v.) or vehicle exhibited the same slope and maximum aggre...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90168-8

    authors： Hilliker KS,Deyo JA,Bell TG,Roth RA

    更新日期：1983-11-01 00:00:00

  • Ultrastructure and composition of thrombi in coronary and peripheral artery disease: correlations with clinical and laboratory findings.

    abstract：INTRODUCTION:Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS:Thrombi removed by t...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2015.02.004

    authors： Kovács A,Sótonyi P,Nagy AI,Tenekedjiev K,Wohner N,Komorowicz E,Kovács E,Nikolova N,Szabó L,Kovalszky I,Machovich R,Szelid Z,Becker D,Merkely B,Kolev K

    更新日期：2015-04-01 00:00:00

  • Growth and function of the normal human placenta.

    abstract：:The placenta is the highly specialised organ of pregnancy that supports the normal growth and development of the fetus. Growth and function of the placenta are precisely regulated and coordinated to ensure the exchange of nutrients and waste products between the maternal and fetal circulatory systems operates at maxim...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2004.06.038

    authors： Gude NM,Roberts CT,Kalionis B,King RG

    更新日期：2004-01-01 00:00:00

  • The presence of gamma' chain impairs fibrin polymerization.

    abstract：INTRODUCTION:A fraction of fibrinogen molecules contain an alternatively spliced variant chain called gamma'. Plasma levels of this variant have been associated with both myocardial infarction and venous thrombosis. Because clot structure has been associated with cardiovascular risk, we examined the effect of gamma' ch...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.11.016

    authors： Gersh KC,Nagaswami C,Weisel JW,Lord ST

    更新日期：2009-07-01 00:00:00

  • Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19*2 allele on clopidogrel responsiveness.

    abstract：INTRODUCTION:The first aim of this study is to evaluate the biological effect of doubling the maintenance dose of clopidogrel in pre-defined clopidogrel "low responders", compared to the biological effect of the standard dose in "responders". The second aim is to test the influence of the CYP 2C19*2 allele on clopidogr...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2007.06.012

    authors： Fontana P,Senouf D,Mach F

    更新日期：2008-01-01 00:00:00