Current status of thrombolytics-the need for better, especially safer, agents.

abstract：:Pergularain e I, a cysteine protease with thrombin-like activity, was purified by ion exchange chromatography from the latex of Pergularia extensa. Its homogeneity was characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), native PAGE and reverse-phase high-performance liquid chromatogr...

journal_title：Thrombosis research

authors： Shivaprasad HV,Rajaiah R,Frey BM,Frey FJ,Vishwanath BS

更新日期：2010-03-01 00:00:00

abstract：:The need for anticoagulation in dialysis patients is common and the incidence of venous thromboembolism (VTE) and atrial fibrillation in this population is high. While direct data are lacking on the management of anticoagulation in dialysis patients, careful weighing of risks and benefits on the basis of evidence from...

journal_title：Thrombosis research

authors： Lo DS,Rabbat CG,Clase CM

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Viscoelastometry enables rapid evaluation of coagulopathy in settings such as cardiac surgery but may be influenced by red cell concentration. METHODS:In order to study the effects of supra-physiological red cell concentrations on viscoelastometry, we compared ROTEM® viscoelastometry and plasma coagulatio...

journal_title：Thrombosis research

authors： Westbury SK,Lee K,Reilly-Stitt C,Tulloh R,Mumford AD

更新日期：2013-08-01 00:00:00

abstract：:Using a stable cross-linked SAK/plg complex, the effects of alpha 2-plasmin inhibitor on plasminogen activation by SAK were investigated. alpha 2-Plasmin inhibitor inhibited dose-dependently plasminogen activation by the SAK/plg complex. When FCB-2 or EACA was added to the reaction mixture of SAK/plg complex and alpha...

journal_title：Thrombosis research

authors： Okada K,Nonaka T,Matsumoto H,Fukao H,Ueshima S,Matsuo O

更新日期：1994-10-15 00:00:00

abstract：INTRODUCTION:Circulating levels of fibrinogen are associated with atherosclerosis and predict future coronary heart disease and stroke. Levels of fibrinogen are correlated among family members, suggesting a heritable component. Variants of the beta-fibrinogen gene subunit on 4q28 are associated with fibrinogen levels b...

journal_title：Thrombosis research

authors： Yang Q,Tofler GH,Cupples LA,Larson MG,Feng D,Lindpaintner K,Levy D,D'Agostino RB,O'Donnell CJ

更新日期：2003-04-15 00:00:00

abstract：INTRODUCTION:Even though thrombocytopenia following transcatheter aortic valve implantation (TAVI) has been described, further investigation of this phenomenon is needed. AIMS:To determine which factors may explain the fall in platelet count that occurs after implantation of a TAVI device, including markers of platele...

journal_title：Thrombosis research

authors： Mitrosz M,Kazimierczyk R,Sobkowicz B,Waszkiewicz E,Kralisz P,Frank M,Piszcz J,Galar M,Dobrzycki S,Musial WJ,Hirnle T,Kaminski KA,Tycinska AM

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Variability in platelet response to clopidogrel and its clinical relevance have been well described. However, the underlying mechanisms remain unclear. Recently, the T744C polymorphism of the P2Y12 receptor gene has been associated with enhanced platelet aggregation in healthy volunteers, suggesting a possib...

journal_title：Thrombosis research

authors： Cuisset T,Frere C,Quilici J,Morange PE,Saut N,Lambert M,Camoin L,Vague IJ,Bonnet JL,Alessi MC

更新日期：2007-01-01 00:00:00

abstract：:The role of free radical generation and its scavenging enzymes in circulating mice polymorphonuclear leukocytes (PMNLs) has been studied following pulmonary thromboembolism. Levels of malonaldehyde (MDA), 02- radical generation, activity of superoxide dismutase (SOD), catalase (CAT), lactate dehydrogenase (LDH), myelo...

journal_title：Thrombosis research

authors： Dikshit M,Kumari R,Srimal RC

更新日期：1992-05-01 00:00:00

abstract：INTRODUCTION:The low-molecular-weight heparins have been demonstrated to have antiangiogenic effects in various assays. We aimed to demonstrate and compare the antiangiogenic effects of four types of commercially available low-molecular weight heparins in the chick embryo chorioallantoic membrane model. MATERIALS AND ...

journal_title：Thrombosis research

authors： Dogan OT,Polat ZA,Karahan O,Epozturk K,Altun A,Akkurt I,Cetin A

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...

journal_title：Thrombosis research

authors： Tabata N,Hokimoto S,Akasaka T,Arima Y,Kaikita K,Kumagae N,Morita K,Miyazaki H,Oniki K,Nakagawa K,Matsui K,Ogawa H

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The quality of treatment with warfarin is mainly assessed by the time in therapeutic range (TTR) in patients with mechanical heart valve prosthesis (MHV). Our aim was to evaluate if International Normalized Ratio (INR) variability predicted a combined endpoint of thromboembolism, major bleeding and death bet...

journal_title：Thrombosis research

authors： Labaf A,Själander A,Stagmo M,Svensson PJ

更新日期：2015-12-01 00:00:00

abstract：:Whole blood electrical aggregometry (WBEA) has become an accepted method to gain quick information on platelet disorders. Compared to the optical method WBEA is closer to physiology and less complicated, but on the other hand more difficult to standardize. Different approaches have been attempted in the past to improv...

journal_title：Thrombosis research

authors： Müller MR,Schreiner W,Wohlfahrt A,Salat A,Wolner E

更新日期：1990-12-15 00:00:00

abstract：INTRODUCTION:Antithrombin deficiency is associated with increased risk of venous thromboembolism (VTE). We aimed to identify variants causing antithrombin deficiency in a Danish population. MATERIALS AND METHODS:We performed Sanger sequencing and, in relevant cases, multiplex ligation-dependent probe amplification ana...

journal_title：Thrombosis research

authors： Kjaergaard AD,Larsen OH,Hvas AM,Nissen PH

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:An association between high red cell distribution width (RDW) and venous thromboembolism (VTE) has been observed. However, it is not known whether this association differs within various manifestations of VTE, nor if there is an interaction between RDW and thrombophilia abnormalities on the risk of VTE. AIM...

journal_title：Thrombosis research

authors： Bucciarelli P,Maino A,Felicetta I,Abbattista M,Passamonti SM,Artoni A,Martinelli I

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:Only sparse information exists on the use of direct oral anticoagulant (DOAC) testing and the impact on clinical management. Here, we evaluated the clinical impact of DOAC measurements in a real-life clinical setting. Moreover, number of tests performed in relation to number of DOAC-treated patients was ev...

journal_title：Thrombosis research

authors： Winther-Larsen A,Hvas AM

更新日期：2019-03-01 00:00:00

abstract：:Protein C has been measured by three different assays (antigenic, amidolytic and chronometric) in 27 end-stage renal insufficient patients before and after hemodialysis. Protein C levels have been compared with other coagulation inhibitors (antithrombin III, protein S) and fibrinolytic parameters. Baseline anticoagula...

journal_title：Thrombosis research

authors： Nguyen P,Toupance O,Chanard J,Potron G

更新日期：1993-03-15 00:00:00

abstract：:Upon stimulation or apoptosis, eukaryotic cells shed membrane vesicles of submicron size. These so-called microparticles (MPs) are detected and characterized based on the exposure of antigens characteristic of their respective parental cells and on the increased distribution of negatively charged phospholipids to the ...

journal_title：Thrombosis research

authors： Lechner D,Weltermann A

更新日期：2008-01-01 00:00:00

abstract：:We investigated on how to effectively administer orally factor VIII preparation to two patients with von Willebrand's disease as volunteers, and the following results were obtained: Bleeding time and aPTT were shortened, but no change of PT was observed. Factor VIII:C increased slightly, but no significant increase wa...

journal_title：Thrombosis research

authors： Sakuragawa N,Niiya K,Kondo S

更新日期：1985-06-15 00:00:00

abstract：INTRODUCTION:Colorectal cancer (CRC) is often complicated by thromboembolic episodes. It has been recognized that blood coagulation proteins play a role in cancer progression. An important inhibitory mechanism is provided by the protein C (PC) system consisting of PC, protein S (PS) and thrombomodulin (TM). Recently, n...

journal_title：Thrombosis research

authors： Sierko E,Wojtukiewicz MZ,Zawadzki R,Zimnoch L,Kisiel W

更新日期：2010-03-01 00:00:00

abstract：:An abnormal prothrombin has been detected in a 26-year-old female, who had no history of excessive bleeding. Prothrombin activity was approximately 10% when measured using either the classical one-stage assay or the assay with Echis carinatus venom, whereas prothrombin antigen level was normal. In keeping with current...

journal_title：Thrombosis research

authors： Morishita E,Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Yamazaki M,Hachiya H,Okamura M,Matsuda T

更新日期：1991-06-15 00:00:00

abstract：INTRODUCTION:Hemolytic uremic syndrome is a thrombotic microangiopathy. Clopidogrel, a recently developed platelet aggregation inhibitor, has not been previously reported as a treatment for this illness. Our study's objective was to explore the efficacy and safety of clopidogrel in children with diarrhea associated hem...

journal_title：Thrombosis research

authors： Seltz LB,Bakel LA,Tiehen J,Gao D,Cadnapaphornchai MA,Lum G,Ford D

更新日期：2012-09-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a common complication in patients with malignant disease. In addition to well-established acquired risk factors for VTE, several genetic risk factors, mainly related to the haemostatic system, are known to influence thrombotic risk. However, the contribution of gene abnormalities to thr...

journal_title：Thrombosis research

authors： Ramacciotti E,Wolosker N,Puech-Leao P,Zeratti EA,Gusson PR,del Giglio A,Franco RF

更新日期：2003-02-15 00:00:00

abstract：:Therapeutic developments have seen significant improvement in mortality over the past thirty years for breast, colorectal and prostate cancer. Lung cancer is the commonest cancer in the world, but has seen little improvement in survival figures. The role of low-molecular-weight heparin (LMWH) in improving cancer survi...

journal_title：Thrombosis research

authors： Noble S

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Procoagulant activity of heparanase has been recently described in several arterial and venous thrombotic disorders. In this study, we aimed to investigate the role of heparanase with regard to thrombus burden, thromboembolism, and treatment success with unfractionated heparin (UFH) in patients with prosth...

journal_title：Thrombosis research

authors： Bayam E,Kalçık M,Gürbüz AS,Yesin M,Güner A,Gündüz S,Gürsoy MO,Karakoyun S,Cerşit S,Kılıçgedik A,Candan Ö,Yaman A,Özkan M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Clauss fibrinogen assay (CFA) is widely used as a screening test to detect fibrinogen disorders. However, CFA alone cannot distinguish quantitative and qualitative defects because it depends on functional fibrinogen activity (Ac), and fibrinogen antigen (Ag) determination is required to classify fibrinogen d...

journal_title：Thrombosis research

authors： Suzuki A,Suzuki N,Kanematsu T,Shinohara S,Arai N,Kikuchi R,Matsushita T

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:Post-thrombotic syndrome (PTS) is a chronic sequel of deep vein thrombosis (DVT). The clot structure and fibrinolytic potential in PTS is currently unknown. OBJECTIVE:To assess the fibrinolytic potential and clot structure in patients with PTS. MATERIALS AND METHODS:Patients with a history of DVT were in...

journal_title：Thrombosis research

authors： Bouman AC,McPherson H,Cheung YW,Ten Wolde M,Ten Cate H,Ariëns RAS,Ten Cate-Hoek AJ

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism (VTE) occurs frequently in at-risk hospitalized patients, and prophylaxis of VTE is significantly underused. We sought to preliminarily assess the validity of Caprini risk assessment model, a famous individual VTE risk assessment model, in Chinese hospitalized patients with VTE. MAT...

journal_title：Thrombosis research

authors： Zhou HX,Peng LQ,Yan Y,Yi Q,Tang YJ,Shen YC,Feng YL,Wen FQ

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...

journal_title：Thrombosis research

authors： Desai PC,Brittain JE,Jones SK,McDonald A,Wilson DR,Dominik R,Key NS,Parise LV,Ataga KI

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect of CYP2C19 polymorphism and co-therapy with esomeprazole on the antiplatelet efficacy of clopidogrel. BACKGROUND:The antiplatelet efficacy of clopidogrel depends on CYP2C19 polymorphism or the co-administration of some kind of proton pump inhibitor (PPI). ...

journal_title：Thrombosis research

authors： Hokimoto S,Akasaka T,Tabata N,Arima Y,Tsujita K,Sakamoto K,Kaikita K,Morita K,Kumagae N,Yamamoto E,Oniki K,Nakagawa K,Ogawa H

更新日期：2015-06-01 00:00:00

abstract：:The release of arachidonic acid, and its subsequent conversion to thromboxane A2, is an important component of platelet activation. The precise mechanism of arachidonic acid release is unknown although cytosolic phospholipase A2 (cPLA2) has been implicated. In the present study the effects of three agonists, the serin...

journal_title：Thrombosis research

authors： McNicol A,Shibou TS

更新日期：1998-10-01 00:00:00