Abstract:
BACKGROUND:Variability in platelet response to clopidogrel and its clinical relevance have been well described. However, the underlying mechanisms remain unclear. Recently, the T744C polymorphism of the P2Y12 receptor gene has been associated with enhanced platelet aggregation in healthy volunteers, suggesting a possible mechanism for modulation of clopidogrel response. AIM OF THIS STUDY:To assess whether the clopidogrel response may be influenced by the T744C P2Y12 gene polymorphism in patients with non ST elevation acute coronary syndrome (NSTE ACS). METHODS:597 NSTE ACS patients were included in our study and were divided into 3 groups: CC homozygotes, CT heterozygotes ad TT homozygotes. All patients received loading doses of 600 mg clopidogrel and 250 mg aspirin at least 12 hours before blood samples. Clopidogrel response was assessed by post-treatment ADP 10 micromol/L-induced platelet aggregation (ADP-Ag), VASP phosphorylation (PRI VASP) and P-selectin expression (PS). Clopidogrel resistance was defined by persistence of High Post-treatment Platelet Reactivity (HPPR=ADP-Ag>70%). RESULTS:Significant variability in the distribution of platelet parameters was observed in the overall study population. No significant difference in platelet parameter profiles was observed within patients having the same genotype, for ADP-Ag (p=0.39), PRI VASP (p=0.97) and PS (p=0.62). The genotype frequencies of the T744C polymorphism of the P2Y12 gene were similar in responders and non responders defining by HPPR (p=0.75). CONCLUSION:Our study did not show any influence of the T744C polymorphism of the P2Y12 receptor gene on clopidogrel response assessed by ADP-Ag, PRI VASP or P-selectin expression in NSTE ACS patients.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Cuisset T,Frere C,Quilici J,Morange PE,Saut N,Lambert M,Camoin L,Vague IJ,Bonnet JL,Alessi MCdoi
10.1016/j.thromres.2007.01.012subject
Has Abstractpub_date
2007-01-01 00:00:00pages
893-9issue
6eissn
0049-3848issn
1879-2472pii
S0049-3848(07)00045-Xjournal_volume
120pub_type
杂志文章abstract::COVID-19 has been associated with an increased risk of thrombotic events; however, the reported incidence of deep vein thrombosis varies depending, at least in part, on the severity of the disease. Aim of this prospective, multicenter, observational study was to investigate the incidence of lower limb deep vein thromb...
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pub_type: 杂志文章,多中心研究
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更新日期:2015-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析,评审
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更新日期:2020-02-01 00:00:00
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更新日期:2014-08-01 00:00:00
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更新日期:2012-07-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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更新日期:2007-01-01 00:00:00