Association between red cell distribution width and risk of venous thromboembolism.

abstract：:Platelets occupy a central role at the interface between thrombosis and inflammation. At sites of vascular damage, adherent platelets physically and functionally interact with circulating leukocytes. Activated platelets release soluble factors into circulation that may have local and systemic effects on blood and vasc...

journal_title：Thrombosis research

authors： Li Z,Yang F,Dunn S,Gross AK,Smyth SS

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The treatment of venous thromboembolism (VTE) in cancer patients remains controversial. PURPOSE:The Italian Society for Thrombosis and Haemostasis (SISET) commissioned a project to develop clinical practice guidelines for the therapy of VTE in patients with malignancies. METHODS:Key questions about the tre...

journal_title：Thrombosis research

authors： Imberti D,Di Nisio M,Donati MB,Falanga A,Ghirarduzzi A,Guarneri D,Piovella F,Santoro RC,Baldini E,Zampogna S,Italian Society for Thrombosis and Haemostasis.

更新日期：2009-11-01 00:00:00

abstract：:Experimental disseminated intravascular coagulation (DIC) can be induced by 4-h sustained infusion of endotoxin in a dose of 100 mg/kg in rats. The experimental model of DIC in rats was used to study the preventive effect of dipyridamole against DIC. Before the infusion of endotoxin, 0.5, 5.0 or 50.0 mg/kg of dipyrida...

journal_title：Thrombosis research

authors： Yoshikawa T,Murakami M,Furukawa Y,Takemura S,Kondo M

更新日期：1983-03-15 00:00:00

abstract：:A recently developed platelet aggregometer using a laser light scattering method is capable of monitoring the increase in size of small-sized platelet aggregates (diameter 9-25 microm), which cannot be detected with the conventional methods. Whether coronary spasm can cause platelet aggregation in the coronary circula...

journal_title：Thrombosis research

authors： Miyamoto S,Ogawa H,Soejima H,Takazoe K,Kajiwara I,Shimomura H,Sakamoto T,Yoshimura M,Kugiyama K,Yasue H,Ozaki Y

更新日期：2001-09-01 00:00:00

abstract：:Using high-resolution real-time two-dimensional ultrasound, we have investigated the role of red cells in the growth of already established platelet aggregates under controlled flow conditions. Platelet rich plasma (PRP) was circulated in vitro in horizontally and vertically arranged tubing at mean shear rate ranging ...

journal_title：Thrombosis research

authors： Machi J,Sigel B,Ramos JR,Justin JR,Feinberg H,LeBreton GC,Robertson AL Jr

更新日期：1984-10-01 00:00:00

abstract：:Heparin with low affinity (LA-heparin) to antithrombin III (AT III) enhanced the rate of inactivation of thrombin by AT III. The enhancement of the rate was saturable with AT III and was proportional to the LA-heparin concentration. Although the rate-enhancement in the presence of LA-heparin decreased with increase in...

journal_title：Thrombosis research

authors： Oshima G,Nagasawa K

更新日期：1986-02-01 00:00:00

abstract：:RS-5186, sodium 6-[2-[1-(1H)-imidazolyl]methyl-4,5-dihydrobenzo[b]thiophene]- carboxylate, inhibited platelet thromboxane A2 (TXA2) synthetase with IC50 values of 6 nM and 13 nM for human and rabbit microsomes, respectively. It had a selectivity for TXA2 synthetase 10(5)-fold greater than that for cyclooxygenase, PGI2...

journal_title：Thrombosis research

authors： Ushiyama S,Ito T,Asai F,Oshima T,Terada A,Matsuda K,Yamazaki M

更新日期：1988-09-01 00:00:00

abstract：:Preanalytical and biological variability both have strong influences on test results of coagulation. Beyond age and gender, increasing emphasis is now being given to a variety of demographic and lifestyle variables, including ethnicity, smoking, diet, and exercise, which should be taken into account when interpreting ...

journal_title：Thrombosis research

authors： Lippi G,Favaloro EJ,Franchini M,Guidi GC

更新日期：2008-01-01 00:00:00

abstract：:An unfractionated heparin (UFH) and a depolymerised derivative of low molecular weight heparin (LMWH) have been compared for their ability to activate platelets suspended in citrated plasma (PRP) or after washing and suspension in hepes buffered tyrode containing fibrinogen. Neither heparin alone induced aggregation o...

journal_title：Thrombosis research

authors： Westwick J,Scully MF,Poll C,Kakkar VV

更新日期：1986-05-15 00:00:00

abstract：:Five criteria for poor response to a 20 min venous occlusion test were applied to 58 patients 3 months or more after acute deep vein thrombosis (DVT). The criteria were arbitrarily defined as the last 5 percentiles of response distributions in an age- and sex-matched healthy control group of 51 subjects. The criteria ...

journal_title：Thrombosis research

authors： Stegnar M,Peternel P,Keber D,Vene N

更新日期：1991-11-15 00:00:00

abstract：:Hypercoagulable states can be detected by measuring activation peptides, enzyme-inhibitor complexes, and fibrin/fibrinogen degradation products, which are markers of hemostatic activation. A series of these prethrombotic markers has been evaluated in the elderly, pregnancy, diabetes and acute myocardial infarction pat...

journal_title：Thrombosis research

authors： López Y,Paloma MJ,Rifón J,Cuesta B,Páramo JA

更新日期：1999-01-15 00:00:00

abstract：:Several inflammatory particles (zymosan, two forms of asbestos, carrageenan) and the soluble inflammatory agent dextran sulphate induced a dose- and time-dependent increase in thromboplastin activity of cultured human monocytes. Two weakly inflammatory particles (latex and anatase) had little effect. The increase larg...

journal_title：Thrombosis research

authors： Dean RT,Prydz H

更新日期：1983-05-15 00:00:00

abstract：:Hemophilia patients with inhibitors against FVIII/FIX present with a major challenge in the clinical practice. In the 1970s such patients were treated in association with emergency situations and essential surgery using huge amounts of FVIII/FIX concentrates often preceded by extracorporal adsorption of antibodies aga...

journal_title：Thrombosis research

authors： Hedner U

更新日期：2010-04-01 00:00:00

abstract：:In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfuncti...

journal_title：Thrombosis research

authors： van der Land V,Peters M,Biemond BJ,Heijboer H,Harteveld CL,Fijnvandraat K

更新日期：2013-01-01 00:00:00

abstract：:The pharmacokinetics of a low molecular weight heparin (LMWH) with a mean mw of 4000-6000 D (KABI 2165, Fragmin) was studied in 6 healthy volunteers after intravenous (iv) and subcutaneous (sc) administration of 120 U (anti FXa)/kg. The half-life in plasma of the anti FXa activity after iv injection was 119 +/- 17 min...

journal_title：Thrombosis research

authors： Bratt G,Törnebohm E,Widlund L,Lockner D

更新日期：1986-06-01 00:00:00

abstract：INTRODUCTION:We conducted this prospective study in order to investigate the hypotheses that an alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass (CPB) surgery and major abdominal surgery and that the levels of fibrin degradation products digested by polymorphonucle...

journal_title：Thrombosis research

authors： Gando S,Kameue T,Sawamura A,Hayakawa M,Hoshino H,Kubota N

更新日期：2007-01-01 00:00:00

abstract：:Hemostatic challenges occur throughout the period of stem cell transplantation (SCT). Endothelial cells injury due to chemotherapy, growth factors, intravenous catheter, and graft-versus-host disease and profound thrombocytopenia are the major components involved in the hemostatic complications. Diffuse alveolar hemor...

journal_title：Thrombosis research

authors： Nadir Y,Brenner B

更新日期：2007-01-01 00:00:00

abstract：:Activated platelets secrete different chemokines, among others CCL5, thereby triggering inflammatory cell recruitment into the vessel wall. Here, we investigated how CCL5 deficiency influences vascular remodeling processes. Experiments were performed in apolipoprotein E and CCL5 double deficient (ApoE(-/-)×CCL5(-/-)) ...

journal_title：Thrombosis research

authors： Czepluch FS,Meier J,Binder C,Hasenfuss G,Schäfer K

更新日期：2016-08-01 00:00:00

abstract：:The enzymatic activities of uPA, and a collagenase-like proteinase in the post-nuclear fraction of cell homogenates of a metastatic carcinomatous cell line following X-ray irradiation were examined by the use of chromogenic substrates and by casein- or gelatin-containing zymographies and electrophoretic gel stained wi...

journal_title：Thrombosis research

authors： Uchida N,Takahashi K,Kasai T,Ishida T,Kwaan HC

更新日期：1994-06-15 00:00:00

abstract：:A blinded randomized multicenter trial of two non-activated prothrombin complex concentrates was carried out to determine the clinical effectivity in the treatment of acute hemarthrosis in hemophiliac patients with inhibitors. The one product was prepared via DEAE Sephadex chromatography, while the second was fraction...

journal_title：Thrombosis research

authors： Gomperts ED,Fannon RB,Lee ML,Kingdon HS,Kantrowitz JL,Addiego JE Jr,Carney J,Corrigan JJ,Hathaway W,Hilgartner MW

更新日期：1986-06-15 00:00:00

abstract：:Washed human platelets were incubated with commercial factor VIII concentrate, or with purified factor VIII coagulant moiety. Platelets were then washed again and lysed by sonication. VIII:Ag and vWf:Ag were measured in the platelet lysate prior to and after incubation of the lysate with phospholipase C (PL-C). Platel...

journal_title：Thrombosis research

authors： Muntean W,Leschnik B,Haas J

更新日期：1987-02-15 00:00:00

abstract：INTRODUCTION:Cancer associated thrombosis is a well-recognized phenomenon that results in considerable patient morbidity and mortality. Malignancy conveys an increased risk for thrombosis and chemotherapy further elevates this risk. The pathophysiological mechanisms underlying this process remain poorly defined. MATER...

journal_title：Thrombosis research

authors： Boles JC,Williams JC,Hollingsworth RM,Wang JG,Glover SL,Owens AP 3rd,Barcel DA,Kasthuri RS,Key NS,Mackman N

更新日期：2012-02-01 00:00:00

abstract：:Activation of human plasminogen by human tissue-type plasminogen activator (t-PA) is accelerated in the presence of cyanogen bromide digests of human fibrin(ogen). In the present study a possible species specificity of this phenomenon was investigated. All combinations of the plasminogens, fibrin monomers and cyanogen...

journal_title：Thrombosis research

authors： Nieuwenhuizen W,Keyser J

更新日期：1985-06-15 00:00:00

abstract：:β(2)glycoprotein I (β(2)GPI) is the major antigen in the antiphospholipid syndrome. It has been shown that β(2)GPI can adapt to different conformations, a circular, a S-shaped and a J-shaped conformation. In literature anticoagulant properties of β(2)GPI have been indicated, though there is no consensus on how β(2)GPI...

journal_title：Thrombosis research

authors： Ninivaggi M,Kelchtermans H,Lindhout T,de Laat B

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:Bleeding after cardiac surgery may be caused by surgical factors, impaired haemostasis, or a combination of both. Transfusion of blood products is used to improve haemostasis, but little is known about what combination is optimal. We hypothesized that addition of both fibrinogen and platelets to blood samp...

journal_title：Thrombosis research

authors： Shams Hakimi C,Fagerberg Blixter I,Hansson EC,Hesse C,Wallén H,Jeppsson A

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS:Thrombi removed by t...

journal_title：Thrombosis research

authors： Kovács A,Sótonyi P,Nagy AI,Tenekedjiev K,Wohner N,Komorowicz E,Kovács E,Nikolova N,Szabó L,Kovalszky I,Machovich R,Szelid Z,Becker D,Merkely B,Kolev K

更新日期：2015-04-01 00:00:00

abstract：:The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific ...

journal_title：Thrombosis research

authors： Hoffmeister KM,Falet H

更新日期：2016-05-01 00:00:00

abstract：:When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. These derivatives are able to combine with human or bovine elastin to form a very stable a...

journal_title：Thrombosis research

authors： Rabaud M,Lefebvre F,Piquet Y,Belloc F,Chevaleyre J,Roudaut MF,Bricaud H

更新日期：1986-07-15 00:00:00

abstract：INTRODUCTION:To test the hypothesis that the platelet microparticle (PMP) and endothelial microparticle (EMP) may contribute to the hypercoagulability associated with microvascular thrombosis in patients with nontraumatc osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS:The study comprised 46 patients wh...

journal_title：Thrombosis research

authors： Kang P,Shen B,Yang J,Pei F

更新日期：2008-01-01 00:00:00

abstract：:A quantitative assessment was made of the distribution of arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) among the individual sub-classes (diacyl, alkylacyl, alkenylacyl) of the various platelet phospholipids of human subjects consuming a fish oil concen...

journal_title：Thrombosis research

authors： Holub BJ,Celi B,Skeaff CM

更新日期：1988-04-01 00:00:00