Soluble fibrinogen derivatives generated by thrombin: affinity for elastin.

abstract：:Collagen-induced platelet aggregation and secretion (ATP-release) in whole-blood and platelet-rich plasma was compared. Although the amount of ATP released was comparable in whole-blood and platelet-rich plasma, the maximum extent of aggregation was greater when platelets were studied in their natural milieu, i.e. who...

journal_title：Thrombosis research

authors： Joseph R,Welch KM,D'Andrea G,Riddle JM

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:The optimal prevention measures against hemodialysis (HD)-associated complications, including all-cause thrombotic events and death, are unclear. METHODS:This prospective study was designed to assess the effect of aspirin on prevention of HD-associated complications. Patients were divided into four groups a...

journal_title：Thrombosis research

authors： Yang Y,Wang C,Jin L,Chen G,Li C,Qi K,Kong D,Wang Y,Song M,Ma L

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Increased levels of circulating tissue factor (TF)-positive microvesicles (MVs) may increase the risk of thrombosis. Indeed, TF-positive MVs are detected in plasma of patients with various types of diseases. In this study, we measured levels of MV TF activity in non-cancer severely ill patients and cancer ...

journal_title：Thrombosis research

authors： Hisada Y,Thålin C,Lundström S,Wallén H,Mackman N

更新日期：2018-05-01 00:00:00

abstract：:Four monoclonal antibodies have been produced, which are specific for the Ca2+ or Sr2(+)-induced conformation of human factor IX. Certain, but not all, gamma-carboxy-glutamic acid residues in factor IX are involved in the epitope expression together with the conformation stabilized by the adjacent region of Gla-domain...

journal_title：Thrombosis research

authors： Sugo T,Mizuguchi J,Kamikubo Y,Matsuda M

更新日期：1990-06-15 00:00:00

abstract：:Fibrin is found in most solid tumours, and there is speculation regarding its role in tumour invasion and metastasis. An assay to quantitate fibrin levels in tissues would be a useful preliminary tool in assessing the above. Such an assay to quantitatively detect levels of fibrin in various types of canine tumour was ...

journal_title：Thrombosis research

authors： Raut S,McEvoy F,Gaffney PJ

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Advances in medical and surgical therapy in children have resulted in increased survival in children with primary illnesses. However, thrombosis is a serious complication of this success and results in mortality and morbidity. Prevention or treatment of thrombosis using warfarin is challenging in children du...

journal_title：Thrombosis research

authors： Bauman ME,Black K,Kuhle S,Wang L,Legge L,Callen-Wicks D,Mitchell L,Bajzar L,Massicotte MP,Western Canadian Children's Heart Network WCCHN.

更新日期：2009-03-01 00:00:00

abstract：:Hemophilia patients with inhibitors against FVIII/FIX present with a major challenge in the clinical practice. In the 1970s such patients were treated in association with emergency situations and essential surgery using huge amounts of FVIII/FIX concentrates often preceded by extracorporal adsorption of antibodies aga...

journal_title：Thrombosis research

authors： Hedner U

更新日期：2010-04-01 00:00:00

abstract：:The role of Protein C in combined factor V/VIII deficiency was examined by reducing the Protein C concentration using warfarin therapy in a patient with the combined deficiency. The factor VIII deficiency was like Hemophilia-A, with deficiency of VIII:C and VIII:C(Ag), but normal VIIIR:Ag and VIIIR:cof. The factor V d...

journal_title：Thrombosis research

authors： Bern MM,Suzuki K,Mann K,Tracy P,Hoyer L,Jensen W,Gallivan M,Arkin C,Davis G

更新日期：1984-12-15 00:00:00

abstract：:Three collagenases were purified from the culture medium of human skin fibroblasts using ammonium sulfate fractionation, ion-exchange chromatography and gel filtration. The cationic collagenase had a molecular weight of 42,000; two anionic collagenases had molecular weights of 63,000 and 115,000. Preincubation of the ...

journal_title：Thrombosis research

authors： Pisoni R,Ciaglowski RE,Brown RK,Walz DA

更新日期：1984-07-15 00:00:00

abstract：OBJECTIVES:To measure the variations of different parameters in the hemostatic system and to analyze their roles in the development of hemostatic disorder in patients with orthotopic liver transplantation (OLT) procedures routinely performed without venovenous bypass. METHODS:The blood coagulation and fibrinolysis par...

journal_title：Thrombosis research

authors： Wang Y,Liu Y,Han R,Zhu Z,Zhang Y,Wang X,Wang L,Shen Z

更新日期：2008-01-01 00:00:00

abstract：:Homogenous preparations of human and rabbit platelets synthesized platelet-activating factor (PAF) when stimulated by calcium ionophore A23187. PAF was isolated by high performance liquid chromatography (HPLC) on a Lichrosorb Si60 column. PAF was well separated from other phospholipids especially sphingomyelin and lys...

journal_title：Thrombosis research

authors： Alam I,Smith JB,Silver MJ

更新日期：1983-04-01 00:00:00

abstract：PURPOSE:The right ventricular outflow tract (RVOT) velocity time integral (VTI), an echocardiographic measure of stroke distance, correlates with cardiac index. We sought to determine the prognostic significance of low RVOT VTI on clinical outcomes among patients with acute pulmonary embolism (PE). MATERIALS AND METHO...

journal_title：Thrombosis research

authors： Yuriditsky E,Mitchell OJL,Sista AK,Xia Y,Sibley RA,Zhong J,Moore WH,Amoroso NE,Goldenberg RM,Smith DE,Brosnahan SB,Jamin C,Maldonado TS,Horowitz JM

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Antithrombin deficiency is associated with increased risk of venous thromboembolism (VTE). We aimed to identify variants causing antithrombin deficiency in a Danish population. MATERIALS AND METHODS:We performed Sanger sequencing and, in relevant cases, multiplex ligation-dependent probe amplification ana...

journal_title：Thrombosis research

authors： Kjaergaard AD,Larsen OH,Hvas AM,Nissen PH

更新日期：2019-03-01 00:00:00

abstract：:A platelet storage pool deficiency (SPD) is present in platelets from cattle with the Chediak-Higashi syndrome (CHS). The most plausible hypothesis for the SPD is that dense granule precursors are simply not formed in CHS megakaryocytes. There is, however, evidence that some recently acquired 5-hydroxytryptamine (5HT)...

journal_title：Thrombosis research

authors： Meyers KM,Costa JL,Magnuson J

更新日期：1990-05-01 00:00:00

abstract：INTRODUCTION:Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR). MATERIALS AND METHODS:To test the hypothesis of relative warfarin resistance i...

journal_title：Thrombosis research

authors： Ames PR,Margaglione M,Ciampa A,Colaizzo D,Ferrara F,Iannaccone L,Vincenzobrancaccio

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND/AIMS:The plasminogen activator (PA)-plasmin system is primarily involved in fibrinolysis, but is also in the patho/physiological events in which breakdown of extracellular matrices is evoked topically. In this present study, we examined the expression of fibrinolytic factors, tissue-type PA (t-PA) and Type 1...

journal_title：Thrombosis research

authors： Noguchi T,Matsuyama S,Akao M,Hagiwara H,Uno S,Seki T,Ariga T

更新日期：2001-11-15 00:00:00

abstract：:The present study has evaluated the effect of some newly synthesized triphenylethylene (TPE) analogs on platelet arachidonic acid metabolism and function. All compounds tested inhibited arachidonic acid induced platelet aggregation and several were superior to aspirin in their relative potency. Introduction of a carbo...

journal_title：Thrombosis research

authors： Rao GH,John V,Hill TD,Vennerstrom JL,White JG,Holmes TJ Jr

更新日期：1986-11-15 00:00:00

abstract：BACKGROUND:The methodology of thromboprophylaxis post minimally invasive esophagectomy (MIE) is unclear. Thus, we compared the efficacy and safety of fondaparinux and nadroparin on the prophylaxis of venous thromboembolism (VTE) after MIE. MATERIALS AND METHODS:We conducted a randomized, double-blind, treatment-contro...

journal_title：Thrombosis research

authors： Song J,Xuan L,Wu W,Shen Y,Tan L,Zhong M

更新日期：2018-06-01 00:00:00

abstract：:The concentration of the glycoprotein (GP) IIb-IIIa complex in thrombasthenic platelets of 8 patients of 6 families has been estimated. In the thrombasthenic platelets of 3 patients this complex is absent (thrombasthenia type I and subtype I). In 2 patients only traces are detectable and in 3 patients GP IIb-IIIa comp...

journal_title：Thrombosis research

authors： Herrmann FH,Meyer M,Gogstad GO,Solum NO

更新日期：1983-12-15 00:00:00

abstract：BACKGROUND:To investigate the impact of atrial fibrillation/flutter (AF) on adverse in-hospital outcomes in hospitalized surgical patients. METHODS:The nationwide German inpatient sample of the years 2005-2018 was used for this analysis. Surgical patients were stratified by AF and compared. Logistic regression models ...

journal_title：Thrombosis research

authors： Keller K,Hobohm L,Engelhardt M

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease. The aim of the study was to investigate the association of neutrophil activation with acute TTP, to assess whether neutrophil activation chang...

journal_title：Thrombosis research

authors： Mikes B,Sinkovits G,Farkas P,Csuka D,Schlammadinger A,Rázsó K,Demeter J,Domján G,Réti M,Prohászka Z

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Proteasome inhibitor bortezomib (PS-341) has been the first proteasome inhibitor that has entered clinical trials with its antiproliferative and proapoptotic effects in patients with multiple myeloma. Recent studies indicate that proteasome inhibitors can be useful in prevention of experimental arterial th...

journal_title：Thrombosis research

authors： Avcu F,Ural AU,Cetin T,Nevruz O

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Medically ill, hospitalized patients are at increased risk for venous thromboembolism (VTE) after discharge. This study aimed to examine thromboprophylaxis patterns, risk factors, and post-discharge outcomes. METHODS:This was a retrospective claims analysis involving administrative claims data and in-pati...

journal_title：Thrombosis research

authors： Mahan CE,Fisher MD,Mills RM,Fields LE,Stephenson JJ,Fu AC,Spyropoulos AC

更新日期：2013-11-01 00:00:00

abstract：:The diagnosis of preeclampsia, with all of its consequences, is at times difficult to establish, especially when the patient has underlying chronic hypertension and is not known from prior prenatal care visits. Many screening tests have been proposed. These should be sensitive, relatively specific, easy to perform, of...

journal_title：Thrombosis research

authors： Saleh AA,Bottoms SF,Gerbasi FR,Mammen EF

更新日期：1994-07-15 00:00:00

abstract：:Two anti-cardiolipin antibody (ACA)-producing cell lines were established, using Epstein-Barr virus transformation followed by a repeated cluster-picking from the same individual with antiphospholipid syndrome who had a history of 8 consecutive fetal losses and deep venous thrombosis. Characterization of the two ACAs ...

journal_title：Thrombosis research

authors： Hasegawa I,Suzuki T,Ishii S,Takakuwa K,Tanaka K

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:To date, only a few case studies have reported occurrence of thrombosis in patients with VonWillebrand disease (VWD). No studies have looked at its incidence in this patient population. The aim of this study was to test our hypothesis that decreased VonWillebrand factor (VWF) levels confer a protective effect...

journal_title：Thrombosis research

authors： Qureshi W,Hassan S,Dabak V,Kuriakose P

更新日期：2012-11-01 00:00:00

abstract：:Epsilon-amino-caproic acid (EACA) induces a clinically-useful anti-haemorrhagic, mildly thrombotic state while ellagic acid (EA) induces a severe hypercoagulable one. Reversal of these states may on occasion be necessary. The effectiveness of the antiplatelet drugs, aspirin and dipyridamole (ASA/D), in reducing thromb...

journal_title：Thrombosis research

authors： Iomhair MM,Lavelle SM

更新日期：1996-06-15 00:00:00

abstract：:One of the primary and most serious treatment-related complications in haemophilia A is the formation of anti-factor VIM (FVIII) antibodies, which significantly impacts patient care. For these patients, immunomodulatory therapy becomes important to induce immunological tolerance to FVIII. Immune tolerance induction (I...

journal_title：Thrombosis research

authors： Kreuz W

更新日期：2008-01-01 00:00:00

abstract：:The effects of hydrogen peroxide on factor Xa-catalyzed prothrombin activation on the surface of vascular endothelial cells, and the inhibitory effect of sphingosine on prothrombin activation were studied in cultured calf pulmonary artery endothelial cells (CPAEC). Hydrogen peroxide enhanced factor Xa-catalyzed prothr...

journal_title：Thrombosis research

authors： Tanabe S,Tamaki T,Wada Y

更新日期：1992-07-01 00:00:00

abstract：:The fibrinogen molecule consists of two sets of Aalpha, Bbeta, and gamma chains assembled into a bilateral disulfide linked (Aalpha, Bbeta, gamma)2 structure. Cleavage of the two A-fibrinopeptides (FPA, Aalpha1-16) from normal Aalpha chains with arginine at position 16 (RFPA) by thrombin or the venom enzyme atroxin tr...

journal_title：Thrombosis research

authors： Shainoff JR,Ratnoff OD,Smejkal GB,DiBello PM,Welches WR,Lill H,Mitkevich OV,Periman P

更新日期：2001-01-15 00:00:00