Abstract：
:Preanalytical and biological variability both have strong influences on test results of coagulation. Beyond age and gender, increasing emphasis is now being given to a variety of demographic and lifestyle variables, including ethnicity, smoking, diet, and exercise, which should be taken into account when interpreting laboratory data. However, there is strong emerging evidence that additional environmental influences, such as pollutants and environmental chemicals, might contribute in a major way to biological variability. A large body of epidemiological evidence now exists to support the view that air pollutants are responsible for shortened prothrombin time, and decreased factor VII, tissue plasminogen activator and platelet count; on the other hand, evidence also suggests that air pollutants may significantly increase fibrinogen, factor VIII, von Willebrand factor and platelet hyperactivity. Although it is impractical to develop reference ranges specific to the daily concentration of air pollutants, the potential influence of air pollution on results of coagulation testing should be recognised when interpreting laboratory findings.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Lippi G,Favaloro EJ,Franchini M,Guidi GCdoi
10.1016/j.thromres.2008.04.010subject
Has Abstractpub_date
2008-01-01 00:00:00pages
50-4issue
1eissn
0049-3848issn
1879-2472pii
S0049-3848(08)00156-4journal_volume
123pub_type
杂志文章,评审abstract：BACKGROUND:Intravenous fluids can impair coagulation and affect the endothelial glycocalyx, whereas glycocalyx shedding itself can cause an impairment of clot formation and firmness. We hypothesized that hydroxyethyl starch 6% (130/0.4) has a more distinct effect on coagulation and glycocalyx shedding than albumin 5%. ...
journal_title：Thrombosis research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.thromres.2019.10.020
更新日期：2019-11-01 00:00:00
abstract：:Clot dissolution using enzymes from the human fibrinolytic system has long been a goal of physicians and scientists. While recent focus has been on activators of the fibrinolytic system, new data support the use of plasmin itself. This supplement reviews the role of plasmin in fibrinolysis and locally administered pla...
journal_title：Thrombosis research
pub_type：
doi：10.1016/j.thromres.2008.06.008
更新日期：2008-01-01 00:00:00
abstract：:A dimorphism in PROS1 gene (c.A2,001G, p.Pro667Pro) has been associated with significantly reduced levels of both free and total protein S in carriers of the GG genotype. It is not known how the GG genotype could influence PS levels in normals, whether it could influence the levels of protein S in carriers of mutation...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2006.10.014
更新日期：2007-01-01 00:00:00
abstract：:We tested whether inhibition of platelet activation by nitric oxide (NO) might be altered by strenuous exercise. Sixteen healthy male non-smokers, aged 20-26 years, underwent treadmill testing. All subjects reached Bruce stage IV without chest pain or abnormal ST-T wave changes. Platelet aggregation by Born's method a...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(97)00162-x
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:Deep vein thrombosis (DVT) is a common multi-factorial disease with a partially understood aetiology. Although the roles of high factor (F)VIII and von Willebrand factor (VWF) levels are recognized, that of ADAMTS13 is still unclear. AIM:To assess the association between ADAMTS13 activity levels, VWF antige...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2020.10.037
更新日期：2021-01-01 00:00:00
abstract：INTRODUCTION:Incidence and risk factors of venous thromboembolism (VTE) are well established in surgical and medical settings, but data in psychiatric units are lacking. The aim of this study was to estimate the incidence of VTE in hospitalized psychiatric patients, and to assess the risk factors for VTE in this specif...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2012.10.002
更新日期：2012-12-01 00:00:00
abstract：:[3H]-Platelet activating factor (Paf-acether, 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) binds to washed human platelets in a specific, dose-dependent, and saturable manner. Scatchard analysis reveals a high affinity site with a KD value of 0.25 +/- 0.033 nM (245 +/- 30 sites per platelet), and a second low a...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(86)90233-1
更新日期：1986-01-15 00:00:00
abstract：INTRODUCTION:Although accumulating evidence within the past 5 years strongly supports the importance of platelet P2X(1) receptors in hemostasis and thrombosis, P2X(1) receptors of platelet and/or its progenitor cell, megakaryocyte, have not been fully characterized. The aim of this study was to electrophysiologically a...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2006.03.007
更新日期：2007-01-01 00:00:00
abstract：:The procoagulant cellular activity (PCA) of leukemic cells was evaluated, before and after endotoxin stimulation, in 38 patients with acute leukemia at presentation subdivided according to the FAB classification. In the M4 and M5 subgroups the stimulated leukemic cells showed a significant increase in the production o...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90317-3
更新日期：1987-03-01 00:00:00
abstract：:Antithrombotic activity of ten pyrazolo pyrimidine derivatives was tested in mouse pulmonary thromboembolism model. Out of these compounds, Thiopurinol (C5H4N4S) showed dose-dependent protection in mice from death/paralysis induced by collagen + adrenaline. It also caused dose-dependent inhibition of thrombus formatio...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(89)90138-2
更新日期：1989-06-15 00:00:00
abstract：:The effect of extracellular matrix components on lipopolysaccharide-induced vascular endothelial cell injury was studied by using lipopolysaccharide-susceptible bovine aortic endothelial cells. For evaluation of lipopolysaccharide-induced injury, we estimated DNA synthesis and cell detachment of bovine aortic endothel...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(99)00226-1
更新日期：2000-04-15 00:00:00
abstract：BACKGROUND:Cancer patients have an increased risk of thrombosis. Tissue factor (TF) antigen and TF activity associated with microparticles in plasma are elevated in patients with various types of cancer. Of these two measurements, TF activity is considered superior to TF antigen levels because the activity more closely...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2007.12.023
更新日期：2008-01-01 00:00:00
abstract：:Danazol, a synthetic androgen reported to increase factor VIII and IX activity levels, was given to 6 hemophiliacs. With danazol therapy (600 mg/da) the APTTs shortened by 30-45% of pre-treatment times. However, the activity levels of the deficient factors did not increase significantly nor consistently with the APTT ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90126-4
更新日期：1985-07-01 00:00:00
abstract：:Previous studies indicated that human placental anticoagulant protein, a member of the lipocortin family, prolonged the clotting time of normal plasma when clotting was induced by brain thromboplastin or by kaolin in the presence of cephalin and calcium. Using a two-stage amidolytic assay to assess factor X activation...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90402-6
更新日期：1987-11-15 00:00:00
abstract：INTRODUCTION:Cell surface thiol isomerase enzymes, principally protein disulphide isomerase (PDI), have emerged as important regulators of platelet function and tissue factor activation via their action on allosteric disulphide bonds. Allosteric disulphides are present in other haemostasis-related proteins, and we have...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.01.034
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:Dabigatran (Dabi) is not routinely monitored. However, in emergency cases quantitative assessment is required and laboratories must provide suitable tests at all hours. Little is known about Dabi effects on thrombin generation. MATERIALS AND METHODS:Patient samples (n=241) were analyzed for functional Dab...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.04.032
更新日期：2015-07-01 00:00:00
abstract：INTRODUCTION:The prevalence and etiology of occult bleeding among patients on warfarin who are screened systematically for new anemia is largely unknown. We aimed to estimate the usefulness of following hemoglobin and mean red cell volume (MCV) with INR in order to screen for developing anemia as an indicator of occult...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2012.05.005
更新日期：2012-09-01 00:00:00
abstract：:The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific ...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/S0049-3848(16)30370-X
更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:Avoiding intracranial hemorrhage (ICH) during warfarin therapy is critical but little is known about factors that affect warfarin-related ICH outcomes. We aimed to define the impact of warfarin on ICH incidence rates and to identify baseline clinical characteristics of patients who experienced ICH and fact...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.10.024
更新日期：2013-01-01 00:00:00
abstract：:Endothelial cells synthesize and release different proteins involved in their function, and some of these proteins may play important roles in the cellular response to injury, infection, or glucocorticoids. We have examined the profile of proteins released from rabbit coronary microvascular endothelial (RCME) and huma...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90202-n
更新日期：1990-01-01 00:00:00
abstract：UNLABELLED:Disturbances of coagulation and fibrinolysis have been reported in patients with chronic uremia. Studies of different coagulation and fibrinolysis parameters in regularly dialyzed patients have yielded conflicting results. Global fibrinolytic capacity (GFC) examines the function of the entire fibrinolytic sy...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2004.08.014
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:According to US Food and Drugs Administration (FDA), 2 hour recombinant tissue plasminogen activator (rt-PA) 100mg infusion is recommended for eligible patients with acute pulmonary embolism (PE). However,there exists evidence implying that a lower dosage of rt-PA can be equally effective but p...
journal_title：Thrombosis research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.thromres.2013.12.026
更新日期：2014-03-01 00:00:00
abstract：:The efficacy and the safety of a new urokinase dosage regimen (loading dose 250,000 IU, initial maintenance dosage 2,000 IU/kg/h in combination with heparin) was studied in ten cases of deep vein thrombosis with regard to the changes of the blood coagulation and fibrinolytic enzyme system. The coagulation analyses dem...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(82)90210-9
更新日期：1982-01-01 00:00:00
abstract：INTRODUCTION:Plasminogen activator inhibitor (PAI-1) may have an independent prognostic value in breast cancer (BC). PAI-1 4G/5G polymorphism may have significance for antigen expression. Thus, we analyzed the possible associations between PAI-1 4G/5G polymorphism, plasma PAI-1 levels, and clinicopathological features ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2009.02.014
更新日期：2009-09-01 00:00:00
abstract：:The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal ro...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2013.04.017
更新日期：2013-06-01 00:00:00
abstract：:Human fibrinogen exposed to 46.5 degrees C was subjected to gel permeation chromatography. The protein eluted in two distinct peaks. The first peak appeared in the void volume containing soluble fibrinogen aggregates, while the other peak represented monomeric fibrinogen. In contrast to the monomeric peak material, th...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(96)00063-1
更新日期：1996-04-15 00:00:00
abstract：:Anticoagulants are effective for preventing both venous and arterial thrombosis. Although antithrombotic agents have been reported to reduce thrombin formation, to our knowledge, the relation between blood viscosity (BV) and antithrombotic agents has not been examined. We examined the effects on whole BV of various do...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(01)00359-0
更新日期：2001-12-01 00:00:00
abstract：:Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPG) on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis. Evidence was provided that heparanase over-expression in canc...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/S0049-3848(10)70018-9
更新日期：2010-04-01 00:00:00
abstract：:The interaction of platelets with collagen involves short aminoacid sequences which recur along the fibres. Platelet aggregation by collagen and serotonin release is inhibited by a synthetic octapeptide LYS-PRO-GLY-GLU- PRO-GLY-PRO-LYS- derived from type III collagen. In contrast, this octapeptide inhibits only weakly...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(83)90061-0
更新日期：1983-12-15 00:00:00
abstract：INTRODUCTION:Hemodialysis grafts often fail because of stenosis at the venous anastomosis resulting in thrombosis. Percutaneous intervention involves thrombolysis with plasminogen activators, mechanical removal of thrombus, and angioplasty of the stenotic lesions. OBJECTIVES:This article describes a phase I trial usin...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2008.06.020
更新日期：2008-01-01 00:00:00
